疏筋活血汤加减方治疗126例腰腿痛气滞血瘀证患者的临床疗效观察

目的:探讨疏筋活血汤加减方治疗腰腿痛气滞血瘀证的临床疗效研究。方法:腰腿痛气滞血瘀证患者126例,将其随机分为观察组68例和对照组58例。对照组口服双氯芬酸钠双释放肠溶胶囊,观察组内服中药疏筋活血汤加减方,并将药渣敷于患处。观察指标为临床疗效评价,VAS评分,M-JOA评分,ODI评分,IL-6和NO,血液流变学。结果:患者经治疗后观察指标具有显著变化,临床总有效率高于对照组;VAS评分、ODI评分明显降低,M-JOA评分升高IL-6、NO和血液流变学均下降,观察组变化幅度明显高于对照组,有统计学意义(P0.05)。结论:疏筋活血汤加减方治疗腰腿痛气滞血瘀证能有效缓解患者的临床症状,改善患者腰腿部功能,疗效满意。     

补肾祛瘀法治疗先兆流产的研究进展

先兆流产是孕期最常见的一种并发症,据流行病学调查其发病率高达10%~15%,属于中医学中的"胎漏、胎动不安"、"妊娠腹痛"等范畴。导致胎漏、胎动不安的主要病机是冲任受损、胎元不固。常见分型有肾虚、血热、气血虚弱和血瘀型[1]。但临床上以肾虚血瘀型最为常见,现就近年来临床上用补肾祛瘀法治疗肾虚血瘀型先兆流产的研究进展作综述。     

The effects of transport by pneumatic tube system on blood cell count,erythrocyte sedimentation and coagulation tests

Introduction:

Today, the pneumatic tube transport system (PTS) is used frequently because of its advantages related to timing and speed. However, the impact of various types of PTS on blood components is unknown. The aim of this study was to examine the influence of PTS on the quality of routine blood cell counts, erythrocyte sedimentation, and certain blood coagulation tests.

Materials and methods:

Paired blood samples were obtained from each of 45 human volunteers and evaluated by blood cell count, erythrocyte sedimentation, and several coagulation tests, including prothrombin time (PT) and activated partial thromboplastin time (aPTT). Blood samples were divided into 2 groups: Samples from group 1 were transported to the laboratory via the PTS, and samples from group 2 were transported to the laboratory manually. Both groups were evaluated immediately by the tests listed above.

Results:

The blood sample test results from groups 1 and 2 were evaluated and compared. No statistically significant differences were observed (P = 0.069–0.977).

Conclusion:

The PTS yielded no observable effects on blood cell counts, erythrocyte sedimentation, or PT and aPTT test results. We concluded that the PTS can be used to transport blood samples and yield reliable results for blood cell counts, erythrocyte sedimentation, and several coagulation tests.     

化瘀法治疗慢性阻塞性肺疾病的研究进展

目的:收集整理并总结化瘀法治疗慢性阻塞性肺疾病(慢阻肺)的文献资料并形成论文。方法:利用文献检索数据库收集相关文献资料并进行整理分析。结果:总结化瘀法治疗慢性阻塞性肺疾病(COPD)的中医理论基础、作用机理及近几年来该法在COPD中的应用。结论:所整理的文献资料具有实用价值,为该研究提供了参考依据。     

A microfluidic chip for direct and rapid trapping of white blood cells from whole blood

Blood analysis plays a major role in medical and science applications and white blood cells (WBCs) are an important target of analysis. We proposed an integrated microfluidic chip for direct and rapid trapping WBCs from whole blood. The microfluidic chip consists of two basic functional units: a winding channel to mix and arrays of two-layer trapping structures to trap WBCs. Red blood cells (RBCs) were eliminated through moving the winding channel and then WBCs were trapped by the arrays of trapping structures. We fabricated the PDMS (polydimethylsiloxane) chip using soft lithography and determined the critical flow velocities of tartrazine and brilliant blue water mixing and whole blood and red blood cell lysis buffer mixing in the winding channel. They are 0.25 μl/min and 0.05 μl/min, respectively. The critical flow velocity of the whole blood and red blood cell lysis buffer is lower due to larger volume of the RBCs and higher kinematic viscosity of the whole blood. The time taken for complete lysis of whole blood was about 85 s under the flow velocity 0.05 μl/min. The RBCs were lysed completely by mixing and the WBCs were trapped by the trapping structures. The chip trapped about 2.0 × 10³ from 3.3 × 10³ WBCs.     

创业政策与创业模式匹配对创业绩效影响机制

尽管我国创业活动在全球经济体处于活跃状态,但我国的创业成功率较低。这主要是因为我国创业政策供给与异质性创业模式的匹配度不高。以供需匹配为视角,借助MOS模型,运用独立样本t检验法和多元层次回归分析法,实证分析了创业政策与创业模式匹配对创业绩效的影响机制。研究结果表明：（1）动机激发和机会增加政策有助于提升生存推动型创业者的自我效能感,为其提供更多的创业资源和创业机会;（2）动机激发和技能培育政策有助于增强机会拉动型创业者的创业自信心,提升其专业知识和实践技能;（3）机会增加和技能培育政策有助于扩展创新驱动型创业者的社会网络,提升其组织管理能力。鉴于此,政府应采取异质性的创业政策供给,即关注生存推动型创业者的动机激发和机会增加,注重机会拉动型创业者的动机强化和技能培育,侧重创新驱动型创业者的技能提升和机会增加。     

Development and validation of a low cost blood filtration element separating plasma from undiluted whole blood

Clinical point of care testing often needs plasma instead of whole blood. As centrifugation is labor intensive and not always accessible, filtration is a more appropriate separation technique. The complexity of whole blood is such that there is still no commercially available filtration system capable of separating small sample volumes (10-100 μl) at the point of care. The microfluidics research in blood filtration is very active but to date nobody has validated a low cost device that simultaneously filtrates small samples of whole blood and reproducibly recovers clinically relevant biomarkers, and all this in a limited amount of time with undiluted raw samples. In this paper, we show first that plasma filtration from undiluted whole blood is feasible and reproducible in a low-cost microfluidic device. This novel microfluidic blood filtration element (BFE) extracts 12 μl of plasma from 100 μl of whole blood in less than 10 min. Then, we demonstrate that our device is valid for clinical studies by measuring the adsorption of interleukins through our system. This adsorption is reproducible for interleukins IL6, IL8, and IL10 but not for TNFα. Hence, our BFE is valid for clinical diagnostics with simple calibration prior to performing any measurement.     

痰瘀互结型高血压病的中医治疗研究进展

研究表明,高血压与痰瘀关系十分密切,而随着生活水平改变,痰瘀互结已成为高血压病的主要常见中医证型,文章就近十年来痰瘀互结型高血压病因病机、相关客观指标、中医药治疗进展作一综述。     

基于SFA模型的科技环境对区域技术效率的影响研究

技术效率是决定经济增长的关键要素,而科技环境是影响技术效率的重要因素,研究科技环境对技术效率的影响对于促进经济增长意义重大。本文研究的科技环境因素包括科技人力资源、政府科技投入和高科技产业规模等。运用随机前沿方法,本文对2000-2006年期间全国28个省、自治区和直辖市的技术效率及其科技环境影响因素进行了回归估计。研究结果表明,我国地区之间的技术效率两级分化严重,东部地区各省市的平均技术效率明显高于中西部地区,全国各地区的技术效率随时间的推移大体呈下降趋势,科技人力资源、政府科技投入和高科技产业规模与技术效率损失显著地负相关。根据以上研究结果,本文最后提出了一系列相关的政策建议。