Non-fragile quantized H∞ output feedback control for nonlinear systems with quantized inputs and outputs

This paper is concerned with non-fragile $H_{\infty }$ control problems for a class of continuous-time nonlinear systems with unknown nonlinearity and quantized inputs and outputs. The construction of both static output feedback (SOF) and observer-based output feedback (OBOF) control laws in the presence of additive interval-bounded controller coefficient variations can be divided into two parts, linear and nonlinear parts. The linear part plays a role in achieving the $H_{\infty }$ performance, while the nonlinear part is used to reduce the quantization effect. However, it should be pointed out that the effect of input and output quantization can be eliminated fully for SOF case by requiring knowledge of all signs of the states, but only the effect of input quantization can be eliminated for OBOF case. It is worth mentioning that three novel alternative methods with strict linear matrix inequality (LMI) conditions are proposed to design both SOF and OBOF controllers. In particular, these three new methods do not introduce any other auxiliary constraints as many existing results do where a matrix equality constraint between system matrix and Lyapunov matrix is often inserted. Finally, the effectiveness and advantages of the proposed control methods are demonstrated by a numerical example.     

Amplification of Antioxidant Activity of Haptoglobin(2-2)–Hemoglobin at Pathologic Temperature and Presence of Antibiotics

It is clear that Haptoglobin binds to Hemoglobin strongly and irreversibly. This binding, protects body tissues against heme-mediated oxidative tissue damages via peroxidase activity of Haptoglobin–Hemoglobin complex. Peroxidase activity of Haptoglobin(2-2)–Hemoglobin complex was determined via measurement of following increase in absorption of produced tetraguaiacol as the second substrate of Haptoglobin–Hemoglobin complex by UV–Vis spectrophotometer at 470 nm and 42°C. The results are showing that peroxidase activity of Haptoglobin(2-2)–Hemoglobin complex is modulated by homotropic effect of hydrogen peroxide as the allosteric substrate. On the other hand, antioxidant activity of Haptoglobin(2-2)–Hemoglobin is increased via heterotropic effect of two antibiotics (especially ampicillin) on the peroxidase activity of the complex. The condition of pathologic temperature along with the administration of ampicillin and/or coamoxiclav is in favor of amplification in antioxidant activity of Haptoglobin(2-2)–Hemoglobin and combating against free radicals in individuals with Hp2-2 phenotype. Therefore, oxidative stress effects have been diminished in the population with this phenotype.     

New General Manager of China Patent Agent (H.K.) Ltd. and Head of China Patents & Trademarks Have Taken Office

Mr Ding Zhongze has resigned, for reason of age, from post of general manager of the China Patent Agent (H.K.) Ltd. and head of the China Patents & Trademarks. Mr Wu Dajian, newly appointed General Manager of the China Patent Agent (H.K.) Ltd. and Head of the China Patents & Trademarks, took office on 11 November 2005.     

Correlation of Microalbuminuria with Estimated GFR (eGFR) by Cockcroft–Gault and MDRD Formula in Type 2 Diabetics and Hypertensives

Increase in urine albumin excretion rate (AER) precede a fall in glomerular filtration rate in patients developing diabetic chronic kidney disease (CKD). Our results have shown that 7 (50 %) of diabetic and hypertensive individuals with decreased GFR do not have increased AER. In this cross-sectional study, we measured AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric method. We correlated the results with eGFR values obtained by Cockcroft–Gault and MDRD method. The method used was not a compensated method. We measured serum creatinine by modified Jaffe’s kinetic method in autoanalyzer XL-600. Analysis of data showed positive correlation between eGFR and microalbuminuria by both the methods with eGFR <60 mL/min/1.73 m². Pearson’s correlation co-efficient (r) was 0.9 (p = 0.0001) by Cockcroft–Gault formula and 0.69 (p = 0.0063) by MDRD formula. Our results concluded that there was positive correlation between AER and eGFR <60 mL/min/1.73 m². We have recognized that these two parameters provide a complimentary benefit in management of cases with CKD.