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1.
Hem Lata G. K. Ahuja A. P. S. Narang Lily Walia 《Indian journal of clinical biochemistry : IJCB》2004,19(2):1-4
Stress is one of the basic factors in the aetiology of a number of diseases such as atherosclerosis, coronary heart disease,
aging, liver disease etc. Hence this work was designed to study the effect of stress in the form of forced immobilisation
stress on lipid peroxidation and lipid profile in rabbits. The study was conducted in 25 healthy rabbits of either sex. Rabbits
were subjected to forced immobilisation for two hours everyday for consecutive seven days. Blood samples were collected on
day 1, 3 and 7 after immobilisation period. Malondialdehyde (MDA), a marker of lipid peroxidation was estimated by TBA assay
method. Lipid profile was analysed by multichannel autoanalyser. There was statistically significant increase in MDA, total
cholesterol, LDL, VLDL and triglycerides with immobilisation. These findings indicate that stress in the form of forced immobilisation
increases lipid peroxidation and alter lipid profile, which may be responsible for pathophysiology of various diseases. 相似文献
2.
Dorota Kostrzewa-Nowak Robert Nowak Zbigniew Jastrz?bski Aleksandra Zar?bska Marta Bichowska Izabela Drobnik-Kozakiewicz ?ukasz Radzimiński Agata Leońska-Duniec Krzysztof Ficek Pawe? Ci?szczyk 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(1):103-113
Background
Numerous data suggest that aerobic-type exercise improves lipoprotein-lipid profiles, cardiorespiratory fitness and body composition in young women. The aim of this study was to evaluate the biological response to high-low impact aerobic fitness among young women.Materials and methods
Thirty-four young women aged 22 (19-24) years were divided into three groups: underweight (N = 10), normal weight (N = 12) and overweight (N = 12). Aerobic capacity, anthropometry and body composition together with complete blood count and lipid profile were determined before and after completion of a 12-week-long training period.Results
The training programme caused a significant decrease in weight (by 4.3 kg, P = 0.003), body mass index (by 1.3 kg/m2, P = 0.003), free fat mass (by 2.1 kg, P = 0.002), total body water (by 0.4 kg, P = 0.036), percentage of fat (by 3 percent points, P = 0.002), all analyzed skinfolds thicknesses, as well as the lipid profile in overweight group, and no changes in normal weight group. Significant changes in weight (by 4.2 kg, P = 0.005), body mass index (by 0.9 kg/m2, P = 0.005), crus skinfold thickness (by 3.3 mm, P = 0.028), and in maximum oxygen uptake (by 2.49 mL/kg/min; P = 0.047) were observed among underweight women. No change in total blood count was observed in all groups.Conclusion
Twelve-week-long fitness training programme of two alternating styles (low and high impact) has a beneficial effect on overweight young women.Key words: body composition, physical fitness, overweight, women 相似文献3.
Abana, a herbal preparation of Himalaya Drug Co. significantly increases HDL—cholesterol and lowers LDL—cholesterol. Moreover, it antagonises the HDL lowering effect of metoprolol. 相似文献
4.
H. K. Jassi A. Jain Sarika Arora R. Chitra 《Indian journal of clinical biochemistry : IJCB》2010,25(2):201-207
Soy isoflavones and soy proteins are being considered as possible alternatives to postmenopausal hormone replacement therapy.
This study was undertaken to evaluate effects of these two preparations on symptoms and lipid profile in postmenopausal women.
The study was done in 75 postmenopausal women with FSH levels = 30 mIU/ml. These women were randomly divided into 3 groups
(n=25). Study group I was given soy proteins 30gm/day containing 60 mg soy isoflavones. Study group II was given soy isoflavones
(60 mg/day). The control group was given casein protein 30 gm/day. The menopausal symptoms were assessed by Kupperman Index.
Fasting blood samples were analyzed for serum lipid profile, apolipoprotein A1 and B, Leutenizing Hormone (LH) and Follicle-Stimulating
Hormone (FSH) at the beginning of therapy, 4 and 12 weeks after initiation of therapy. A highly significant improvement in
postmenopausal symptoms was observed in both the study groups. A highly significant improvement was seen in serum lipid profile
and Apolipoprotein A1 and B in women taking soy proteins whereas women taking soy isoflavones demonstrated significant improvement
in serum triglycerides only. Both soy proteins and soy isoflavones are helpful in alleviating postmenopausal symptoms but
soy proteins offer a greater health advantage due to their beneficial effect on serum lipid profile. 相似文献
5.
Maninder Kaur Kiranjeet Kaur Gurdeep Kaur Bedi Gurpreet Singh Sidhu Roopan Sikand 《Indian journal of clinical biochemistry : IJCB》2000,15(2):63-67
Forty patients suffering from mild to moderate degree of hypertension were put on felodipine. Their lipid profile was analysed
before the start of their therapy and consecutively at two and four months after starting felodipine. There was a statistically
significant fall in the levels of serum cholesterol, serum triglycerides and serum total lipids; though no appreciable variation
was observed in HDL and LDL cholesterol levels. At baseline there were a few patients who had higher than the normal range
of the serum lipid profile. Analysis of these patients showed a highly significant fall in the levels of serum cholesterol,
serum triglycerides, serum LDL-cholesterol and serum total lipids i.e. felodipine modified the lipid profiles of hypertensive
patients in a positive way. 相似文献
6.
N. P. Suryawanshi A. K. Bhutey A. N. Nagdeote A. A. Jadhav G. S. Manoorkar 《Indian journal of clinical biochemistry : IJCB》2006,21(1):126-130
The study was designed to find out the correlation between lipid peroxidation, lipoprotein levels to severity and complication
of diabetes mellitus. Degree of lipid peroxidation was measured in terms of malondialdehyde (MDA) along with lipid profile
and blood glucose in diabetes mellitus. It is categorised into insulin dependent diabetes mellitus (IDDM), non insulin dependent
diabetes mellitus (NIDDM) and diabetes mellitus(DM) with complication.
Total 112 known diabetic patients and 52 non-diabetic controls were studied. These patients were grouped as per the concentration
of fasting blood glucose level i.e. controlled, poorly controlled, and uncontrolled group. There are significant increase
in the lipid peroxide (MDA) and lipid profile except HDL cholesterol which is decreased, has been found in all groups as compared
to controls In NIDDM group lipid peroxidation was markedly increased than IDDM group and it was higher in DM with complications.
Other finding observed was that the level of lipid peroxide increased as per the increase in concentration of blood glucose.
The increase lipid peroxidation in the hyperglycemic condition may be explained, as the superoxide dismutase enzyme which
is antioxidant becomes inactive due the formation of superoxide radical within the cell. Maximum lipid peroxidation leads
to the damage of the tissue and organs which results into complication in diabetic patients. High levels of total cholesterol
appear due to increased cholesterol synthesis. The triglyceride levels changes according to the glycemic, control. The increase
may be due to overproduction of VLDL-TG.
It is concluded that good metabolic control of hyperglycemia will prevent in alteration in peroxidation and the lipid metabolism,
which may help in good prognosis and preventing manifestation of vascular and secondary complication in diabetes mellitus. 相似文献
7.
M. Nandini M. Abdul Rahiman S. Narasimha Rao 《Indian journal of clinical biochemistry : IJCB》2000,15(2):161-166
The effect of dietary supplementation with Oil sardine (Sardinella longiceps) fish at 2/3 fat replacement, on serum lipids in the cholesterol-stressed copper loaded rats was studied. Hypercholesterolemic
state observed during copper toxicity was not alleviated by sardines. Copper loading significantly decreased the triglyceride
levels and the activity of β-hydroxy β-methyl glutaryl (HMG) CoA reductase. Fish supplementation was further effective in
reducing the triglyceride levels in copper loaded rats. Significant increase in the serum phospholipid was observed in the
fish supplemented rats during copper overload. The finding suggests that hypolipidemic potential of fish is certainly altered
to some extent in copper toxicity since, it is well known that copper enhances the formation of free radicals. Thus it may
be concluded that sardine fish is not effective in reducing the cholesterol levels during copper toxicity. 相似文献
8.
近几年我国高中学生体质测试结果呈现逐年下降趋势。文章探讨有氧运动对高三学生身体素质和心肺功能的影响。方法:采用对比实验的方法,实验前后均采用TSN100系列学生体质测量仪器、TSN100-TJ系列台阶指数脉搏测试仪、意大利COSMED肺功能测试仪采集数据。结论:10周有氧运动能改善体质较差的高三学生的身体素质和心肺功能。 相似文献
9.
Ajai Kumar M. C. Pant H. N. Pandey J. L. Aggarwal R. S. Sharma L. D. Joshi S. Singh 《Indian journal of clinical biochemistry : IJCB》1993,8(1):47-50
Effect of feeding ripe and unripe papaya fruit pulps were investigated on blood lipid profile of normal male adult albino rabbits by giving them pulps separately at the dose of 15 and 30g per day along with standard diet over a period of six weeks. As compared to controls both fruit pulps resulted in highly significant (p<0.001) and consistent lowering of serum cholesterol, low density lipoprotein cholesterol and triglycerides and elevation in phospholipids and high density lipoprotein cholesterol levels at 1,3 and 6 weeks of fruit pulp feeding indicating a dose dependent effect. Observations clearly support medicinal value ofC. Papaya in the management of atherosclerosis, fatty liver, ischaemic changes and consequential myocardial infarction. 相似文献
10.
Jayanta De Ananda Mukhopadhyay Pradip Kumar Saha 《Indian journal of clinical biochemistry : IJCB》2006,21(2):165-168
Four groups of subjects: normal healthy normotensive nonpregnant women (Group A), normal normotensive pregnant women (Group
B), women with preeclamptic toxaemia (Group C) and eclamptic women (Group D): with fifty subjects in each group, were investigated
for serum lipid profile in the third trimester of pregnancy. There was significant increase in serum triglyceride and VLDL
cholesterol leve as well as decrease in LDL cholesterol in normal pregnancy, while total cholesterol and HDL cholesterol levels
did not show any statistically significant alteration. The preeclampsia (Group C) was associated with a significant rise in
triglyceride and VLDL cholesterol and fall in HDL cholesterol concentration, while eclamptic women showed significant fall
in HDL cholesterol and rise in LDL cholesterol as compared to normal pregnant women. However, interestingly, elevation of
the ratios of total cholesterol: HDL cholesterol and triglyceride: HDL cholesterol as well as diminuition of the ratio of
HDL cholesterol: VLDL cholesterol showed statistical significance in pregnancy induced hypertension in both Groups C and D,
while eclamptic women showed significant elevation of LDL cholesterol: HDL cholesterol ratio in addition. 相似文献
11.
Shivananda Nayak Arun Maiya Manjunath Hande 《Indian journal of clinical biochemistry : IJCB》2005,20(1):47-51
The role of treadmill exercise on blood glucose homeostasis in noninsulin dependent diabetes mellitus (NIDDM) were studied
using males between age of 45 and 60 years (X-52), who were clinically and biochemically-confirmed cases of NIDDM were taken
into study group. Control group comprised of 10 males between age group of 45 to 60 (X-53) years. All the subjects were assessed
by physician and were investigated to confirm diabetic status. The whole study period was extended for 6 weeks. The significant
decrease in postprandial blood sugar (44.4 mg% for the study group and 32.2mg% for the control group) with a significant inter
group difference (P<0.05) was observed. The mean decrease in fasting blood sugar (39.4mg% for the study group and 27.4mg%
for the control group), with a marginal inter group difference (P<0.05) was observed. The treadmill exercise was found to
be a definite tool in addition to drug and diet in glycemic control. 相似文献
12.
12hrs fasting samples of 1485 apparently healthy, Assamese population in the age group of 20–80 yrs., mostly from the urban
area of Assam were tested for serum lipid profile that includes total cholesterol, triacylglycerol, high density lipoprotein
cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) over
a period of three years. The values (median and range in mg/dl) obtained were 170 (93–263); 110 (40–256); 40 (23–73); 103
(40–173) and 22 (8–51) respectively. After grouping these subjects according to the age and sex no significant difference
were observed between most of the groups. Median and upper range of total cholesterol, HDL-C and LDL-C were found to be higher
in women than in men in all the age groups. But triacylglycerol and VLDL-C concentrations were observed to be higher in the
men than women except in age group of 61–70 yrs. It can be suggested that lipid values obtained in this study can be used
as the reference value, based on which clinical correlation can be made. 相似文献
13.
Serum lipids and lipoproteins were estimated in 29 patients with acute myocardial infarction during acute phase (day 1,2,3),
predischarge and after three months. Serum total lipids, total cholesterol (TC) and LDL-cholesterol (LDLc) showed no significant
change during the hospital stay and three months followup. HDL-cholesterol (HDLc), however, started falling from day 2 onwards
with statistically significant reduction at pre-discharge and remained so at 3 months. The ratios of TC/HDLc and LDLc/HDLc
showed significant increase on predischarge day as compared to day 1. Serum triglycerides also showed an increasing trend
after myocardial infarction with a significant increase on day 3 and predischarge as compared to day 1. it is concluded that
the optimum time for assessment of serum lipid profile in patients with myocardial infarction seems to be within 24 hours
of the acute episode. 相似文献
14.
Diabetics showed significantly raised levels of total and LDL cholesterol, (257.0±68.88 mg% 173.5±67.7mg% respectively) compared
to controls matched with age, sex and socioeconomic status. No significant difference was observed in these parameters in
diabetics with and without retinopathy. 相似文献
15.
This study was undertaken to evaluate the effects of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines
in humans. Twenty adult healthy subjects were supplemented with 1g/day fish oil concentrate capsules for 2 weeks. Fasting
blood samples were taken at baseline and again after 2 week intervention. Fish oil supplementation significantly lowered fasting
serum concentrations of total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (P <
0.01). Also high density lipoprotein increased significantly compared with baseline value (P < 0.01). Fish oil did not significantly
altere the fasting blood glucose concentration but significantly reduced the serum cytokines (P < 0.001). This study demonstrated
that eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) supplementation altered serum lipids, lipoprotein and cytokine
concentrations in normal human subjects even at the small dose of 660 mg of EPA plus DHA per day. It appears that EPA plus
DHA can be a safe and perhaps beneficial supplement to inflammatory diseases. 相似文献
16.
M. Cariappa K. Poornima M. Nandini K. Asha H. P. Kedilaya 《Indian journal of clinical biochemistry : IJCB》2005,20(1):103-108
Habitual consumption of moderate amounts of fish is associated with reduced mortality from coronary heart disease. However
the beneficial effects of fish enriched diet seem contradictory, due to the susceptibility of the PUFAs in them to oxidation.
It is also acclaimed that vegetarians in general, have a lower serum total cholesterol and LDL-cholesterol and a better antioxidant
status. This contradiction was the basis for the study, where the validity of the above finding was tested in a general population
consuming a vegetarian or predominantly fish diet as a regular dietary habit. The oxidant status and the lipid profile of
23 vegetarians and 22 fish eaters was studied by estimating the plasma lipid peroxides measured as malondialdehyde (MDA) and
the lipid parameters viz. Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and triglycerides (TG). Statistical analysis was
carried out to compare the MDA values and the lipemic status between the two groups. MDA was also correlated with the various
lipid indices among the study groups. None of the compared and correlated values was statistically significant, although certain
altered trends were seen. From this study, it may be concluded that oxidant status and lipid profile does not vary significantly
in the two groups, suggesting that neither a vegetarian diet nor a fish diet has a definite benefit over the other. 相似文献
17.
Shyamali Pal 《Indian journal of clinical biochemistry : IJCB》2005,20(2):18-23
The laboratory of the present author is a participant of Randox International Quality Assessment Scheme (RIQAS). The author
receives twenty six samples for thirty nine general chemistry analysis per year, reports of which are to be sent fortnightly.
Amongst thirty nine analytes there are partial lipid profile parameters like total cholesterol and triglycerides. So, the
author decided to run a pilot study of full lipid profile from these samples. At the first phase four samples from two different
cycles were considered as test materials. The reports of these samples were quite satisfactory. The trial run was given for
fifteen consecutive days. (Presented by the author in the Annual Conference of ACBI, 2004).
The success of trial runs for fifteen days proved that EQA samples from RIQAS may be used for full lipid profile analysis.
Results were compared against Randox internal quality control samples (IQA) and were found to be accurate and reproducible. 相似文献
18.
B. Talukdar S. Verma S. C. Jain M. Majumdar 《Indian journal of clinical biochemistry : IJCB》1996,11(2):129-133
We conducted a controlled study on effect of selected yoga practive in the control and management of 50 cases of essential hypertension and equal number of healthy (nonhypertensive) controls. Free radical cellular damage is considered to be the underlying common biological factor in essential hypertension. We, therefore, investigated lipid profile lipid peroxidation and Na+K+ ATPase activities of plasma membrane of subjects with essential hypertension. It was found that hypertensive subjects had an elevated lipid peroxidation and decreased Na+K+ ATPase activity in plasma membrane as compared to normotensive healthy controls, the specific yoga training protocol which was administered not only helped to decrease blood pressure but also retard the progression of ceellular damage due to free radicals. 相似文献
19.
Devendra K. Rai Prashant Kumar Rai Aradhna Gupta Geeta Watal Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201
Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides
such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein,
total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses
of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease
in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats
exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum
lipids in rat. 相似文献
20.
A. S. Yadav V. R. Bhagwat I. M. Rathod 《Indian journal of clinical biochemistry : IJCB》2006,21(1):106-110
The present study was undertaken to explore the relationship of plasma homocysteine with other biochemical parameters in ischemic
heart disease. Plasma levels of total homocysteine was measured by HPLC—fluorescence detection with internal standard in 60
ischemic heart disease patients and were compared with 30 age matched normal healthy controls. The significant increase of
plasma homocysteine was observed in both myocardial infarction and chronic stable ischemic heart disease patients when compared
with the controls. The hyperhomocysteinemia appears be to due to increased body demand of vitamins such as folic acid, vitamin
B12, B6, B2 either alone or in combination to regulate normal homocysteine metabolism. 相似文献