第十三届中国青年女科学家奖获奖者风采(1)

<正>王琳,华中科技大学附属协和医院教授,再生医学中心主任、博导。师从美国著名再生医学专家、美国哈佛大学Mooney院士,回国后创建了华中地区第一个再生医学研究中心。2011年获比尔盖茨"探索大挑战"创新奖,2012年入选中组部青年千人计划,2014年当选中华医学会再生医学全国常委,2016年获教育部"霍英东青年教师奖"。     

预测性遗传检查——个性化医疗的重要基石

基因挑战医学，基因渗入医学 21世纪的基因组科学和基因组医学（genomic medicine）将给人类的医疗保健卫生事业带来革命性的变革。这场深层次的变革起始于基因组挑战医学——从基因水平上认识和研究疾病，受惠于基因渗入医学——从基因水平上诊断、预防和治疗疾病。目前在数千种疾病中，已克隆了已知多个致病基因，遗传医学不但早就被列为医学的25个专科之一，而且渗入到内科，     

做好医学档案管理工作信息化的相关建议

据调查了解,很多医院由于资源有限、管理水平落后、管理理念模糊等原因,导致医学档案管理工作的发展受阻,给档案管理带来了极大的难度与挑战。随着互联网的不断发展,医学档案管理工作面临着新的机遇与挑战。     

论医学毕业生实习教育策略

结合西部大开发战略决策，总结我院20年来培养医学毕业生实习教育的经验，为医学生在新形势下带珲了机遇与挑战，并提出了双向选择。为培养优质、高效、符合我国国情的医药卫生人才，作者系统地将我院医学毕业实习生的临床教育管理问题，进行前詹性回顾总结与剖析，期待探索出一条可持续发展的育才之路。     

加入WTO对我国医学图书情报事业的影响及对策

加入WTO后，给我国医学图书情报带来良好的发展机遇，也受到严峻的挑战。医学图书情报工作者必须抓住机遇，更新观念，建立科学合理的管理体制和运行机制；学会游戏规则，保护知识产权，强化专利意识；改变服务模式，重视市场营销，提高信息服务水平；加强信息技术创新，提高服务保障能力；尊重知识，尊重人才，制定切实可行的人才培养和吸引政策，不断提高我国医学图书情报服务工作的能力和水平。     

时代激流下 针灸医学路——记首都医科大学附属北京中医医院针灸中心

在中华民族五千年的璀璨历史中,针灸作为我国传统医学的一个重要分支,不仅蕴藏了中国文化的博大精深,且在不断发展中走向成熟完善。源远流长的针灸医学传承至现代,尤其是建国以来,因其从整体观出发的医学理念及其显著的治疗效果得到了迅速的发展,多项研究成果被广泛地运用到临床治疗中。同时,21世纪的针灸医学发展面临着前所未有的机遇和挑战,对针灸学的发展方向探讨也成为许多针灸界学者共同关心的课题:针灸医学如何在临床诊疗中得到更好地传承?如何在多样化治疗中规范地发展?如何在国际范围内提升针灸医学的学术影响力?沉重的使命落在了这个时代的针灸     

数字化图书馆带来的挑战

本文讨论了数字化图书馆的建设和发展带来的挑战与机遇，需要怎样面对挑战，把握机遇。     

解放军医学图书馆学科化信息服务的SWOT分析

用SWOT分析理论,分析解放军医学图书馆学科化服务的优势、劣势、挑战与机遇,并在此基础上提出发展建议.     

论知识经济条件下的馆员素质

21世纪是知识经济的时代，在新的时代中，医学图书馆面临着严峻的挑战，又预示着一次发展的机遇。提高馆员素质，使他们具备良好的政治思想修养、高尚的职业道德修养、广博的生物医学知识、全面的计算机知识、较高的医学外语水平、较强的综合业务能力，向一专多能的复合型人才和学者型人才发展，才能在未来的知识经济时代的竞争中稳操胜券。     

干细胞与再生医学的发展现状及重要意义

文章主要分析了干细胞和再生医学在当今医学研究领域中的发展现状,认为干细胞和再生医学是医学研究领域中的一门新兴学科,它对医学的发展具有引领作用。为凝聚研究力量、规划研究方向和合理整合研究资源,促进我国再生医学研究的发展,认真审视干细胞与再生医学在我国医学研究领域中的布局已成为一个很迫切的问题。     

Regenerative Medicine and New Labour life science policy: rhetorics of success,narratives of sustainability and survival

Advances in stem cell science and tissue engineering are being turned into applications and products through a novel medical paradigm known as regenerative medicine. This paper begins by examining the vulnerabilities and risks encountered by the regenerative medicine industry during a pivotal moment in its scientific infancy: the 2000s. Under the auspices of New Labour, British medical scientists and life science innovation firms associated with regenerative medicine, received demonstrative rhetorical pledges of support, aligned with the publication of a number of government initiated reports presaged by Bioscience 2015: Improving National Health, Increasing National Wealth. The Department of Health and the Department of Trade and Industry (and its successors) held industry consultations to determine the best means by which innovative bioscience cultures might be promoted and sustained in Britain. Bioscience 2015 encapsulates the first chapter of this sustainability narrative. By 2009, the tone of this storyline had changed to one of survivability. In the second part of the paper, we explore the ministerial interpretation of the ‘bioscience discussion cycle’ that embodies this narrative of expectation, using a computer-aided content analysis programme. Our analysis notes that the ministerial interpretation of these reports has continued to place key emphasis upon the distinctive and exceptional characteristics of the life science industries, such as their ability to perpetuate innovations in regenerative medicine and the optimism this portends – even though many of the economic expectations associated with this industry have remained unfulfilled.     

Preface to Special Topic: Biological microfluidics in tissue engineering and regenerative medicine

In this special issue of Biomicrofluidics, many manifestations of biological microfluidics have been highlighted that have significance to regenerative biology and medicine. The collated articles demonstrate the applicability of these biological microfluidics for studying a wide range of biomedical problems most useful for understanding and shining light on basic biology to those applications relevant to clinical medicine.     

Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation

Embryonic stem cells (ESCs) are pluripotent with multilineage potential to differentiate into virtually all cell types in the organism and thus hold a great promise for cell therapy and regenerative medicine. In vitro differentiation of ESCs starts with a phase known as embryoid body (EB) formation. EB mimics the early stages of embryogenesis and plays an essential role in ESC differentiation in vitro. EB uniformity and size are critical parameters that directly influence the phenotype expression of ESCs. Various methods have been developed to form EBs, which involve natural aggregation of cells. However, challenges persist to form EBs with controlled size, shape, and uniformity in a reproducible manner. The current hanging-drop methods are labor intensive and time consuming. In this study, we report an approach to form controllable, uniform-sized EBs by integrating bioprinting technologies with the existing hanging-drop method. The approach presented here is simple, robust, and rapid. We present significantly enhanced EB size uniformity compared to the conventional manual hanging-drop method.     

科研项目产出绩效评价研究——以干细胞科研领域为例

基于对2008—2018年国家自然科学基金在干细胞领域的资助情况进行多维度分析,揭示我国干细胞领域受资助项目的数量、机构、地区和领域分布。同时,从数量、质量和影响力三个维度对依托这些项目所发表的SCI论文进行评价,以评估项目的资助效果。     

Genome editing in large animals: current status and future prospects

Large animals (non-human primates, livestock and dogs) are playing important roles in biomedical research, and large livestock animals serve as important sources of meat and milk. The recently developed programmable DNA nucleases have revolutionized the generation of gene-modified large animals that are used for biological and biomedical research. In this review, we briefly introduce the recent advances in nuclease-meditated gene editing tools, and we outline these editing tools’ applications in human disease modeling, regenerative medicine and agriculture. Additionally, we provide perspectives regarding the challenges and prospects of the new genome editing technology.     

基于实践应用能力培养为核心的《壮医针刺学》课程的实践教学探索

《壮医针刺学》是壮医学专业的一门主干课程,壮医针刺疗法是壮医的特色临床治病技法之一,学生对壮医针刺疗法在临床实践应用中的掌握熟练程度,是衡量壮医学专业人才培养掌握临床技法方面的重要指标之一。文章针对《壮医针刺学》教学中存在的一些问题,进行了初步的探讨,提出并在教学中初步开展了从课堂到课外实践教学的一些措施,为培养和提高壮医学专业学生的临床实践应用能力提供了参考。     

Characterization and Classification of Mesenchymal Stem Cells in Several Species Using Surface Markers for Cell Therapy Purposes

Mesenchymal stem cells are multipotent cells capable of replicating as undifferentiated cells, and have the potential of differentiating into mesenchymal tissue lineages such as osteocytes, adipocytes and chondrocytes. Such lineages can then be used in cell therapy. The aim of present study was to characterize bone marrow derived mesenchymal stem cells in four different species, including: sheep, goat, human and mouse. Human bone-marrow mesenchymal stem cells were purchased, those of sheep and goat were isolated from fetal bone marrow, and those of mouse were collected by washing bone cavity of femur and tibia with DMEM/F12. Using flow-cytometry, they were characterized by CD surface antigens. Furthermore, cells of third passage were examined for their osteogenic and adipogenic differentiation potential by oil red and alizarin red staining respectively. According to the results, CD markers studied in the four groups of mesenchymal stem cells showed a different expression. Goat and sheep expressed CD44 and CD166, and weakly expressed CD34, CD45, CD105 and CD90. Similarly, human and mouse mesenchymal cells expressed CD44, CD166, CD105 and CD90 whereas the expression of CD34 and CD45 was negative. In conclusion, although all mesenchymal stem cells display plastic adherence and tri-lineage differentiation, not all express the same panel of surface antigens described for human mesenchymal stem cells. Additional panel of CD markers are necessary to characterize regenerative potential and possible application of these stem cells in regenerative medicine and implantology.     

Bio-electrospraying and aerodynamically assisted bio-jetting whole human blood: Interrogating cell surface marker integrity

Bio-electrospraying and aerodynamically assisted bio-jetting are two direct cell handling approaches recently pioneered, which have demonstrated significant applicability to the life sciences. These two bioprotocols have undergone scientific rigor, which have seen these techniques been explored in conjunction with a wide range of immortalized, primary and stem cells, and those whole organisms. Those studies have demonstrated a cellular population of >70% viable post-treatment in comparison with controls. Although, these studies assessed cellular viability, cell surface molecules play a critical role in several cellular functions, in particular, have importance to tissue engineering and regenerative medicine. Thus, in the studies reported herein, we demonstrate post-treated viable cells retain their cell surface marker expression levels in comparison to controls, over both short and long time points. Therefore, these studies further push back the frontiers of both bio-electrosprays and aerodynamically assisted bio-jetting in their endeavor as novel strategies for tissue engineering and regenerative biology∕medicine with possible targeted clinical utility.