Measuring the change in R&D efficiency of the Japanese pharmaceutical industry

This paper presents a data envelopment analysis (DEA)/Malmquist index methodology for measuring the change in R&D efficiency at both firm and industry levels. Letting each of ten firms in each year be a separate decision-making unit, and employing one input and three outputs in a DEA case of R&D activity input-output lag, we measure “total factor R&D efficiency” change of Japanese pharmaceutical firms for decade 1983-1992 as defined by the period of R&D input. Decomposing Malmquist index into catch-up and frontier shift components and using “cumulative indices” proposed in this study, we evaluate R&D efficiency change for each firm and empirically show that R&D efficiency of Japanese pharmaceutical industry has almost monotonically gotten worse throughout the study decade.     

Effects of R&D and networking on the export decision of Japanese firms

This paper examines how internal R&D intensity and external networking channels are related with the firm's export decision, based on a large firm-level data set covering all manufacturing industries in Japan without any firm-size threshold. Internal R&D is not the only determinant of exporting, while it is strongly related with exports in the science-based sector. Collaborations with other firms on joint projects and operations of subsidiaries overseas are significantly linked to exports of large-sized firms, while affiliations with business associations and R&D intensity are critical for small-sized firms to export. Connections with computer networks have a weaker impact.     

Global R&D activities of Japanese MNCs in the US: A triangulation approach

We examined 79 Japanese MNCs’ R&D subsidiaries in the US from the knowledge-based view. We found: (1) subsidiaries’ R&D strategies generally encouraged knowledge flows; (2) subsidiaries’ R&D alliances promoted knowledge flows; (3) R&D subsidiaries with process-oriented incentives promoted vertical knowledge flows; (3) autonomous R&D subsidiaries promoted knowledge flows from the local environments to the subsidiary; (4) R&D subsidiaries with a high level of knowledge flows accumulated a high level of knowledge; and (5) R&D subsidiaries with a high level of accumulated knowledge achieved high overall performance. Our interviews with 30 R&D subsidiaries and 10 parent companies supplement these findings.     

Institutionalizing end-user demand steering in agricultural R&D: Farmer levy funding of R&D in The Netherlands

The purpose of this paper is to critically examine the institutionalization of demand-driven modes of working in the R&D planning process and reveal possible weaknesses, through an analysis of a system of collective R&D funding by farmers. The findings indicate that, although end-users have the opportunity to raise issues that lead to R&D, queries are influenced by several actors in the R&D planning process in such a way that they do not adequately reflect farmers’ innovation needs. Conclusions are that more emphasis is required on joint demand articulation and involvement of end-users and other stakeholders in the innovation process, and on the institutional development of R&D funding organizations in order to adopt a more inclusive view on innovation.     

MNCs’ offshore R&D networks in host country's regional innovation system: The case of Taiwan-based firms in China

China has become a hot spot of R&D internationalization and a growing number of Taiwan-based firms have indeed set up R&D units in China. Taking into account China's substantial regional variations in economic development, innovation capacity, and knowledge productivity, such notions as regional innovation system (RIS) and local innovative milieu may become more relevant to the study on relationships between China and its inward R&D internationalization. Therefore, the key issue for this paper is what locational advantages of an RIS within a host country affect the network linkages and networking strategy of multinational corporations’ (MNCs’) offshore R&D units. The paper aims to enrich the current understanding of R&D internationalization in several ways. First, the paper attempts to examine the R&D networking underlying R&D internationalization by Taiwan-based firms in China, with particular reference to the sub-national level inside China. Second, the paper tries to establish a link between the literature of R&D internationalization and that of RIS, with a modified version of Dunning's eclectic paradigm. Efforts are made to map the relationship between foreign subsidiaries’ local R&D networks and their host RISs inside China. Third, the paper takes advantage of a government databank to adopt a quantitative approach, the Seemingly Unrelated Bivariate Probit Regression model, with foreign subsidiaries as the unit of analysis, to highlight the role played by some aspects of the RIS in determining the local R&D networking of Taiwanese subsidiaries in China. Our evident shows that MNCs’ offshore R&D units that purse home-based technology exploitation strategy, the mainstream strategy regarding the developing host country, tend to be located in a host region with a strong knowledge application and exploitation subsystem, while an RIS with a strong knowledge generation and diffusion subsystem, within such a developing country as China, may induce MNCs’ local R&D units to pursue home-base technology augmenting strategy. On balance, not only the location choice but also the local R&D linkages of MNCs’ offshore subsidiaries are related to appropriate fits between the RIS and the subsidiaries’ innovation network inside the host country.     

Determinants of R&D cooperation in Japanese start-ups

This paper explores the determinants of R&D cooperation in Japanese start-ups. Using a sample from an original survey conducted in 2008, we examine the effects of founder-, firm-, and industry-specific characteristics on R&D cooperation by type of partners. Our findings indicate that founder-specific characteristics such as educational background, prior innovation output, and affiliation to academic associations are fairly important in determining R&D cooperation with academic institutes (universities and public research institutes). We also provide evidence that founders’ prior innovation output and work experience have positive and significant effects on R&D cooperation with business partners. With respect to firm-specific characteristics, it is found that firms investing more in R&D tend to engage in R&D cooperation, regardless of the type of partners. Furthermore, it is found that independent firms are less likely to cooperate in R&D with academic institutes than subsidiaries and affiliated firms.     

Creating advantage in peripheral regions: The role of publicly funded R&D centres

Regional investment in R&D, technological development and innovation is perceived as being strongly associated with productivity, growth and sustained international competitiveness. One policy instrument by which policy makers have attempted to create regional advantage has been the establishment of publicly funded research centres (PRCs). In this paper we develop a logic model for this type of regional intervention and examine the outputs and longer-term outcomes from a group of (18) publicly funded R&D centres. Our results suggest some positive regional impacts but also identify significant differences in terms of innovation, additionality and sustainability between university-based and company-based PRCs. University-based PRCs have higher levels of short-term additionality, demonstrate higher levels of organisational innovation but prove less sustainable. Company-based PRCs demonstrate more partial additionality in the short-term but ultimately prove more sustainable.     

The dynamics of R&D network in the IT industry

In this paper, we provide an empirical analysis of evolving networks of successful R&D collaborations in the IT industry (consisting of firms that obtained patents in the technological category of computers and communication) in the U.S. between 1985 and 1995. We first show that the R&D network has become more extensive, more clustered, and more unequal in the sense that ‘stars’ have emerged in the network. We then analyze the effect of the existing network structure in the process of new R&D collaboration formation. We control for unobserved similarities among firms based on the community structures within the network that the algorithm developed by Girvan and Newman (2004) identifies and find a significant cyclic closure and preferential-attachment effect.     

Does R&D performance decline with firm size?—A re-examination in terms of elasticity

There have been many previous studies exploring the relationship between R&D performance and firm size; however, to our knowledge, this issue has never been examined in terms of R&D output elasticity. This paper therefore sets out to re-examine the relationship of the two variables using R&D output elasticity as a measure of R&D performance. A total of 126 manufacturing firms, listed on the Taiwan Stock Exchange over the period from 1994 to 2000, are taken as the analytical sample. One practical consideration for choosing these particular firms is the relative abundance of data available for the variables for a longitudinal investigation. The estimates suggest that there is an approximating ‘U-type’ relationship between R&D productivity and firm size. This finding suggests that both large and small firms have higher R&D productivity, and even when the sample is divided into the high-tech and traditional sectors, such a finding still holds. Therefore, in contrast to the prior studies, this study shows that size offers advantage in R&D performance.     

On the road again: Researcher mobility inside the R&D network

This paper examines the roles of international assignments and other forms of researcher mobility inside the integrated R&D networks of six of the largest European pharmaceutical companies. From in-depth interviews with R&D managers and scientists it is found that, while the use of international assignments is both limited and often not aimed specifically at the transfer of knowledge, other forms of short-term mobility are widely employed. But what is transferred through such short-term visits is narrow in focus and often related to specific projects whereas international assignments enable the transfer of broader and more complex knowledge. The potential impact of these changes in the inter-unit mobility patterns of researchers may be to limit both the exploitation of potential synergies across disciplines and the creation of enduring and strong personal ties among researchers working in distant locations.     

政府补贴对产业共性技术可持续研发行为的影响研究

结合共性技术研发过程,提出了共性技术可持续研发行为的概念框架,借鉴Stackelberg主从博弈思想,本文构建了共性技术供给及后续商业开发承担企业、市场收益实现承担企业和政府三方博弈模型,考虑企业在产业中不同的主导地位,研究政府不同补贴对共性技术可持续研发行为的影响。结果表明：政府应谨慎同时提供两类补贴;当共性技术研发努力成本较高时,政府应优先使用研发努力补贴;当市场收益实现承担企业占主导地位,研发努力成本较低时政府应优先选择使用单位成本补贴;无论是否处于主导地位,企业技术水平对政府补贴相关参数均有较大影响,政府制定补贴政策时须给予充分考虑。研究结论为政府补贴政策制定及共性技术研发实践提供了一定的参考。     

Behavioural additionality of R&D subsidies: A learning perspective

The use of R&D grants as a policy instrument has been motivated by economic arguments of market failure. Neo-classical econometric studies have analysed the additionality of one Euro of subsidies on both the investments of companies in the R&D process and the output of that R&D process. More recently, behavioural additionality has been launched as a third form of additionality. In contrast to input and output additionality, behavioural additionality is related to changes in the processes that take place within the firm. In this paper, we analyse the determinants of the behavioural additionality of R&D grants. To explain the mechanism through which behavioural additionality is obtained, we use organizational learning theory as a guide to formulate our hypotheses. Hypotheses are tested using a telephone survey of 192 recipients of R&D grants provided by the IWT in Flanders in 2001–2004, matched to a sample of 84 firms that undertake innovation activities but which had never had a grant bid accepted. We find that congenital learning and interorganizational learning lead to increased behavioural additionality. However, these learning effects decrease with the number of subsidized projects that are undertaken by the company.     

Inter-firm R&D partnering in pharmaceutical biotechnology since 1975: Trends, patterns, and networks

This paper analyses a large, longitudinal database on inter-firm R&D partnerships formed in the high-tech pharmaceutical biotechnology industry since 1975. Our research indicates an overall growth in the number of annually, newly established R&D partnerships where research partners consistently prefer contractual partnerships to equity-based alliances. In the networks that develop through these R&D partnerships, small, entrepreneurial biotechnological companies take a leading role during the 1980s when biotechnology first became relevant for the pharmaceutical industry. The 1990s, however, show a different pattern with established, large pharmaceutical companies becoming more dominant, acting as nodal players with multiple partnerships with a variety of other companies.     

政府补贴对纺织企业研发投入的影响

本文基于资源基础理论、信号传递理论及制度观等,以我国纺织行业上市公司为研究样本,研究政府补贴对纺织企业研发投入的影响,并分析地区知识产权保护水平与企业所有权性质的调节作用。研究发现:政府补贴在一定界限内会促进研发投入增加,超过一定界限时会产生挤出效应,政府补贴与研发投入之间呈倒U形关系;企业所有权性质与地区知识产权保护水平都有显著调节效应,政府补贴发挥的激励作用在民营企业内更强,在地区知识产权保护水平较高的地方也较强;联合调节作用表现为:当地区知识产权保护水平较高时,政府补贴对研发投入的影响会因为企业所有权性质不同而有较大差异,且在民营企业内促进作用更显著,反之,政府补贴对研发投入的影响程度在国有和民营企业中差异不明显;政府补贴与企业研发投入之间的关系在纺织业、纺织服装业、化纤制造业3个子行业中有区别,政府研发补贴对化纤制造业研发投入激励作用最大,其次是纺织服装业,而纺织业中则不显著。     

Application of real options analysis for pharmaceutical R&D project valuation—Empirical results from a survey

Real options analysis was often recommended as an emerging valuation technique for high-risk investment projects. Former inter-sectoral surveys have drawn an ambivalent picture of real options usage in general. In addition, there is a lack of sector-specific investigations. In the following article the results of an in-depth analysis of collected empirical data regarding the application of this new tool in the pharmaceutical sector is presented by capturing the internal view from the pharmaceutical companies themselves and the external view from the health care departments of financial service firms. R&D stage specific modi of application, reasons for reluctance in the employment of real options and their assumed future prospects are elucidated.     

R&D spillovers from subsidized firms that fail: Tracing knowledge by following employees across firms

Public R&D subsidies aim to target particularly risky R&D and R&D with large externalities. One would expect many such projects to fail from a commercial point of view, but they may still produce knowledge with social value. Such knowledge is likely to be embodied in workers or teams of workers. I test for knowledge diffusion from subsidised technology firms transmitted through the labor market. The specific case analysed is a series of Norwegian IT-programs so far considered unsuccessful. It has been argued that know-how built up during the programs still ‘fertilize’ the IT-industry. I find limited support for this claim.     

Relative efficiency of R&D activities: A cross-country study accounting for environmental factors in the DEA approach

This paper applies the production framework associated with the data envelopment analysis (DEA) method to evaluate the relative efficiency of R&D activities across countries. R&D capital stocks and manpower are treated as inputs while patents and academic publications are considered as outputs. A three-stage approach, which involves using DEA for evaluating efficiency and using Tobit regressions for controlling the external environment, is applied to 30 countries in recent years. The results show that less than one-half of the countries are fully efficient in R&D activities and that more than two-thirds are at the stage of increasing returns to scale. Most countries have a more significant advantage in producing SCI cum EI publications than in generating patents.     

FDI, transfer pricing and the measurement of R&D intensity

An important determinant of a region's attractiveness to foreign investors is its rate of corporation tax. Besides stimulating real economic activity, low corporation tax rates also induce multinational corporations to shift profits into the jurisdiction, frequently through the manipulation of transfer prices. This practice can lead to a substantial distortion of output figures. Since national or sectoral R&D intensities are usually measured relative to output, transfer pricing also therefore distorts these measurements. The present paper proposes a simple alternative measure of R&D intensity. Implementation on Irish data shows that the two approaches yield substantially different results.     

Technological similarity,post-acquisition R&D reorganization,and innovation performance in horizontal acquisitions

This paper aims to disentangle the mechanisms through which technological similarity between acquiring and acquired firms influences innovation in horizontal acquisitions. We develop a theoretical model that links technological similarity to: (i) two key aspects of post-acquisition reorganization of acquired R&D operations – the rationalization of the R&D operations and the replacement of the R&D top manager, and (ii) two intermediate effects that are closely associated with the post-acquisition innovation performance of the combined firm – improvements in R&D productivity and disruptions in R&D personnel. We rely on PLS techniques to test our theoretical model using detailed information on 31 horizontal acquisitions in high- and medium-tech industries. Our results indicate that in horizontal acquisitions, technological similarity negatively affects post-acquisition innovation performance and that this negative effect is not mediated by the reorganization of the acquired R&D operations. However, replacing the acquired firm's R&D top manager leads to R&D productivity improvements that positively affect innovation performance.     

Taiwanese IT firms’ offshore R&D in China and the connection with the global innovation network

Although it is evident that technology is becoming increasingly globalized, resulting in the expansion of R&D internationalization by firms, despite this discernible trend, the substantial body of literature in this area is based mainly on the experience of the developed country. This paper aims to contribute to the understanding of this issue by examining the R&D internationalization of a newly-industrializing country, Taiwan being a prime example, and its connection with the global production network. We begin with an examination of the literature on R&D internationalization and globalization, based upon which we propose a conceptual framework adapted from Dunning’s eclectic paradigm. In doing so, we set out to develop arguments based not only on the reasons why cross-strait R&D internationalization may be undertaken by Taiwanese information technology (IT) firms, but also the likely patterns of their R&D portfolios across the strait. Drawing on an original questionnaire survey and firm-level interviews, the paper presents and discusses empirical data on the cross-strait R&D deployment of Taiwanese IT firms. It then goes a stage further, using the ‘smiling curve’, to put forward a ‘holistic’ view of the cross-border innovation network in the IT hardware industry, in order to determine what cross-strait R&D internationalization means to the global production network.