Seizing control?: The experience capture experiments of Ringley &; Mann

Will the proliferation of devices that provide the continuous archival and retrieval of personal experiences (CARPE) improve control over, access to and the record of collective knowledge as Vannevar Bush once predicted with his futuristic memex? Or is it possible that their increasing ubiquity might pose fundamental risks to humanity, as Donald Norman contemplated in his investigation of an imaginary CARPE device he called the “Teddy”? Through an examination of the webcam experiment of Jenni Ringley and the EyeTap experiments of Steve Mann, this article explores some of the social implications of CARPE. The authors’ central claim is that focussing on notions of individual consent and control in assessing the privacy implications of CARPE while reflective of the individualistic conception of privacy that predominates western thinking, is nevertheless inadequate in terms of recognizing the effect of individual uptake of these kinds of technologies on the level of privacy we are all collectively entitled to expect. The authors urge that future analysis ought to take a broader approach that considers contextual factors affecting user groups and the possible limitations on our collective ability to control the social meanings associated with the subsequent distribution and use of personal images and experiences after they are captured and archived. The authors ultimately recommend an approach that takes into account the collective impact that CARPE technologies will have on privacy and identity formation and highlight aspects of that approach.     

Genetic Variant Arg399Gln G>A of XRCC1 DNA Repair Gene Enhanced Cancer Risk Among Indian Population: Evidence from Meta-analysis and Trial Sequence Analyses

The X-ray repair cross-complementation group 1 (XRCC1) gene plays an important role in base excision repair pathway. Several studies have reported contradictory results for XRCC1 exon 10 (Arg399Gln, G23990A, rs25487) gene polymorphism and cancer risk in Indian population, making it difficult to interpret them. Therefore, we have conducted a meta-analysis to evaluate the more precise association between XRCC1 exon 10 G>A gene polymorphism and risk of cancer by published studies. We searched PubMed (Medline) and Google scholar web databases to cover all studies published on association between XRCC1 exon 10 G>A gene polymorphism and cancer risk until August 2016. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to appraise the strength of association. Heterogeneity, publication bias and sensitivity analysis were also assessed. Twenty-five published studies had fulfilled the inclusion criteria comprising 4131 confirmed cancer cases and 5013 controls. When all studies were polled together, overall significant association was found between XRCC1 exon 10 G>A polymorphism and cancer risk in variant allele carrier (A vs. G: OR 1.217, 95% CI 1.056–1.402, p = 0.007), homozygous (AA vs. GG: OR 1.359, 95% CI 1.036–1.783, p = 0.027), dominant (AA+AG vs. GG OR 1.208, 95% CI 1.006–1.450, p = 0.043) and recessive (AA vs. AG+GG: OR 1.315, 95% CI 1.029–1.680, p = 0.029) genetic models. Further sensitivity analysis supported the stability of our result by showing similar ORs before and after removal of a single study. The present meta-analysis suggested that the XRCC1 exon 10 G>A polymorphism contribute cancer risk in Indian population, and supports that individuals with risk allele A and AA genotype are at higher risk of developing cancer.     

Effect of Tulsi (<Emphasis Type="Italic">Ocimum sanctum</Emphasis> Linn.) Supplementation on Metabolic Parameters and Liver Enzymes in Young Overweight and Obese Subjects

Ocimum sanctum Linn. (also known as Tulsi) is a sacred Indian plant, the beneficial role of which, in obesity and diabetes is described traditionally. This is a randomized, parallel group, open label pilot study to investigate the effect of O. sanctum on metabolic and biochemical parameters in thirty overweight/obese subjects, divided into two groups A and B. Group A (n = 16) received one 250 mg capsule of Tulsi (O. sanctum) extract twice daily in empty stomach for 8 weeks and group B (n = 14) received no intervention. Statistically significant improvements in the values of serum triglycerides (p = 0.019); low density lipoprotein (p = 0.001); high density lipoprotein (p = 0.001); very low density lipoprotein (p = 0.019); Body Mass Index, BMI (p = 0.005); plasma insulin (p = 0.021) and insulin resistance (p = 0.049) were observed after 8 weeks in the O. sanctum intervention group. The improvement in HDL-C in the intervention group when compared to the control group was also statistically significant (p = 0.037). There was no significant alteration of the liver enzymes SGOT and SGPT in both the intervention (p = 0.141; p = 0.074) and control arms (p = 0.102; p = 0.055) respectively. These observations clearly indicate the beneficial effects of O. sanctum on various biochemical parameters in young overweight/obese subjects.     

Genetic Variation in <Emphasis Type="Italic">CD166</Emphasis> Gene and Its Association with Bladder Cancer Risk in North Indian Population

Adhesion molecules play a key role in cancer progression and tumorigenesis. Genetic polymorphism of adhesion molecules may alter the normal functioning thereby leading to bladder cancer susceptibility. Hence we aimed to evaluate three SNPs of CD166 gene (CD166rs6437585 C/T, CD166rs10511244 C/T, and CD166rs1157 A/G) in bladder cancer patients and normal controls of North Indian population. A total of 270 healthy controls and 240 confirmed bladder cancer patients were recruited for this study. Three SNPs of CD166 gene viz. CD166rs6437585 C/T, CD166rs10511244 C/T, and CD166rs1157 A/G were selected for this study. CD166rs6437585 C/T and CD166rs10511244 C/T were genotyped by Taqman allelic discrimination assay and CD166rs1157 A/G was genotyped by PCR–RFLP. The statistical analysis was done using the SPSS software, version 16.0 (SPSS, Chicago, IL), and p < 0.05 was considered statistically significant. Haplotypic analysis was done by using SNP analyzer version 1.2A. CD166rs6437585 C/T and CD166rs10511244 C/T showed significant association with reduced risk in bladder cancer while CD166rs1157 A/G showed significant high risk along with association at genotypic and allelic levels. Haplotypic analysis showed 1.8-folds risk in CCG combination, whereas CTA and TCG showed significant association with reduced risk. Further stratification on the basis of smoking, tumor grade/stage and BGC therapy revealed no association of these three polymorphic sites of CD166. Our study suggests that CD166rs6437585 C/T and CD166rs10511244 C/T are predictive for the reduced risk of bladder cancer, whereas CD166rs1157 A/G had shown significant association with high risk of bladder cancer in North Indians. This somehow suggests that CD166rs1157 A/G can be used as a marker for risk prediction of bladder cancer.     

A citation and co-citation analysis of 10 years of KM theory and practices

In a previous issue of Knowledge Management Research & Practice (KMRP), we analysed the content and keywords of all articles published in the first decade of KMRP. With this article, we extend our preliminary analysis to the citation and co-citations made by these articles. The study covers all the 256 articles published. The most cited article was A dynamic theory of organisational knowledge creation by Nonaka. The most cited KMRP article was by Nonaka and Toyama: The knowledge-creating theory revisited: knowledge creation as a synthesizing process. The co-citation analysis of the 100 most cited articles in KMRP publications showed that four groups of topics emerged, one around communities and situated learning, the second group around networks, knowledge transfer and research methods, a third group around the foundations of knowledge management and a fourth group around intellectual capital.     

Bionomics of Mansonioides mosquitoes in relation to community structure of hydrophytes/breeding habitats in Cherthala,Kerala

Three species of Mansonioides vectors viz.,Ma. annulifera, Ma. uniformis andMa. indiana were found in Cherthala taluk, Kerala which is one of the endemic areas due toB. malayi. The immatures of Mansonioides thrive mainly in association with macrophytic hydrophytes such asP. stratiotes, S. molesta andE. crassipes in perennial habitats (ponds, channels/ canals etc.,) andI. miliaceae in seasonal habitats (fallow lands etc.) Breeding potential was higher (130.19) in clean ponds withP. stratiotes, compared to that of polluted ones (40.69). However, the polluted habitats infested with the same host plants were found to be the most productive forMa. annulifera, with an average daily adult emergence rate of 601/100 sq.m.). The clean habitats played a major role in the contribution ofMa. uniformis, whereS. molesta in the perennial habitats and I. miliaceae in the seasonal fallow lands were the favourable plants contributing a daily output of 12.5/100 sq.m and 221.81/100 sq.m. respectively.E. crassipes infested polluted habitats formed the major source forMa. indiana, the emergence rate being 13.89/100 sq.m. The perennial habitats supported mainly the breeding ofMa. annulifera (70.82%), whereas the seasonal habitats contributed the major chunk ofMa. uniformis (92.54%) andMa. indiana (71.43%). The bionomics of Mansonioides mosquitoes are thus shown to be greatly influenced by the community structure of hydrophytes and also the nature of breeding habitats.     

Violent video games and morality: a meta-ethical approach

This paper considers what it is about violent video games that leads one reasonably minded person to declare “That is immoral” while another denies it. Three interpretations of video game content are discussed: reductionist, narrow, and broad. It is argued that a broad interpretation is required for a moral objection to be justified. It is further argued that understanding the meaning of moral utterances—like “x is immoral”—is important to an understanding of why there is a lack of moral consensus when it comes to the content of violent video games. Constructive ecumenical expressivism is presented as a means of explaining what it is that we are doing when we make moral pronouncements and why, when it comes to video game content, differing moral attitudes abound. Constructive ecumenical expressivism is also presented as a means of illuminating what would be required for moral consensus to be achieved.     

The role of Lean principles in supporting knowledge management in IT outsourcing relationships

Knowledge management (KM) in information technology outsourcing (ITO) is important to the organizations which pursue long-term strategic benefits and innovation. Effective KM mechanism in outsourcing enables both parties to continuously exchange knowledge and promotes collective learning. This paper investigates the role of Lean principles in supporting KM in ITO relationships. Drawn from the knowledge-based view of the firm, knowledge accessing and knowledge integration and utilization are identified as two key KM processes in outsourcing. Three case studies conducted in different service industries with 18 interviews indicate that the two KM processes were supported by four Lean principles: respect for people, continuous improvement, systems thinking, and proactive behavior. Those principles can be implemented with different tools at different organizational levels. This study reveals the relevance between Lean and KM in ITO relationships, which has not been reported by the KM literature. It also provides implications to ITO practitioners for the implementation of Lean principles.     

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of <Emphasis Type="Italic">Musa cavendish</Emphasis> Fruit

Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks. Changes in plasma glucose, lipid profile along with kidney function before and after treatment with EMC were recorded. The ethanolic extract of peels of Musa cavendish reduced blood glucose, serum triglyceride, cholesterol, LDL cholesterol and creatinine levels and improvement in body weight, liver glycogen, serum HDL cholesterol, serum albumin and total protein level when compared with untreated rats. Musa cavendish has lipid lowering, nephroprotective and antidiabetic property by regulating glucose uptake in the liver and muscles by restoring the intracellular energy balance.     

Society-in-the-loop: programming the algorithmic social contract

Recent rapid advances in Artificial Intelligence (AI) and Machine Learning have raised many questions about the regulatory and governance mechanisms for autonomous machines. Many commentators, scholars, and policy-makers now call for ensuring that algorithms governing our lives are transparent, fair, and accountable. Here, I propose a conceptual framework for the regulation of AI and algorithmic systems. I argue that we need tools to program, debug and maintain an algorithmic social contract, a pact between various human stakeholders, mediated by machines. To achieve this, we can adapt the concept of human-in-the-loop (HITL) from the fields of modeling and simulation, and interactive machine learning. In particular, I propose an agenda I call society-in-the-loop (SITL), which combines the HITL control paradigm with mechanisms for negotiating the values of various stakeholders affected by AI systems, and monitoring compliance with the agreement. In short, ‘SITL = HITL + Social Contract.’     

R&amp;D collaboration: role of <Emphasis Type="Italic">B</Emphasis>a in knowledge-creating networks

Research and development (R&D) collaboration between universities and business is a vital form of new knowledge creation in knowledge-intensive high-technology business environments. Increasingly, collaboration occurs in networks. A key element in forming these collaborate networks is shared knowledge creation, which is dependent on the Ba, the SECI process, and knowledge assets. This paper argues that Ba plays a major role for successful knowledge creation through R&D collaboration between university and business. A Ba is a perception of a place – which can be virtual – and a shared purpose. The absence of a Ba is a significant barrier to success, but building a Ba takes collaborative time and effort. This paper addresses the problems in the successful formation of such networks based on insights from biotechnology, an area where this type of collaboration has been and still is common, but not always successful or unproblematic.     

Cytochrome P450 Genes (CYP2E1 and CYP1A1) Variants and Susceptibility to Chronic Hepatitis B Virus Infection

Hepatitis B virus (HBV) infection is a worldwide health concern which is associated with significant morbidity and mortality. Both viral and host factors have a significant effect on infection, replication and pathogenesis of HBV. The aim of this study was to investigate the effect of CYP2E1 and CYP1A1 genetic variants on susceptibility to HBV. 143 individuals including 54 chronic HBV patients and 89 healthy controls were enrolled in the genotyping procedure. rs2031920 and rs3813867 at CYP2E1 as well as rs4646421 and rs2198843 at CYP1A1 loci were studied in all subjects using PCR–RFLP (restriction fragment length polymorphism) analysis. Both variants at CYP2E1 locus were monomorphic in all studied subjects. Genotype frequency of rs4646421 was significantly different between chronic HBV patients and healthy blood donors (P = 0.04, OR 4.31; 95% CI 1.04–17.7). Furthermore, individuals carrying at least one C allele (CC or CT genotypes) for rs4646421 seemed to have a decrease risk of hepatitis in comparison with TT genotype (P = 0.039). Our results showed a relationship between rs4646421 TT genotype (rare genotype) and the risk for developing chronic HBV infection (four times higher). Further studies are needed to examine the role of CYP1A1 polymorphism in susceptibility to chronic HBV infection.     

<Emphasis Type="Italic">DRD4</Emphasis> and <Emphasis Type="Italic">DAT1</Emphasis> VNTR Genotyping in Children with Attention Deficit Hyperactivity Disorder

The dopamine receptor-D4 and the dopamine transporter have been investigated for their role in attention deficit hyperactivity disorder (ADHD) in children. Reports of their genetic association with ADHD have shown mixed results. The aim of the study was to evaluate the association of variable number tandem repeats (VNTRs) of the DRD4 and DAT1 genes with ADHD in children. A pilot 1:1 case control study, with 44 clinically confirmed ADHD cases and 44 age/gender matched healthy controls, was conducted at a tertiary care centre in Mumbai. Variable number tandem repeats of DRD4 exon 3, DAT1 intron 8 and 3′UTR were genotyped by PCR-AGE. Several allele repeats of the genes were observed in the screened subjects. Statistical significance was observed for the 10R/10R genotype of the DAT1 3′UTR VNTR between cases and controls.     

Objections to Ostritsch’s argument in “The amoralist challenge to gaming and the gamer’s moral obligation”

This paper raises three objections to the argument presented by Ostritsch in The amoralist challenge to gaming and the gamer’s moral obligation, in which the amoralist’s mantra “it’s just a game” is viewed as an illegitimate rebuttal of all moral objections to (typically violent) video games. The first objection focuses on Ostritsch’s ‘strong sense’ of player enjoyment, which I argue is too crude, given the moral work it is meant to be doing. Next, I question the legitimacy of Ostritsch’s claim that certain video games are immoral. I examine what is involved in making this claim and what would be required for a normative position to be established: none of which is addressed by Ostritsch. Finally, I challenge the legitimacy of his claim that players are obliged not to play certain video games in certain ways (i.e., games endorsing immorality as ‘fun games’). I distinguish between immoral and suberogatory actions, arguing that the latter is in fact more applicable to cases Ostritsch has in mind, and that one is not obliged not to engage in these actions.     

A sensemaking model of knowledge in organisations: a way of understanding knowledge management and the role of information technologies

The objective of the paper is to demonstrate how a sensemaking model of knowledge enables better and deeper understanding of knowledge management (KM) processes in organisations and the role of information technologies (IT) in these processes. Inspired and informed by a sensemaking view of organisations, the model identifies four types of knowledge, corresponding to four sensemaking levels: the individual, collective, organizational, and cultural. Each knowledge type, as the paper shows, is of different nature and has different characteristics but is constituted and affected by all other knowledge types. An organisation is thus seen as a ‘distributed knowledge system’ composed of numerous instances of these four knowledge types and their dynamic interplay. By drawing from three empirical studies, the paper illustrates how the sensemaking model of knowledge can be applied to investigate different ways companies (try to) manage knowledge and use IT-based systems to improve KM and ultimately company performance. A deeper understanding of these processes through the lens of the model reveals mechanisms and forces underlying KM phenomena that help explain why some processes were successful and others failed. The paper intends to make the following contributions: propose a theoretical framework of knowledge and KM in organizations, which is reasonably comprehensive and empirically grounded and also demonstrate its relevance and usefulness to both researchers and practitioners as they investigate and make sense of specific KM processes and IT applications in practice.     

Aflatoxins: Implications on Health

Environmental occurrence of Aspergillus and other fungal spores are hazardous to humans and animals. They cause a broad spectrum of clinical complications. Contamination of aflatoxins in agri-food and feed due to A. flavus and A. parasiticus result in toxicity in humans and animals. Recent advances in aspergillus genomics and aflatoxin management practices are encouraging to tackle the challenges posed by important aspergillus species.     

The effect of internal social capital on knowledge sharing

On the basis of the Chinese schema, we propose that internal social capital manifests itself in the form of ‘guanxi’, trust, and norms. We discuss the concept of interpersonal relationships within the context of Chinese culture by embedding the guanxi concept into a model to investigate the relationships among the three dimensions. We used a survey-based methodology to collect data from 230 employees of the top 100 high-technology firms in Taiwan and structural equation modelling (SEM) with LISREL 8.54 to examine the hypotheses model. The results indicated that at the individual level, guanxi is positively related to both trust and norms, which are also positively related to knowledge sharing. The mediating effects of trust and norms were also found to be significant. Trust directly influences knowledge sharing, and plays a mediating role between knowledge sharing and guanxi. This suggests that knowledge sharing is likely to occur when trust exists among employees. The results further indicate that norms mediate the relationship between guanxi and knowledge sharing. Guanxi among members influences knowledge sharing; therefore, organizations require a feasible solution using the relational norms mechanism. Previous studies have either emphasized the direct influence of social capital or regarded all variables to be of similar importance for knowledge sharing; however, no clear explanations have been provided explaining its influence on knowledge sharing. We advance understanding of why social capital enhances knowledge sharing among employees and the means by which this occurs.     

International academic knowledge creation and ba. A case study from Finland

Knowledge is created through discourse in ba that is the physical, mental and/or virtual arena of knowledge creation. This article studies ba in international humanist (H-group), technical (T-group) and scientific (S-group) research groups. These international groups consist of members originating from many countries. The empirical evidence is derived from interviews and discourse analysis of three research groups from the University of Oulu which, by staff, is the most international large university in Finland. The article advances understanding of ba by considering the theory of ba in relation to the discourse and exploratory case study. In the case groups, ba is formed in relation to the knowledge type created, suitable characteristics of a group member and structural factors related to administrative responsibilities. Humanist knowledge, with abstract concepts and philosophical discussions, is created with deeper attention to language and social bonds inside the H-group than the more accurate scientific and technical knowledge in the S- and T-groups.