Influence of ACTN3 R577X polymorphism on ventilatory thresholds related to endurance performance

The purpose of this study was to verify the association between ACTN3 polymorphism and physiological parameters related to endurance performance. A total of 150 healthy male volunteers performed a maximal incremental running test to determine the speeds corresponding to ventilatory threshold (VT) and respiratory compensation point (RCP). Participants were genotyped and divided into terciles based on the analysed variables. Genotype frequencies were compared through χ² test between lower and higher terciles, with the lowest or highest values of each analysed variable. ACTN3 XX genotype was over-represented in higher tercile for VT and RCP. Odds ratio also showed significantly higher chances of XX individuals to be in higher tercile compared to RR (7.3) and RR + RX (3.5) for VT and compared to RR genotype (8.1) and RR + RX (3.4) for RCP. Thus, XX individuals could attain the VT and RCP at higher speeds, suggesting that they are able to sustain higher running speeds in lower exercise intensity domains. It could result in higher lipid acids oxidation, saving muscle glycogen and delaying the fatigue during prolonged exercises, which could be the advantage mechanism of this genotype to endurance performance.     

ACTN3 R577X polymorphism and performance phenotypes in young Chinese male soldiers

Abstract

Alpha-actinin-3 (ACTN3) is absent in 18% of healthy Caucasian individuals owing to homozygosity for a premature stop codon (X) at amino acid 577 (rs1815739). Previous studies have shown a strong association between ACTN3 genotype and human athletic performance. In a study of 452 young Chinese male soldiers, we examined the distribution of ACTN3 genotypes and alleles and analysed the association between ACTN3 genotypes and athletic performance. We found that the frequencies of the ACTN3 R577X genotype (RR 39.8%, RX 43.4%, and XX 16.8%) and R577X allele (R 61.5%, X 38.5%) in young Chinese males were not significantly different from those in Caucasians. We only observed a significant association (P = 0.025) between ACTN3 R577X genotypes and grip strength. Participants with the XX genotype displayed significantly lower handgrip strength than individuals with the RR genotype (P = 0.021), but the difference between XX and RX means (P = 0.258) and that between RR and RX means (P = 0.42) was not significant. We did not observe a strong association between the ACTN3 R577X genotypes and sprint phenotypes or endurance phenotypes. In conclusion, our results indicate that the ACTN3 R577X polymorphism is most strongly associated with grip strength in young Chinese male soldiers.     

Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review

PurposeThe aim of this study was to review, systematically, evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training programs.MethodsA computerized literature search was performed in the electronic databases PubMed, Web of Science, and SPORTDiscus, from inception until November 2020. All included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X polymorphism.ResultsOur search identified 492 records. After the screening of titles, abstracts, and full texts, 13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the analysis. These studies were performed in 6 different countries (Spain, Japan, Brazil, China, the Republic of Korea, and Italy) and involved a total participant pool of 1093 participants. Of the studies, 2 studies involved only women, 5 studies involved only men, and 6 studies involved both men and women. All the studies included were classified as high-quality studies (≥6 points in the Physiotherapy Evidence Database (PEDro) scale score). Overall, evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 investigations. Six studies observed a significant association between ACTN3 R577X polymorphism and exercise induced muscle damage: 2 with non-contact ankle injury, 3 with non-contact muscle injury, and 1 with overall non-contact injury.ConclusionThe present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries, such as muscle injury, ankle sprains, and higher levels of exercise-induced muscle damage.     

The association between the ACTN3 R577X polymorphism and noncontact acute ankle sprains

Ankle sprains are one of the most severe musculoskeletal soft tissue injuries during physical activity. Although many risk factors have been offered, it is unclear why some individuals develop noncontact ankle sprains when participating in comparable levels of physical exertion under identical environmental conditions and others do not. The ACTN3 gene that encodes the α-actinin-3 protein, which is, only expressed in the Z line of fast glycolytic muscle fibres was found to associate with power/strength performance. The aim of this study was therefore to investigate whether the ACTN3 gene polymorphism is associated with noncontact acute ankle sprains. One hundred and forty-two participants with clinically diagnosed noncontact acute ankle sprains as well as 280 physically active controls participants without any history of ankle sprains were included in this case–control genetic association study. The RR genotype (odds ratio (OR) = 0.56; 95% confidence interval (CI), 0.32–0.65, P = 0.011) and R allele (OR = 0.64; 95% CI, 0.37–0.68, P = 0.002) of the ACTN3 were significantly low-represented in the acute ankle sprains group compared with the control group. The ACTN3 R577X is associated with acute ankle sprains in Chinese participants in this study. This is the first study to suggest that an individual with a RR genotype is at a decreased risk of acute ankle sprains.     

ACTN3 R577X polymorphism and performance phenotypes in young Chinese male soldiers

Alpha-actinin-3 (ACTN3) is absent in 18% of healthy Caucasian individuals owing to homozygosity for a premature stop codon (X) at amino acid 577 (rs1815739). Previous studies have shown a strong association between ACTN3 genotype and human athletic performance. In a study of 452 young Chinese male soldiers, we examined the distribution of ACTN3 genotypes and alleles and analysed the association between ACTN3 genotypes and athletic performance. We found that the frequencies of the ACTN3 R577X genotype (RR 39.8%, RX 43.4%, and XX 16.8%) and R577X allele (R 61.5%, X 38.5%) in young Chinese males were not significantly different from those in Caucasians. We only observed a significant association (P = 0.025) between ACTN3 R577X genotypes and grip strength. Participants with the XX genotype displayed significantly lower handgrip strength than individuals with the RR genotype (P = 0.021), but the difference between XX and RX means (P = 0.258) and that between RR and RX means (P = 0.42) was not significant. We did not observe a strong association between the ACTN3 R577X genotypes and sprint phenotypes or endurance phenotypes. In conclusion, our results indicate that the ACTN3 R577X polymorphism is most strongly associated with grip strength in young Chinese male soldiers.     

上海市青少年运动员ACTN3 R577X基因多态性与爆发力素质及其表型指标的关联研究

目的：探讨ACTN3 R577X多态性与青少年运动员爆发力素质及其表型指标的关联性,并检验ACTN3 R577X作为分子标记在青少年运动员科学选材中应用的可行性。方法：选取上海地区青少年业余体校青少年运动员96名,其中男运动员58名,女运动员38名,根据项目特点分为爆发力组和耐力组;利用SNaPshot SNP分型技术对采集的DNA样本进行基因分型。爆发力组运动员进行立定跳远、原地纵跳指标的测试。结果：青少年爆发力组运动员ACTN3 R577X基因型分布与青少年耐力组运动员(x2=7.289,P<0.05)和对照组人群(x2=6.831,P<0.05)均存在显著性差异;青少年爆发力组运动员的ACTN3 R577X等位基因频率与青少年耐力组运动员(x2=7.498,P<0.01)和对照组人群(x2=7.923,P<0.01)均存在显著性差异。在青少年爆发力组男、女运动员中,RR、RX基因型运动员的立定跳远和原地纵跳成绩都要显著性高于XX基因型的运动员（P<0.05,P<0.01）。结论 ACTN3基因 R577X多态性与上海地区青少年运动员爆发力素质存在关联,ACTN3基因 R577X多态性与立定跳远、原地纵跳等爆发力素质表型指标存在关联,ACTN3 基因R577X多态性可以作为青少年速度力量型运动员选材的分子标记。     

ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study

Abstract

We tested the hypothesis that the performance of rapid movements represents body size-independent indices of muscle power. Physical education students (n = 159) were tested on various vertical jump (jump height and average power calculated from the ground reaction force) and muscle strength tests. When non-normalized data were used, a principal components analysis revealed a complex and inconsistent structure where jump height and muscle power loaded different components, while muscle strength and power partially overlapped. When the indices of muscle strength and power were properly normalized for body size, a simple and consistent structure of principal components supported the hypothesis. Specifically, the recorded height and muscle power calculated from the same jumps loaded the same components, separately for the jumps predominantly based on concentric actions and jumps based on a rapid stretch – shortening cycle of the leg extensors. The finding that the performance of rapid movements assesses the same physical ability as properly normalized tests of muscle power could be important for designing and interpreting the results of batteries of physical performance tests, as well as for understanding some basic principles of human movement performance.     

ACTN3基因R577X多态性与运动能力的关联性研究:Meta分析

目的:采用Meta分析定量评价ACTN3基因R577X多态性与耐力素质和速度力量素质的相关性;方法:以耐力型项目运动员组和对照组的XX/(RR+RX)OR、X/R OR和速度力量型项目运动员组和对照组的RR/(RX+XX)OR、R/X OR值为统计量,检索截止至2010年11月的相关文献,制定文献筛选标准,对纳入研究进行异质性检验,数据合并和发表偏倚检验;结果:涉及耐力型项目研究11项和力量速度型项目研究10项分别纳入meta分析,其中,耐力型项目研究共包含运动员组2 220例和对照组3 410例,力量速度型项目研究共包含运动员组1 140例和对照组2 800例.速度力量型项目RR/(RX+RR)OR=1.40(95%CI=1.21～1.62,P<0.01),R/X OR=1.33(95%CI=1.20～1.48,P<0.01),亚组分析欧裔人群RR/(RX+RR)OR=1.37(95%CI=1.17～1.60,P<0.01);R/X OR=1.37(95%CI=1.22～1.53,P<0.01),Egger's检验和Begg's检验均未发现显著发表偏倚;结论:ACIN3基因R577X多态性存在种族差异,RR基因型和R等位基因是速度力量素质的保护因素.欧裔人群中,RR基因型和R等位基因与速度力量素质显著关联.ACTN3基因R577X多态性可以作为速度力量型项目运动员基因选材的候选位点之一,但用于耐力型项目运动员的基因选材尚证据不足.     

The validity and reliability of the GymAware linear position transducer for measuring counter-movement jump performance in female athletes

The current study aimed to assess the validity and test–retest reliability of a linear position transducer when compared to a force plate through a counter-movement jump in female participants. Twenty-seven female recreational athletes (19 ± 2 years) performed three counter-movement jumps simultaneously using the linear position transducer and force plate for validity. In addition, 11 elite female athletes (23 ± 6 years) performed 3 counter-movement jumps with the linear position transducer on three separate days for test–retest reliability. Pearson correlations for jump height between the devices were at a high level (r = .90), with the linear position transducer overestimating jump height by 7.0 ± 2.8 cm. The reliability measured by the linear position transducer resulted in a mean intraclass correlation of .70 for jump height, .90 for peak velocity, and .91 for mean velocity. The linear position transducer was reliable for measuring counter-movement jumps in elite female athletes; however, caution should be taken for one-off jump measures as it may over-estimate jump height.     

Knowledge is power: Issues of measuring training and performance in cycling

ABSTRACT

Mobile power meters provide a valid means of measuring cyclists’ power output in the field. These field measurements can be performed with very good accuracy and reliability making the power meter a useful tool for monitoring and evaluating training and race demands. This review presents power meter data from a Grand Tour cyclist’s training and racing and explores the inherent complications created by its stochastic nature. Simple summary methods cannot reflect a session’s variable distribution of power output or indicate its likely metabolic stress. Binning power output data, into training zones for example, provides information on the detail but not the length of efforts within a session. An alternative approach is to track changes in cyclists’ modelled training and racing performances. Both critical power and record power profiles have been used for monitoring training-induced changes in this manner. Due to the inadequacy of current methods, the review highlights the need for new methods to be established which quantify the effects of training loads and models their implications for performance.     

The influence of performance level,age and gender on pacing strategy during a 100-km ultramarathon

The aim of this study is to analyse the influence of performance level, age and gender on pacing during a 100-km ultramarathon. Results of a 100-km race incorporating the World Masters Championships were used to identify differences in relative speeds in each 10-km segment between participants finishing in the first, second, third and fourth quartiles of overall positions (Groups 1, 2, 3 and 4, respectively). Similar analyses were performed between the top and bottom 50% of finishers in each age category, as well as within male and female categories. Pacing varied between athletes achieving different absolute performance levels. Group 1 ran at significantly lower relative speeds than all other groups in the first three 10-km segments (all P < 0.01), and significantly higher relative speeds than Group 4 in the 6th and 10th (both P < 0.01), and Group 2 in the 8th (P = 0.04). Group 4 displayed significantly higher relative speeds than Group 2 and 3 in the first three segments (all P < 0.01). Overall strategies remained consistent across age categories, although a similar phenomenon was observed within each category whereby ‘top’ competitors displayed lower relative speeds than ‘bottom’ competitors in the early stages, but higher relative speeds in the later stages. Females showed lower relative starting speeds and higher finishing speeds than males. ‘Top’ and ‘bottom’ finishing males displayed differing strategies, but this was not the case within females. Although pacing remained consistent across age categories, it differed with level of performance within each, possibly suggesting strategies are anchored on direct competitors. Strategy differs between genders and differs depending on performance level achieved in males but not females.     

The effect of individualised sprint training in elite female team sport athletes: A pilot study

ABSTRACT

This study aimed to evaluate whether an individualised sprint-training program was more effective in improving sprint performance in elite team-sport players compared to a generalised sprint-training program. Seventeen elite female handball players (23 ± 3 y, 177 ± 7 cm, 73 ± 6 kg) performed two weekly sprint training sessions over eight weeks in addition to their regular handball practice. An individualised training group (ITG, n = 9) performed a targeted sprint-training program based on their horizontal force-velocity profile from the pre-training test. Within ITG, players displaying the lowest, highest and mid-level force-velocity slope values relative to body mass were assigned to a resisted, an assisted or a mixed sprint-training program (resisted sprinting in the first half and assisted sprinting in the second half of the intervention period), respectively. A control group (CG, n = 8) performed a generalised sprint-training program. Both groups improved 30-m sprint performance by ~1% (small effect) and maximal velocity sprinting by ~2% (moderate effect). Trivial or small effect magnitudes were observed for mechanical outputs related to horizontal force- or power production. All between-group differences were trivial. In conclusion, individualised sprint-training was no more effective in improving sprint performance than a generalised sprint-training program.     

Relationship between physiological parameters and performance during a half-ironman triathlon in the heat

Abstract

Triathlon is a popular outdoor endurance sport performed under a variety of environmental conditions. The aim of this study was to assess physiological variables before and after a half-ironman triathlon in the heat and to analyse their relationship with performance. Thirty-four well-trained triathletes completed a half-ironman triathlon in a mean dry temperature of 29 ± 3ºC. Before and within 1 min after the end of the race, body mass, core temperature, maximal jump height and venous blood samples were obtained. Mean race time was 315 ± 40 min, with swimming (11 ± 1%), cycling (49 ± 2%) and running (40 ± 3%) representing different amounts of the total race time. At the end of the competition, body mass changed by ?3.8 ± 1.6% and the change in body mass correlated positively with race time (r = 0.64; P < 0.001). Core temperature increased from 37.5 ± 0.6ºC to 38.8 ± 0.7ºC (P < 0.001) and post-race core temperature correlated negatively with race time (r = ?0.47; P = 0.007). Race time correlated positively with the decrease in jump height (r = 0.38; P = 0.043), post-race serum creatine kinase (r = 0.55; P = 0.001) and myoglobin concentrations (r = 0.39; P = 0.022). In a half-ironman triathlon in the heat, greater reductions in body mass and higher post-competition core temperatures were present in faster triathletes. In contrast, slower triathletes presented higher levels of muscle damage and decreased muscle performance.     

Effects of adding a weekly eccentric-overload training session on strength and athletic performance in team-handball players

To investigate the influence of adding a weekly eccentric-overload training (EOT) session in several athletic performance’s tests, 18 team-handball players were assigned either to an EOT (n?=?11) or a Control (n?=?7) group. Both groups continued to perform the same habitual strength training, but the EOT group added one session/week during a 7-week training programme consisting of four sets of eight repetitions for the bilateral half-squat and unilateral lunge exercises. The test battery included handball throwing velocity, maximum dynamic strength (1RM), countermovement jump (CMJ), 20?m sprint, triple hop for distance, and eccentric/concentric power in both the half-squat and lunge exercises. Data were analysed using magnitude-based inferences. Both groups improved their 1RM in the half squat, 20?m sprint time, and CMJ performance to a similar extent, but the EOT group showed a beneficial effect for both right [(42/58/0), possibly positive] and left [(99/1/0), very likely positive] triple hop for distance performance. In addition, the EOT group showed greater power output improvements in both eccentric and concentric phases of the half-squat (difference in percent of change ranging from 6.5% to 22.0%) and lunge exercises (difference in per cent of change ranging from 13.1% to 24.9%). Nevertheless, no group showed changes in handball throwing velocity. Selected variables related to team-handball performance (i.e. functional jumping performance, power output) can be improved by adding a single EOT session per week, highlighting the usefulness of this low-volume/high-intensity training when aiming at optimizing dynamic athletic performance.     

Upper and lower thresholds of fat-free mass index in a large cohort of female collegiate athletes

ABSTRACT

Fat-free mass index (FFMI) is a height-adjusted metric of fat-free mass which has been suggested as a useful method of body composition assessment in athletic populations. The purpose of this study was to determine sport-specific FFMI values and the natural upper threshold of FFMI in female athletes. 372 female collegiate athletes (Mean±SD; 20.03±1.55 years, 167.55±7.50 cm, 69.46±13.04 kg, 24.18±5.48% bodyfat) underwent body composition assessment via dual-energy x-ray absorptiometry. FFMI was adjusted to height via linear regression and sport-specific reference values were determined. Between-sport differences were identified using one-way ANOVA with Tukey post-hoc tests. Average FFMI was 18.82±2.08 kg/m²; height-adjusted values were not significantly different (p<0.05) than unadjusted values. FFMI in rugby athletes (20.09±2.23 kg/m²) was found to be significantly higher (p<0.05) than in gymnastics (18.62±1.12 kg/m²), ice hockey (17.96±1.04 kg/m²), lacrosse (18.58±1.84 kg/m²), swim & dive (18.16±1.67 kg/m²), and volleyball (18.04±1.13 kg/m²). FFMI in cross country (16.56±1.14 kg/m²) and synchronized swimming (17.27±1.47 kg/m²) was significantly lower (p<0.05) than in Olympic weightlifting (19.69±1.98 kg/m²), wrestling (19.15±2.47 kg/m²), and rugby. The upper threshold for FFMI in female athletes (97.5^th percentile) was 23.90 kg/m². These results can be used to guide personnel decisions and assist with long-term body composition, training, and nutritional goals.     

自我设限策略在体育运动中的运用及其对运动表现的影响

试图检验自我效能和自尊是否可以作为两种自我设限策略——声称式的和行为式的——预测指标,并且比较了两种策略和运动表现的关系。以体育学院篮球专业部分新生为研究对象,结果表明:声称式的自我设限策略和自尊显著负相关,而行为式的自我设限策略和自我效能显著负相关。运动表现和行为式的自我设限负相关,和声称式的自我设限不相关。研究结果表明两种自我设限策略和不同的影响因素相联系,并且对运动表现有不同的影响。     

Effect of resistance training regimens on treadmill running and neuromuscular performance in recreational endurance runners

Abstract

The purpose of this study was to assess the effects of heavy resistance, explosive resistance, and muscle endurance training on neuromuscular, endurance, and high-intensity running performance in recreational endurance runners. Twenty-seven male runners were divided into one of three groups: heavy resistance, explosive resistance or muscle endurance training. After 6 weeks of preparatory training, the groups underwent an 8-week resistance training programme as a supplement to endurance training. Before and after the 8-week training period, maximal strength (one-repetition maximum), electromyographic activity of the leg extensors, countermovement jump height, maximal speed in the maximal anaerobic running test, maximal endurance performance, maximal oxygen uptake ([Vdot]O_2max), and running economy were assessed. Maximal strength improved in the heavy (P = 0.034, effect size ES = 0.38) and explosive resistance training groups (P = 0.003, ES = 0.67) with increases in leg muscle activation (heavy: P = 0.032, ES = 0.38; explosive: P = 0.002, ES = 0.77). Only the heavy resistance training group improved maximal running speed in the maximal anaerobic running test (P = 0.012, ES = 0.52) and jump height (P = 0.006, ES = 0.59). Maximal endurance running performance was improved in all groups (heavy: P = 0.005, ES = 0.56; explosive: P = 0.034, ES = 0.39; muscle endurance: P = 0.001, ES = 0.94), with small though not statistically significant improvements in [Vdot]O_2max (heavy: ES = 0.08; explosive: ES = 0.29; muscle endurance: ES = 0.65) and running economy (ES in all groups < 0.08). All three modes of strength training used concurrently with endurance training were effective in improving treadmill running endurance performance. However, both heavy and explosive strength training were beneficial in improving neuromuscular characteristics, and heavy resistance training in particular contributed to improvements in high-intensity running characteristics. Thus, endurance runners should include heavy resistance training in their training programmes to enhance endurance performance, such as improving sprinting ability at the end of a race.     

Comparison of twitch contractile properties of plantarflexor muscles in Nordic combined athletes,cross-country skiers,and sedentary men

Abstract

The purpose of this study was to compare twitch contractile properties of skeletal muscles in male athletes who train for power and endurance simultaneously (Nordic combined athletes) with athletes who train for endurance (cross-country skiers) and sedentary individuals. Ten Nordic combined athletes, 13 cross-country skiers, and 14 sedentary males aged 20–26 years participated. To determine the contractile properties of the plantarflexor muscles during isometric twitch, the posterior tibial nerve in the popliteal fossa was stimulated by supramaximal square wave pulses of 1 ms duration. Twitch peak force, maximal rates of force development and relaxation, contraction and half-relaxation times were measured. The percentage increase in twitch peak force after a 5-s maximal voluntary contraction (MVC) was taken as an indicator of post-activation potentiation. Nordic combined athletes had a significantly greater twitch post-activation potentiation and rate of force development and shorter contraction time than the other two groups (P < 0.05). They also had a greater (P < 0.05) twitch peak force than cross-country skiers. No significant differences in measured twitch contraction characteristics were found in cross-country skiers and sedentary males. We conclude that the twitch contractile properties of the plantarflexor muscles differed markedly in athletes who train for power and endurance simultaneously compared with athletes who predominantly train for endurance. As an indicator of long-term adaptation to simultaneous power and endurance training, increased twitch force-generation and potentiation capacity, and shortening of twitch contraction times in the plantarflexor muscles were observed in Nordic combined athletes.     

Temporal trends in the sit-ups performance of 9,939,289 children and adolescents between 1964 and 2017

ABSTRACT

We estimated international/national temporal trends in sit-ups performance for children and adolescents, and examined relationships between national trends in sit-ups performance and national trends in health-related/sociodemographic indicators. Data were obtained by systematically searching studies reporting on temporal trends in sit-ups performance for apparently healthy 9–17 year-olds, and by examining nationally representative fitness datasets. Trends at the country-sex-age level were estimated by sample-weighted regression models relating the testing year to mean sit-ups performance. International/national trends were estimated by a post-stratified population-weighting procedure. Pearson’s correlations quantified relationships between national trends in sit-ups performance and national trends in health-related/sociodemographic indicators. A total of 9,939,289 children and adolescents from 31 countries/special administrative regions between 1964 and 2017 collectively showed a large improvement of 38.4% (95% CI: 36.8 to 40.0) or 7.1% per decade (95% CI: 6.8 to 7.4). Large international improvements were experienced by all age and sex groups, with the rate of improvement slowing from 1964 to 2000, stabilizing near zero until 2010, before declining. Trends differed between countries, with national trends in vigorous physical activity a strong, positive correlate of national trends in sit-ups performance. More sit-ups data are needed from low- and middle-income countries to better monitor trends in muscular fitness.     

中外田径十项全能运动成绩比较研究

通过查阅并整理中外男子优秀十项全能运动员十年来的运动成绩,运用文献资料法、比较研究法、数理统计法,对运动成绩进行对比研究,结果表明我国男子十项全能运动整体水平与世界存在一定的差距,依据我国运动员各单项中国纪录成绩,提高我国全能运动整体水平应在1500m和400m单项上,尤其在1500m项目上,为今后运动员选材和训练提供一定的参考价值。