Acute cardiovascular responses to interval exercise: A systematic review and meta-analysis

ABSTRACT

Interval exercise training is increasingly recommended to improve health and fitness; however, it is not known if cardiovascular risk is different from continuous exercise protocols. This systematic review with meta-analyses assessed the effect of a single bout of interval exercise on cardiovascular responses that indicate risk of cardiac fibrillation and infarction compared to continuous exercise. Electronic databases Medline, CINAHL, Embase, Scopus and Cochrane were searched. Key inclusion criteria were: (1) intervals of the same intensity and duration followed by a recovery period and (2) reporting at least one of blood pressure, heart rate variability, arterial stiffness or function. Cochrane Risk of Bias tool and GRADE approach were used. Meta-analyses found that systolic blood pressure responses to interval exercise did not differ from responses to continuous exercise immediately (MD 8 mmHg [95% CI ?32, 47], p = 0.71) or at 60 min following exercise (MD 0 mmHg [95% CI ?2, 1], p = 0.79). However, reductions in diastolic blood pressure and flow-mediated dilation with interval exercise were observed 10–15 min post-exercise. The available evidence indicates that interval exercise does not convey higher cardiovascular risk than continuous exercise. Further investigation is required to establish the safety of interval exercise for clinical populations.     

Acute responses to sprint-interval and continuous exercise in adults with and without exercise-induced bronchoconstriction

The purpose was to compare the airway response to sprint interval exercise (SIE) and continuous exercise (CE) in active adults with exercise-induced bronchoconstriction (EIBC), and to compare ventilatory and oxygen delivery responses between adults with and without EIBC. Adults with EIBC (n = 8, 22.3 ± 3.0 years) and adults without EIBC (n = 8, 22.3 ± 3.0 years) completed a SIE (4 × 30 s sprints separated by 4.5 min of active recovery) and CE (20 min at 65% peak power output) session. Lung function was assessed at baseline, during exercise, and up to 20 min post-exercise. Ventilatory parameters and tissue saturation index (TSI) were recorded continuously throughout the sessions. The decline in forced expiratory volume in 1 s was similar following SIE (?8.6 ± 12.6%) and CE (?9.0 ± 9.3%) in adults with EIBC. There were no significant differences in any of the ventilatory parameters or in TSI during SIE or CE between those with and without EIBC. These findings suggest that SIE and CE affect airway responsiveness to a similar extent. Future research using a lower intensity CE protocol in an inactive sample of adults with EIBC is needed.     

Sympathoadrenal and parasympathetic responses to exercise

Exhaustive exercise is associated with a persistent sensation of weakness and sometimes nausea suggesting abdominal vagal activity. We measured plasma indices of sympathoadrenal (adrenaline, noradrenaline, dopamine) and vagal (pancreatic polypeptide) activity before, during and after submaximal and maximal exercise in healthy young subjects. Plasma adrenaline, noradrenaline and dopamine increased to 8.5 (range 7.4–40.5), 48.0 (32.3–100.5) and 1.8 (1.2–6.6) nmol l^–1 respectively (n = 5), during maximal exercise and decreased towards control values within 15 min of rest. Pancreatic polypeptide (n = 10) increased only during maximal exercise and reached its highest value, 48 (21–145) pmol l^–1, after exertion. The results conform to an increase in sympathetic activity during exercise and a persistent vagal activity after intense exercise which could contribute to the sensation of weakness.     

Physiological responses to laboratory-based soccer-specific intermittent and continuous exercise

The aim of this study was to devise a laboratory-based protocol for a motorized treadmill that was representative of work rates observed during soccer match-play. Selected physiological responses to this soccer-specific intermittent exercise protocol were then compared with steady-rate exercise performed at the same average speed. Seven male university soccer players (mean - s : age 24 - 2 years, height 1.78 - 0.1 m, mass 72.2 - 5.0 kg, VO 2max 57.8 - 4 ml·kg -1 ·min -1 ) completed a 45-min soccer-specific intermittent exercise protocol on a motorized treadmill. They also completed a continuous steady-rate exercise session for an identical period at the same average speed. The physiological responses to the laboratory-based soccer-specific protocol were similar to values previously observed for soccer match-play (oxygen consumption approximately 68% of maximum, heart rate 168 - 10 beats·min -1 ). No significant differences were observed in oxygen consumption, heart rate, rectal temperature or sweat production rate between the two conditions. Average minute ventilation was greater ( P ? 0.05) in intermittent exercise (81.3 - 0.2l·min -1 ) than steady-rate exercise (72.4 - 11.4l·min -1 ). The rating of perceived exertion for the session as a whole was 15 - 2 during soccer-specific intermittent exercise and 12 - 1 for continuous exercise ( P ? 0.05). The physiological strain associated with the laboratory-based soccer-specific intermittent protocol was similar to that associated with 45 min of soccer match-play, based on the variables measured, indicating the relevance of the simulation as a model of match-play work rates. Soccer-specific intermittent exercise did not increase the demands placed on the aerobic energy systems compared to continuous exercise performed at the same average speed, although the results indicate that anaerobic energy provision is more important during intermittent than during continuous exercise at the same average speed.     

Physiological responses to laboratory-based soccer-specific intermittent and continuous exercise

The aim of this study was to devise a laboratory-based protocol for a motorized treadmill that was representative of work rates observed during soccer match-play. Selected physiological responses to this soccer-specific intermittent exercise protocol were then compared with steady-rate exercise performed at the same average speed. Seven male university soccer players (mean +/- s: age 24 +/- 2 years, height 1.78 +/- 0.1 m, mass 72.2 +/- 5.0 kg, VO2max 57.8 +/- 4 ml x kg(-1) x min(-1)) completed a 45-min soccer-specific intermittent exercise protocol on a motorized treadmill. They also completed a continuous steady-rate exercise session for an identical period at the same average speed. The physiological responses to the laboratory-based soccer-specific protocol were similar to values previously observed for soccer match-play (oxygen consumption approximately 68% of maximum, heart rate 168 +/- 10 beats x min(-1)). No significant differences were observed in oxygen consumption, heart rate, rectal temperature or sweat production rate between the two conditions. Average minute ventilation was greater (P < 0.05) in intermittent exercise (81.3 +/- 0.2 l x min(-1)) than steady-rate exercise (72.4 +/- 11.4 l x min(-1)). The rating of perceived exertion for the session as a whole was 15 +/- 2 during soccer-specific intermittent exercise and 12 +/- 1 for continuous exercise (P < 0.05). The physiological strain associated with the laboratory-based soccer-specific intermittent protocol was similar to that associated with 45 min of soccer match-play, based on the variables measured, indicating the relevance of the simulation as a model of match-play work rates. Soccer-specific intermittent exercise did not increase the demands placed on the aerobic energy systems compared to continuous exercise performed at the same average speed, although the results indicate that anaerobic energy provision is more important during intermittent than during continuous exercise at the same average speed.     

运动对24小时动态血压的影响

采用文献资料法综述近年来国内外有关运动对24小时动态血压的影响的研究表明,一次性运动后会导致血压在一定时间下降(可持续22小时),有时甚至低于对照水平(运动后低血压),长期进行中等强度的有氧运动对血压正常者或高血压患者24小时的动态血压具有较好的降压效果。遗传、神经体液因素的改变、血管结构及血管反应性的改变、体重降低以及胰岛素抵抗的降低等都可部分解释运动的降压作用。     

Effects of strength and endurance exercise order on endocrine responses to concurrent training

The present study examined the effect of strength and endurance training order on the endocrine milieu associated with strength development and performance during concurrent training. A randomised, between-groups design was employed with 30 recreationally resistance-trained males completing one of four acute experimental training protocols; strength training (ST), strength followed by endurance training (ST-END), endurance followed by strength training (END-ST) or no training (CON). Blood samples were taken before each respective exercise protocol, immediately upon cessation of exercise, and 1?h post cessation of exercise. Blood samples were subsequently analysed for total testosterone, cortisol and lactate concentrations. Ability to maintain 80% 1RM during strength training was better in ST and ST-END than END-ST (both p?<?.05). Immediately following the respective exercise protocols all training interventions elicited significant increases in testosterone (p?<?.05). ST and END-ST resulted in greater increases in cortisol than ST-END (both p?<?.05). The testosterone:cortisol ratio was similar following the respective exercise protocols. Blood lactate concentrations post-training were greater following END-ST and ST than ST-END (both p?<?.05). Conducting endurance exercise prior to strength training resulted in impaired strength training performance. Blood cortisol and lactate concentrations were greater when endurance training was conducted prior to strength training than vice versa. As such, it may be suggested that conducting endurance prior to strength training may result in acute unfavourable responses to strength training when strength training is conducted with high loads.     

High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: Implications for exercise adherence

Abstract

The aim of this study was to objectively quantify ratings of perceived enjoyment using the Physical Activity Enjoyment Scale following high-intensity interval running versus moderate-intensity continuous running. Eight recreationally active men performed two running protocols consisting of high-intensity interval running (6×3 min at 90% [Vdot]O_2max interspersed with 6×3 min active recovery at 50% [Vdot]O_2max with a 7-min warm-up and cool down at 70% [Vdot]O_2max) or 50 min moderate-intensity continuous running at 70% [Vdot]O_2max. Ratings of perceived enjoyment after exercise were higher (P < 0.05) following interval running compared with continuous running (88 ± 6 vs. 61 ± 12) despite higher (P < 0.05) ratings of perceived exertion (14 ± 1 vs. 13 ± 1). There was no difference (P < 0.05) in average heart rate (88 ± 3 vs. 87 ± 3% maximum heart rate), average [Vdot]O₂ (71 ± 6 vs. 73 ± 4%[Vdot]O_2max), total [Vdot]O₂ (162 ± 16 vs. 166 ± 27 L) or energy expenditure (811 ± 83 vs. 832 ± 136 kcal) between protocols. The greater enjoyment associated with high-intensity interval running may be relevant for improving exercise adherence, since running is a low-cost exercise intervention requiring no exercise equipment and similar relative exercise intensities have previously induced health benefits in patient populations.     

Influence of gender on ventilatory efficiency during exercise in young children

Abstract

In this study, we assessed the ventilatory response in 84 children (46 males: age 8.1 ± 1.0 years, body mass 34.2 ± 7.9 kg, height 1.32 ± 0.16 m; 38 females: age 8.0 ± 0.8 years, body mass 31.7 ± 8.7 kg, height 1.31 ± 0.08 m) during a cycle ergometer test to determine if there was an influence of gender on ventilatory efficiency. The test commenced at 25 W and increased by 10 W every minute. Expired air was collected through a face mask and analysed breath by breath. The ventilatory anaerobic threshold was determined according to gas exchange methods and we focused our attention on the analysis of carbon dioxide production ([Vdot]CO₂), ventilation ([Vdot] _E), the ratio [Vdot] _E/[Vdot]CO₂ and its slope. Differences between the sexes at maximal power output were strongly significant for [Vdot] _E and [Vdot]CO₂ (P = 0.0001 and P = 0.0004 respectively) and moderately significant for the [Vdot] _E/[Vdot]CO₂ ratio (P = 0.05). The slope of [Vdot] _E versus [Vdot]CO₂ was 30.8 ± 4.2 for males and 29.4 ± 3.2 for females, with no difference between the sexes (P = 0.1). In conclusion, although the peak values of [Vdot] _E and [Vdot]CO₂ were significantly different between the sexes, there were no such differences in ventilatory efficiency during a maximal incremental test expressed as the slope of [Vdot] _E/[Vdot]CO₂, at least in young children.     

Intensity-dependent reductions in resting blood pressure following short-term isometric exercise training

To reduce resting blood pressure, a minimum isometric exercise training (IET) intensity has been suggested, but this is not known for short-term IET programmes. We therefore compared the effects of moderate- and low-intensity IET programmes on resting blood pressure. Forty normotensive participants (22.3 ± 3.4 years; 69.5 ± 15.5 kg; 170.2 ± 8.7 cm) were randomly assigned to groups of differing training intensities [20%EMG_peak (~23%MVC, maximum voluntary contraction, or 30%EMG_peak (~34%MVC)] or control group; 3 weeks of IET at 30%EMG_peak resulted in significant reductions in resting mean arterial pressure (e.g. ?3.9 ± 1.0 mmHg, P < 0.001), whereas 20%EMG_peak did not (?2.3 ± 2.9 mmHg; P > 0.05). Moreover, after pooling all female versus male participants, IET induced a 6.9-mmHg reduction in systolic blood pressure in female participants, but only a 1.5-mmHg reduction in systolic blood pressure in male participants, although the difference was not significant. An IET intensity between 20%EMG_peak and 30%EMG_peak is sufficient to elicit significant resting blood pressure reductions in a short-term training period (3 weeks). In addition, sexual dimorphism may exist in the magnitude of reductions, but further work is required to confirm this possibility, which could be important in understanding the mechanisms responsible.     

Cardiorespiratory and perceptual responses of two interval training and a continuous training protocol in healthy young men

High Intensity Interval Training (HIIT) can be performed with different effort to rest time-configurations, and this can largely influence training responses. The purpose of the study was to compare the acute physiological responses of two HIIT and one moderate intensity continuous training (MICT) protocol in young men. A randomised cross-over study with 10 men [age, 28.3?±?5.5years; weight, 77.3?±?9.3?kg; height, 1.8?±?0.1?m; peak oxygen consumption (VO₂peak), 44?±?11?mL.kg^?1.min^?1]. Participants performed a cardiorespiratory test on a treadmill to assess VO₂peak, velocity associated with VO₂peak (vVO₂peak), peak heart rate (HRpeak) and perceived exertion (RPE). Then participants performed three protocols equated by distance: Short HIIT (29 bouts of 30s at vVO₂peak, interspersed by 30s of passive recovery, 29?min in total), Long HIIT (3 bouts of 4?min at 90% of vVO₂peak, interspersed by 3?min of recovery at 60% of vVO₂peak, 21?min in total) and MICT (21?min at 70% of vVO₂peak). The protocols were performed in a randomised order with ≥48 h between them. VO₂, HRpeak and RPE were compared. VO₂peak in Long HIIT was significantly higher than Short HIIT and MICT (43?±?11 vs 32?±?8 and 37?±?8?mL.kg^?1.min^?1, respectively, P?P?P?2, HR and RPE than Short HIIT and MICT, suggesting a higher demand on the cardiorespiratory system. Short HIIT and MICT presented similar physiologic and perceptual responses, despite Short HIIT being performed at higher velocities.     

日周期节律变化在运动中对体液调节激素、电解质及血浆容量的影响

目的:研究运动中人体日周期节律变化对体液调节激素及电解质、血浆容量产生的影响.方法:16名身体健康的男性大学生参加二次、相隔一周的功率自行车运动实验(分别在早晨5:00和下午5:00),受试者以心率140次/min运动1 h,之后休息1 h.分别在运动前、中和休息期间测定血浆心钠素(ANP)、醛固酮(ALD)、精氨酸加压素(AVP)、血红蛋白(Hb)、红细胞压积(Hct),血、尿渗透压(Osm)和血、尿钠(Na )、钾(K )离子等,同时测定血浆容量(△PV)和体重(△W)的变化.结果:运动前ANP(早晨:42.1±3.2,下午:33.9±1.5 Pg/ml,P=0.0096)、ALD(早晨:92±10,下午:57±5 Pg/ml,P=0.0005)和AVP(早晨:25.5±0.5,下午:22.7±0.8Pg/ml,P=0.0013)早晨比下午高,呈现昼夜节律变化,它们在运动中明显升高,而且早晨和下午的节律性差异在运动中仍然明显.在早晨运动比下午运动导致更多的血浆容量的减少(早晨:-7.2±3%,下午:-4.5±2%,P=0.02)和体重的下降(早晨:1.03±0.2,下午:0.87±0.1,P=0.0235).结论:①体液调节激素呈现早晨高下午低的昼夜节律变化,这种节律变化在运动中仍然明显,对维持体液平衡起到重要的作用;②运动导致的脱水在早晨比在下午更严重,提示在早晨不适宜从事大负荷运动、训练,可能导致严重的脱水.     

The respiratory time and flow profile at volitional exercise termination

Abstract

In this study, we examine the effect of exercise on the time and flow characteristics of the respiratory cycle profile at the point of volitional exercise termination. Eight males (mean age 29 years, s = 10; body mass 74 kg, s = 7; height 1.75 m, s = 0.04) undertook a cycle test to volitional exhaustion on a cycle ergometer, which allowed peak oxygen uptake ([Vdot]O_2peak) to be measured (mean 51 ml · kg^?1 · min^?1, s = 7). At a later date, two sub-maximal tests to volitional exhaustion were completed in a random order at 76% (s = 6) and 86%[Vdot]O_2peak (s = 7). As expected, the magnitude of the respiratory flow and time characteristics varied with the three exercise intensities, as did the point of exercise termination and terminal ventilation rates, which varied from 7 to 27 min and 112 to 132 litres · min^?1 respectively. More importantly, however, at exercise termination some of the characteristics were similar, particularly the breathing frequency (at termination 49 breaths · min^?1), the ratio between inspiration and total breath time (0.5), and the later occurrence of peak inspiratory flow (0.24 – 0.48 s). The coincident unity of these time and flow profile characteristics at exercise termination illustrates how the integration of timing and flow during breathing influence exercise capacity in non-elite athletes.     

The effects of resistance exercise with and without different degrees of blood-flow restriction on perceptual responses

The aim was to compare exercise with and without different degrees of blood-flow restriction on perceived exertion (RPE) and discomfort. Participants were assigned to Experiment 1, 2, or 3. Each completed protocols differing by pressure, load, and/or volume. RPE and discomfort were taken before and after each set. For pressure and RPE, the 20% one repetition maximum (1RM) blood-flow restriction conditions were affected by increasing the pressure from 40% to 50% blood-flow restriction (~12 vs. ~14). This did not appear to happen within the 30% 1RM blood-flow restriction conditions or the higher pressures in the 20% 1RM conditions. The similar RPE between 20% and 30% 1RM to failure was expected given both were to failure. For discomfort, ratings were primarily affected by load at the lowest pressure. Increasing pressure to 50% blood-flow restriction increased discomfort at 20% 1RM (~2.6 vs. ~4). There was a further increase when increasing to 60% blood-flow restriction (~4 vs. ~4.8). The high-load condition had the lowest discomfort, while ratings were highest with 20% 1RM to failure. In conclusion, exercise with blood-flow restriction does not appear to augment the perceptual response observed with low-load exercise to failure.     

A short bout of high-intensity intermittent exercise before moderate-intensity prolonged exercise as a mean to potentiate fat oxidation ?

ABSTRACT

Moderate-intensity continuous exercise (MICE) improves fat oxidation. High-intensity intermittent exercise (HIIE) is thought to have a greater potential for fat oxidation but it might be too demanding in the long term for patients. We hypothesized that an initial bout of HIIE could maximize fat oxidation during MICE and the following passive recovery. Eighteen healthy participants performed two acute isocaloric exercise sessions at random. MICE consisted of 45-min cycling at 50% of maximal aerobic power (Pmax). COMB began with five 1-min bouts of HIIE at Pmax (interspaced with 1-min recovery periods) followed by 35-min MICE. Gas exchange allowed substrate oxidation rate assessment.

Expressed as a % of energy expenditure, fat oxidation (%) increased during in the passive recovery following COMB (Recovery: 36.0 ± 19.4 vs 23.0 ± 20.3%; ES: 0.66; p < 0.0001). An initial bout of HIIE preceding a prolonged moderate-intensity exercise may potentiate fat oxidation during the following recovery. This might be relevant for health management of overweight/obese persons.     

Perceptual and cognitive responses during exercise: Relationships with metamotivational state and dominance

Abstract

In this study, we examined ratings of perceived exertion (RPE) and attentional focus during exercise in relation to telic and paratelic metamotivational dominance and state. Thirty regular exercisers (11 females, 19 males), of whom 10 were telic dominant (mean Paratelic Dominance Scale score=6.2±2.9), 10 paratelic dominant (mean PDS score=23.8±1.4), and 10 non-dominant (mean PDS score=15.4±0.7) completed two exercise trials. In the first trial, the participants completed a maximal ramped exercise test on a motorized treadmill to determine their gas exchange threshold (the speed at which determined exercise intensity of the subsequent trial). Throughout the second trial (a 30-min treadmill run), the participants reported their metamotivational state, RPE, and attentional focus (associative or dissociative) at 5-min intervals. Heart rate was recorded at 3, 8, 13, 18, 23, and 28 min and expired air was analysed for oxygen consumption (VO₂) between 1–3, 6–8, 11–13, 16–18, 21–23, and 26–28 min. There was no main effect of dominance or dominance×time interaction on any variables (P >0.05). Oxygen consumption did not differ between states but RPE was higher in the telic than paratelic state at 25 and 30 min (t ₂₈=2.87, P <0.05; t _26.77=3.88, P <0.05, respectively). Attentional focus was more associative in the telic than paratelic state at 20, 25, and 30 min (t ₂₈=? 3.73, P <0.05; t ₂₈=? 4.85, P <0.01; t ₂₈=? 5.15, P <0.05, respectively) and heart rate was higher at 23 min in the telic state (t ₂₇=3.40, P <0.05). During the latter stages of exercise, the telic metamotivational state, not dominance, was related to a more associative attentional focus and higher RPE. Our results support the use of reversal theory (Apter, 2001) to understand perceptual and cognitive responses during aerobic exercise, but an experimental design in which state is manipulated is needed to examine the effects of metamotivational dominance and state on perceptual and cognitive responses.     

The influence of drink temperature on thermoregulatory responses during prolonged exercise in a moderate environment

Abstract

Nine males cycled at 53% (s = 2) of their peak oxygen uptake ([Vdot]O_2peak) for 90 min (dry bulb temperature: 25.4°C, s = 0.2; relative humidity: 61%, s = 3). One litre of flavoured water at 10 (cold), 37 (warm) or 50°C (hot) was ingested 30 – 40 min into exercise. Immediately after the 90 min of exercise, participants cycled at 95%[Vdot]O_2peak to exhaustion to assess exercise capacity. Rectal and mean skin temperatures and heart rate were recorded. The gradient of rise in rectal temperature was influenced (P < 0.01) by drink temperature. Mean skin temperature was highest in the hot trial (cold trial: 34.2°C, s = 0.5; warm trial: 34.4°C, s = 0.5; hot trial: 34.7°C, s = 0.6; P < 0.01). Significant differences were observed in heart rate (cold trial: 132 beats · min^?1, s = 13; warm trial: 134 beats · min^?1, s = 12; hot trial: 139 beats · min^?1, s = 13; P < 0.05). Exercise capacity was similar between trials (cold trial: 234 s, s = 69; warm trial: 214 s, s = 52; hot trial: 203 s, s = 53; P = 0.562). The heat load and debt induced via drinking resulted in appropriate thermoregulatory reflexes during exercise leading to an observed heat content difference of only 33 kJ instead of the predicted 167 kJ between the cold and hot trials. These results suggest that there may be a role for drink temperature in influencing thermoregulation during exercise.