β-内酰胺酶的活性检测和抑制研究进展

β-内酰胺类抗生素是20世纪的伟大发明之一,拯救了数以万计生命.然而,随着抗生素临床应用的普及,由β-内酰胺酶导致的致病菌耐药性问题也日益突出.耐药菌的进化和传播严重影响到人类健康和全球社会经济发展.因此,检测/抑制β-内酰胺酶的活性对合理使用抗生素、有效治疗感染类疾病具有重要意义.目前,特异性检测、抑制β-内酰胺酶的相关方法和临床应用已有报道.本综述主要阐述细菌产生β-内酰胺酶的耐药机理,总结近年来β-内酰胺酶荧光探针和抑制剂的发展,以期为今后设计特异性高、灵敏度强的该类荧光探针和抑制剂提供理论依据,解决抗生素耐药性问题.     

牛乳中抗生素的残留与危害现状

抗生素越来越多地被应用于畜牧业中，其在乳制品中的残留问题也备受关注．乳品中残留抗生素不仅危害人体的健康，而且会影响经济贸易的正常进行．为了让广大民众及企业对牛乳中抗生素残留问题有更深的了解，章从牛乳中抗生素的残留来源、危害、现状、管理及检测方法等方面进行综述，以期提高民众的消费意识和牛乳生产的商业道德水平，保障消费的权益．     

显色反应快速检验多种抗生素类药物

目的：综述59种抗生素类药品的显色反应，为药品监督检验提供快速检验方法．方法：事先配制好13种试液，利用化学显色反应，对常见的59种抗生素84种剂型进行检验．结果：不同种类的药品。显其特有的颜色，如有不同，则可疑为假劣药品．结论：方法简便、快速，鉴别假劣药品的准确率高．     

正确使用抗生素

<正> 20世纪,人们分离出了多种抗生素,目前已知的天然抗生素不少于9000种,其中很多抗生素在各种常见细菌性疾病的治疗中发挥了重要的作用。几十年来,用抗生素救活的人不计其数。抗生素应用于医学具有划时代的意义。我们说抗生素可以化腐朽为神奇一点也不算夸张。正因为如此,抗生素成了临床各科医师最常用的一类药物。1 抗生素的副作用抗生素在治疗疾病中有积极的一面,但其副作用也不可低估,特别是在使用不当,如剂量过大或用药时间过长时,抗生素会引起各种不良反应,有的甚至相当严重。(1)链霉素、卡那霉素可引起眩晕、耳鸣、耳聋。     

青霉烯类抗生素及其构效关系

青霉烯 ,是一类抗菌谱广 ,抗菌活性高 ,对肾脱氢肽酶 -I稳定的抗生素 ,本文介绍了青霉烯类抗生素的特征、抗菌性及其活性的构效关系 ,交介绍了用分子力学和分子轨道方法对其效关系进行的理论阐述。     

HPLC测定凯里地区动物组织中抗生素的残留量

为了解凯里地区动物肝肾组织中抗生素残留量的状况，应用高效液相色谱法进行了测定，测定结果显示动物肝肾组织中抗生素残留量存在超标现象．     

微机运算（2.2）法抗生素微生物检定

微机运算（２．２）法抗生素微生物检定刘学军，刘迎元目前．许多单位没有足够的资金购置ＺＹ—３００Ａ型多功能抑菌圈自动测试仪。但是．如果能充分利用微机的计算功能来运算（２．２）法抗生素微生物检定．也不乏是一种迅速准确计算抗生素效价及统计分析实验结果的好办...     

泉州市售牛奶中抗生素残留的分析

为了解和比较泉州市市售生牛奶及消毒纯牛奶中抗生素残留情况，从泉州市不同区域及两个奶牛场采集生牛奶150份．几大超市采购消毒纯牛奶100份．按国家标准GB／T4789．27-2003，采用TTC法进行检测，检测出生牛奶中阳性27份，可疑15份，阳性率18％，可疑率10％；国产消毒纯牛奶75份，阳性14份，阳性率18．7％；进口纯牛奶25份，阳性0份，阳性率0％，调查结果显示，本市产的生牛奶中抗生素残留阳性率比国产消毒纯牛奶高，牛奶中抗生素残留的情况仍较为严重，应引起广大消费者的注意，并倡议政府部门应加强对食品安全的管理和执行力度，以尽快改善此现状。     

如何用好家庭小药箱

7岁的小红患有支气管炎，其父母总要在家里备些抗生素．每当小红出现发病症状就给她服一些，有时也能控制病情．可时间长了．很多药物慢慢失效了。她母亲听说罗红霉素效果不错，就找人配了一些备着。不久前小红发病时给她服了一些。可小红不仅发热不退，几天后还出现黄疸．到医院检查才知道是患了药物性肝炎，住院治疗后才慢慢好起来。医生说。罗红霉素有损伤肝脏的副作用。而给小红服用的剂量又大了一些。     

简述抗生素广泛使用带来的问题

随着科学技术的不断进步与发展,在人类与疾病相互斗争的长河中,致病性生物茵与人类抗生素的使用一直处于演变与发展之中.新的抗生素不断出现和使用为感染性疾病的治疗提供了有利的武器,但同时人类长期、大量的使用抗生素,也使得致病茵对抗生索逐渐发生适应,产生了耐药性,这将是人类面临的严峻问题.     

卡思卡特城堡

It is worthy of noting that, whilst Crookston Castle witnessed the earlier and happier portion of Mary's variegated life,     

只要努力,不要后悔

There are numbers of crossroads on our long and unpredictable life journey where we totally have no idea about which direction to choose. No matter what our decision is, we should not turn back, but face the music and go ahead instead. I am this kind of girl who always does try without regretting, one example is how I dealt with my love.     

浅谈移民问题

Migration occurs behind a variety of reasons and has a great effect on the whole world. People may migrate in order to improve their economic situation, or in order to escape civil strife, persecution, and environmental disasters. The impact of migration is complex, bringing both benefits anddisadvantages. This paper briefly talks about the causes of migration, the allocation of benefits, and the ways in which individual countries and the international community deal with this important subject.     

Sister Carrie, an Adherent of Desires

Sister Carrie is one of the most controversial characters in American literature.Thought as a "fallen woman" firstly,she was defined as a "new woman" by some critics later. However, by digging into the motivaton behind the whole process of Carrie's "success", the relationship between Carrie and her creator (the author), the social conditions of then American, it can be found that Carrie has never been free-standing on her thought and she has never found her real-sdf even after becoming a famous actress. In a society dominated by mass consumerism Carrie is only an adherent of her own desires. She also is a representative of all those country girls flooded into cities, a symbol and a sacrifice of the urbanization of America in a time countryside was overcome by cities.     

Improvement of one-cycle controller by use of proportional integral differential controller

1.IntroductionOne-cyclecontrolmethod,whichwasproposedaboutonedecadeago[1],hasbecomeanattractivemethodinspecialfieldssuchaspowerfactorcorrection[2-6],switchingamplifiers[7,8],etc.Themainideaofthiscontrollerisbasedonintegrationofdiodevoltageinone-cycleandforcesittobeexactlyequaltothereferencevalue.Themainadvantageofthiscontrollerisitsrealtimeabilitytorejectthevariationofinputvoltage[1].Despitethisgreatability,ithasnogoodperformancesinrejectingofloaddisturbanceandfollowingreferencecommands.Espec…     

胡主席在印度,我却在中国

Today, Sunday morning, I sit thinking and typing at my computer. My thoughts are in my homeland, India and my body is in China. The body is here and mind there for a good reason. Mr. Hu is president and I am resident and both are in each other's countries (what a difference the absence of one small letter makes!). Mr. Hu will return in a few days and I will stay on longer.     

STORIES

正A One day a pig went to the stable(马棚)to see his good friend,an oldhorse,and was going to stay there forthenight.Night came and it was time forsleep.The pig went into the straw heap(稻草堆)and lay comfortably.A longtime passed,but the horse was stillstanding there and did not move.Thepig asked the horse why he did not go tosleep."Standing like this is the begin-ning ofsleeping,"answered the horse.     

巧妙引语(英文)

正1.Any fool can count the seeds in an apple.Only God can count all the apples in one seed.2.Happy families are all alike;every unhappy family is unhappy in its own way.3.Memories are the key not to the past,but to the future.4.Sometimes in the dark you see what you want to see.5.There is a great difference between     

Information for Authors

正Scope and Policy The Journal of Chongqing University-English Edition(JCQU-E)is a peerreviewed journal publishing research articles in multiple disciplines of science and technology,covering civil and environmental engineering,chemical engineering,biotechnology,mechanical and electrical engineering,computer and data processing,mining,metallurgy,materials science,and interdisciplines thereof.