基于微波无源探测隐身目标的方法研究

在现代战争中,对于优化设计和涂有吸波材料的隐身目标一般常规雷达无法发现,提出了一种利用微波无源遥感的新方法来探测目标,利用微波辐射计来探测和识别空中隐身目标,它采用测量大气热噪声方法对目标进行探测,不仅能够探测隐身目标,而且本身也具有隐身功能.通过机理和方法分析表明：用微波辐射计探测隐身目标的方法是可行的,它不仅本身不发射功率,具有自隐身功能,而且还可以全天侯、全天时探测隐身或常规目标,因此可在军事上可获得广泛的应用,关键问题是要提高微波辐射计的空间分辨率和温度分辨率.     

炎性乳腺癌的诊断和治疗

[目的]:探索炎性乳腺癌的诊断和治疗.[方法]:10例经病理或细胞学检查确诊的炎性乳腺癌先给2~3个周期的CAF(阿霉素+环磷先胺+氟尿嘧啶)方案化疗,然后行总量的2/3量的乳腺及同侧腋窝的放射治疗,放疗结束后休息2周即行乳癌根治切除术,术后切口愈合后再给剩余1/3量的放射治疗,照射胸壁及同侧腋窝和锁骨上使放射总量达到60~70 Gy/野,在放疗前后穿插化疗(CAF)4个周期.[结果]:1例患者未完成治疗出院后1个月死亡.9例患者完成上述序惯治疗,全部病例乳腺红肿、高张消退,乳腺内肿块及同侧腋窝淋巴结明显缩小.手术切除标本检查有5例乳腺内找到癌灶,其中典型炎性癌1例、单纯癌2例、硬癌2例,4例乳腺组织内未找到癌灶.同侧腋窝淋巴结见癌转移7例,同侧锁骨上淋巴结见癌转移2例.生存时间1~28个月,中位生存时间12个月.[结论]:炎性乳腺癌通过序惯治疗可以提高治疗的有效性、延长生命,提高生存质量.     

碎片拼合的轮廓提取和曲率计算

Canny算子在对物体进行轮廓提取时,会不可避免地漏检一些明显的边界,导致轮廓的不连续. 提出了一种几何方法来定位、度量轮廓上的间断点, 然后将其准确地填充起来. 在获得轮廓的完整信息后, 文中提出采用卷积积分的方法, 通过线性插值对轮廓进行重采样来计算各离散点曲率. 该方法保证了卷积窗口内离散点分布得均匀、一致, 并且使得每一离散点与其权重都满足一一对应关系, 从而保证了曲率计算的精确性. 同时给出了相关参数的选择方法. 实验结果表明,算法是准确和稳定可靠的.     

求解整数线性规划的一种等值线法

借鉴求解整数线性规划分支定界法的思路,通过构造与其对应线性规划最优解的等值线平行的过滤条件,使其整数线性规划的可行域变小,只从局部可行域上通过枚举找出整数线性规划的最优解.     

乳腺癌的免疫调节治疗(英文)简

Standard treatment options for breast cancer include surgery, chemotherapy, radiation, and targeted therapies, such as adjuvant hormonal therapy and monoclonal antibodies. Recently, the recognition that chronic inflammation in the tumor microenvironment promotes tumor growth and survival during different stages of breast cancer development has led to the development of novel immunotherapies. Several immunotherapeutic strategies have been studied both preclinically and clinically and already have been shown to enhance the efficacy of conven- tional treatment modalities. Therefore, therapies targeting the immune system may represent a promising next-generation approach for the treatment of breast cancers. This review will discuss recent findings that elucidate the roles of suppressive immune cells and proinflammatory cytokines and chemokines in the tumor-promoting microen- vironment, and the most current immunotherapeutic strategies in breast cancer.     

Population validity for educational data mining models: A case study in affect detection

Information and communication technology (ICT)‐enhanced research methods such as educational data mining (EDM) have allowed researchers to effectively model a broad range of constructs pertaining to the student, moving from traditional assessments of knowledge to assessment of engagement, meta‐cognition, strategy and affect. The automated detection of these constructs allows EDM researchers to develop intervention strategies that can be implemented either by the software or the teacher. It also allows for secondary analyses of the construct, where the detectors are applied to a data set that is much larger than one that could be analyzed by more traditional methods. However, in many cases, the data used to develop EDM models are collected from students who may not be representative of the broader populations who are likely to use ICT. In order to use EDM models (automated detectors) with new populations, their generalizability must be verified. In this study, we examine whether detectors of affect remain valid when applied to new populations. Models of four educationally relevant affective states were constructed based on data from urban, suburban and rural students using ASSISTments software for middle school mathematics in the Northeastern United States. We found that affect detectors trained on a population drawn primarily from one demographic grouping do not generalize to populations drawn primarily from the other demographic groupings, even though those populations might be considered part of the same national or regional culture. Models constructed using data from all three subpopulations are more applicable to students in those populations than those trained on a single group, but still do not achieve ideal population validity—the ability to generalize across all subgroups. In particular, models generalize better across urban and suburban students than rural students. These findings have important implications for data collection efforts, validation techniques, and the design of interventions that are intended to be applied at scale.     

虚拟现实技术在教育领域的应用

建构主义认为环境的体验对学习者构建知识是非常必要的.本文分析了虚拟现实技术的基本原理和重要特性,指出虚拟现实技术是解决在实现建构式学习中诸多困难的有效途径.     

Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice

Breast cancer is one of the malignant tumors with the highest morbidity and mortality. It is helpful to reduce the rate of tumor recurrence and metastasis by treating breast cancer with adjuvant chemotherapy, so as to increase the cure rate or survival of patients. In recent years, liposomes have been regarded as a kind of new carrier for targeted drugs. Being effective for enhancing drug efficacy and reducing side effects, they have been widely used for developing anticancer drugs. As a kind of anthracycline with high anticancer activity, doxorubicin can treat or alleviate a variety of malignant tumors effectively when it is used on its own or in combination with other anticancer drugs. Although liposomal doxorubicin has been extensively used in the adjuvant chemotherapy of breast cancer, its exact therapeutic efficacy and side effects have not been definitely proven. Various clinical studies have adopted different combined regimes, dosages, and staging, so their findings differ to certain extent. This paper reviews the clinical application of liposomal doxorubicin in the adjuvant chemotherapy of breast cancer and illustrates therapeutic effects and side effects of pegylated liposomal doxorubicin (PLD) and non-PLD (NPLD) in clinical research, in order to discuss the strategies for applying these drugs in such adjuvant chemotherapy, looking forward to providing references for related research and clinical treatment in terms of dosage, staging, combined regimes, and analysis methods and so on.     

BRCA1/2 associated hereditary breast cancer

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes,focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial;further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.     

中草药对治疗癌症恶病质动物模型有效性的系统性回顾（英文）

本综述总结利用中草药治疗癌症恶病质的临床前研究及其潜在的机制,是首个针对中草药治疗癌症恶病质动物模型成效进行系统性回顾评价的研究。本文通过检索PubMed、EMBASE、Allied and Complementary Medicine Database以及Web of Science四大代表性的资料库(检索时间至2016年12月),就中草药治疗癌症恶病质的随机对照动物试验进行系统性回顾分析,并采用CAMARADE评分清单进行质量评价。分析结果显示:在十四项中草药及其化合物中,除了姜黄素外其他如黄连、黄连素、病得灵、清暑益气汤、黄芩、补中益气汤、六君子汤、橙皮苷、苍术呋喃烃、十全大补汤、小柴胡汤、知母及黄柏等都已被证实可以通过抗炎、调节神经内分泌途径、调节泛素蛋白酶体系统或蛋白质合成来改善癌症恶病质的症状。因此,利用中草药治疗癌症恶病质是一种有效的方法。然而该结论尚需要有更详细的分子机制和活性化合物的实验研究验证。     

利用AutoCAD VBA获取等高线上高程点的方法

提出了对等高线进行定距分段,获取等高线上的高程点三维坐标数据的方法,并给出处理方法的程序代码和应用实例.     

Radiofrequency ablation versus hepatic resection for breast cancer liver metastasis: a systematic review and meta-analysis

Objective

To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for breast cancer liver metastases (BCLMs).

Methods

Studies that had examined the outcomes for both RFA and HR for BCLM were identified by searching the electronic databases PubMed, EMBASE, and the Cochrane Library. Pooled analyzes of the overall survival (OS), disease-free survival (DFS), and short-term outcomes of BCLM were performed.

Results

Patients with BCLM gained many more survival benefits from HR than from RFA with regard to the 3-year OS rate (combined odds ratio (OR) 0.41, 95% confidence interval (CI) 0.29–0.59, P<0.001), 5-year OS rate (combined OR 0.38, 95% CI 0.32–0.46, P<0.001), 3-year DFS (combined OR 0.36, 95% CI 0.27–0.49, P<0.001), and 5-year DFS (combined OR 0.51, 95% CI 0.40–0.66, P<0.001). RFA had fewer postoperative complications (combined OR 0.30, 95% CI 0.20–0.44, P<0.001) and shorter hospital stays (combined OR -9.01, 95% CI -13.49–4.54, P<0.001) than HR.

Conclusions

HR takes precedence over RFA in the treatment of patients with BCLM, considering the better survival rate. RFA gives rise to fewer complications and can be carried out with a shorter hospital stay, compared to HR. RFA should be reserved for patients who are not optimum candidates for resection.

     

科学模型及模型认知素养发展策略

"模型认知"是科学概念学习和科学探究的思维模式,发展"模型认知"素养有助于深化科学思维和科学能力.本研究从科学模型入手,分析科学模型的涵义和特征;根据教学实际情况,将科学模型赋予学科背景化,探究化学模型的特点和具体教学主题中学生模型认知素养的水平层级表现,提出化学教学中发展学生模型认知素养的有效策略.     

费歇判别法在乳房癌诊断中的应用

研究了乳房肿瘤的分类问题，通过对500个已知肿瘤性质(良性或恶性)细胞核的显微图像的10个量化特征进行统计分析，利用费歇判别法，建立了费歇判别模型，给出了判别准则，对未知乳房肿瘤性质的病例进行了成功的诊断；最后对变量进行了合理的缩减．本方法具有良好的实用性和操作性．     

微波自动测量教学实验系统

针对原有微波测量教学实验装置进行自动化改造设计,形成以单片机8051为控制中心,由步进电机伺服系统、信号调理电路、液晶显示部分及数据分析软件等构成的微波自动测量系统,实现了自动测量并在液晶屏上显示测量线的场强波形或阻抗圆图等.该微波自动测量系统界面友好,操作简单,在速度、精度及重复性等方面较手动测量系统有很大的改善,具有很强的实用性,满足了实验教学的需求.     

HER2 over-expression and response to different chemotherapy regimens in breast cancer

Purpose To exam the relationship between HER2 over-expression and different adjuvant chemotherapies in breast cancer. Patients and Methods A total of 1625 primary breast cancer patients who received post-surgery adjuvant chemotherapy in Tianjin Cancer Hospital, China, from July 2002 to November 2005 were included in the study. Among them, 600 patients were given CMF (CTX MTX 5-Fu) regimen, 600 given CEF (CTX E-ADM 5-Fu) regimen, and 425 given anthracyclines plus taxanes regimen, with mean follow-up time of 42 months. Results In CMF treatment group, the 3-year disease free survival (DFS)in HER2 over-expressed patients was lower than that of the HER2-negative ones (89.80% vs 91.24%, P=0.0348); in node-positive subgroup, the 3-year DFS was 84.72% in HER2 over-expressed patients, and 90.18% in the HER-2-negative ones (P=0.0271).Compared to CMF regimen, anthracyclines and anthracyclines plus taxanes regimens are more effective (P＜0.05) in node-positive HER2 over-expression than those in the node-negative. Conclusion HER2 over-expression is an independent index for predicting poor prognosis and short DFS for breast cancer patients. HER2 over-expressed patients are resistant to CMF regimen chemotherapy, but sensitive to anthracyclines-based or anthracyclines plus taxanes regimen. HER2 expression can be taken as a marker for therapies in breast cancer.     

Optimal velocity functions for car-following models

The integral part of the optimal velocity car-following models is the optimal velocity function （OVF）, which can be derived from measured velocity-spacing data. This paper discusses several characteristics of the OVF and presents regression analysis on two classical datasets, the Lincoln and Holland tunnels, with different possible OVFs. The numerical simulation of the formation of traffic congestion is conducted with three different heuristic OVFs, demonstrating that these functions give results similar to those of the famous Bando OVF （Bando et al., 1995）. Also an alternative method is present for determining the sensitivity and model parameters based on a single car driving to a fixed barrier.     

Enrollment projection models for institutional planning

This paper examines alternative techniques for projecting freshman enrollment in specific academic departments. Departmental enrollment projections provided by four different projection models are compared to actual departmental enrollments at a selected institution. Two of the models use only historical data, while the other two models are sensitized to current developments as indicated by the expressed major choices of prospective freshmen. The use of discriminant analysis to establish differential enrollment probabilities is also explored.Although different models do a better job for different curricular departments, the smallest mean squared error across all departments was obtained with the simplest projection technique. The use of the preliminary major choice of prospective freshmen did not improve departmental projections, and the student characteristics explored in this study did not differentiate enrolled from non-enrolled students adequately enough to improve enrollment projection accuracy.Based on the results obtained at this one institution, therefore, it would appear that simple and straightforward projection models can be as useful as complex and sophisticated models.This is an expanded version of an earlier paper read at the 1971 Association of Institutional Research Forum in Denver, Colorado.