共查询到4条相似文献,搜索用时 0 毫秒
1.
Michael B. Adinortey Ben A. Gyan Jonathan P. Adjimani Philomena E. Nyarko Charity Sarpong Francis Y. Tsikata Alexander K. Nyarko 《Indian journal of clinical biochemistry : IJCB》2011,26(4):366-372
There is scanty information on the role of genetic factors, especially those relating to haptoglobin (Hp) phenotypes in the
expression of complications among diabetes mellitus patients in Ghana. In this study, we investigated whether there is any
association between Hp phenotypes and diabetic complications and to determine if association of the Hp phenotypes with diabetic
complications in Ghanaian diabetics differ from those in Caucasians. A total of 398 participants were randomly recruited into
the study. These comprised diabetic patients numbering 290 attending a diabetes Clinic in Ghana and 108 non-diabetic controls
from the same community. Analyses of the results indicate that most of the diabetics with complications were of the Hp 2–2
(35%) and Hp 2–1 (23.9%) phenotypes. Fewer diabetics were found to be of the Hp 2–1 M phenotype. The controls were mostly
of Hp 1–1 and Hp 2–1 M phenotypes. The odds ratio of having complications in a diabetic with an Hp 2–2 phenotype was 18.27
times greater than that for Hp 0–0. Hp 2–2 phenotype with its poor antioxidant activity may therefore be a useful predictor
for the propensity of an individual to develop diabetes complications. 相似文献
2.
Chavan VU Durgawale PP Sayyed AK Sontakke AV Attar NR Patel SB Patil SR Nilakhe SD 《Indian journal of clinical biochemistry : IJCB》2011,26(3):283-289
Twenty-four hour urinary albumin excretion (UAE) is considered as gold standard method for albuminuria measurement, but collection
of 24-h urine is inconvenient. The aim of present study was to evaluate whether albumin: creatinine ratio (ACR) and urinary
albumin concentration (UAC) in different spot urine samples correlate or not with 24-h UAE for screening of microalbuminuria
in type 2 diabetic patients. We collected first morning void (FMV), random urine sample (RUS) and 24-h urine, separately on
consecutive days from 104 type 2 diabetic patients. ACR and UAC in each spot urine sample compared with 24-h UAE with regard
to Pearson correlation coefficient. Pearson’s correlation of albumin: creatinine ratio (ACR) with 24-h UAE was (r = 0.802 and 0.623) in first morning void (FMV) and random urine sample (RUS), respectively. Pearson’s correlation coefficient
of urinary albumin concentration (UAC) compared with 24-h UAE was (r = 0.943 and 0.920), in FMV and RUS, respectively, P < 0.01. Results revealed that values in first morning void (FMV) were better correlated with 24-h urinary albumin excretion
(UAE), than the values in random urine sample (RUS). We conclude that the first morning void (FMV) may be able to replace
24-h urine collection, preferably urinary albumin concentration (UAC) in the initial screening of microalbuminuria in diabetic
patients. 相似文献
3.
Suwipar Deebukkhum Patchanrin Pingmuangkaew Orathai Tangvarasittichai Surapon Tangvarasittichai 《Indian journal of clinical biochemistry : IJCB》2012,27(3):239-245
Type 2 diabetes mellitus (T2D) patients are increased risk for cardiovascular disease (CVD) and chronic kidney disease (CKD). Many studies had demonstrated that CKD is significantly associated with CVD. We aim to indicate the using estimated creatinine clearance (eCrCl), homocysteine (tHcy), and high sensitivity-C-reactive protein (hs-CRP) levels, may have an impact on the interpretation risk for nephropathy and CVD. eCrCl was using the Cockroft-Gault formula, eCrCl levels were stratified according to the Kidney Disease Outcome Quality Initiative definition. We measured serum tHcy, hs-CRP, and the other biochemical variables in 54 T2D patients compared with 40 age matched healthy controls (NDM). T2D patients were significantly lower eCrCl than NDM (P < 0.05). T2D patients also showed significantly higher in tHcy, hs-CRP, and MDA levels than NDM subjects (P < 0.05). The eCrCl was significantly correlated with tHcy and hs-CRP levels in T2D patients (r = −0.504, P < 0.001; r = −0.282, P = 0.047). eCrCl had an impact on interpretation for CKD, especially in T2D patients. Decrease eCrCl concomitant with increased in tHcy, hs-CRP, and MDA levels may present a higher risk for future diabetic nephropathy and CVD. 相似文献