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1.
Jujuboside A (JuA) is a main component of Jujubogenin extracted from the seeds of Ziziphus. The authors have not seen any
report on JuA's direct effect on the neurons of the central nervous system. This study aimed to assess the effect of JuA on
paired-pulse responses of dentate gyrus granule cells in urethane-anaestherized rats, used intracerebroventricular (i. c.
v.) JuA to mimic in vitro bath conditions in vivo. Paired-pulse stimuli with 80ms interpulse interval were used to stimulate
the perforant pathway. Evoked responses were recorded in the dentate gyrus cell layer after i. c. v. administration of 0.9%
normal saline or JuA. In the first responses, the slopes of excitatory postsynaptic potential (EPSP1) and the amplitudes of
population spike (PS1) decreased significantly after administration of JuA while the PS1 latencies increased significantly.
In the second responses, the EPSP2 slopes and PS2 latencies were changed similarly to those of the first ones, but PS2 amplitudes
increased. The results showed that JuA may have some inhibitory effect on the granule cell excitability mediated by presynaptic
mechanism but may have little effect on the excitability mediated by postsynaptic mechanism since the second evoked N-methyl-D-aspartic
mediating paired-pulse facilitation is a postsynaptic mechanism.
Project supported by the National Key Scientific and Technological Planning Fund of China (Grant 99-929-04-03), and by the
Visiting Scholar Fund of Key Laboratory from the Education Ministry of China 相似文献
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