Contextual Constraints on Memory Retrieval at Six Months

In 3 experiments, 6-month-old infants learned to move a mobile by kicking and were tested 1 to 21 days later for retention of the newly acquired memory as a function of the training and testing contexts. In Experiment 1, decreasing the relative distinctiveness of the training and testing context did not impair retrieval of the newly acquired memory. In Experiment 2, however, testing in a different context completely eliminated retention after delays of 1 and 3 days, when retention was otherwise perfect; after progressively longer delays, retention improved paradoxically. The familiarity or novelty of the test context was not a factor in the failure of infants to recognize the mobile in the altered context after 1 day. In Experiment 3, the effect of an altered context was assessed in a reactivation paradigm. After the training memory was forgotten, infants were presented with the original mobile as a reminder and were tested for retention of the training memory 1 day later. When either the reminding context or the testing context was different, they exhibited no retention. These findings reveal that memory retrieval at 6 months is highly specific to the setting in which the memory is acquired. We propose that infants learn what specific events are associated with what specific places prior to the age when they can locomote independently and acquire a spatiotemporal map of the relations between those places.     

Ontogenetic forgetting of stimulus attributes

The effects of age on the forgetting of stimulus attributes in a differential fear-conditioning paradigm were examined with 18- and 70-day-old rats tested in either the original conditions or shifted stimulating conditions at one of three retention intervals (1, 48, and 120 h). Adults displayed significant shifts at each retention interval, with those tested in the original context displaying greater fear than those tested in the shifted conditions. By contrast, by 48 h the 18-day-olds had forgotten the specific attributes of the training situation and began treating the two stimulating conditions as functionally equivalent (Experiment 1). In Experiment 2, we tracked the ontogenetic emergence of adult-like memory for stimulus attributes and found a dramatic increase in memory capability by 25 days of age. Experiment 3 illustrated that the forgotten memory attributes of infants may be retrieved by administering a 90-sec cuing treatment 10 min prior to the 48-h test. Implications for the phenomenon of infantile amnesia are discussed.     

Contextual cues and memory retrieval in rats: Alleviation of forgetting by a pretest exposure to background stimuli

With a relatively complex maze, reliable forgetting is clearly seen when the training-test interval is 25 days. This forgetting is evidenced by the longer time taken to run the maze and in an increase in the number of errors from the last training trial to the first test trial. In this case, forgetting is a lapse, not a loss, since performance attains the last training trial level at a subsequent test. Furthermore, a reminder which does not in itself contain sufficient information to facilitate performance of a naive animal, significantly improves maze performance of animals which have “forgotten,” even on the first retention test. With the use of additional control groups, it is shown that there must be a memory lapse before contextual cues can be demonstrated to be effective in facilitating memory retrieval.     

The effect of prior practice on memory reactivation and generalization

Three experiments examined the effect of practice on memory performance by 18-month-old infants. Infants were tested using an imitation paradigm; an adult demonstrated a series of actions with objects and infants were given the opportunity to reproduce those actions following a delay. Some infants practiced the target actions before the retention interval (practice) and some did not (no practice). In Experiment 1, a reminder treatment alleviated forgetting by infants who practiced but failed to alleviate forgetting by infants who did not practice. In Experiments 2A and 2B, infants who practiced generalized to novel test stimuli after a 24-hr delay, whereas infants without practice did not. Results suggest practice influences the accessibility and generality of infants' memories.     

Background stimuli as a reminder after spontaneous forgetting: Role of duration of cuing and cuing-test interval

With a relatively complex maze, reliable forgetting is seen clearly when the training-to-test interval is 25 days. This forgetting is demonstrated by longer time to run the maze and by an increase in the number of errors and retracings from the last training trials to the first test trial. In this case, forgetting is a lapse, not a loss, since performance attains the last training trial level at a subsequent test. Furthermore, a reminder—a 90-sec exposure to background stimuli in the experimental room just prior to the test trial—that does not in itself contain sufficient information to facilitate performance in naive animals, significantly improves maze performance in rats that have “forgotten,” even on the first test trial. Two additional experiments were aimed at assessing the role of time and duration of pretest cuing. In the first experiment, the animals were presented the reminder (90 sec in duration) at different times before the test trial. The results show that this reminder significantly alleviates forgetting only when presented just prior to the test, and is less effective when given 1 or 24 h before the test. In the second experiment, contextual cues, which were presented just prior to testing in all experimental groups, varied in duration. The results showed that (1) animals given the reminder treatment for only 10 sec perform at the same level as controls; (2) cuing for 30 sec and especially for 90 sec alleviates forgetting; and (3) a longer exposure to background stimuli (300 sec) leads to intermediate levels of performance, probably due to a partial extinction of the cue value of these stimuli.     

Pretest cuing after forgetting of a food-motivated maze task in rats: Synergistic action of context and reinforcement

It is now well known in animal studies that spontaneous forgetting, as well as performance decrements resulting from other sources, can be alleviated by means of pretest treatments. Several previous experiments have shown that reliable forgetting is observed after a 25-day training-to-test interval on a relatively complex maze. This forgetting can be alleviated by pretest exposure to background stimuli in the experimental room. The effects of this treatment can be modulated by varying either the duration of the treatment or the length of the cuing-test interval. The purpose of the experiment presented here was twofold: (1) to demonstrate the multidimensionality of memories in our paradigm by comparing the effects of different reminder treatments, namely pretest access to the reinforcer and contextual cuing, and (2) to test the general hypothesis, formulated by Spear (1978, p. 418), that “the elicitation and retrieval of the target attribute of a memory depend on the arousal of a sufficientnumber or kind of the remaining attributes of this memory.” The data showed that pretest food reinforcement had no significant effect on retention performance; that pretest contextual cuing did, in some precise conditions, alleviate forgetting; and that some combinations of context and reinforcement had what amounted to a synergistic action on retention performance.     

Contextual Variation and Memory Retrieval at Six Months

In 2 experiments we asked whether training in multiple contexts could eliminate context-dependent memory retrieval at 6 months as it does for adults. We found that 24-hour retention was disrupted when infants were trained in one context and tested in another but not when they were trained in multiple contexts prior to testing in a novel context (Experiment 1). After a long delay, however, training in multiple contexts did not facilitate memory retrieval in a novel context: An otherwise effective retrieval cue (the training mobile) did not alleviate forgetting 3 weeks later when it was presented in a novel context (Experiment 2). These findings demonstrate that multiple learning contexts can override the debilitating effects of an altered context on memory retrieval at 6 months, but only over the short term. The resistance of older memories to retrieval in novel contexts after long periods of disuse may be adaptive, insuring that potentially inappropriate or irrelevant memories will not be expressed.     

Long-Term Memory for Context-Specific Category Information at Six Months

The ability of 6-month-old infants to remember a functional category acquired in a specific context was assessed in 3 experiments via an operant procedure in which infants learned to perform a specific action (a footkick) to activate an object suspended before them. In Experiment 1, infants trained with different exemplars in the same context transferred responding to a novel exemplar in the same but not a different context 24 hours later. Experiment 2 revealed that infants' reactivated memory of category training remained intact and context-specific after 3 weeks. In Experiment 3, a novel category exemplar was able to reactivate the forgotten memory of category training only in the encoding context. At 6 months, information about the place where categories are constructed is prerequisite for retrieval of a category concept from long-term memory. This requirement insures that early category concepts remain stable over relatively long periods.     

The effect of crying on long-term memory in infancy

The influence of crying on infants' long-term memory for a learned response was investigated in 3 experiments. In each, infants were trained to move a crib mobile containing 10 identical objects by means of kicking and were then exposed to a reinforcer containing only 2 of these components. This shift in component numerosity produced crying in 53% of the infants. Infants who cried in response to the reward shift evidenced no retention of the contingency 1 week later (Experiment 1) but did have excellent retention at 1 day (Experiment 2). In Experiment 3, a brief reactivation treatment alleviated forgetting at 3 weeks regardless of the presence of crying in response to the change in mobiles. An unexpected recency effect characterized the efficacy of the reactivation treatment. The results indicate that crying in response to the violation of a reward-expectation habit functions as an amnesic agent to produce accelerated forgetting.     

从迫选再认测验看记忆编码过程的加工机制

人类记忆具有复杂的认知功能,可表现为多种类型,如内隐记忆、外显记忆等,不同的记忆类型在编码过程中是否就存在着差异?本文通过两阶段的迫选再认,分别以词和面孔为刺激,在单一测验中区分出记住、启动、忘记和虚报四种不同的记忆类型,然后比较不同类型的记忆项目在编码过程中的加工差异,结果发现记住和启动项目在学习阶段所获得的加工资源要多于忘记项目,而虚报项目所得到的加工资源最少,表明不论是外显还是内隐记忆,在编码阶段都需要获得一定的加工资源,否则就会从记忆痕迹中消失,甚至产生错误记忆。     

Differential effects of several retrieval cues over time: Evidence for time-dependent reorganization of memory

The retention performance following partial training (15 trials) of a brightness-discrimination avoidance task has been shown to fluctuate over time, with a drop in performance 1 h after training (Kamin effect), a long-term spontaneous improvement (LTSI) after 3 days, and long-term spontaneous forgetting after 21 days. The purpose of this paper was to determine if these time-dependent modulations of retention performance reflect time-dependent modifications in the organization of the attributes that constitute the memory trace. We studied the relative effectiveness of several pretest cuings on retention performance when they were delivered just before a retention test occurring 1 h, 3 days, or 21 days following initial training. Some cuing treatments were related to a particular training event (conditioned or unconditioned stimulus, experimental context). Compound cuings, composed of two or more training events, were also studied to test a possible additive effect between retrieval cues. To demonstrate time-dependent modifications in the memory trace, a differential effectiveness over time was expected for at least some retrieval cues. The results show that cuing may compensate for performance deficits (1 h or 21 days), but does not further enhance performance when spontaneously improved (3 days). No detectable additive effects of retrieval cues were obtained. However, these results provide information that suggests a time-dependent effectiveness for some cuing treatments. In the last experiment, we investigated this possibility by studying the effects of each of these treatments when delivered after either a 1-h or a 21-day retention interval. The results confirm a time-dependent decrease in effectiveness of a pretest exposure to the CS and an increase in effectiveness over time of a pretest exposure to the experimental context or to a well-ordered sequence of events. Such differential retrievability of a partially learned episode according to both the nature of the cues and the length of the retention interval suggests a time-dependent reorganization of memory attributes.     

Categorization and memory retrieval by three-month-olds

84 3-month-olds were tested in 3 studies of the acquisition and long-term retention of category-specific information. Infants who were trained with a perceptibly different member of an alphanumeric category on each of 3 days generalized responding to a novel instance of the original training category but not a novel member of a novel category during a 24-hour novelty test. 2 weeks later, when infants displayed no evidence of remembering their prior training experience, categorization was reinstated if a novel exemplar from the original training category was used as the retrieval cue in a memory reactivation procedure. A novel exemplar from a novel category was not an effective retrieval cue. The effectiveness of the category-specific retrieval cue was a function of its physical similarity to the individual exemplars encountered during training, not testing. The background against which the alphanumeric exemplars were displayed during training was not an effective retrieval cue in either the 24-hour novelty test or the memory reactivation procedure, indicating that all invariant stimulus attributes do not contribute equally as category cues. These data are the first to document retention of category-specific information after extended intervals. A popular account of categorization holds that infants abstract invariant features from individual exemplars and form a schema or distinctive memory representation of these shared features against which subsequent exemplars are compared. The present data provide support for a more parsimonious account of categorization, based on the retrieval of information about individual exemplars, that does not require an assumption of prototype formation.     

Does contextual change determine long-term forgetting?

A series of experiments were run to test the hypothesis that “spontaneous forgetting” could result from subtle contextual changes. The first experiment demonstrated that when Sprague-Dawley male rats are trained in a runway alley with a food reinforcer, retention performance is dramatically affected by a change in the pattern of the walls of the training apparatus when testing takes place 1, 3, or 5 days following training and not after 1 week. Experiment 2 demonstrated that this performance deficit cannot be alleviated by any of the three selected cuing treatments, whereas “spontaneous forgetting” (resulting from a training-to-test interval of 14 days) can be. These data indicate that the detrimental effect of contextual change reduces over time, and that such an effect cannot be interpreted in terms of retrieval failure. These results lend strong support to the argument that the disruptive contextual change effect is basically different from the disruptive effect that results from an extended training-to-test interval.     

Infants' Forgetting of Correlated Attributes and Object Recognition

Infants as young as 3 months of age can encode the relations among object features. Because object recognition depends critically upon a match between perceived feature configurations and representations of the object in long-term memory, the present experiments focused on infants' long-term memory for feature correlations. In 3 experiments with 72 3-month-olds, we documented the forgetting functions of different feature correlations, examined their relation to infants' memory for individual features, and replicated the findings with different stimuli. Infants were trained to activate a mobile composed of two kinds of blocks that differed in color, the figures displayed on them, and the figures' colors and were tested after different delays with recombinations of either the block colors, the figures, or the figure colors. Infants remembered some of the original feature combinations for up to 3 days but forgot all of them after 4 days. Even after 4 days, however, infants remembered the individual features that had entered into the original combinations. These results demonstrate that very young infants not only encode the relations among object features but also remember them for several days. Moreover, there is a dissociation in memory between features and feature relations: Feature relations are forgotten sooner than the individual features that comprise those relations.     

A conditioning analysis of infant long-term memory.

The long-term retention of conditioned operant footkicks by 3-month-old infants was assessed in 2 studies. In both, infants were trained in a conjugate reinforcement paradigm in which footkicks produced conjugate activation of the components of an overhead crib mobile. After 2 training sessions, retention (cued recall, savings) was assessed cross-sectionally in a third session scheduled after varying intervals. In experiment 1, 32 infants were tested after intervals of 48, 72, 96, or 120 hours; in experiment 2, 24 infants were tested after 96, 144, 192, or 336 hours. No evidence of forgetting was observed for as long as 192 hours following original training. Although both retention measures indicated a significant memory deficit in the group tested after 336 hours (2 weeks), some individuals continued to exhibit substantial recall and savings after this retention interval. A conditioning analysis was viewed as a logical means by which to bridge the gap between animal and adult human models of memory.     

Reactivation of an appetitive discrimination memory following retroactive interference

The present experiment employed an appetitive spatial discrimination response to examine alleviation of forgetting induced by retroactive interference. For separate groups of rats, a footshock that had occurred during acquisition contingent upon a correct response was tested for its effectiveness as a reactivation treatment. The results indicated that the footshock effectively alleviated forgetting, but only for rats experiencing the shock stimulus during original learning. These results suggest that a reactivation treatment may arouse affective or stimulus properties in common with the target memory to elicit retrieval of that memory.     

Effects of cuing in an “irrelevant” context

Normally, retention of an avoidance response by a rat is impaired when the test context is novel or does not correspond to the training context. Experiment 1 demonstrates that such an impairment of test performance can be alleviated if a rat receives a cuing treatment or reminder of training in the novel test context prior to testing. Experiment 2 indicates that when rats receive avoidance training in one context and then receive a reminder of training in a novel context, they perform more poorly when tested in the training context than do animals that receive no reminder. This finding is discussed in relation to current theories of contextual influence over retention performance.     

State-Dependent Memory in Infants

Why do infants remember some things and not others? Human infants frequently cycle through different states such as calm attentiveness, wakeful activity, and crying. Given that cognitive processes do not occur in isolation, such fluctuations in internal state might influence memory processing. In the present experiment, declarative memory in 9-month-old infants (N = 96) was heavily state dependent. Infants exhibited excellent retention of a deferred imitation task after a 15-min delay if their state at encoding was identical to their state at retrieval (e.g., calm). Infants failed to exhibit retention if their state at encoding was different from their state at retrieval (e.g., calm vs. animated). Infant memory processing depends on internal cues.     

Auditory Context and Memory Retrieval in Young Infants

Three-month-old infants were trained to move an overhead crib mobile while 1 of 2 musical selections was played. Retention was assessed 1 or 7 days later in the presence of either the same music or a different musical selection. in Experiment 1, the musical selections were very different (classical versus jazz); in Experiment 2, they were much more similar (two classical pieces). Infants in both experiments displayed 1 day retention regardless of wich music was played during the retention test. At 7 days, retention was seen only when the music played during the retention test matched the training music. These data are consistent with similar findings showing that 3-month-old infants'memory is disrupted at long retention intervals when the context present during retention testing does not match the learning context. As the infant's memory wanes, context appears to function as a necessary cue for the retrieval of acquired expectancies.     

Order and duration of stimuli are important determinants of reactivation

Prior cuing treatments intended to alleviate the forgetting of a conditioned avexsion-to an odor were tested with 18-day-old rats. Previous experiments had shown that when such pups were conditioned with the use of a CS?/CS+ procedure, pretest presentation of the CS? or US, but not the CS+, alleviated the forgetting otherwise seen after a 3-h retention interval. In Experiment 1, it was determined that the forgetting was not alleviated if the GS? was either preceded or followed by presentation of the CS+, despite the fact that the CS?/CS+ ordering mimicked that of original conditioning. Experiment 2 was an examination of the balance of extinction and reactivation effects caused by presenting the CS+ for varying durations following the 3-h retention interval. The forgetting over this interval was alleviated if the CS+ was presented for 5 or 15 sec, but not 30 sec. With an increase in duration of exposure from 15 to 30 sec, the consequences of the CS+ as a prior cuing treatment apparently shifted from reactivation to extinction. Experiment 3 was a test of the interaction between the consequences of different lengths of CS+ exposure and the effectiveness of adding CS? to the CS+ as a reactivation treatment. The varied effectiveness of reactivation treatments is discussed interms of a change in stimulus conditions from training to reactivation.