架构大学与市场的桥梁：美国大学技术转化机构——麻省理工学院的个案研究

美国麻省理工学院(MIT)的技术转化活动取得了瞩目的成绩,这与其校内技术转化机构的设立和运作是分不开的.MIT的技术转化机构主要包括技术许可办公室,产业联络规则、资助项目办公室.这些机构有明确的政策法规指导,相互协调、促进,形成一个技术转化体系;各机构工作人员专业化,使大学在技术转化活动中处于主动地位.大学通过设立技术转化机构,在为全校教师和研究者提供技术转化活动全程指导的同时,也保证了大学的学术性方向.     

Evaluation of preanalytical and postanalytical phases in clinical biochemistry laboratory according to IFCC laboratory errors and patient safety specifications

IntroductionThe aim of the study was to determine the current state of laboratory’s extra-analytical phase performance by calculating preanalytical and postanalytical phase quality indicators (QIs) and sigma values and to compare obtained data according to desired quality specifications and sigma values reported by The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Working Group – Laboratory errors and Patient Safety.Materials and methodsPreanalytical and postanalytical phase data were obtained through laboratory information system. Rejected samples in preanalytical phase were grouped according to reasons for rejection and frequencies were calculated both monthly and for 2019. Sigma values were calculated according to “short term sigma” table.ResultsThe number of rejected samples in laboratory was 643 out of 191,831 in 2019. Total preanalytical phase rejection frequency was 0.22%. According to the reasons for rejection, QIs and sigma values were: “Samples with excessive transportation time”: 0.0036 and 5.47; “Samples collected in wrong container” 0.02 and 5.11. In December, QIs and sigma values were: “Samples with excessive transportation time”: 0.01 and 5.34; “Samples collected in wrong container”: 0.03 and 4.98. The postanalytical QIs and sigma values were: “Reports delivered outside the specified time”: 0.34 and 4.21; “Turn around time of potassium”: 56 minute and 3.84, respectively. There were no errors in “Critical values of inpatients and outpatients notified after a consensually agreed time”.ConclusionsExtra-analytical phase was evaluated by comparing it with the latest quality specifications and sigma values which will contribute to improving the quality of laboratory medicine.     

Accidental digitoxin intoxication: an interplay between laboratory and clinical medicine

Introduction:

Two Italian adults arrived at the Emergency Department referring diarrhea, nausea and vomiting for 4 days; weakness, fatigue and visual hallucinations were also complained of. Patients reported the ingestion of some leaves of a plant, which they supposed to be “donkey ears”, a week before. Physical examination showed hypotension and bradycardia and ECG examination disclosed sinus rhythm and repolarization abnormalities (scooping of the ST-T complex) in both patients and a 2:1 AV block in the man.

Materials and methods:

Digoxin concentration was evaluated twice for each patient (at the admission and after 4 hours) by the automated immunoassay system ADVIA Centaur^®. Digitoxin concentration was evaluated by liquid chromatography-mass spectrometry (LC-MS/MS).

Results:

Despite clinical picture was suggestive of digitalis intoxication, digoxin levels were undetectable. Due to the more severe clinical picture, the male patient was treated with anti-digoxin antibodies (Digifab^®) achieving a good clinical improvement and remission of the AV block within two hours. Initial diagnosis was confirmed by LC-MS/MS showing high digitoxin concentrations, but digoxin was undetectable. Patients remained stable and 48 hours later were discharged from the hospital.

Conclusion:

Whereas digoxin determination frequently relies on monoclonal antibodies which do not cross-react to digitoxin, polyclonal antibodies constituting Digifab^® recognize a large spectrum of cardiac glycosides, including digitoxin. This report emphasizes the primary role of the clinical approach to patients in the emergency setting and how an active communication and a continuous sharing of professional experiences between Laboratory and Clinicians ensure an early and correct diagnosis.     

Validation of a laboratory and hospital information system in a medical laboratory accredited according to ISO 15189

Introduction

The aim of the study was to present a protocol for laboratory information system (LIS) and hospital information system (HIS) validation at the Institute of Clinical Chemistry and Laboratory Medicine of the Merkur University Hospital, Zagreb, Croatia.

Materials and methods:

Validity of data traceability was checked by entering all test requests for virtual patient into HIS/LIS and printing corresponding barcoded labels that provided laboratory analyzers with the information on requested tests. The original printouts of the test results from laboratory analyzer(s) were compared with the data obtained from LIS and entered into the provided template. Transfer of data from LIS to HIS was examined by requesting all tests in HIS and creating real data in a finding generated in LIS. Data obtained from LIS and HIS were entered into a corresponding template. The main outcome measure was the accuracy of transfer obtained from laboratory analyzers and results transferred from LIS and HIS expressed as percentage (%).

Results:

The accuracy of data transfer from laboratory analyzers to LIS was 99.5% and of that from LIS to HIS 100%.

Conclusion:

We presented our established validation protocol for laboratory information system and demonstrated that a system meets its intended purpose.     

Assessing differences between university and federal laboratory postdoctoral scientists in technology transfer

While there are numerous studies of university technology transfer, there have been relatively few studies of technology transfer at federal labs. Moreover, studies of university technology transfer have focused on faculty, not post-doctoral scientists. They have also ignored identity and sensemaking theories in organizational behavior, which are relevant in the context of technology transfer. We fill these gaps by examining differences between university post-doctoral scientists and federal lab post-doctoral scientists, in terms of how they engage in technology transfer. Our qualitative analysis is based on extensive interviews of post-doctoral scientists and their supervisors/principal investigators (PIs) at two major research universities and four large federal labs. We find that federal lab scientists are more influenced by mission-driven research and their sense of public service, as compared to university scientists who are motivated more by curiosity-driven research. These motivational differences may constitute significant barriers to technology transfer in federal labs. As compared to their university counterparts, federal lab scientists appear to experience more cognitive dissonance in pursuing commercialization of their research and have more sophisticated resolution strategies for dealing with such dissonance. We also find that PIs at federal labs are not highly incentivized to engage in technology transfer. We discuss additional research needs, as well as the managerial and training implications of our findings.     

Robust hierarchical control of a laboratory helicopter

This paper deals with the robust position control problem for a three degree-of-freedom (3DOF) laboratory helicopter. The 3DOF helicopter system is a nonlinear multiple-input multiple-output (MIMO) uncertain system, and has the elevation, pitch, and travel angles. The proposed robust controller is a hierarchical controller including an attitude controller and a position controller. The position controller generates the desired reference of the pitch angle based on the tracking error of the travel angle, while the attitude controller achieves the reference tracking of the pitch and elevation angles. It is proven that the tracking errors of the three angles can converge into the given neighborhoods ultimately. Experimental results on the laboratory helicopter demonstrate the effectiveness of the proposed hierarchical control strategy.