人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种作用的计算机模拟研究

建立了人体细胞间液多相模型,研究了人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种的作用.结果表明,Pr(Ⅲ)能够影响Zn(Ⅱ)的物种分布.Zn(Ⅱ)主要分布于[Zn(HSA)],[Zn(IgG)]和[Zn(Cys)2H]中.Pr(Ⅲ)不能与Zn(Ⅱ)竞争HSA和IgG配体;但是,Pr(Ⅲ)能够与Zn(Ⅱ)竞争磷酸盐和碳酸盐配体,这会引起Zn(Ⅱ)物种的重新分布.     

1,4-N,N-取代哌嗪类药物中间体的合成

本研究以二乙醇胺为原料和SOCl2反应,得二-(2-氯乙基)胺。二-(2-氯乙基)胺与3-氯苯胺发生取代反应生成1-(3-氯苯基)哌嗪,再与1-溴-3-氯丙烷发生取代反应生成1-(3-氯苯基)-4-(3-氯丙基)哌嗪。1-(3-氯苯基)-4-(3-氯丙基)哌嗪是进一步合成1,4-N,N-取代哌嗪类药物的重要中间体。     

LP(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls

Lipoprotein Lp(a) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. To evaluate this in a North-Indian population, 130 CAD patients and 130 controls were analyzed. The size of the apo(a) phenotypic isoforms was inversely proportional to Lp(a) concentrations. The mean concentration of Lp(a) in the CAD patients was 42±34 mg/dl whereas in the normal subjects it was much lower, 27±27 mg/dl. 157 subjects out of the total 260 subjects showed plasma levels of >20mg/dl. The frequency of high Lp(a) levels was much higher in patients(73%) than controls (43%). These data suggest (1) that there is heterogeneity of the Lp(a) polymorphism, (2) Higher Lp(a) levels were found in patients than in the controls, (3) Patients showed 1.5 fold increase in Lp(a) levels as compared to the controls. We conclude that low molecular weight apo(a) isoforms are significantly associated with increased risk of CAD in the North-Indian population.     

Polyelectrolyte multilayer surface functionalization of poly(dimethylsiloxane) (PDMS) for reduction of yeast cell adhesion in microfluidic devices

Polyelectrolyte multilayers (PEMs) based on the combinations poly(diallyldimethylammonium chloride)∕poly(acrylic acid) (PDADMAC∕PAA) and poly(allylamine hydrochloride)∕PAA (PAH∕PAA) were adsorbed on poly(dimethylsiloxane) (PDMS) and tested for nonspecific surface attachment of hydrophobic yeast cells using a parallel plate flow chamber. A custom-made graft copolymer containing poly(ethylene glycol) (PEG) side chains (PAA-g-PEG) was additionally adsorbed on the PEMs as a terminal layer. A suitable PEM modification effectively decreased the adhesion strength of Saccharomyces cerevisiae DSM 2155 to the channel walls. However, a further decrease in initial cell attachment and adhesion strength was observed after adsorption of PAA-g-PEG copolymer onto PEMs from aqueous solution. The results demonstrate that a facile layer-by-layer surface functionalization from aqueous solutions can be successfully applied to reduce cell adhesion strength of S. cerevisiae by at least two orders of magnitude compared to bare PDMS. Therefore, this method is potentially suitable to promote planktonic growth inside capped PDMS-based microfluidic devices if the PEM deposition is completed by a dynamic flow-through process.     

人体血浆中Tb(Ⅲ)物种的计算机模拟研究

建立了人体血浆多相模型,研究了人体血浆体系中Tb(Ⅲ)物种的分布.结果表明,Tb(Ⅲ)的物种形式随着Tb(Ⅲ)的量浓度的变化而变化.当Tb(Ⅲ)的量浓度低于4.000×10-8mol/L时,大部分Tb(Ⅲ)物种以可溶态存在;当Tb(Ⅲ)的量浓度高于4.000×10-8mol/L而低于1.667×10-2mol/L时,沉淀物种(TbPO4和Tb2(CO3)3)成为Tb(Ⅲ)的主要物种.可溶的Tb(Ⅲ)在量浓度低于1.0×10-4mol/L时,主要与运铁蛋白键合,分布于[Tb(Tf)]中;当Tb(Ⅲ)的量浓度高于1.0×10-4mol/L时,运铁蛋白耗尽,可溶的Tb(Ⅲ)主要分布于[Tb(HSA)],[Tb2(Tf)],[Tb(Ox)]和[Tb(Cit)]等物种中.     

government policies for technological innovation: criteria for an experimental approach

The United States Government has had only limited success in conducting complex experiments on incentives to promote technological innovation in the public and private sectors. Political pressure for early success has distorted programme objectives and encouraged policy demonstrations under conditions favouring ‘successful’ outcomes, rather than true policy experiments.A wide range of conceptual and practical problems must be confronted before undertaking a major programme of experimentation in national policy related to technological innovation. Experiments to test the effect of specific governmental policies on the rate of and direction of technological innovation should be rigorously selected and designed so as to provide valid results that are useful to decision-makers. The problem of selecting experiments can be dealt with by applying selection criteria that relate to the importance of the problem or barrier in the innovation process to be overcome, to the implications of implementing the policy that will over-come the problem, and to the technical design and feasibility of conducting the experiment. Suggested criteria include: (1) value of the information generated; (2) leverage of the solution; (3) importance of the target population; (4) political acceptability of the policy; (5) legal aspects of the policy; (6) target population support; (7) cost acceptability; (8) policy effectiveness and range; (9) policy equity; (10) understanding of the policy; (11) administrative feasibility; (12) ease of policy monitoring; (13) organizational structure for implementation; (14) sound experimental hypothesis; (15) careful experimental design; (16) experimental feasibility; (17) time scale of the experiment; (18) experimental cost, and (19) relative cost-effectiveness.The proposed selection criteria are demonstrated using a current experiment of the US National Science Foundation.     

关于增广商群结构问题的讨论

对任意有限群G的整群环ZG,设Δn(G)是ZG的n次增广理想,记Qn(G)=Δn(G)/Δn 1(G)为G的增广商群.本文给出了Qn(G)的一组与G的Sylowp-子群相关的生成元,并且在利用这组生成元和已有结果的基础上对二面体群D2tk(k奇)之增广商群Qn(D2tk)的结构进行了讨论,证明了Qn(D2tk)Qn(D2t).     

杭州市区婴幼儿秋冬季腹泻的病原学初步研究

报道应用电子显微镜技术对４６例杭州市区婴幼儿秋冬季腹泻大便进行了电子显微镜观察。研究结果：轮状病毒感染１６例占３４．８％、环状病毒７例占１５．２％、小圆形病毒８例占１７．４％、Ｎｏｒ－ｗａｌｋ病毒６例占１３％，细菌性感染７例占１５．２％，其它２例占４．４％。     

根平方平均的最优凸组合不等式

本文得到最大值α和最小值β,使得对所有的a,b>0,a≠b双向不等式αC(a,b)+(1-α)A(a,b)相似文献   

黏性土主要力学指标之间的经验关系分析

本文对齐齐哈尔地区143组黏性土标贯击数(N)、压缩模量(Es)、承载力特征值(fak)对比数据进行了相关分析。建立了黏性土标贯击数(N)与压缩模量(Es)及压缩模量(Es)与承载力特征值(fak)的相关方程。     

On the uniqueness of the minimal solution to the matrix polynomial equation A(λ)X(λ)+Y(λ)B(λ)=C(λ)

The uniqueness of the minimal solution of the matrix equation A(λ)X(λ)+Y(λ)B(λ)=C(λ) is discussed in this paper. It is proved that Barnett's condition for uniqueness can be obtained when only A(λ) or B(λ) (not necessarily both) is regular. Furthermore, it is shown that if such a minimal solution exists, it is not unique if and only if both matrices are nonregular.     

近20年苏锡常地区土地利用格局变化及其驱动因素分析

土地利用变化是全球生态环境变化研究的重要组成部分。苏锡常地区作为我国传统的人口密集区和土地高度集约化利用区，土地利用历史悠久。1980年以来, 苏锡常地区社会经济发生了巨大变化，从而引起土地利用/土地覆盖格局的相应变化。本文利用1980年、1995年和2000年的Landsat TM数据对苏锡常地区的土地利用情况进行测量，取得研究区土地利用变化的转移矩阵，据此对苏锡常地区1980年～2000年的土地利用变化情况进行分析，揭示土地利用变化的驱动因素，以得到耕地、林地、草地、建设用地、水域和未利用地变化的驱动因子，为协调土地资源与社会经济发展的关系、制定合理的土地资源利用体系、促进土地资源和社会经济的可持续发展提供依据。研究表明：1980年～2000年苏锡常地区土地利用变化的驱动因素受人文因素和自然因素的共同影响，但主要是受社会经济政策因素影响，自然因素具有相对稳定性。     

Process evaluation of implementing knowledge management tools in public health

Translating formal and informal knowledge into public health (PH) action is essential given that PH professionals rely on up-to-date and context-specific information for effective programme planning, implementation, and evaluation. Knowledge management (KM) provides possible solutions to this challenge. We conducted an evaluation of a pilot implementation of four KM tools: (1) After Action Review; (2) Communities of Practice; (3) Peer Assist and; (4) Organizational Yellow Pages. The evaluation focused on fidelity, feasibility, and acceptability of the tools. Three main messages emerged from the study findings: (1) KM tools can be implemented in a PH context for the sharing of explicit and tacit knowledge, (2) enabling organizational environments were important for implementation, and (3) the provision of a facilitator during the implementation period was also important and appreciated by study participants.     

Some biochemical markers in various neoplasms: A multivariate analysis

The analysis of biochemical parameters in 162 patients with various neoplastic disorders along with 50 normal subjects showed significant rise in serum alkaline phosphatase and lactate dehydrogenase as compared to normal subjects. 21 patients with other monoclonal gammopathies which include infection and immunological diseases were also studied. Parameters such as serum calcium, uric acid, total protein, albumin and globulin were also analyzed in 42 (26%) cases of multiple myeloma, 27 (17%) cases of gastro-intestinal malignancies, 22 (14%) cases of urogenital malignancies, 11 (6%) cases of carcinoma breast, 4 (2%) cases of bone tumors, 21 (12%) cases of other monoclonal gammopathies, including 7 (4%) cases of infection and 14 (8%) cases of immunological diseases. The results indicate use of enzymes alkaline phosphatase and lactate dehydrogenase in neoplastic disorders.     

Prevalence of insulin resistance in first degree relatives of type-2 diabetes mellitus patients: A prospective study in north Indian population

A total of 172 first degree relatives (FDRs) and 178 controls were included in this study. All the cases and controls were subjected to various anthropometric measurements, fasting and postprandial glucose estimation, fasting insulin measurement and fasting lipid profile. Results revealed the prevalence of Impaired Fasting Glucose (IFG) (cases 37% Vs controls 11.6%), Impaired Glucose Tolerance (IGT) (cases 34.3% Vs controls 11.2%) and diabetes (cases 11.05% controls 3.37%) was significantly higher in first degree relatives. Insulin resistance was measured using various methods, which included fasting plasma insulin (FPI), Homeostasis Model Assessment for Insulin Resistance (HOMA_IR), insulin sensitivity index (ISI) (Mffm/l). Prevalence of insulin resistance (Insulin Resistance) as observed comparing FPI and HOMA_IR in cases and controls was 43.6% and 11.24% (P=0.005) and 37.8% and 12.47% (P=0.000) respectively. Prevalence of IR (Insulin Resistance) observed in cases having Normal Glucose Tolerance (NGT), Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT) and diabetes mellitus measuring FPI Vs HOMA_IR was 37.5% vs 30.2%, 45% vs 40%, 38.98% vs 37.28% and 36.84% vs 31.57% as accordingly. However, ISI (Mffm/l) was not found to be a promising index for IR due to its poor specificity. Though HOMA is taken as gold standard for measurement of IR globally, our study observed fasting plasma insulin representing high sensitivity (89.7%) and specificity (93.3%) as compared to HOMA. Thus FPI had emerged in this work as a simple and reliable test for diagnosing insulin resistance across the population susceptible to develop diabetes including FDRs.     

C60球烯的制备及其表征

报道了C_(60)球烯的制备分离过程,并对所获得的纯C_(60)粉末样品和膜样品进行了~(13)C核磁共振,傅里叶红外以及Raman谱研究.结果表明:C_(60)样品在红外有4个吸收峰,分别位于528、578、1182、1429cm~(-1)处;在Raman谱中观察到3个峰,分别位于273、469、1465cm(-1)处;~(13)C核磁共振谱则表明在143.2 ppm化学位移处有一单峰,这些都与理论计算值相符,很好地证实了C_(60)的全碳和高度对称的球形结构.     

Levels of cerebrospinal fluid acetylcholinesterase in tuberculous and pyogenic meningitis in children

Total acetylcholinesterase (AChE) activity was estimated in cerebrospinal fluid (CSF) using colorimetric method in 64 cases with tuberculous meningitis, (TBM) (n=64), pyogenic meningitis (PM) (n=60) and in controls (n=39) of paediatric age group. Mean CSF—AChE values of both TBM and PM were significantly higher when compared with controls (p<0.001) but no significant change between TBM and PM was observed (p<0.01). It is suggested that inflammation of meninges due to the infection may attribute to a change in the function of blood brain barrier (BBB) causing higher CSF—AChE values in these diseases.     

血管紧张素原基因CD235Met-Thr变异与高血压脑梗塞发病的相关性

探讨汉族人群血管紧张素原(AGT)基因CD235Met-Thr变异与高血压合并脑梗塞发生的关系.采用突变基因分离聚合酶链反应(MS-PCR)方法检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的M235T等位基因型.BI组AGT基因T/T基因型频率和T等位基因频率(分别为0.720和0.811)显著高于C组(分别为0.516和0.700,P＜0.05)和EH组(分别为0.537和0.716,P＜0.05).结果提示,AGT基因CD235Met-Thr变异增加了汉族人群高血压合并脑梗塞发病的易感性.     

KIBS规范化对生产率的影响:路径模型及实证检验

KIBS规范化及其作用的研究尚未引起学术界广泛关注。应用探索性因子分析和验证性因子分析的方法研究KIBS规范化及服务生产率的内涵结构,之后提出规范化影响生产率的"纵向影响路径模型"和"横向影响路径模型"。利用结构方程模型(SEM)中的路径分析方法对这两个模型进行实证检验。本文的理论贡献在于实证了:(1)服务工作规范化的内涵结构维度包括规范化输入要素和规范化转化要素;(2)服务生产率的内涵结构可分别由内部绩效和外部绩效,或过程绩效和结果绩效来表征;(3)规范化不直接影响结果绩效和外部绩效,而是分别通过过程绩效和内部绩效产生影响;(4)规范化转化要素在对服务生产率影响中起着重要的中间作用。