食管癌术后胸腔胃对呼吸功能的影响

目的:探讨食管癌手术后胸腔胃对呼吸功能的影响.方法:选取食管癌病人220例,行食管癌切除食管胃弓上吻合术110例,弓下吻合术110例.在手术前3d和手术后1、2、3、5、7、10、14d进行肺功能和血气分析测定,动态观察呼吸功能的变化规律.结果:弓上吻合术较弓下吻合术动脉氧分压、肺功能各项指标低.动脉氧分压于术后第二天降至最低,以后呈逐渐升高趋势,至术后14d恢复到术前的90%.肺功能各项指标于术后第二天降至最低,以后呈逐渐升高趋势,至术后14d恢复到术前的60%.结论:食管癌术后胸腔胃对呼吸功能有重大影响,弓上吻合术较弓下吻合术呼吸功能减退更加明显.     

精密输液器用于食道癌术后患者的效果观察

目的:观察精密输液器降低静脉炎发生率的效果.方法:将食道癌术后患者随机分为观察组(64例)和对照组(56例),观察组应用一次性精密输液器输液,对照组应用一次性普通输液器输液,观察两组静脉炎发生率及静脉炎严重度.结果:观察组静脉炎发生率9.4%,Ⅱ级以上静脉炎发生率0%,对照组静脉炎发生率57.1%,Ⅱ级以上静脉炎发生率16.1%,两组比较有显著性差异(P<0.01).结论:使用一次性精密输液器可有效降低静脉炎发生率,减轻患者痛苦,提高生存质量.     

食管癌组织中Survivin和Ki67的表达及临床意义

目的:观察Survivin和Ki67在食管鳞癌中的表达,并探讨Survivin与Ki67的表达关系及其临床意义.方法:应用免疫组织化学法检测70例食管鳞癌组织石蜡切片Survivin和Ki67的表达,分析Survivin表达与临床病理因素及Ki67的关系.结果:Survivin在食管鳞癌组织中的表达率为72.9%(51/70),Ki67在食管鳞癌组织中的表达率为67.1%(47/70).Survivin表达和Ki67表达与食管鳞癌分化程度、淋巴结转移、TNM分期明显相关(P＜0.05).Survivin表达和Ki67表达呈正相关(P＜0.05).结论:Survivin和Ki67可作为判断食管癌组织恶性程度和预后的指标之一.     

介入化疗对直肠癌血管内皮生长因子及微血管的影响

目的探讨介入化疗对直肠癌血管内皮生长因子表达(VEGF)及微血管计数(MVD)的影响.方法对34例直肠癌患者介入化疗前后的肿瘤组织,用CD34对VEGF表达进行测定,并进行MVD计数.结果本组患者介入化疗前及后4至5周VEGF阳性表达率分别为61.7%(21/34)、32.4%(11/34),MVD计数明显降低,差异均有显著性意义(P＜0.01);结论介入化疗能降低直肠癌组织VEGF的表达,减少MVD计数,提示介入化疗可能调节直肠癌的分化程度,减少术后转移.     

胃肠道癌术后化疗T细胞亚群和sIL-2R的比较研究

目的:比较化疗前后T细胞亚群和sIL-2R水平及术后腹腔化疗和静脉化疗T细胞亚群和sIL-2R水平有无差异。方法:54例胃肠道癌症患者,分两组27例,一组接受腹腔化疗,另一组接受静脉化疗,检测血清中T细胞亚群和sIL-2R水平。结果:化疗后血清CD3、CD4和sIL-2R水平较化疗前明显下降(P<0.01)。CD3、CD4、CD8在两治疗组之间相似(P>0.01),但sIL-2R水平腹腔化疗低(0.05P相似文献   

高等院校网络信息安全管理研究

高等院校校园信息化的过程中出现了许多信息安全问题,针时此类问题的现状,根据高校信息管理制度进行分类、归纳,提出建立完善的人机并行监督管理机制和对BBS进行规范完善性重塑的建议.     

nm23在食道癌、胃肠癌组织中的表达及其意义

目的:探讨nm23在食道癌、胃肠癌发展中的作用及其意义。方法:应用S-P免疫组织化学方法检测nm23基因在39例食道癌、39例胃癌、42例肠癌标本中的表达。结果:无淋巴结转移组nm23阳性表达率显著高于淋巴结转移组,且nm23低表达与癌的浸润深度有关;与患者的性别、癌的分化程度等生物学行为无关。结论:食道癌、胃肠癌nm23低表达者具有较强的浸润转移能力,nm23可作为预测食道癌、胃肠癌转移及预后的临床指标。     

Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice

Breast cancer is one of the malignant tumors with the highest morbidity and mortality. It is helpful to reduce the rate of tumor recurrence and metastasis by treating breast cancer with adjuvant chemotherapy, so as to increase the cure rate or survival of patients. In recent years, liposomes have been regarded as a kind of new carrier for targeted drugs. Being effective for enhancing drug efficacy and reducing side effects, they have been widely used for developing anticancer drugs. As a kind of anthracycline with high anticancer activity, doxorubicin can treat or alleviate a variety of malignant tumors effectively when it is used on its own or in combination with other anticancer drugs. Although liposomal doxorubicin has been extensively used in the adjuvant chemotherapy of breast cancer, its exact therapeutic efficacy and side effects have not been definitely proven. Various clinical studies have adopted different combined regimes, dosages, and staging, so their findings differ to certain extent. This paper reviews the clinical application of liposomal doxorubicin in the adjuvant chemotherapy of breast cancer and illustrates therapeutic effects and side effects of pegylated liposomal doxorubicin (PLD) and non-PLD (NPLD) in clinical research, in order to discuss the strategies for applying these drugs in such adjuvant chemotherapy, looking forward to providing references for related research and clinical treatment in terms of dosage, staging, combined regimes, and analysis methods and so on.     

钛离子注入烟草引起种子发芽率及叶片含钾量变化的研究

通过不同剂量的钛离子注入烟草种子研究,结果表明不同剂量的处理结果差异显著,低剂量的处理有利于种子发芽率和叶片含钾量的提高, 而高剂量的处理辐射损伤效应明显,发芽率迅速下降,含钾量也明显降低.在本实验条件下,3×1017Ti+/cm2处理对烟草当代生长及品质提高有利.     

热休克蛋白(HSP70、HSP27)在食管癌组织中表达的意义

目的 :探讨HSP70和HSP2 7在食管癌组织中的表达情况。方法 :采用SP免疫组织化学染色检测 5 9例食管癌组织中HSP70和HSP2 7。结果 :HSP70和HSP2 7的总阳性率分别为 6 4.4 1% (38/5 9)和 5 8.6 2 % (34/5 8) ,HSP70和HSP2 7的共同阳性率为 30 .0 0 % (9/30 )。结论 :在食管癌中HSP70和HSP2 7普遍表达。     

95后大学生思想政治教育模式的探索与研究

当代95后大学生性格特点鲜明,主要表现为缺乏独立性、自私;心理素质差,遇事容易极端;网络成瘾、手机控严重,针对以上95后大学生的特点,通过改变辅导员的工作方法,采用谈心谈话建立与学生之间的信任感,适当地开展激励教育模式,同时利用网络媒体开展工作,提高辅导员职业素养,不断探索有效的思想政治教育的模式。     

震区教育重建的应对策略——以台湾“9．21”地震为例

“5．12”汶川大地震使震区的校园建筑垮塌严重,导致师生伤亡惨重。人们在哀痛之余不禁思考着这样的问题：如何加强震后灾区的教育重建工作,制定和落实学校建筑抗震标准,提高学校师生的防震意识,最大限度地减少大地震给学校带来的人员伤亡和财产损失。通过介绍台湾学校在‘9．21”地震后重建政策和举措,提出相关政策性建议,以便为大陆学校完善安全标准和措施,改善和加强地震灾情教育,提供咨询和应对策略。     

大学非英语专业学生英语课外听力训练情况调查与研究

本文作者在扼要地回顾了与英语听力训练有关的理论观点的基础上,采用问卷调查的方式对大学非英语专业学生课外英语听力情况进行了调查,分析了调查数据,并在此基础上就如何加强学生英语课外听力训练提出了建议。     

涎腺粘液表皮样癌术后生存的临床病理因素分析

目的：探讨影响涎腺粘液表皮样癌患者术后生存的相关病理因素。方法：对98例涎腺粘液表皮样癌患者进行回顾性研究,分析影响患者术后生存的相关临床病理因素。通过SPSS10.0软件分析,筛选出影响粘液表皮样癌患者术后生存的主要临床病理因素。结果：与术后生存率相关的主要临床病理因素包括：临床分期、患者年龄、镜下是否发现坏死。结论：临床分期、患者年龄是影响涎腺粘液表皮样癌术后生存的主要临床因素,镜下坏死是影响涎腺粘液表皮样癌患者术后生存的主要病理因素。     

Efficacy of amiodarone and lidocaine for preventing ventricular fibrillation after aortic cross-clamp release in open heart surgery: a meta-analysis of randomized controlled trials

Objective

The relative preventative efficacy of amiodarone and lidocaine for ventricular fibrillation (VF) after release of an aortic cross-clamp (ACC) during open heart surgery has not been determined. This meta-analysis was designed to systematically evaluate the influence of amiodarone, lidocaine, or placebo on the incidence of VF after ACC.

Methods

Prospective randomized controlled trials (RCTs) that compared the VF-preventative effects of amiodarone with lidocaine, or amiodarone or lidocaine with placebo were included. PubMed, EMBASE, and the Cochrane Library were searched for relevant RCTs. Fixed or randomized effect models were applied according to the heterogeneity of the data from the selected studies.

Results

We included eight RCTs in the analysis. Pooled results suggested that the preventative effects of amiodarone and lidocaine were comparable (relative risk (RR)=1.12, 95% confidence interval (CI): 0.70 to 1.80, P=0.63), but both were superior to the placebo (amiodarone, RR=0.71, 95% CI: 0.51 to 1.00, P=0.05; lidocaine, RR=0.63, 95% CI: 0.46 to 0.88, P=0.006). The percentage of patients requiring electric defibrillation counter shocks (DCSs) did not differ significantly among patients administered amiodarone (RR=0.21, 95% CI: 0.04 to 1.19, P=0.08), lidocaine (RR=2.44, 95% CI: 0.13 to 44.02, P=0.55), or the placebo (RR=0.56, 95% CI: 0.25 to 1.25, P=0.16).

Conclusions

Amiodarone and lidocaine are comparably effective in preventing VF after ACC, but the percentage of patients who subsequently require DCSs does not differ among those administered amiodarone, lidocaine, or placebo.