Skeletal muscle glycogen concentration and metabolic responses following a high glycaemic carbohydrate breakfast

The purpose of this study was to examine the influence of a carbohydrate-rich meal on post-prandial metabolic responses and skeletal muscle glycogen concentration. After an overnight fast, eight male recreational/club endurance runners ingested a carbohydrate (CHO) meal (2.5 g CHO x kg(-1) body mass) and biopsies were obtained from the vastus lateralis muscle before and 3 h after the meal. Ingestion of the meal resulted in a 10.6 +/- 2.5% (P < 0.05) increase in muscle glycogen concentration (pre-meal vs post-meal: 314.0 +/- 33.9 vs 347.3 +/- 31.3 mmol x kg(-1) dry weight). Three hours after ingestion, mean serum insulin concentrations had not returned to pre-feeding values (0 min vs 180 min: 45 +/- 4 vs 143 +/- 21 pmol x l(-1)). On a separate occasion, six similar individuals ingested the meal or fasted for a further 3 h during which time expired air samples were collected to estimate the amount of carbohydrate oxidized over the 3 h post-prandial period. It was estimated that about 20% of the carbohydrate consumed was converted into muscle glycogen, and about 12 % was oxidized. We conclude that a meal providing 2.5 g CHO x kg(-1) body mass can increase muscle glycogen stores 3 h after ingestion. However, an estimated 67% of the carbohydrate ingested was unaccounted for and this may have been stored as liver glycogen and/or still be in the gastrointestinal tract.     

The effect of pre-exercise carbohydrate feedings on the intensity that elicits maximal fat oxidation

The aim of the present study was to examine the effect of ingesting 75?g of glucose 45?min before the start of a graded exercise test to exhaustion on the determination of the intensity that elicits maximal fat oxidation (Fat_max). Eleven moderately trained individuals ( V?O_2max: 58.9±1.0?ml?·?kg^?1?·?min^?1; mean±s_x¯ ), who had fasted overnight, performed two graded exercise tests to exhaustion, one 45?min after ingesting a placebo drink and one 45?min after ingesting 75?g of carbohydrate in the form of glucose. The tests started at 95?W and the workload was increased by 35?W every 3?min. Gas exchange measures and heart rate were recorded throughout exercise. Fat oxidation rates were calculated using stoichiometric equations. Blood samples were collected at rest and at the end of each stage of the test. Maximal fat oxidation rates decreased from 0.46±0.06 to 0.33±0.06?g?·?min^?1 when carbohydrate was ingested before the start of exercise (P?<0.01). There was also a decrease in the intensity which elicited maximal fat oxidation (60.1±1.9% vs 52.0±3.4% V?O_2max) after carbohydrate ingestion (P?<0.05). Maximal power output was higher in the carbohydrate than in the placebo trial (346±12 vs 332±12?W) (P?<0.05). In conclusion, the ingestion of 75?g of carbohydrate 45?min before the onset of exercise decreased Fat_max by 14%, while the maximal rate of fat oxidation decreased by 28%.     

The effects of acute carbohydrate and caffeine feeding strategies on cycling efficiency

To assess the effect of carbohydrate and caffeine on gross efficiency (GE), 14 cyclists (V?O_2max 57.6 ± 6.3 ml.kg^?1.min^?1) completed 4 × 2-hour tests at a submaximal exercise intensity (60% Maximal Minute Power). Using a randomized, counter-balanced crossover design, participants consumed a standardised diet in the 3-days preceding each test and subsequently ingested either caffeine (CAF), carbohydrate (CHO), caffeine+carbohydrate (CAF+CHO) or water (W) during exercise whilst GE and plasma glucose were assessed at regular intervals (~30 mins). GE progressively decreased in the W condition but, whilst caffeine had no effect, this was significantly attenuated in both trials that involved carbohydrate feedings (W = ?1.78 ± 0.31%; CHO = ?0.70 ± 0.25%, p = 0.008; CAF+CHO = ?0.63 ± 0.27%, p = 0.023; CAF = ?1.12 ± 0.24%, p = 0.077). Blood glucose levels were significantly higher in carbohydrate ingestion conditions (CHO = 4.79 ± 0.67 mmol·L^?1, p < 0.001; CAF+CHO = 5.05 ± 0.81 mmol·L^?1, p < 0.001; CAF = 4.46 ± 0.75 mmol·L^?1; W = 4.20 ± 0.53 mmol·L^?1). Carbohydrate ingestion has a small but significant effect on exercise-induced reductions in GE, indicating that cyclists’ feeding strategy should be carefully monitored prior to and during assessment.     

Caffeine lowers perceptual response and increases power output during high-intensity cycling

The aim of this study was to determine the effects of caffeine ingestion on a ‘preloaded’ protocol that involved cycling for 2?min at a constant rate of 100% maximal power output immediately followed by a 1-min ‘all-out’ effort. Eleven male cyclists completed a ramp test to measure maximal power output. On two other occasions, the participants ingested caffeine (5?mg?·?kg^?1) or placebo in a randomized, double-blind procedure. All tests were conducted on the participants' own bicycles using a Kingcycle? test rig. Ratings of perceived exertion (RPE; 6–20 Borg scale) were lower in the caffeine trial by approximately 1 RPE point at 30, 60 and 120?s during the constant rate phase of the preloaded test (P?<0.05). The mean power output during the all-out effort was increased following caffeine ingestion compared with placebo (794±164 vs 750±163?W; P?=?0.05). Blood lactate concentration 4, 5 and 6?min after exercise was also significantly higher by approximately 1?mmol?·?l^?1 in the caffeine trial (P?<0.05). These results suggest that high-intensity cycling performance can be increased following moderate caffeine ingestion and that this improvement may be related to a reduction in RPE and an elevation in blood lactate concentration.     

The addition of whey protein to a carbohydrate–electrolyte drink does not influence post-exercise rehydration

The addition of whey protein to a carbohydrate–electrolyte drink has been shown to enhance post-exercise rehydration when a volume below that recommended for full fluid balance restoration is provided. We investigated if this held true when volumes sufficient to restore fluid balance were consumed and if differences might be explained by changes in plasma albumin content. Sixteen participants lost ~1.9% of their pre-exercise body mass by cycling in the heat and rehydrated with 150% of body mass lost with either a 60 g · L^?1 carbohydrate drink (CHO) or a 60 g · L^?1 carbohydrate, 20 g · L^?1 whey protein isolate drink (CHO-P). Urine and blood samples were collected pre-exercise, post-exercise, post-rehydration and every hour for 4 h post-rehydration. There was no difference between trials for total urine production (CHO 1057 ± 319 mL; CHO-P 970 ± 334 mL; P = 0.209), drink retention (CHO 51 ± 12%; CHO-P 55 ± 15%; P = 0.195) or net fluid balance (CHO ?393 ± 272 mL; CHO-P ?307 ± 331 mL; P = 0.284). Plasma albumin content relative to pre-exercise was increased from 2 to 4 h during CHO-P only. These results demonstrate that the addition of whey protein isolate to a carbohydrate–electrolyte drink neither enhances nor inhibits rehydration. Therefore, where post-exercise protein ingestion might benefit recovery, this can be consumed without effecting rehydration.     

Effect of water ingestion on endurance capacity during prolonged running

This study examined the influence of water ingestion on endurance capacity during submaximal treadmill running. Four men and four women with a mean (± S.E.) age of 21.4 ± 0.7 years, height of 169 + 2 cm, body mass of 63.1 ± 2.9 kg and VO ₂ max of 51.1 ± 1.8 ml kg^?1 min^?1, performed two randomly assigned treadmill runs at 70% VO ₂ max to exhaustion. No fluid was ingested during one trial (NF‐trial), whereas a single water bolus of 3.0 ml kg^?1 body mass was ingested immediately pre‐exercise and serial feedings of 2.0 ml kg^?1 body mass were ingested every 15 min during exercise in a fluid replacement trial (FR‐trial). Run time for the NF‐trial was 77.7 ± 7.7 min, compared to 103 ± 12.4 min for the FR‐trial (P<0.01). Body mass (corrected for water ingestion) decreased by 2.0 ± 0.2% in the NF‐trial and 2.7 ± 0.2% in the FR‐trial (P<0.01), while plasma volume decreased by 1.1 ± 1.1% and 3.5 ± 1.1% in the two trials respectively (N.S.). However, these apparent differences in circulatory volume were not associated with differences in rectal temperature. Respiratory exchange ratios indicated increased carbohydrate metabolism (73% vs 64% of total energy expenditure) and suppressed fat metabolism after 75 min of exercise in the NF‐trial compared with the FR‐trial (NF‐trial, 0.90 ± 0.01; FR‐trial, 0.86 ± 0.03; P<0.01). Blood glucose concentrations were similar in both trials, while blood lactate concentrations were higher in the NF‐trial at the end of exercise (4.83 ± 0.34 vs 4.18 ± 0.38 mM; P<0.05). In summary, water ingestion during prolonged running improved endurance capacity.     

The influence of carbohydrate and protein ingestion during recovery from prolonged exercise on subsequent endurance performance

Abstract

Ingesting carbohydrate plus protein following prolonged exercise may restore exercise capacity more effectively than ingestion of carbohydrate alone. The objective of the present study was to determine whether this potential benefit is a consequence of the protein fraction per se or simply due to the additional energy it provides. Six active males participated in three trials, each involving a 90-min treadmill run at 70% maximal oxygen uptake (run 1) followed by a 4-h recovery. At 30-min intervals during recovery, participants ingested solutions containing: (1) 0.8 g carbohydrate · kg body mass (BM)^?1 · h^?1 plus 0.3 g · kg^?1 · h^?1 of whey protein isolate (CHO-PRO); (2) 0.8 g carbohydrate · kg BM^?1 · h^?1 (CHO); or (3) 1.1 g carbohydrate · kg BM^?1 · h^?1 (CHO-CHO). The latter two solutions matched the CHO-PRO solution for carbohydrate and for energy, respectively. Following recovery, participants ran to exhaustion at 70% maximal oxygen uptake (run 2). Exercise capacity during run 2 was greater following ingestion of CHO-PRO and CHO-CHO than following ingestion of CHO (P ≤ 0.05) with no significant difference between the CHO-PRO and CHO-CHO treatments. In conclusion, increasing the energy content of these recovery solutions extended run time to exhaustion, irrespective of whether the additional energy originated from sucrose or whey protein isolate.     

The influence of a 6.5% carbohydrate-electrolyte solution on performance of prolonged intermittent high-intensity running at 30°C

Nine male student games players consumed either flavoured water (0.1 g carbohydrate, Na⁺ 6 mmol · l^?1), a solution containing 6.5% carbohydrate-electrolytes (6.5 g carbohydrate, Na⁺ 21 mmol · l^?1) or a taste placebo (Na⁺ 2 mmol · l^?1) during an intermittent shuttle test performed on three separate occasions at an ambient temperature of 30°C (dry bulb). The test involved five 15-min sets of repeated cycles of walking and variable speed running, each separated by a 4-min rest (part A of the test), followed by 60 s run/60 s rest until exhaustion (part B of the test). The participants drank 6.5 ml · kg^?1 of fluid as a bolus just before exercise and thereafter 4.5 ml · kg^?1 during every exercise set and rest period (19 min). There was a trial order effect. The total distance completed by the participants was greater in trial 3 (8441 ± 873 m) than in trial 1 (6839 ± 512, P < 0.05). This represented a 19% improvement in exercise capacity. However, the trials were performed in a random counterbalanced order and the participants completed 8634 ± 653 m, 7786 ± 741 m and 7099 ± 647 m in the flavoured water (FW), placebo (P) and carbohydrate-electrolyte (CE) trials, respectively (P = 0.08). Sprint performance was not different between the trials but was impaired over time (FW vs P vs CE: set 1, 2.41 ± 0.02 vs 2.39 ± 0.03 vs 2.39 ± 0.03 s; end set, 2.46 ± 0.03 vs 2.47 ± 0.03 vs 2.47 ± 0.02 s; main

effect time, P < 0.01). The rate of rise in rectal temperature was greater in the carbohydrate-electrolyte trial (rise in rectal temperature/duration of trial, °C · h^?1; FW vs CE, P < 0.05; P vs CE, N.S.). Blood glucose concentrations were higher in the carbohydrate-electrolyte than in the other two trials (FW vs P vs CE: rest, 4.4 ± 0.1 vs 4.3 ± 0.1 vs 4.2 ± 0.1 mmol · l^?1; end of exercise, 5.4 ± 0.3 vs 6.4 ± 0.6 vs 7.2 ± 0.5 mmol · l^?1; main effect trial, P < 0.05; main effect time, P < 0.01). Plasma free fatty acid concentrations at the end of exercise were lower in the carbohydrate-electrolyte trial than in the other two trials (FW vs P vs CE: 0.57 ± 0.08 vs 0.53 ± 0.11 vs 0.29 ± 0.04 mmol · l^?1; interaction, P < 0.01). The correlation between the rate of rise in rectal temperature (°C · h^?1) and the distance completed was ?0.91, ?0.92 and ?0.96 in the flavoured water, placebo and carbohydrate-electrolyte conditions, respectively (P < 0.01). Heart rate, blood pressure, plasma ammonia, blood lactate, plasma volume and rate of perceived exertion were not different between the three fluid trials. Although drinking the carbohydrate-electrolyte solution induced greater metabolic changes than the flavoured water and placebo solutions, it is unlikely that in these unacclimated males carbohydrate availability was a limiting factor in the performance of intermittent running in hot environmental conditions.     

Effect of combined carbohydrate-protein ingestion on markers of recovery after simulated rugby union match-play

Abstract

In this study, we investigated the effect of ingesting carbohydrate alone or carbohydrate with protein on functional and metabolic markers of recovery from a rugby union-specific shuttle running protocol. On three occasions, at least one week apart in a counterbalanced order, nine experienced male rugby union forwards ingested placebo, carbohydrate (1.2 g · kg body mass^?1 · h^?1) or carbohydrate with protein (0.4 g · kg body mass^?1 · h^?1) before, during, and after a rugby union-specific protocol. Markers of muscle damage (creatine kinase: before, 258 ± 171 U · L^?1 vs. 24 h after, 574 ± 285 U · L^?1; myoglobin: pre, 50 ± 18 vs. immediately after, 210 ± 84 nmol · L^?1; P < 0.05) and muscle soreness (1, 2, and 3 [maximum soreness = 8] for before, immediately after, and 24 h after exercise, respectively) increased. Leg strength and repeated 6-s cycle sprint mean power were slightly reduced after exercise (93% and 95% of pre-exercise values, respectively; P < 0.05), but were almost fully recovered after 24 h (97% and 99% of pre-exercise values, respectively). There were no differences between trials for any measure. These results indicate that in experienced rugby players, the small degree of muscle damage and reduction in function induced by the exercise protocol were not attenuated by the ingestion of carbohydrate and protein.     

Understanding mental toughness in Australian soccer: Perceptions of players,parents, and coaches

Abstract

This study was designed to investigate the effect of ingesting a glucose plus fructose solution on the metabolic responses to soccer-specific exercise in the heat and the impact on subsequent exercise capacity. Eleven male soccer players performed a 90 min soccer-specific protocol on three occasions. Either 3 ml · kg^?1 body mass of a solution containing glucose (1 g · min^?1 glucose) (GLU), or glucose (0.66 g · min^?1) plus fructose (0.33 g · min^?1) (MIX) or placebo (PLA) was consumed every 15 minutes. Respiratory measures were undertaken at 15-min intervals, blood samples were drawn at rest, half-time and on completion of the protocol, and muscle glycogen concentration was assessed pre- and post-exercise. Following the soccer-specific protocol the Cunningham and Faulkner test was performed. No significant differences in post-exercise muscle glycogen concentration (PLA, 62.99 ± 8.39 mmol · kg wet weight^?1; GLU 68.62 ± 2.70; mmol · kg wet weight^?1 and MIX 76.63 ± 6.92 mmol · kg wet weight^?1) or exercise capacity (PLA, 73.62 ± 8.61 s; GLU, 77.11 ± 7.17 s; MIX, 83.04 ± 9.65 s) were observed between treatments (P > 0.05). However, total carbohydrate oxidation was significantly increased during MIX compared with PLA (P < 0.05). These results suggest that when ingested in moderate amounts, the type of carbohydrate does not influence metabolism during soccer-specific intermittent exercise or affect performance capacity after exercise in the heat.     

The creatine content of Creatine Serum™ and the change in the plasma concentration with ingestion of a single dose

Three samples of Creatine Serum? ATP Advantage from Muscle Marketing USA, Inc. were assayed for creatine by two different techniques by four independent laboratories, and for creatinine by two different techniques by two laboratories. A further sample was assayed for phosphorylcreatine. Dry weight and total nitrogen were also analysed. Six male volunteers ingested in random order, over 3 weeks: (A) water; (B) 2.5?g creatine monohydrate (Cr?·?H₂O) in solution; and (C) 5?ml Creatine Serum? (reportedly containing an equivalent amount of Cr?·?H₂O). Blood samples were collected before and up to 8?h after each treatment and plasma was analysed for creatine and creatinine. Eight-hour urine samples were analysed for creatine. Ingestion of 2.5?g creatine monohydrate in solution resulted in a significant increase in plasma creatine (from 59.1±11.8?μmol?·?l^?1 to 245.3±74.6?μM μmol?·?l^?1; mean±s) and urinary creatine excretion. No increase in plasma or urinary creatine or creatinine was found on ingestion of Creatine Serum? or water. Analysis showed 5?ml of Creatine Serum? to contain <10?mg Cr?·?H₂O and approximately 90?mg creatinine. Phosphorylcreatine was not detectable and only a trace amount of phosphorous was present. Total nitrogen analysis ruled out significant amounts of other forms of creatine. We conclude that the trace amounts of creatine in the product would be too little to affect the muscle content even with multiple dosing.     

Influence of ingesting a carbohydrate-electrolyte solution before and during a 1-hour run in fed endurance-trained runners

Abstract

The aim of this study was to determine whether the ingestion of a carbohydrate-electrolyte solution would improve 1-h running performance in runners who had consumed a meal 3 h before exercise. Ten endurance-trained male runners completed two trials that required them to run as far as possible in 1 h on an automated treadmill that allowed changes in running speed without manual input. Following the consumption of the pre-exercise meal, which provided 2.5 g carbohydrate per kilogram body mass (BM), runners ingested either a 6.4% carbohydrate-electrolyte solution or placebo solution (i.e. 8 ml · kg BM^?1) 30 min before and 2 ml · kg BM^?1 at 15-min intervals throughout the 1-h run. There were no differences in total distance covered (placebo: 13,680 m, s = 1525; carbohydrate: 13,589 m, s = 1635) (P > 0.05). Blood glucose and lactate concentration, respiratory exchange ratio, and carbohydrate oxidation during exercise were not different between trials (P > 0.05). There were also no differences in ratings of perceived exertion, felt arousal or pleasure–displeasure between trials (P > 0.05). In conclusion, the ingestion of a 6.4% carbohydrate-electrolyte solution did not improve 1-h running performance when a high carbohydrate meal was consumed 3 h before exercise.     

A single session of resistance exercise does not reduce postprandial lipaemia

This study investigated the effect of a single session of resistance exercise on postprandial lipaemia. Eleven healthy normolipidaemic men with a mean age of 23 (standard error = 1.4) years performed two trials at least 1 week apart in a counterbalanced randomized design. In each trial, participants consumed a test meal (1.2?g fat, 1.1?g carbohydrate, 0.2?g protein and 68 kJ?·?kg^?1 body mass) between 08.00 and 09.00?h following a 12?h fast. The afternoon before one trial, the participants performed an 88?min bout of resistance exercise. Before the other trial, the participants were inactive (control trial). Resistance exercise was performed using free weights and included four sets of 10 repetitions of each of 11 exercises. Sets were performed at 80% of 10-repetition maximum with a 2?min work and rest interval. Venous blood samples were obtained in the fasted state and at intervals for 6?h postprandially. Fasting plasma triacylglycerol (TAG) concentration did not differ significantly between control (1.03?±?0.13?mmol?·?l^?1) and exercise (0.94?±?0.09?mmol?·?l^?1) trials (mean?± standard error). Similarly, the 6?h total area under the plasma TAG concentration versus time curve did not differ significantly between the control (9.84?±?1.40?mmol?·?l^?1?·?6?h^?1) and exercise (9.38?±?1.12?mmol?·?l^?1?·?6?h^?1) trials. These findings suggest that a single session of resistance exercise does not reduce postprandial lipaemia.     

Creatine co-ingestion with carbohydrate or cinnamon extract provides no added benefit to anaerobic performance

The insulin response following carbohydrate ingestion enhances creatine transport into muscle. Cinnamon extract is promoted to have insulin-like effects, therefore this study examined if creatine co-ingestion with carbohydrates or cinnamon extract improved anaerobic capacity, muscular strength, and muscular endurance. Active young males (n?=?25; 23.7?±?2.5?y) were stratified into 3 groups: (1) creatine only (CRE); (2) creatine+ 70?g carbohydrate (CHO); or (3) creatine+ 500?mg cinnamon extract (CIN), based on anaerobic capacity (peak power·kg^?1) and muscular strength at baseline. Three weeks of supplementation consisted of a 5?d loading phase (20?g/d) and a 16?d maintenance phase (5?g/d). Pre- and post-supplementation measures included a 30-s Wingate and a 30-s maximal running test (on a self-propelled treadmill) for anaerobic capacity. Muscular strength was measured as the one-repetition maximum 1-RM for chest, back, quadriceps, hamstrings, and leg press. Additional sets of the number of repetitions performed at 60% 1-RM until fatigue measured muscular endurance. All three groups significantly improved Wingate relative peak power (CRE: 15.4% P?=?.004; CHO: 14.6% P?=?.004; CIN: 15.7%, P?=?.003), and muscular strength for chest (CRE: 6.6% P?P?P?P?P?P?P?=?.013; CHO: 10.0% P?=?.007; CIN: 17.3% P?P?=?.021) and CIN (15.5%, P?相似文献   

Carbohydrate intake and training efficacy – a randomized cross-over study

Carbohydrate (CHO) availability during endurance exercise seems to attenuate exercise-induced perturbations of cellular homeostasis and might consequently diminish the stimulus for training adaptation. Therefore, a negative effect of CHO intake on endurance training efficacy seems plausible. This study aimed to test the influence of carbohydrate intake on the efficacy of an endurance training program on previously untrained healthy adults. A randomized cross-over trial (8-week wash-out period) was conducted in 23 men and women with two 8-week training periods (with vs. without intake of 50g glucose before each training bout). Training intervention consisted of 4x45 min running/walking sessions/week at 70% of heart rate reserve. Exhaustive, ramp-shaped exercise tests with gas exchange measurements were conducted before and after each training period. Outcome measures were maximum oxygen uptake (VO_2max) and ventilatory anaerobic threshold (VT). VO_2max and VT increased after training regardless of CHO intake (VO_2max: Non-CHO 2.6 ± 3.0 ml*min^?1*kg^?1 p = 0.004; CHO 1.4 ± 2.5 ml*min^?1*kg^?1 p = 0.049; VT: Non-CHO 4.2 ± 4.2 ml*min^?1*kg^?1 p < 0.001; CHO 3.0 ± 4.2 ml*min^?1*kg^?1 p = 0.003). The 95% confidence interval (CI) for the difference between conditions was between +0.1 and +2.1 ml*min^?1*kg^?1 for VO_2max and between ?1.2 and +3.1 for VT. It is concluded that carbohydrate intake could potentially impair the efficacy of an endurance training program.     

Protection against muscle damage in competitive sports players: the effect of the immunomodulator AM3

Strenuous physical exercise of the limb muscles commonly results in damage, especially when that exercise is intense, prolonged and includes eccentric contractions. Many factors contribute to exercise-induced muscle injury and the mechanism is likely to differ with the type of exercise. Competitive sports players are highly susceptible to this type of injury. AM3 is an orally administered immunomodulator that reduces the synthesis of proinflammatory cytokines and normalizes defective cellular immune fractions. The ability of AM3 to prevent chronic muscle injury following strenuous exercise characterized by eccentric muscle contraction was evaluated in a double-blind and randomized pilot study. Fourteen professional male volleyball players from the First Division of the Spanish Volleyball League volunteered to take part. The participants were randomized to receive either placebo (n?=?7) or AM3 (n?=?7). The physical characteristics (mean±s) of the placebo group were as follows: age 25.7±2.1 years, body mass 87.2±4.1?kg, height 1.89±0.07?m, maximal oxygen uptake 65.3±4.2?ml?·?kg^?1?·?min^?1. Those of the AM3 group were as follows: age 26.1±1.9 years, body mass 85.8±6.1?kg, height 1.91±0.07?m, maximal oxygen uptake 64.6±4.5?ml?·?kg^?1?·?min^?1. All participants were evaluated for biochemical indices of muscle damage, including concentrations of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatine kinase (CK) and its MB fraction (CK-MB), myoglobin, lactate dehydrogenase, urea, creatinine and γ-glutamyltranspeptidase, both before and 30 days after treatment (over the peak of the competitive season). In the placebo group, competitive exercise (i.e. volleyball) was accompanied by significant increases in creatine kinase (494±51 to 560±53?IU?·?l^?1, P?<?0.05) and myoglobin (76.8±2.9 to 83.9±3.1?μg?·?l^?1, P?<?0.05); aspartate aminotransferase (30.8±3.0 to 31.1±2.9?IU?·?l^?1) and lactate dehydrogenase (380±31 to 376±29?IU?·?l^?1) were relatively unchanged after the 30 days maximum effort. AM3 not only inhibited these changes, it led to a decrease from baseline serum concentrations of creatine kinase (503±49 to 316±37?IU?·?l^?1, P?<?0.05) and myoglobin (80.1±3.2 to 44.1±2.6?IU?·?l^?1, P?<?0.05), as well as aspartate aminotransferase (31.1±3.3 to 26.1±2.7?IU?·?l^?1, P?<?0.05) and lactate dehydrogenase (368±34 to 310±3?IU?·?l^?1, P?<?0.05). The concentration of CK-MB was also significantly decreased from baseline with AM3 treatment (11.6±1.2 to 5.0±0.7?IU?·?l^?1, P?<?0.05), but not with placebo (11.4±1.1 to 10.8±1.4?IU?·?l^?1). In conclusion, the use of immunomodulators, such as AM3, by elite sportspersons during competition significantly reduces serum concentrations of proteins associated with muscle damage.     

Impact of carbohydrate mouth rinsing on time to exhaustion during Ramadan: A randomized controlled trial in Jordanian men

Mouth rinsing using a carbohydrate (CHO) solution has been suggested to improve physical performance in fasting participants. This study examined the effects of CHO mouth rinsing during Ramadan fasting on running time to exhaustion and on peak treadmill speed (V_peak). In a counterbalanced crossover design, 18 sub-elite male runners (Age: 21?±?2 years, Weight: 68.1?±?5.7?kg, VO_2max: 55.4?±?4.8?ml/kg/min) who observed Ramadan completed a familiarization trial and three experimental trials. The three trials included rinsing and expectorating a 25?mL bolus of either a 7.5% sucrose solution (CHO), a flavour and taste matched placebo solution (PLA) for 10?s, or no rinse (CON). The treatments were performed prior to an incremental treadmill test to exhaustion. Three-day dietary and exercise records were obtained on two occasions and analysed. Anthropometric characteristics were obtained and recorded for all participants. A main effect for mouth rinse on peak velocity (V_peak) (CHO: 17.6?±?1.5?km/h; PLA: 17.1?±?1.4?km/h; CON: 16.7?±?1.2?km/h; P?η_p²?=?0.49) and time to exhaustion (CHO: 1282.0?±?121.3?s; PLA: 1258.1?±?113.4?s; CON: 1228.7?±?98.5?s; P?=?.002, η_p²?=?0.41) was detected, with CHO significantly higher than PLA (P?P?P?>?.05). Energy availability from dietary analysis, body weight, and fat-free mass did not change during the last two weeks of Ramadan (P?>?.05). This study concludes that carbohydrate mouth rinsing improves running time to exhaustion and peak treadmill speed under Ramadan fasting conditions.     

Nutritional needs of elite endurance athletes. Part I: Carbohydrate and fluid requirements

Abstract

Both carbohydrate depletion and dehydration have been shown to decrease performance whilst severe dehydration can also cause adverse health effects. Therefore carbohydrate and fluid requirements are increased with exercise. Ingestion of 200–300?g of CHO 3–4?h prior to exercise is an effective strategy in order to meet daily CHO demands and increase CHO availability during the subsequent exercise period. There is little evidence that CHO during the hour immediately prior to exercise has adverse effects such as rebound hypoglycaemia. CHO ingestion during exercise has been shown to improve performance as measured by enhanced work output or decreased exercise time to complete a fixed amount of work. Recent studies have demonstrated that exogenous CHO oxidation rates can be increased by ingesting combinations of CHO that use different intestinal CHO transporters. After exercise maximal muscle glycogen re-synthesis rates can be achieved by ingesting CHO at a rate of ～1.2?g/kg/h, in relatively frequent (e.g., 15–30?min) intervals for up to 5?h following exercise. Protein amino acid mixtures may increase glycogen synthesis further but only if relatively small amounts of CHO are ingested.

Hypohydration and hyperthermia alone have negative effects on performance but their combination is particularly serious, both in terms of performance and health. Dehydration can be prevented by fluid ingestion pre exercise and during exercise. Because of large individual differences it is difficult to individualise the advice. Perhaps the best guidance for athletes is to weigh themselves to assess fluid losses during training and racing and limit weight losses to 1% during exercise lasting longer than 1.5?h. Excessive fluid intake has been associated with hyponatremia. Post exercise the volume of fluid ingested and sodium intake are important determinants of rehydration.     

Effect of creatine plus caffeine supplements on time to exhaustion during an incremental maximum exercise

Abstract

This study investigated the effects of acute caffeine ingestion following short-term creatine supplementation on an incremental cycling to exhaustion task. Twelve active males performed the task under three conditions: baseline condition (BASE, no ergogenic aid), creatine plus caffeine condition (CRE + CAF), and creatine with placebo condition (CRE + PLA). Following the establishment of BASE condition, participants were administered CRE + CAF (0.3 g·kg^?1·day^?1 of creatine for 5 days followed by 6 mg·kg^?1 of caffeine 1 h prior to testing) and CRE + PLA (0.3 g·kg^?1·day^?1 of creatine for 5 days followed by 6 mg·kg^?1 of placebo 1 h prior to testing) in a double-blind, randomized crossover and counterbalancing protocol. No significant differences were observed in relative maximal oxygen consumption ([Vdot]O_2max) (51.7±5.5, 52.8±4.9 and 51.3±5.6 ml·kg^?1·min^?1 for BASE, CRE + CAF and CRE + PLA, respectively; P>0.05) and absolute [Vdot]O_2max (3.6±0.4, 3.7±0.4 and 3.5±0.5 l·min^?1 for BASE, CRE + CAF and CRE + PLA, respectively; P>0.05). Blood samples indicated significantly higher blood lactate and glucose concentrations in the CRE + CAF among those in the BASE or CRE + PLA condition during the test (P<0.05). The time to exhaustion on a cycling ergometer was significantly longer for CRE + CAF (1087.2±123.9 s) compared with BASE (1009.2±86.0 s) or CRE + PLA (1040.3±96.1 s). This study indicated that a single dose of caffeine following short-term creatine supplementation did not hinder the creatine–caffeine interaction. In fact, it lengthened the time to exhaustion during an incremental maximum exercise test. However, this regime might lead to the accumulation of lactate in the blood.     

Caffeine improves muscular performance in elite Brazilian Jiu-jitsu athletes

Scientific information about the effects of caffeine intake on combat sport performance is scarce and controversial. The aim of this study was to investigate the effectiveness of caffeine to improve Brazilian Jiu-jitsu (BJJ)-specific muscular performance. Fourteen male and elite BJJ athletes (29.2?±?3.3?years; 71.3?±?9.1?kg) participated in a randomized double-blind, placebo-controlled and crossover experiment. In two different sessions, BJJ athletes ingested 3?mg?kg^?1 of caffeine or a placebo. After 60?min, they performed a handgrip maximal force test, a countermovement jump, a maximal static lift test and bench-press tests consisting of one-repetition maximum, power-load, and repetitions to failure. In comparison to the placebo, the ingestion of the caffeine increased: hand grip force in both hands (50.9?±?2.9 vs. 53.3?±?3.1?kg; respectively p?p?=?.02), and time recorded in the maximal static lift test (54.4?±?13.4 vs. 59.2?±?11.9?s; p?p?=?.02), maximal power obtained during the power-load test (750.5?±?154.7 vs. 826.9?±?163.7?W; p?p?=?.04). In conclusion, the pre-exercise ingestion of 3?mg?kg^?1 of caffeine increased dynamic and isometric muscular force, power, and endurance strength in elite BJJ athletes. Thus, caffeine might be an effective ergogenic aid to improve physical performance in BJJ.