Intratrial proactive interference in rats’ serial alternation performance in the radial maze

Rats acquired a serial alternation task in an eight-arm radial maze that was partitioned into four pairs of arms. Each pair was associated with a different distal stimulus. Rats were initially forced to the left or right arm in each pair (the study segment) before being exposed to both arms in each pair (the free-choice or test segment). Only the previously blocked arm of each pair remained baited. Following initial training, proactive interference (PI) was induced by presenting rats with a forced-choice (prestudy) segment containing arm positions opposite those in the subsequent study segment. Such trials generated poorer free-choice accuracy than did trials without a prestudy segment. Forcing rats to both arms in the pair in a prestudy segment produced only transient PI. A slight improvement in rats’ free-choice performance was obtained by forcing them to the same arm position, but only when the test segment was delayed by 30 min. Increasing the interval between the prestudy and study segments from 2 to 30 min eliminated PI, but only when free-choice testing was delayed by 2 min rather than by 30 min. These results suggest that intratrial PI in this preparation was primarily due to confusion about which arm position in each pair had been visited during the last forced-choice segment.     

Age-related differences in rats’ spontaneous alternation

Fifteen-day-old rats made random choices in a T-maze, while adult levels of alternation (approximately 70%) were noted among 30-day-olds. Also, younger pups were insensitive to a lengthening of the intertrial interval, unlike older animals whose rate of alternation decreased when a 1-h delay was interposed between arm entries. These findings are consistent with the hypothesis that hippocampal development is a factor in the ontogeny of postweaning locomotion. The unsystematic pattern of goal-arm selections among 15-day-olds suggests that ontongenetic variation in the utilization of stimuli may underlie developmental shifts in spontaneous alternation.     

The effects of maze-arm length on performance in the radial-arm maze

Rats trained in a 16-arm radial maze with arms half the standard length demonstrated extremely low, but above chance, choice accuracy (Experiment 1). Rats trained in a 12-arm maze with short arms demonstrated a substantially higher degree of adjacent-arm responding than did rats trained in the same maze with long maze arms and, when response stereotypy was disrupted by a forced-choice procedure, the short-arm group chose less accurately than the long-arm group (Experiment 2). In a 16-arm maze with 8 short arms and 8 long arms, there was a strong preference for short arms and no evidence for a difference in the ability to discriminate previously visited arms from unvisited arms as a function of arm length, as measured by a two-alternative forced-choice procedure (Experiment 3). These results are interpreted as indicating that arm length affects a choice criterion, with a relatively lax criterion being applied to shorter arms.     

Long-delay,one-trial conditioned preference and retention in monkeys (Cebus apella)

Cebus monkeys explored a small T-maze for 5 min, and their preference for the striped or black arm of the maze was assessed. On the next day, the experimental animals were placed into the nonpreferred arm for a 1-min period (exposure to the CS), removed from the T-maze for a 30-min delay interval, and then returned to the startbox of the maze, where they received a food reward (UCS). One control group (CS only) received the placement experience but was not rewarded after the 30-min period. A second control group (noncontingent UCS) received the reward in the startbox but not the placement experience. A second preference test showed that the experimental, but not the control, animals reversed their original preference, now showing a preference for the arm associated with reward. A retention test given 4 months after three such training-test trials revealed considerable retention of the preferences exhibited by the experimental and CS-only control subjects.     

Control of performance by short-term memory in honeybees

Individual honeybees foraging at a laboratory window were trained with a correction method to choose between blue and yellow targets, one of which contained sucrose solution. There were two trials on each visit, with the locus of the sucrose predictable only on the second. Animals differentially rewarded on Trial 2 for choosing the rewarded color of Trial 1, for choosing the alternative color, or for choosing the target in the rewarded position of Trial 1 independently of its color, all showed a small but persistent preference for the rewarded color, with no significant preference for the rewarded position. When the positions of the colored targets were the same on Trial 2 as on Trial 1 (color and position confounded), there was a more substantial but equally persistent preference on Trial 2 for the rewarded color-position of Trial 1, whether the animals were differentially rewarded for perseveration or for alternation. The results provide further evidence of unlearned control of performance by short-term memory in honeybees but no indication of learned control.     

Facilitative effect of a pretest exposure to the CS: Analysis and implications for the memory trace

Retention of a brightness discrimination avoidance task by rats is impaired (Kamin effect) following a 1-h training-to-test interval (TTI), is enhanced after a 3-day TTI (reminiscence, or long-term spontaneous improvement), and is disrupted following a 21-day TTI (long-term forgetting). An exposure to the conditioned stimulus (CS), delivered 5 mm before a 1-h delayed retention test, not only compensated for the performance deficit that corresponds to the Kamin effect, but induced a large improvement in performance similar to that normally obtained after a 3-day TTI. It can be proposed that such cuing may act either by accelerating a natural memory-trace maturation process or by improving the retrievability of the memory trace. Since these possibilities lead to opposite predictions concerning the length of the facilitation induced by cuing, the effect of a pretest exposure to the CS on performance obtained during a 1-h delayed retention test was studied after several cuing-to-test intervals (0, 5, 10, or 20 min). The results, which indicate that cuing transiently enhanced subsequent retention performance, more convincingly support the retrieval hypothesis. The effects of pretest exposure to the CS (which occurred 5 min before testing) were also examined 10 min, 1 h, or 24 h after initial training. The results indicate that the facilitative effect of cuing obtained when retention performance was disrupted shortly after training (1-h TTI) was also obtained after a 24-h retention interval, in the absence of performance disruption. An interpretation of the facilitative effect of a pretest exposure to the CS is proposed, and implications concerning the memory trace are further discussed in relation to the multidimensional hypothesis.     

Delayed matching in the pigeon: Interference produced by the prior delayed matching trial

Pigeons’ delayed matching performance on Trial n was examined as a function of whether the correct and incorrect comparison stimuli from Trial n?1 were maintained in the same role on Trial n (positive transitions), were reversed in role on Trial n (negative transitions), or were absent on Trial n (neutral transitions). Relative to neutral transitions, positive transitions did not significantly facilitate performance. Negative transitions, however, produced significant proactive interference on Trial n, and the magnitude of proactive interference was greater when the Trial n retention interval was 1 sec than when it was 0 sec. As the intertriai interval increased from 2 to 10 sec, the amount of interference dissipated. The results suggest that a prior delayed matching trial can serve as a significant source of forgetting but not a significant source of facilitation on an immediately following delayed matching trial.     

Reinstatement-induced recovery of a taste-LiCl association following extinction

Water-deprived rats were given a single exposure to saccharin and LiCl, either paired or unpaired. Half the subjects then received three saccharin-only exposures (extinction) in the training enclosure, followed by a single LiCl-only presentation (unconditioned stimulus reinstatement) 8 days after conditioning. The remaining subjects received six saccharin-only exposures, followed by LiCl reinstatement 13 days after conditioning. In both cases LiCl reinstatement occurred outside the training/test context. Appreciable recovery from extinction was observed after the partial loss of taste aversion obtained with three extinction sessions and the 8-day conditioning-reinstatement interval, but not after the asymptotic loss of taste aversion obtained with six extinction sessions and the 13-day conditioning-reinstatement interval. Conditioned taste aversions appear to be similar to more traditional associations with respect to both extinction and reinstatement-induced recovery from extinction. The results are discussed with reference to the event-memory, contextual-conditioning, and facilitated-retrieval hypotheses of postextinction reinstatement effects.     

Coherence of retrieval cues,rather than additivity,determines prior cuing effectiveness in the rat

In previous studies, we have shown that adding a supplementary cue in a prior-cuing treatment may dramatically reduce its initial effectiveness. This series of experiments was aimed at testing the hypothesis that such a lack of additivity among retrieval cues could be due to the combined reactivation of memory attributes related to incompatible behavioral responses. For that purpose, rats were partially trained to reach the lighted arm (light condition; usual training condition) or the darkened arm (dark condition) of a Y-maze in order to avoid an electric foot-shock. The first experiment demonstrates that animals learned the two versions of the task similarly and that an exposure to the light similarly acts as an effective retrieval cue after a 24-h interval. In the second experiment, the effectiveness of exposure to the grid alone and to the light alone as well as to the combined light + grid cue was investigated after a 21-day training-to-test interval in the light condition, where light was related to safety and grid was associated with the shock, and in the dark condition, where both light and grid were related to the shock. The results indicate that whereas the compound light + grid cue was an ineffective retrieval cue in the light condition, it acted as an effective retrieval cue in the dark condition, supporting the hypothesis that coherence between retrieval cues is a necessary condition for effective cuing.     

HIV非职业暴露后的预防现状

非职业暴露后预防(nPEP)是指包括对性暴露后与静脉药物注射暴露后的预防H IV感染的措施.应该尽可能早的开始(暴露后72 h内),用多种药物联合治疗连续28 d.nPEP中心理咨询也是重要的组成部分.抗逆转录病毒治疗首选2个核苷类逆转录酶抑制剂.相对于职业暴露来说nPEP在预防H IV感染方面没有很好的效果.容易失败的原因主要有:①延时治疗;②非职业暴露者对PEP治疗依从性差;③反复多次发生暴露;④进行肛交是预防H IV感染所面临的一个严峻的问题;⑤不合理的药物组合.     

Effects of reward amount and reward omission on short-term retention

A series of four experiments studied the retention of the response made on a just-preceding trial as a function of the presence, and amount, of food reward given on that trial. Rats were trained to alternate arm choices in a T-maze, and then were tested for alternation with 5- or 30-sec delays between runs. When the subjects had received prior experience with the reward amounts used in testing, larger rewards led to better retention than did small or no rewards. However, when reward omission first occurred during the test phase, it produced more alternation on the following trial than did reward presence. The results suggest that both reward amount and surprisingness determine short-term retention of responses paired with the rewards.     

Effects of organizational pictures and modality as a feedback strategy on learner comprehension and satisfaction

One of the strongest instructional interventions documented in educational literature is the use of feedback to influence learning outcomes. However, there is lack of empirical research specifically pertaining to the use of multimedia in the feedback message. The purpose of this research was to test whether organizational pictures and modality as a feedback strategy had an effect on learner comprehension and satisfaction. The research design was a 2 Multimedia (Picture Present vs. Picture Absent) × 2 Modality (Narration vs. On-screen Text) × Trial (Trial 1 vs. Trial 2) with Multimedia and Modality serving as between-subject conditions and Trial serving as a repeated measure. One-hundred fifteen university students participated in the study. Findings show statistically significant increases in comprehension scores from Trial 1 to Trial 2 assessments for all four treatment conditions. Learners in the Picture present conditions were statistically more satisfied with the learning experience. Additionally, we used eye-tracking to verify the extent to which the pictures were used in the feedback message. A discussion and recommendations for future research and feedback design are provided.     

General transfer across sensory modalities survives reductions in the original conditioned reflex in the rabbit

Two experiments demonstrated that transfer of training between CSs from different sensory modalities survived substantial reductions in responding to the first CS. In both experiments, animals received three stages of training. Stage 1 entailed CS-US training with a CS from one modality (e.g., light), and Stage 3 entailed CS-US training with a CS from another modality (e.g., tone). The experiments differed in treatment during Stage 2. In Experiment 1, animals either remained in their home cages or received unreinforced exposures to the first CS, which extinguished the original CR. In Experiment 2, the animals received either continued CS-US training or exposure to the CS and US but at a long interval (2,800 msec), which eliminated the original CR. As the baseline for detection of transfer effects, each experimental group had a control group that received Stage 1 training with a 2,800-msec CS-US interval, which produced minimal CR acquisition. The results of both experiments revealed substantial positive transfer across CS modalities regardless of the treatment during Stage 2. The transfer did not appear immediately on test presentations of the second CS in Stage 3. Rather, the transfer appeared as an enhancement in the rate of CR acquisition after reinforced training with the second CS had commenced. The results are discussed with respect to stimulus generalization, neutralization of background stimuli, and learning processes superordinate to specific associations.     

Arousal and short-term memory: Effects of caffeine and trial spacing on delayed-alternation performance

Two experiments tested the prediction of Kesner’s (1973) parallel memory-stores theory that arousal reduces retention in short-term memory. Using rats as subjects, the effect of caffeine on delayed-alternation performance in a spatial discrimination was investigated. Trial spacing was also manipulated, both alone and in combination with the drug variable. The results showed that, with massed trials, caffeine facilitated alternation at the short delay and inhibited it at the longer delays tested. Using spaced trials, caffeine decreased alternation at all delays. Spaced trials produced overall superior performance as compared with massed trials. This pattern of results is consistent with the view that caffeine reduces short-term retention but, paradoxically, can also increase performance under massed trials by decreasing proactive interference (i.e., retention) from earlier trials.     

Ordinal position in the serial learning of rats

Rats were runway trained on each of two, three-trial series consisting of different varieties of reward (X, Y, and Z) and nonreward (N) serving as trial outcomes. The two series are represented as XNY and ZNN. Distinguishing the two series were different brightness and texture cues on the runway floor. Transfer tests, conducted after the rats had developed faster running for rewarded trials than for nonrewarded trials and slower running on Trial 2 of ZNN than on Trial 2 of XNY, provided evidence that trial position, rather than item memories, was controlling the discriminations. In Experiment 1, reversing the floor cues completely reversed the discriminations. In Experiment 2, transfer to NNN did not change the routine patterns of approach that had been established.     

Comparative analysis of delayed alternation learning in cats,mice, and guinea pigs

The performance of cats, guinea pigs, and mice in a delayed alternation paradigm was compared both during initial learning and following a 10-day retention interval. The testing situation (a modified T-maze), the length of the delay period (10 sec), and the amount of training per session and per week were kept identical for all three species. The results indicated that (1) animals of all three species acquired the task within similar time spans, (2) a considerable variance was apparent in the performance of individual animals independent of their species, and (3) guinea pigs, as a group, appeared to need a somewhat longer time to acquire delayed alternation than did mice and cats. Relearning of the task following the 10-day interval seemed to follow similar laws in all three species.     

A longitudinal comparison of the WISC and WISC-R with special education pupils

The purpose of this study was to determine the degree of comparability between the WISC and the WISC-R over time. Hypotheses were tested using a sample of 276 mildly mentally handicapped children enrolled in special education classes who had received a WISC (Trial 1) and a WISC or WISC-R (Trial 2) after an interval of approximately three years. The sample was grouped on the basis of test administered in Trial 2. Group I contained those children who received the WISC on Trial 2 and included 183 children, of whom 121 were males and 62 were females. Mean age at time of initial testing was 8–10; mean age at second testing was 11–8. Group II was composed of 93 children who had been posttested on the WISC-R and included 72 males and 21 females. Mean age at initial testing was 9–5; mean age at posttest was 13–0. The study was conducted in five school districts and one county department of education. Verbal IQ, Performance IQ, and Full Scale IQ for both instruments administered were transcribed from the special education folders of the children. The design used to test hypotheses was repeated measures analysis of variance. Data analysis resulted in rejection of the hypotheses that the WISC-R yields mean Verbal, Performance, and Full Scale IQ scores greater than or equal to the corresponding mean IQ scores of the WISC. It was concluded that the WISC-R may unfairly penalize special education children who are reevaluated with this instrument. Fluctuations in IQ scores due to the instrument of measurement must be recognized, and appropriate action should be taken to insure that children are evaluated for special class placement on comparable bases.     

Occult drug exposure in young children evaluated for physical abuse: An opportunity for intervention

BackgroundAlthough screening for drug exposure is an important consideration in the evaluation of suspected child maltreatment, limited data are available on the frequency of drug exposure in children with suspected physical abuse.ObjectiveTo examine occult drug and pharmaceutical exposure in young children with suspected physical abuse.Participants and settingChildren ages 2 weeks –59 months evaluated for physical abuse by a tertiary referral center Child Protection Team.MethodsCross-sectional study of young children diagnosed with high, intermediate, or low concern for physical abuse and tested for occult drug exposure from 2013-2017. Chart review was performed to determine adherence to recommended testing and drug test results with comparison between groups.ResultsOccult drug exposures were found in 5.1% (CI 3.6–7.8) of 453 children tested: 6.0% (CI 3.6–10.0) of 232 children with high concern for physical abuse, 5.0% (CI 2.7–9.3) of 179 children with intermediate concern, and 0% of 42 children with low concern. As adherence to protocol-based screening improved during the second half of the study, so did the overall rate of detection of occult drug exposures (7.9%, CI 5.2–11.9) in 252 children with intermediate or high concern for physical abuse. Most exposures were to cocaine, although non-prescribed pharmaceutical exposures were also detected.ConclusionsUp to 7.9% of young children suspected of being physically abused also had an occult drug exposure. Given the adverse health consequences associated with exposure to a drug-endangered environment, screening for occult drug exposure should be considered in the evaluation of young children with intermediate or high concern for physical abuse.     

Interval between preexposure and test determines the magnitude of latent inhibition: Implications for an interference account

The effect of a retention interval on latent inhibition was studied in three experiments by using rats and the conditioned taste-aversion procedure. In Experiment 1, we demonstrated an apparent loss of latent inhibition (i.e., a strengthening of the aversion) in preexposed subjects that experienced a retention interval of 12 days between conditioning and the test. In Experiment 2, we found no effect of this retention interval on the habituation of neophobia produced by the phase of exposure to the flavor. In Experiment 3, we showed that interposing a retention interval between preexposure and conditioning produced effects exactly comparable to those seen in Experiment 1. The implications of these results for rival theories of latent inhibition, as an acquisition deficit or as a case of interference at retrieval, are discussed.     

Dissociation of patterned alternation learning and the partial reinforcement extinction effect in preweanling rats

Sprague-Dawley rat pups aged 14 or 18 days were trained on a patterned (single) alternation schedule with either an 8- or a 105-sec intertriai interval (ITI). At the 8-sec ITI, alternation learning was obtained at both ages, but the older age group learned more rapidly. There was no evidence of response alternation at the 105-sec ITI at either age. Continuously reinforced (CRF) and partially reinforced (PRF) groups trained and extinguished along with the patterned alternation (PA) group at the 105-sec ITI showed a robust partial reinforcement extinction effect (PREE) at both ages. Moreover, there was no difference in the rate of extinction of the PRF and PA groups at either age (i.e., no effect of N-length). A PREE can therefore be obtained in infant rats under conditions that apparently preclude the formation of sequential associations. The implications of this finding for the ontogeny of instrumental learning and extinction are discussed.