LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies

Endometrial stromal tumors(ESTs) include endometrial stromal nodule(ESN), low-grade endometrial stromal sarcoma(LG-ESS), high-grade endometrial stromal sarcoma(HG-ESS), and undifferentiated uterine sarcoma(UUS). Since these are rare tumor types, there is an unmet clinical need for the systematic therapy of advanced LG-ESS or HG-ESS. Cytogenetic and molecular advances in ESTs have shown that multiple recurrent gene fusions are present in a large proportion of LG-ESSs, and HG-ESSs are identified by the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon(YWHAE)-family with sequence similarity 22(FAM22) fusion. Recently, a group of ESSs harboring both zinc finger CCCH domain-containing protein7 B(ZC3H7B)-B-cell lymphoma 6 corepressor(BCOR) fusion and internal tandem duplication(ITD) of the BCOR gene have been provisionally classified as HG-ESSs. In this review, we firstly describe current knowledge about the molecular characteristics of recurrent aberrant proteins and their roles in the tumorigenesis of LG-ESSs and HG-ESSs. Next, we summarize the possibly shared signal pathways in the tumorigenesis of LG-ESSs and HG-ESSs, and list potentially actionable targets. Finally, based on the above discussion, we propose a few promising therapeutic strategies for LG-ESSs and HG-ESSs with recurrent gene alterations.     

The determinants of parenting: a process model

This essay is based on the assumption that a long-neglected topic of socialization, the determinants of individual differences in parental functioning, is illuminated by research on the etiology of child maltreatment. Three domains of determinants are identified (personal psychological resources of parents, characteristics of the child, and contextual sources of stress and support), and a process model of competent parental functioning is offered on the basis of the analysis. The model presumes that parental functioning is multiply determined, that sources of contextual stress and support can directly affect parenting or indirectly affect parenting by first influencing individual psychological well-being, that personality influences contextual support/stress, which feeds back to shape parenting, and that, in order of importance, the personal psychological resources of the parent are more effective in buffering the parent-child relation from stress than are contextual sources of support, which are themselves more effective than characteristics of the child.     

Externalizing behaviors of Ukrainian children: The role of parenting

The purpose of this study was to assess the association of positive and negative parenting with child externalizing problems. Quantitative data were collected during face-to-face interviews with 320 parents of children 9–16 years of age (50% males) in 11 communities in Eastern, Southern, and Central Ukraine. The study estimated the relationship between parenting practices and child externalizing behaviors such as aggression, delinquency, and attention problems. Results revealed that positive parenting, child monitoring, and avoidance of corporal punishment were associated with fewer child externalizing symptoms. Results also indicated that child male gender and single parenting had significant and positive association with child externalizing behaviors. This study extends international psychosocial knowledge on children and families. These findings can be used to design programs and foster dialogs about the role of family and social environments in the development of externalizing disorder among researchers, representatives of governmental and nongovernmental organizations, and mass media that work with child abuse prevention in Ukraine.     

Multiple characteristic alterations and available therapeutic strategies of cellular senescence

Given its state of stable proliferative inhibition, cellular senescence is primarily depicted as a critical mechanism by which organisms delay the progression of carcinogenesis. Cells undergoing senescence are often associated with the alteration of a series of specific features and functions, such as metabolic shifts, stemness induction, and microenvironment remodeling. However, recent research has revealed more complexity associated with senescence, including adverse effects on both physiological and pathological processes. How organisms evade these harmful consequences and survive has become an urgent research issue. Several therapeutic strategies targeting senescence, including senolytics, senomorphics, immunotherapy, and function restoration, have achieved initial success in certain scenarios. In this review, we describe in detail the characteristic changes associated with cellular senescence and summarize currently available countermeasures.     

Education,parenting and family: The social geographies of family learning

This paper explores the relationship between education, parenting and family through the prism and particularities of family learning. Family learning is an example of an educational initiative, primarily aimed at parents and linked to wider policy concerns, which can be explored through a mapping of its social geographies; family learning is played out across and productive of different sites, spaces and identities. Based on qualitative research undertaken in West London, this paper draws on individual and group interviews with mothers participating in family learning classes and interviews with family learning providers. The key argument we extend is that focusing on the social geographies of family learning ‐ of home, school, work, community and nation ‐ allows us to see how educational initiatives extend the state's reach in family life, producing particular normative versions of family and ‘good’ parenting operating at a range of interconnecting scales. Education remains a cornerstone of family policy in the UK and detailed analyses of specific initiatives at the point of implementation – how they are practiced and received – is vital for better understanding their diverse and varied effects in contemporary society.     

The rhythms of pedagogy: an ethnographic study of parenting education practices

Educational research is increasingly turning to conceptual frameworks from a range of disciplines in order to enrich understandings of education, pedagogy and learning. This paper draws on the work of Henri Lefebvre, specifically rhythmanalysis, to explore the nature and the function of pedagogy. The context is an ethnographic study of parenting education and pedagogic practices in a child and family service in Sydney. Three features of rhythmanalysis are discussed: kinds of rhythm, rhythms and bodies, and oppositions such as repetition and difference, fast and slow and secret and public. Through these concepts, intricate connections between rhythm and pedagogy are identified, including rhythms as providing a pedagogic imperative, rhythms as content and mechanisms at the heart of pedagogy and rhythms as outcomes of learning. The paper argues that rhythmanalysis opens up possibilities for new questions, different kinds of empirical sensibilities and distinctive accounts of pedagogy and learning in continuing education.     

The knowledgeable parenting style: stance takings and subject positions in media encounters

In today’s media-saturated societies it can be assumed that encounters with therapists and other experts may have implications for adult learning. Taking the point of departure in the idea of public pedagogy, and by using a close-up analysis of interview talk, the pedagogical agency the media may have on parenting is investigated. Drawing upon the discursive notions of styles, stance takings and subject positions, a pattern of regularities emerges called ‘the knowledgeable parenting style’. The knowledgeable parent is fashioned through various, yet typical ways of assuming stances and negotiating positions in media encounters, by displaying recognition, discrimination and insight. The study illustrates how the media’s claim on a pedagogical role is acknowledged, however, what is provided to be valuable competence is not just accepted. While the interviewed adults mainly exclude themselves from that site of public intervention, the knowledge provided and instructions given are depicted as having the potential of facilitating learning for ‘other parents’. Apparently, the ways in which people rhetorically approach and systematically establish stances also reveal subject positions associated with learning. A dynamic space is created where the displayed norms for adequate behaviour, and invitations to act upon that knowledge, are subject to constant tension.     

The social ecology and early parenting of Caucasian adolescent mothers

Social characteristics, maternal behaviors, and the home environments of Caucasian adolescent and nonadolescent mothers were investigated in a sample of 50 primiparous low- and middle-class women and their 4-month-old infants. The mothers were interviewed about their child-care network and about stressful life events that may have occurred since the infant's birth. The HOME inventory was completed and videotapes of 2 hours of home observations were coded to assess maternal proximity, verbalizations, activity, and physical contact with the infant. Interview data indicated that adolescent mothers relied more frequently on other teenagers and other network members for help in child care than nonadolescent mothers. In addition, they also received more frequent support from their mothers and less frequent help from their partner's and partner's mother and siblings than nonadolescent mothers. During the home visit, they were less verbal with their infants and scored significantly lower on the Responsiveness and Maternal Involvement subscales as well as on the total HOME inventory; these results were replicated on subgroups matched for socioeconomic status, emphasizing the unique social context and parenting practices of teenage mothers.     

Styles of parenting

IN THIS BRIEF OVERVIEW, THE AUTHOR CONTRASTS TWO CURRENT PARENTING STYLES: Attachment Parenting and Babywise Parenting.     

Poverty,family resources and children's early educational attainment: The mediating role of parenting

This study uses longitudinal data from the UK Millennium Cohort Study to show the extent to which episodic and more persistent poverty in early childhood and the lack of other family resources disadvantage children at the start of their school careers in terms of whether they have achieved the target indicator of ‘good level of achievement’ on the Foundation Stage Profile. Positive parenting is shown to be an important contributor to school achievement that matters for children, regardless of poverty experience or family disadvantage. It is also shown to be an important mediator in redressing the effects of poverty and disadvantage.     

Early motherhood and harsh parenting: The role of human,social, and cultural capital

ObjectiveThis study examined the role of maternal human, social, and cultural capital in the relationship between early motherhood and harsh parenting behavior.MethodsThis study used data from the Fragile Families and Child Wellbeing (FFCW) Study. Harsh parenting behaviors by mothers who were 19 years or younger at birth of the focal child (n = 598) were compared with that of adult mothers 26 years or older (n = 1,363). Measures included: For harsh parenting behavior, three proxies were created from the Parent to Child version of the Conflict Tactics Scales (CTS-PC) and self-reports of maternal spanking. For maternal human capital, education, employment, and depression were used. For maternal social capital, expected-social support, paternal support, and lone caregiver status were included. For maternal cultural capital, religious attendance and attachment to race/ethnic heritage were used.ResultsMultivariate analyses indicated that adolescent motherhood has a significant impact on all three harsh parenting behavior outcomes even after controlling for demographic and maternal capital characteristics. Working since the birth of the focal child, depression scores, paternal support, expected-social support, and attendance at religious services made independent contributions to the prediction of harsh parenting behavior.ConclusionsFindings emphasize the importance of the prevention of adolescent motherhood and suggest intervention strategies for reducing the risk of maternal harsh parenting behavior. Further study is necessary to examine the complicated relationships among maternal capital and parenting. One method may be to focus on the development of measures of maternal capital, notably measures of expectations regarding and perceptions of received capital.Practice implicationsFindings from this study have implications for social work practice, particularly for the prevention of adolescent pregnancy and intervention with adolescent mothers and their children. First, the study calls for more recognition of school social work and intervention programs in school settings as important components of prevention services. Second, the importance of identifying fathers and helping them become involved and connected with their young families are highlighted. Finally, practitioners should become more aware of the role of culture in young families as the effect of cultural capital on parenting behavior becomes better understood.     

Development pathways from abusive parenting to delinquency: The mediating role of depression and aggression

This study investigated the long-term relationship between abusive parenting and adolescent mental health, and the path to delinquent behavior. Longitudinal data from 5th through 7th graders from the Korean Children and Youth Panel Survey (KCYPS) were analyzed to examine if abusive parenting was a predictor of early adolescent delinquency behavior, via aggression and depression as mediating factors. The results were as follows. First, parental abuse (both emotional and physical) was found to have significant effects on children's psychosocial factors (aggression and depression), while parental neglect (both emotional and physical) had significant effects on depression alone and not on aggression. Second, aggression exerted significant effects on both violent and non-violent delinquent behaviors, while depression had a significant effect on only non-violent delinquent behaviors. Third, children's psychosocial factors (aggression and depression) played significant mediating roles between earlier abusive parenting and delinquent behaviors. Fourth, for children living in a family with their grandparents, paths from abusive parenting, psychosocial adaptation, and later delinquent behaviors were not significant, implying that living with grandparents played a protective factor in these relationships.     

The effects of the Webster-Stratton parenting program on maltreating families: fostering strengths

OBJECTIVE: This study examined the effects of the Webster-Stratton parenting program on the parenting skills of maltreating mothers and on the autonomy of their children (3-8 years). METHOD: A randomized controlled trial was used. Twenty-six maltreating families were randomly assigned to one of two conditions: the 16-hour weekly intervention group, or the 4-month wait list control group. Pre- and post-intervention independent assessments included a 2-hour home visit involving videotaped mother-child interactions during two prescribed, 10-minute play activities. RESULTS: Compared to the control group, treatment mothers demonstrated significant improvement in involvement and marginally significant improvement in autonomy-support, but no improvement in structure. Treatment group children showed no significant improvement in autonomy when compared to control group children. CONCLUSIONS: This parenting program proved effective with maltreating parents. The lack of demonstrated effect on children may reflect the need for a larger and more sustained treatment dose and/or the need to include parent-child interaction opportunities in the program. At the same time, while treatment gains were limited to the parent, the high treatment adherence rate (92% attended six or more of the eight program sessions) and low attrition rate (n=1) indicate that the treatment gains may hold potential for more thorough examination.     

Validity of the parenting inventory: Young children

The Parenting Inventory: Young Children (PI) is a rating scale that measures the developmental expectations and behaviors of parents of children who are between the ages of 1 and 4 years, 11 months. Using a representative urban sample of 1,056 mothers, the PI was found to discriminate successfully between parents with children of different ages and to have substantial item-construct correlations (content validity). The PI was not strongly related to the Adult-Adolescent Parenting Inventory, a measure of parenting attitudes (discriminant validity). Reasons for this latter finding are discussed. Potential uses of the PI for practitioners working with parents in the schools are described.     

论防范突发事件的价值及策略

突发事件是指在某种必然因素支配下出人意料地发生，给社会造成严重危害、损失或影响，而且需要立即处理的负面事件。与突发事件过程中其他阶段相比较而言，突发事件的防范是一种既经济又简便的方法。     

The impact of previous perinatal loss on subsequent pregnancy and parenting

The loss of any pregnancy through miscarriage, ectopic pregnancy, stillbirth, or neonatal death presents as a significant life crisis for any woman and has far-reaching implications into a couple's future aspirations. Planning another pregnancy after dealing with a perinatal loss is difficult and plagued by ambivalence, doubts, and insecurities. Despite this ambivalence, a majority of women do become pregnant within a year following a perinatal loss. Four recurring issues surrounding perinatal loss and subsequent pregnancy have been identified in this literature review: the effect of the grief process on the subsequent pregnancy; parental coping mechanisms during the subsequent pregnancy; replacement or vulnerable child syndrome; and parenting issues with the subsequent live-born child. Issues surrounding anxiety as a coping mechanism during a pregnancy following a perinatal loss are documented consistently in the literature; however, less is known about the impact that a loss has on parenting behaviors with subsequent children. Further research is imperative to examine these issues in more detail so that evidence-based practices can be established and updated. Health care providers are in a unique position to assist these couples in dealing with the issues that a perinatal loss may place on subsequent pregnancies. By providing a reassuring and supportive environment, women can achieve a positive pregnancy outcome with the correct tools to decrease anxiety and enhance attachment to the subsequent healthy child.     

The role of parenting styles in children's problem behavior

This study investigated the combination of mothers' and fathers' parenting styles (affection, behavioral control, and psychological control) that would be most influential in predicting their children's internal and external problem behaviors. A total of 196 children (aged 5-6 years) were followed up six times from kindergarten to the second grade to measure their problem behaviors. Mothers and fathers filled in a questionnaire measuring their parenting styles once every year. The results showed that a high level of psychological control exercised by mothers combined with high affection predicted increases in the levels of both internal and external problem behaviors among children. Behavioral control exercised by mothers decreased children's external problem behavior but only when combined with a low level of psychological control.