Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles

In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to utilize the developed ANN model in optimizing the ultrasound application to achieve a target drug release at the tumor site by controlling power density and ultrasound duration via an ANN-based model predictive control. The parameters of the controller are then tuned to achieve good reference signal tracking.     

In-vitro effect of a diabetic serum factor on the generation of superoxide free radical,it’s quenching ability and lysosomal degranulation in normal polymorpho nuclear leucocytes

Normal polymorpho nuclear leucocytes (PMNL) when assaulted with diabetic serum factorin-vitro, recorded enhanced generation of oxygen free radical, and lysosomal degranulation. It also caused a decrease in the cytosolic superoxide dismutase activity. Time-plot studies revealed PMNL susceptibility to diabetic serum factor for oxidative injury and concomitant decrease in SOD, consequential for lysosomal degranulation.     

Evaluation of the radioprotective effect of turmeric extract and vitamin E in mice exposed to therapeutic dose of radioiodine

The aim of this study was to evaluate the radioprotective effect of turmeric extract (40 mg/kg body weight) and vitamin E (α- tocopherol acetate, 400 IU/kg body weight) supplementation on lipid peroxidation, reduced glutathione and antioxidant defense enzymes in various organs like liver, kidney and salivary glands at 24 h in adult Swiss mice. ¹³¹Iodine exposure significantly increased lipid peroxidation in kidney and salivary glands in comparison to control animals. Pre supplementation with turmeric extract for 15 days showed significant lowering of lipid peroxidation in kidney. On the other hand vitamin E pre supplementation showed marked reduction in lipid peroxidation in salivary glands. Reduced glutathione levels decreased significantly in liver after radiation exposure. However, pre supplementation with turmeric extract and vitamin E did not improve glutathione levels in liver. In conclusion, we have observed differential radioprotective effect of turmeric extract and vitamin E in kidney and salivary glands. However, Vitamin E seems to offer better radioprotection for salivary glands which is known to be the major site of cellular destruction after radioiodine therapy in patients.