Fatigue reduces the complexity of knee extensor torque during fatiguing sustained isometric contractions

Abstract

The temporal structure, or complexity, of muscle torque output reflects the adaptability of motor control to changes in task demands. This complexity is reduced by neuromuscular fatigue during intermittent isometric contractions. We tested the hypothesis that sustained fatiguing isometric contractions would result in a similar loss of complexity. To that end, nine healthy participants performed, on separate days, sustained isometric contractions of the knee extensors at 20% MVC to task failure and at 100% MVC for 60?s. Torque and surface EMG signals were sampled continuously. Complexity and fractal scaling were quantified by calculating approximate entropy (ApEn) and the detrended fluctuation analysis (DFA) α scaling exponent. Global, central and peripheral fatigue were quantified using maximal voluntary contractions (MVCs) with femoral nerve stimulation. Fatigue reduced the complexity of both submaximal (ApEn from 1.02?±?0.06 to 0.41?±?0.04, P?<?0.05) and maximal contractions (ApEn from 0.34?±?0.05 to 0.26?±?0.04, P?<?0.05; DFA α from 1.41?±?0.04 to 1.52?±?0.03, P?<?0.05). The losses of complexity were accompanied by significant global, central and peripheral fatigue (all P?<?0.05). These results demonstrate that a fatigue-induced loss of torque complexity is evident not only during fatiguing intermittent isometric contractions, but also during sustained fatiguing contractions.     

Greater fatigability in knee-flexors vs. knee-extensors after a standardized fatiguing protocol

The present study aimed to investigate the effects of a standardized fatiguing protocol on central and peripheral fatigue in knee-flexors and knee-extensors. Thirteen healthy men (age: 23?±?3 years; height: 1.78?±?0.09 m; body-mass: 73.6?±?9.2?kg) volunteered for the present study. Maximal voluntary contraction (MVC), Electromyography (EMG) activity, voluntary activation level (VAL) as an index of central fatigue and twitch potentiation as an index of peripheral fatigue were measured before and after the fatiguing protocol. The fatiguing protocol consisted of a 0.6 duty-cycle to exhaustion (6?s isometric contraction, 4?s recovery) at 70% MVC. After the fatiguing protocol, MVC decreased in both (Effect-size (ES)?=?1.14) and knee-extensors (ES?=?1.14), and EMG activity increased in both knee-flexors (ES?=?2.33) and knee-extensors (ES?=?1.54). Decreases in VAL occurred in knee-flexors (ES?=?0.92) but not in knee-extensors (ES?=?0.04). Decreases in potentiation occurred in both knee-flexors (ES?=?0.84) and knee-extensors (ES?=?0.58). The greater central occurrence of fatigue in knee-flexors than in knee-extensors may depend on the different muscle morphology and coupled with a greater tolerance to fatigue in knee-extensors. The present data add further insight to the complicated knee-flexors-to-knee-extensors strength relationship and the mechanisms behind the different occurrence of fatigue.     

Knee extension fatigue attenuates repeated force production of the elbow flexors

Abstract

Non-local muscle fatigue has been demonstrated with unilateral activities, where fatiguing one limb alters opposite limb forces. Fewer studies have examined if non-local fatigue occurs with unrelated muscles. The purpose of this study was to investigate if knee extensors fatigue alters elbow flexors force and electromyography (EMG) activity. Eighteen males completed a control and fatiguing session (randomised). Blood lactate was initially sampled followed by three maximal voluntary contractions (MVC) with the elbow flexors and two with the knee extensors. Thereafter, subjects either sat (control) or performed five sets of bilateral dynamic knee extensions to exhaustion using a load equal to the dominant limb MVC (1-min rest between sets). Immediately afterwards, subjects were assessed for blood lactate and unilateral knee extensors MVC, and after 1 min performed a single unilateral elbow flexor MVC. Two minutes later, subjects performed 12 unilateral elbow flexor MVCs (5 s contraction/10 s rest) followed by a third blood lactate test. Compared to control, knee extensor force dropped by 35% (p < 0.001; ES = 1.6) and blood lactate increased by 18% (p < 0.001; ES = 2.8). Elbow flexor forces were lower after the fatiguing protocol only during the last five MVCs (p < 0.05; ES = ～0.58; ～5%). No changes occurred between conditions in EMG. Elbow flexor forces significantly decreased after knee extensors fatigue. The effect was revealed during the later stages of the repeated MVCs protocol, demonstrating that non-local fatigue may have a stronger effect on repeated rather than on single attempts of maximal force production.     

Neuromuscular variables affecting the magnitude of force loss after eccentric exercise

The aim of this study was to examine neuromuscular variables contributing to differences in force loss after participants were exposed to the same relative bout of eccentric exercise. Thirty-six males performed 50 maximal eccentric contractions of the elbow flexors and were stratified into high responders (n?=?10) and low responders (n?=?10) based on force loss 36 h after exercise. Maximal voluntary isometric contractions (MVCs) and electromyography (EMG) were measured at baseline and 36 h after exercise. During eccentric exercise, mean peak torque, mean end-range torque from the final 25% of each trial and total angular impulse were computed over 25 contractions in each of two bouts. The slope of the change in these values for each 25 eccentric contractions was calculated for each participant using linear regression. At baseline, MVC was not different between groups (low responders: 97.0?±?9.6 N?·?m; high responders: 82.7?±?6.4 N?·?m; P?=?0.08). High responders demonstrated a 68% (range 62-78%) reduction in MVC and low responders a 39% (29-48%) reduction after exercise. Peak torque, end-range torque and total angular impulse were 13%, 40% and 33% higher, respectively, in the low than in the high responders (peak torque: P?=?0.0002; end-range torque: P?<?0.0001; total angular impulse: P?<?0.001). The rate of decline in peak torque slope was greater in high than in low responders (P?=?0.044). In conclusion, lower peak torque, end-range torque and total angular impulse during eccentric contractions and a greater peak torque slope may identify high responders to eccentric exercise.     

Stretching and deep and superficial massage do not influence blood lactate levels after heavy-intensity cycle exercise

Abstract

The study aimed to assess the role of deep and superficial massage and passive stretching recovery on blood lactate concentration ([La^?]) kinetics after a fatiguing exercise compared to active and passive recovery. Nine participants (age 23 ± 1 years; stature 1.76 ± 0.02 m; body mass 74 ± 4 kg) performed on five occasions an 8-min fatiguing exercise at 90% of maximum oxygen uptake, followed by five different 10-min interventions in random order: passive and active recovery, deep and superficial massage and stretching. Interventions were followed by 1 hour of recovery. Throughout each session, maximum voluntary contraction (MVC) of the knee extensor muscles, [La^?], cardiorespiratory and metabolic variables were determined. Electromyographic signal (EMG) from the quadriceps muscles was also recorded. At the end of the fatiguing exercise, [La^?], MVC, EMG amplitude, and metabolic and cardiorespiratory parameters were similar among conditions. During intervention administration, [La^?] was lower and metabolic and cardiorespiratory parameters were higher in active recovery compared to the other modalities (P < 0.05). Stretching and deep and superficial massage did not alter [La^?] kinetics compared to passive recovery. These findings indicate that the pressure exerted during massage administration and stretching manoeuvres did not play a significant role on post-exercise blood La^? levels.     

Larger strength losses and muscle activation deficits in plantar flexors induced by backward downhill in reference to distance-matched forward uphill treadmill walk

We tested the hypothesis that backward downhill walking (eccentric component) impairs both voluntary activation and muscle contractile properties in the plantar flexors and delays recovery as compared to a gradient and distance-matched uphill walk. Fourteen males performed two 30-min walking exercises (velocity: 1?m/?s; grade: 25%; load: 12% of body weight), one downhill (DW) and one uphill (UP), in a counterbalanced order, separated by 6?weeks. Neuromuscular test sessions were performed before, after, 24-, 48- and 72-h post-exercise, including motor nerve stimulations during brief (5?s) and sustained (1?min) maximal isometric voluntary contractions of the plantar flexors. DW (?18.1?±?11.1%, P?P?=.15), decreased torque production during brief contractions for at least three days post-exercise (P?P?P?=?.024) and DW (?25.6?±?10.3%, P?P?=?.001) was lower in DW than UP. Peak twitch torque and maximum rates of torque development and relaxation were equally reduced after UP and DW (P?P?P?>?.05). Using a direct comparison, the capacity to drive the plantar flexors during sustained contractions remains sub-optimal during the three-day recovery period in response to non-exhaustive, downhill backward walking in reference to an uphill exercise matched for distance covered.     

Motor unit activation strategy during a sustained isometric contraction of finger flexor muscles in elite climbers

The aim of the study was to evaluate, by an electromyographic (EMG) and mechanomyographic (MMG) combined approach, whether years of specific climbing activity induced neuromuscular changes towards performances related to a functional prevalence of fast resistant or fast fatigable motor units. For this purpose, after the maximum voluntary contraction (MVC) assessment, 11 elite climbers and 10 controls performed an exhaustive handgrip isometric effort at 80% MVC. Force, EMG and MMG signals were recorded from the finger flexor muscles during contraction. Time and frequency domain analysis of EMG and MMG signals was performed. In climbers: (i) MVC was higher (762 ± 34 vs 512 ± 57 N; effect size: 1.64; confidence interval: 0.65–2.63; P < 0.05); (ii) endurance time at 80% MVC was 43% longer (34.2 ± 3.7 vs 22.3 ± 1.5 s; effect size: 1.21; confidence interval: 0.28–2.14; P < 0.05); (iii) force accuracy and stability were greater during contraction (P < 0.05); (iv) EMG and MMG parameters were higher throughout the entire isometric effort (P < 0.05). Collectively, force, EMG and MMG combined analysis revealed that several years of specific climbing activity addressed the motor control system to adopt muscle activation strategies based on the functional prevalence of fast resistant motor units.     

Free-weight resistance exercise on pulse wave reflection and arterial stiffness between sexes in young,resistance-trained adults

We sought to determine the sex-specific effects of an acute bout of free-weight resistance exercise (RE) on pulse wave reflection (aortic blood pressures, augmentation index (AIx), AIx at 75?bpm (AIx@75), augmentation pressure (AP), time of the reflected wave (Tr), subendocardial viability ratio (SEVR)), and aortic arterial stiffness in resistance-trained individuals. Resistance-trained men (n?=?14) and women (n?=?12) volunteered to participate in the study. Measurements were taken in the supine position at rest, and 10 minutes after 3 sets of 10 repetitions at 75% 1-repetition maximum on the squat, bench press, and deadlift. A 2?×?2?×?2 ANOVA was used to analyse the effects of sex (men, women) across condition (RE, control) and time (rest, recovery). There were no differences between sexes across conditions and time. There was no effect of the RE on brachial or aortic blood pressures. There were significant condition?×?time interactions for AIx (rest: 12.1?±?7.9%; recovery: 19.9?±?10.5%, p?=?.003), AIx@75 (rest: 5.3?±?7.9%; recovery: 24.5?±?14.3%, p?=?.0001), AP (rest: 4.9?±?2.8?mmHg; recovery: 8.3?±?6.0?mmHg, p?=?.004), and aortic arterial stiffness (rest: 5.3?±?0.6?ms; recovery: 5.9?±?0.7?ms, p?=?.02) with significant increases during recovery from the acute RE. There was also a significant condition?×?time for time of the reflected wave (rest: 150?±?7?ms; recovery: 147?±?9?ms, p?=?.02) and SEVR (rest: 147?±?17%; recovery: 83?±?24%, p?=?.0001) such that they were reduced during recovery from the acute RE compared to the control. These data suggest that an acute bout of RE increases AIx, AIx@75, and aortic arterial stiffness similarly between men and women without significantly altering aortic blood pressures.     

The influence of pre-warming on the physiological responses to prolonged intermittent exercise

To examine the influence of pre-warming on the physiological responses to prolonged intermittent exercise in ambient temperatures of 21.5?±?0.6°C and relative humidities of 35.7?±?5.4% (mean?±?s), six healthy men performed intermittent treadmill running (30-s bouts at 90% of maximal oxygen uptake separated by 30-s static recovery periods) to exhaustion after active pre-warming, passive pre-warming and pre-exercise rest (control). Exercise time to exhaustion was significantly different between all conditions (active, 51.8?±?7.2?min; passive, 38.5?±?11.1?min; control, 72.0?±?17.2?min; P <?0.05). These changes in performance time were closely associated with a significant decline in both the rate of heat storage and heat storage capacity (P <?0.05). Rectal temperature, heart rate and ratings of perceived exertion were significantly higher during exercise in the two pre-warming conditions than in the control condition (P <?0.05). Ratings of perceived exertion were also significantly higher during exercise following passive pre-warming compared with active pre-warming (P <?0.05). During exercise there were no significant differences in serum prolactin, plasma norepinephrine and plasma free fatty acid concentrations between conditions. We conclude that both active and passive pre-warming promote a reduction in prolonged intermittent exercise capacity in environmental temperatures of 21°C compared with pre-exercise rest. These performance decrements were dependent upon the mode of pre-warming and closely reflected alterations in body heat content.     

Effect of warm-up exercise on delayed-onset muscle soreness

Abstract

In this study, we wished to determine whether a warm-up exercise consisting of 100 submaximal concentric contractions would attenuate delayed-onset muscle soreness and decreases in muscle strength associated with eccentric exercise-induced muscle damage. Ten male students performed two bouts of an elbow flexor exercise consisting of 12 maximal eccentric contractions with a warm-up exercise for one arm (warm-up) and without warm-up for the other arm (control) in a randomized, counterbalanced order separated by 4 weeks. Muscle temperature of the biceps brachii prior to the exercise was compared between the arms, and muscle activity of the biceps brachii during the exercise was assessed by surface integral electromyogram (iEMG). Changes in visual analogue scale for muscle soreness and maximal voluntary isometric contraction strength (MVC) of the elbow flexors were assessed before, immediately after, and every 24 h for 5 days following exercise, and compared between the warm-up and control conditions by a two-way repeated-measures analysis of variance. The pre-exercise biceps brachii muscle temperature was significantly (P<0.01) higher for the warm-up (35.8±0.2°C) than the control condition (34.4±0.2°C), but no significant differences in iEMG and torque produced during exercise were evident between conditions. Changes in muscle soreness and MVC were not significantly different between conditions, although these variables showed significant (P<0.05) changes over time. It was concluded that the warm-up exercise was not effective in mitigating delayed-onset muscle soreness and loss of muscle strength following maximal eccentric exercise.     

The influence of hip mobility and quadriceps fatigue on sagittal spinal posture and muscle activation in rugby scrum performance

Rugby Union scrumming puts the spine under a high degree of loading. The aim of the current study was to determine how sagittal hip range of motion and quadriceps fatigue influence force output, spinal posture, and activation of the trunk and quadriceps muscles in rugby scrumming. Measures of sagittal hip flexion/extension range of motion were collected from 16 male varsity and club first XV level participants. Sagittal spine motion (electromagnetic motion capture), trunk and quadriceps activation (electromyography), and applied horizontal compressive force (force plate) were measured during individual machine scrumming. Participants performed a 5-trial scrum block involving 5?s of contact with 1–2?min recovery between each trial. They then performed a fatiguing protocol (wall sit to failure) and immediately returned to the scrum machine to perform another five trials. Though there was no significant influence of fatigue on the horizontal compressive force applied during contact (P?=?.83), there was a 52% increase in cervical flexion (P?P?P?相似文献   

Influence of a caffeine mouth rinse on sprint cycling following glycogen depletion

Attenuated performance during intense exercise with limited endogenous carbohydrate (CHO) is well documented. Therefore, this study examined whether caffeine (CAF) mouth rinsing would augment performance during repeated sprint cycling in participants with reduced endogenous CHO. Eight recreationally active males (aged 23?±?2?yr, body mass 84?±?4?kg, stature 178?±?7?cm) participated in this randomized, single-blind, repeated-measures crossover investigation. Following familiarization, participants attended two separate evening glycogen depletion sessions. The following morning, participants completed five, 6?s sprints on a cycle ergometer (separated by 24?s active recovery), with mouth rinsing either (1) a placebo solution or (2) a 2% CAF solution. During a fifth visit, participants completed the sprints without prior glycogen depletion. Repeated-measures ANOVA identified significant main effect of condition (CAF, placebo, and control [P?P?P?P?P?P?相似文献   

Chain-loaded variable resistance warm-up improves free-weight maximal back squat performance

The acute influence of chain-loaded variable resistance exercise on subsequent free-weight one-repetition maximum (1-RM) back squat performance was examined in 16 recreationally active men. The participants performed either a free-weight resistance (FWR) or chain-loaded resistance (CLR) back squat warm-up at 85% 1-RM on two separate occasions. After a 5-min rest, the participants attempted a free-weight 1-RM back squat; if successful, subsequent 5% load additions were made until participants failed to complete the lift. During the 1-RM trials, 3D knee joint kinematics and knee extensor and flexor electromyograms (EMG) were recorded simultaneously. Significantly greater 1-RM (6.2?±?5.0%; p?p?p?>?.05) was found in concentric EMG, eccentric or concentric knee angular velocity, or peak knee flexion angle. Performing a CLR warm-up enhanced subsequent free-weight 1-RM performance without changes in knee flexion angle or eccentric and concentric knee angular velocities; thus a real 1-RM increase was achieved as the mechanics of the lift were not altered. These results are indicative of a potentiating effect of CLR in a warm-up, which may benefit athletes in tasks where high-level strength is required.     

Forearm oxygenation and blood flow kinetics during a sustained contraction in multiple ability groups of rock climbers

Currently, the physiological mechanisms that allow elite level climbers to maintain intense isometric contractions for prolonged periods of time are unknown. Furthermore, it is unclear whether blood flow or muscle oxidative capacity best governs performance. This study aimed to determine the haemodynamic kinetics of 2 forearm flexor muscles in 3 ability groups of rock climbers. Thirty-eight male participants performed a sustained contraction at 40% of maximal voluntary contraction (MVC) until volitional fatigue. Oxygen saturation and blood flow was assessed using near infrared spectroscopy and Doppler ultrasound. Compared to control, intermediate, and advanced groups, the elite climbers had a significantly (P < 0.05) higher strength-to-weight ratio (MVC/N), de-oxygenated the flexor digitorum profundus significantly (P < 0.05) more (32, 34.3, and 42.8 vs. 63% O₂, respectively), and at a greater rate (0.32, 0.27, and 0.34 vs. 0.77 O₂%·s^?1, respectively). Furthermore, elite climbers de-oxygenated the flexor carpi radialis significantly (P < 0.05) more and at a greater rate than the intermediate group (36.5 vs. 14.6% O₂ and 0.43 vs. 0.1O₂%·s^?1, respectively). However, there were no significant differences in total forearm ? blood flow. An increased MVC/N is not associated with greater blood flow occlusion in elite climbers; therefore, oxidative capacity may be more important for governing performance.     

Sex-related differences in joint-angle-specific hamstring-to-quadriceps function following fatigue

Abstract

The purpose of this study was to examine the effect of fatiguing exercise on sex-related differences in the function of hamstring and quadriceps muscles at several angular velocities and joint angles. Physically active participants (50 male: 28.7?±?4.5y, 1.82?±?0.07 m, 82.3?±?6.87?kg; 50 female: 27.0?±?5.8y, 1.61?±?0.08 m, 68.75?±?9.24?kg) carried out an isokinetic assessment to determine concentric and eccentric torques during knee extension and flexion actions at three different angular velocities (60/180/300°/s). The H/Q_FUNCT was calculated using peak torque (PT) values at 3 different joint-angle-specific (15°, 30° and 45° of knee flexion). A repeated measures analysis of variance (ANOVA) was used to compare within group results. Between group comparisons of sex-related differences were assessed by independent T-tests. Fatiguing exercise in males resulted in a decrease in H/Q_FUNCT ratios for each angle of knee flexion at both 60°/s and 300°/s angular velocities (p?<?0.05). In females, significant decreases in H/Q_FUNCT ratios were observed following fatiguing exercise for each angle of knee flexion and angular velocity (p?<?0.01). Significant differences in H/Q_FUNCT ratios following fatiguing exercise were evident between males and females at each joint angle and angular velocity (p?<?0.01). These findings indicate sex related differences in H/Q_FUNCT ratios following fatiguing exercise. Females have greater reductions in torque and H/Q_FUNCT ratios following fatigue than their male counterparts. This potentially exposes females to higher risks of injury, particularly when fatigued. Practitioners should attend to the imbalance in fatigue resistance of hamstring and quadriceps function, particularly in female athletes.     

The efficacy of downhill running as a method to enhance running economy in trained distance runners

Running downhill, in comparison to running on the flat, appears to involve an exaggerated stretch-shortening cycle (SSC) due to greater impact loads and higher vertical velocity on landing, whilst also incurring a lower metabolic cost. Therefore, downhill running could facilitate higher volumes of training at higher speeds whilst performing an exaggerated SSC, potentially inducing favourable adaptations in running mechanics and running economy (RE). This investigation assessed the efficacy of a supplementary 8-week programme of downhill running as a means of enhancing RE in well-trained distance runners. Nineteen athletes completed supplementary downhill (?5% gradient; n?=?10) or flat (n?=?9) run training twice a week for 8 weeks within their habitual training. Participants trained at a standardised intensity based on the velocity of lactate turnpoint (vLTP), with training volume increased incrementally between weeks. Changes in energy cost of running (E_C) and vLTP were assessed on both flat and downhill gradients, in addition to maximal oxygen uptake (?O_2max). No changes in E_C were observed during flat running following downhill (1.22?±?0.09 vs 1.20?±?0.07?Kcal?kg^?1?km^?1, P?=?.41) or flat run training (1.21?±?0.13 vs 1.19?±?0.12?Kcal?kg^?1?km^?1). Moreover, no changes in E_C during downhill running were observed in either condition (P?>?.23). vLTP increased following both downhill (16.5?±?0.7 vs 16.9?±?0.6?km?h^?1 _, P?=?.05) and flat run training (16.9?±?0.7 vs 17.2?±?1.0?km?h^?1, P?=?.05), though no differences in responses were observed between groups (P?=?.53). Therefore, a short programme of supplementary downhill run training does not appear to enhance RE in already well-trained individuals.     

Hiking strap force decreases during sustained upwind sailing

The hypothesis, that sailing upwind in wind speeds above 12 knots causes fatigue, which manifests as a reduction in exerted hiking strap force and/or maximal isometric voluntary contraction force (MVC) of the knee extensors, was evaluated. Additionally, it was investigated if a relationship exists between maximal exerted hiking force (hMVC) and sailing performance. In part 1 of the study, 12 national level athletes sailed upwind for 2?×?10?min while hiking strap forces were continuously acquired. Before, in between and after sailing periods, the MVC of the knee extensors was measured. In part 2 of the study, hMVC was measured dry land in a hiking bench and correlated with the overall results at a national championship. Hiking strap force decreased from the first to the last minute in both 10?min sailing periods (430?±?131 vs. 285?±?130?N, P?<?.001 and 369?±?74 vs. 267?±?97 N, P?<?.001, respectively), but MVC was similar before, between and after the two 10?min sailing periods (878?±?215 vs. 852?±?202 vs. 844?±?211 130?N). In part 2, a significant positive correlation (r²?=?0.619, P?<?.01) was observed between hMVC and regatta results. In conclusion, upwind sailing in wind speeds above 12 knots causes sailing-specific fatigue as evidenced by a marked reduction in exerted hiking strap force. However, MVC of the knee extensors was not compromised ～45?s after hiking was terminated. Additionally, sailing performance is related to maximal hiking force.     

Changes in muscle activity with increasing running speed

Electromyographic (EMG) activity of the leg muscles and the ground reaction forces were recorded in 17 elite male middle-distance runners, who performed isometric maximal voluntary contractions (MVC) as well as running at different speeds. Electromyograms were recorded from the gluteus maximus, vastus lateralis, biceps femoris, gastrocnemius and tibialis anterior. The results indicated that the averaged EMG (aEMG) activities of all the muscles studied increased (P?<?0.05) with increasing running speed, especially in the pre-contact and braking phases. At higher speeds, the aEMG activities of the gastrocnemius, vastus lateralis, biceps femoris and gluteus maximus exceeded 100% MVC in these same phases. These results suggest that maximal voluntary contractions cannot be used as an indicator of the full activation potential of human skeletal muscle. Furthermore, the present results suggest that increased pre-contact EMG potentiates the functional role of stretch reflexes, which subsequently increases tendomuscular stiffness and enhances force production in the braking and/or propulsive phases in running. Furthermore, a more powerful force production in the optimal direction for increasing running speed effectively requires increased EMG activity of the two-joint muscles (biceps femoris, rectus femoris and gastrocnemius) during the entire running cycle.