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1.
Valerie Yule 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1996,42(1-3):187-203
In the past, it has not been possible to teach oneself to read at home, because learners could not read the books to teach them. Videos and interactive compact discs have changed that situation and challenge current assumptions of the pedagogy of literacy. This article describes an experimental adult literacy project using video technology. The language used is English, but the basic concepts apply to any alphabetic or syllabic writing system. A half-hour cartoon video can help adults and adolescents with learning difficulties. Computer-animated cartoon graphics are attractive to look at, and simplify complex material in a clear, lively way. This video technique is also proving useful for distance learners, children, and learners of English as a second language. Methods and principles are to be extended using interactive compact discs.
Zusammenfassung In der Vergangenheit war es nicht möglich, sich selbst in Heimarbeit lesen beizubringen, da die Lernenden die Lehrbücher nicht lesen konnten. Videos und interaktive Compact discs haben diese Situation geändert und gegenwärtige Meinungen zur Pädagogik der Alphabetisierung herausgefordert. Dieser Artikel beschreibt ein experimentelles Erwachsenenalphabetisierungsprogramm, das Videotechnologie anwendet. Arbeitssprache ist Englisch, aber das Grundkonzept gilt für jedes alphabetische oder syllabische Schreibsystem. Ein halbstündiges Zeichentrickvideo soll Erwachsenen und Jugendlichen mit Lernschwierigkeiten helfen. Computeranimierte Zeichentrickgraphiken sind attraktive Lernmittel, die komplexes Material klar und lebendig vereinfachen. Diese Videotechnik dient auch Fernlerndenden, Kindern und Lernenden mit Englisch als Zweitsprache. Methoden und Prinzipien müssen durch den Gebrauch von interaktiven Compakt Discs erweitert werden.
Resumen Durante el pasado, no ha sido posible el autoaprendizaje de la lectura en el hogar, ya que los lectores no estaban en condiciones de leer los libros de enseñanza. Ahora, los videos y los discos compactos interactivos cambiaron esta situación, creando un desafío para los conceptos corrientes de la pedagogía de alfabetización. Este artículo describe un proyecto experimental de alfabetización de adultos mediante el uso de tecnología de video. El lenguaje utilizado es el inglés, pero los conceptos básicos son aplicables para cualquier sistema de escritura alfabética o silábica. Un video de dibujos animados de media hora de duración puede ayudar a los adultos y adolescentes con dificultades de aprendizaje. Las gráficas animadas por computadora son atractivas para el espectador y simplifican materias complejas de un modo claro y ameno. Esta técnica de video también está mostrando su utilidad para el estudio a distancia, para la instrucción de niños y para el aprendizaje del inglés como segunda lengua. Los métodos y los principios también se pueden ampliar mediante la utilización de discos compactos interactivos.
Résumé Jusqu'à présent, il n'était pas possible d'apprendre à lire seul chez soi, puisque les apprenants ne pouvaient pas lire les manuels d'enseignement. La vidéographie et le disque compact interactif ont modifié cette situation et remettent en cause les principes courants de la pédagogie de l'alphabétisation. L'article décrit un projet expérimental d'alphabétisation des adultes qui exploite la technologie vidéo. La langue utilisée est l'anglais, mais les concepts de base peuvent être appliqués à tout système d'écriture alphabétique ou syllabique. Un dessin animé sur vidéo d'une demi-heure se propose d'aider les adultes et adolescents éprouvant des difficultés. Les graphiques animés par électronique sont agréables à regarder et illustrent de façon claire et vivante les matières complexes. Cette technique vidéo se révèle également utile pour les apprenants à distance, les enfants et pour l'enseignement de l'anglais en seconde langue. Les méthodes et principes d'utilisation de disques compact interactifs restent à développer.
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2.
Guang-yong Ye Ke-yi Wang Qiao-di Gui Min Wang 《Journal of Zhejiang University. Science. B》2018,19(8):654-661
Objective
The purpose of this study was to determine the role of Ureaplasma urealyticum-derived lipidassociated membrane proteins (LAMPs) in the host innate immune system, specifically their effect on Toll-like receptors (TLRs).Methods
LAMPs were derived from U. urealyticum strains, and human amniotic epithelial cells (HAECs) were isolated from healthy full-term placentas. Cytokine concentrations were determined by enzyme-linked immunosorbent assay (ELISA) and TLR2 mRNA by real-time PCR. Expression of TLR2 was confirmed by Western blotting and immunohistochemistry.Results
LAMPs induced HAECs to produce inflammatory cytokines interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α. Cytokine production was reduced after blocking TLR2 using TLR2 inhibitor (anti-hTLR2-IgA).Conclusions
LAMPs isolated from U. urealyticum induced TLR2-dependent up-regulation of inflammatory genes and cytokines in HAECs.3.
Wojciech Szczęsny Magdalena Kuligowska-Prusińska Stanisław Dąbrowiecki Jakub Szmytkowski Adrian Reśliński Maciej Słupski 《Journal of Zhejiang University. Science. B》2018,19(1):65-70
Purpose
Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls.Materials and methods
The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).Results
A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.Conclusions
The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.4.
Objective
To investigate the protective effects of parecoxib from oxidative stress induced by hydrogen peroxide (H2O2) in rat astrocytes in vitro.Methods
All experiments included 4 groups: (1) negative control (NC) group, without any treatment; (2) H2O2 treatment group, 100 µmol/L H2O2 treatment for 24 h; (3) and (4) parecoxib pretreatment groups, 80 and 160 µmol/L parecoxib treatment for 24 h, respectively, and then treated with 100 µmol/L H2O2. Several indices were investigated, and the expressions of Bax, Bcl-2, and brain-derived neurotrophic factor (BDNF) were quantified.Results
Compared to the NC group, exposure to H2O2 resulted in significant morphological changes, which could be reversed by pretreatment of parecoxib. In addition, H2O2 treatment led to loss of viability (P=0.026) and increased intracellular reactive oxygen species (ROS) levels (P<0.001), and induced apoptosis (P<0.01) in the primary astrocytes relative to the NC group. However, in the parecoxib pretreatment groups, all the above changes reversed significantly (P<0.05) as compared to the H2O2 treatment group, and were nearly unchanged when compared to the NC group. Mechanical investigation showed that dysregulated Bax, Bcl-2, and BDNF could be implicated in these changes.Conclusions
Our results indicated that parecoxib provided a protective effect from oxidative stress induced by exposure to H2O2.5.
Jian-fang Zhu Lian-hui Chen Ke Yuan Li Liang Chun-lin Wang 《Journal of Zhejiang University. Science. B》2018,19(10):807-814
Objective
The aim of this study was to explore the association of dopamine receptor D2 (DRD2) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up.Methods
This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and DRD2 polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance.Results
One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30?8.58).Conclusions
The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.6.
Ajit Nighat Jabeen A.K. Handa Uma 《The Journal of Agricultural Education and Extension》2013,19(2):169-170
Abstract
Purpose
To explain how training and education events (TEEs) can be designed to increase the likelihood of achieving behavioural objectives. 相似文献7.
Heng Li Xiao-fei Shen Xin-e Zhou Yan-e Shi Lu-xia Deng Yi Ma Xiao-ying Wang Jing-yu Li Ning Huang 《Journal of Zhejiang University. Science. B》2017,18(5):410-420
Objective
To investigate the antibacterial mechanism of high-mobility group nucleosomal-binding domain 2 (HMGN2) on Escherichia coli K12, focusing on the antibacterial and antibiofilm formation effects. Its chemotactic activity on human neutrophils was also investigated.Methods
Human tissue-derived HMGN2 (tHMGN2) was extracted from fresh uterus fiber cystadenoma and purified by HP1100 reversed-phase high-performance liquid chromatography (RP-HPLC). Recombinant human HMGN2 (rHMGN2) was generated in E. coli DE3 carrying PET-32ac(+)- HMGN2. Antibacterial activity of HMGN2 was determined using an agarose diffusion assay and minimum inhibitory concentration (MIC) of HMGN2 was determined by the microdilution broth method. Bacterial membrane permeability assay and DNA binding assay were performed. The antibiofilm effect of HMGN2 was investigated using a crystal violet assay and electron microscopy scanning. The activating effect and chemotactic activity of HMGN2 on neutrophils were determined using a nitroblue tetrazolium (NBT) reduction assay and Transwell chamber cell migration assay, respectively.Results
HMGN2 showed a relatively high potency against Gram-negative bacteria E. coli and the MIC of HMGN2 was 16.25 μg/ml. Elevated bacterial membrane permeability was observed in HMGN2-treated E. coli K12. HMGN2 could also bind the bacterial plasmid and genomic DNA in a dose-dependent manner. The antibiofilm effect of HMGN2 on E. coli K12 was confirmed by crystal violet staining and scanning electron microscopy. However, the activating effects and chemotactic effects of HMGN2 on human neutrophils were not observed.Conclusions
As an antimicrobial peptide (AMP), HMGN2 possessed a good capacity for antibacterial and antibiofilm activities on E. coli K12. This capacity might be associated with disruption of the bacterial membrane and combination of DNA, which might affect the growth and viability of E. coli.8.
Eva-Guadalupe LIZRRAGA-PAULíN Susana-Patricia MIRANDA-CASTRO Ernesto MORENO-MARTíNEZ Alma-Virginia LARA-SAGAHóN Irineo TORRES-PACHECO 《Journal of Zhejiang University. Science. B》2013,14(2):87-96
Objective:To evaluate the effect of chitosan(CH) and hydrogen peroxide(H2O2) seed coatings and seedling sprinklings on two different maize varieties by measuring their phenology,the H2O2 presence,the catalase(CAT) activity,and the protein quantity.Methods:Seven groups of ten seeds for each maize variety were treated with CH(2%(20 g/L) and 0.2%(2 g/L)) or H2O2(8 mmol/L) by coating,sprinkling,or both.Germination and seedling growth were measured.One month after germination,the presence of H2O2 in seedlings in the coated seed treatments was evaluated.Protein content and CAT activity were determined under all treatments.Results:H2O2 seed coating enhanced the germination rate and increased seedling and stem length in the quality protein maize(QPM) variety.Seedlings had a higher emergence velocity under this treatment in both varieties.CH and H2O2 sprinklings did not have an effect on seedling phenology.Exogenous application of H2O2 promoted an increase of endogenous H2O2.CH and H2O2 seedling sprinkling increased the protein content in both maize varieties,while there was no significant effect on the CAT activity of treated seeds and seedlings.Conclusions:CH and H2O2 enhance some phenological and biochemical features of maize depending on their method of application. 相似文献
9.
Xiao-fen He Jun-jun Wei Sheng-yun Shou Jian-qiao Fang Yong-liang Jiang 《Journal of Zhejiang University. Science. B》2017,18(3):239-248
Objective
To investigate the analgesic effects of electroacupuncture (EA) at 2 and 100 Hz on type 2 diabetic neuropathic pain (DNP) and on the expressions of the P2X3 receptor and calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG).Methods
Rat type 2 DNP was induced by a high calorie and high sugar diet fed for 7 weeks, plus a single intraperitoneal injection of streptozotocin (STZ) after 5 weeks. EA at 2 and 100 Hz was carried out once every day after 7 weeks for 7 consecutive days. Body weight, serum fasting insulin (FINS), fasting blood glucose (FBG), insulin sensitivity index (ISI), and paw withdrawal latency (PWL) were measured. The expressions of L4–L6 DRG P2X3 receptors and CGRP were assessed by immunofluorescence.Results
Type 2 DNP was successfully induced as shown by the increased body weight, FINS, and FBG, as well as the reduced ISI and PWL. Expressions of P2X3 receptors and CGRP in L4–L6 DRGs increased. EA at both 2 and 100 Hz relieved type 2 DNP, but the analgesic effect of EA was stronger at 2 Hz. P2X3 receptor expression decreased in L4–L6 DRGs following EA at 2 Hz and in L5 and L6 DRGs following EA at 100 Hz. EA at both 2 and 100 Hz down-regulated CGRP overexpression in L4–L6 DRGs.Conclusions
These findings indicate that EA at 2 Hz is a good option for the management of type 2 DNP. The EA effect may be related to its down-regulation of the overexpressions of the DRG P2X3 receptors and CGRP in this condition.10.
Xiao-xuan Guo Yong Wang Kai Wang Bao-ping Ji Feng Zhou 《Journal of Zhejiang University. Science. B》2018,19(7):559-569
Objective
The present study aims at determining the stability of a popular type 2 diabetes rat model induced by a high-fat diet combined with a low-dose streptozotocin injection.Methods
Wistar rats were fed with a high-fat diet for 8 weeks followed by a one-time injection of 25 or 35 mg/kg streptozotocin to induce type 2 diabetes. Then the diabetic rats were fed with regular diet/high-fat diet for 4 weeks. Changes in biochemical parameters were monitored during the 4 weeks.Results
All the rats developed more severe dyslipidemia and hepatic dysfunction after streptozotocin injection. The features of 35 mg/kg streptozotocin rats more resembled type 1 diabetes with decreased body weight and blood insulin. Rats with 25 mg/kg streptozotocin followed by normal diet feeding showed normalized blood glucose level and pancreatic structure, indicating that normal diet might help recovery from certain symptoms of type 2 diabetes. In comparison, diabetic rats fed with high-fat diet presented decreased but relatively stable blood glucose level, and this was significantly higher than that of the control group (P>0.05).Conclusions
This model easily recovers with normal diet feeding. A high-fat diet is suggested as the background diet in future pharmacological studies using this model.11.
Fernando Landini Maite Beramendi 《The Journal of Agricultural Education and Extension》2013,19(5):381-399
ABSTRACT
Purpose
This article aims at designing and validating a psychometric scale to assess extensionists’ and advisors’ beliefs about extension and innovation. 相似文献12.
13.
《International Journal for Educational and Vocational Guidance》2009,9(3):221-225
Announcements
Announcements 相似文献14.
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《International Journal for Educational and Vocational Guidance》2010,10(3):207-210
ANNOUNCEMENTS
Announcements 相似文献16.
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18.
Naama Sabar 《Educational technology research and development : ETR & D》2000,48(4):100-102
International Review
Introduction 相似文献19.
20.
《Educational technology research and development : ETR & D》1996,44(3):102-102