Amnesia induced by hypothermia as a function of treatment-test interval and recooling in rats

In Experiment I, a repeated tests procedure was employed to assess hypothermia-induced amnesia of a footshock experience. Rats tested 4 h after training treatment showed no memory loss, but amnesia was present at 24 h. Although recovery of memory was obtained when the same animals were cooled 2 h prior to a 50-h test, repeated testing also tended to attenuate amnesia. In Experiment II, independent groups were tested at 6 or 50 h after training treatment. Again, memory of the footshock was present at the short, but not at the long, interval. Recooling shortly prior to the 50-h test eliminated amnesia. Experiment III indicated that the return of memory produced by recooling did not persist if testing was delayed. These findings suggested that hypothermia may function as an important contextual cue for memory retrieval.     

Ontogenetic forgetting of stimulus attributes

The effects of age on the forgetting of stimulus attributes in a differential fear-conditioning paradigm were examined with 18- and 70-day-old rats tested in either the original conditions or shifted stimulating conditions at one of three retention intervals (1, 48, and 120 h). Adults displayed significant shifts at each retention interval, with those tested in the original context displaying greater fear than those tested in the shifted conditions. By contrast, by 48 h the 18-day-olds had forgotten the specific attributes of the training situation and began treating the two stimulating conditions as functionally equivalent (Experiment 1). In Experiment 2, we tracked the ontogenetic emergence of adult-like memory for stimulus attributes and found a dramatic increase in memory capability by 25 days of age. Experiment 3 illustrated that the forgotten memory attributes of infants may be retrieved by administering a 90-sec cuing treatment 10 min prior to the 48-h test. Implications for the phenomenon of infantile amnesia are discussed.     

The pattern of responding after extensive extinction

Extensive extinction greatly reduces response rate and increases the relative frequency of short interresponse times, but does not affect temporal learning or operant response rate. In each of two experiments, 24 rats were trained in a multiple cued interval procedure with three stimuli (noise, light, and clicker) at three intervals (30, 60, and 120 sec). In Experiment 1, after 50 sessions of extinction, response rate decreased from about 25 to 0.5 responses/min, but temporal discriminations were maintained and the initial response gradients in reacquisition had a pattern that corresponded with the original (rather than current) training conditions. In Experiment 2, these results were replicated and extended by examination of the effect of stimulus duration on response patterns during extinction, but its lack of effect on reacquisition. The similarity of the initial performance in reacquisition to the asymptotic performance in acquisition was presumably due to the similarity of context. The individual subject data may be downloaded from www.psychonomic.org/archive.     

Spacing extinction trials alleviates renewal and spontaneous recovery

Studies of extinction in classical conditioning situations can reveal techniques that maximize the effectiveness of exposure-based behavior therapies. In three experiments, we investigated the effect of varying the intertrial interval during an extinction treatment in a fear-conditioning preparation with rats as subjects. In Experiment 1, we found less fear at test (i.e., more effective extinction) when extinction trials were widely spaced, relative to intermediate or massed extinction trials. In Experiment 2, we used an ABA renewal procedure and observed that spaced trials attenuated renewal of conditioned fear relative to massed trials. In Experiment 3, we used a similar design, but instead of changing the physical context at the time of testing, we interposed a retention interval after the extinction treatment to produce a change in the temporal context. The results showed less spontaneous recovery of fear after spaced than after massed extinction trials. These results suggest that extinction is more enduring when the extinction trials are spaced rather than massed. Although the benefits of spacing trials are small when there is no contextual change from extinction to testing, a change in either physical or temporal context following massed extinction trials leads to a recovery from extinction, which is reduced when the trials are spaced.     

Impact of brief or extended extinction of a taste aversion on inhibitory associations: Evidence from summation,retardation, and preference tests

In five conditioned taste aversion experiments with rats, summation, retardation, and preference tests were used to assess the effects of extinguishing a conditioned saccharin aversion for three or nine trials. In Experiment 1, a summation test showed that saccharin aversion extinguished over nine trials reduced the aversion to a merely conditioned flavor (vinegar), whereas three saccharin extinction trials did not subsequently influence the vinegar aversion. Experiment 2 clarified that result, with unpaired controls equated on flavor exposure prior to testing; the results with those controls suggested that the flavor extinguished for nine trials produced generalization decrement during testing. In Experiment 3, the saccharin aversion reconditioned slowly after nine extinction trials, but not after three. Those results suggested the development of latent inhibition after more than three extinction trials. Preference tests comparing saccharin consumption with a concurrently available fluid (water in Experiment 4, saline in Experiment 5) showed that the preference for saccharin was greater after nine extinction trials than after three. However, saccharin preference after nine extinction trials was not greater, as compared with that for either latent inhibition controls (Experiments 4 and 5) or a control given equated exposures to saccharin and trained to drink saline at a high rate prior to testing (Experiment 5). Concerns about whether conditioned inhibition has been demonstrated in any flavor aversion procedure are discussed. Our findings help explain both successes and failures in demonstrating postextinction conditioned response recovery effects reported in the conditioned taste aversion literature, and they can be explained using a memory interference account.     

Memories of reward events and expectancies of reward events may work in tandem

A common assumption is that expectancies of reward events in instrumental tasks are established on the basis of Pavlovian conditioning. According to the tandem hypothesis, tested in the four runway investigations reported here employing rats, memories of reward events may serve as the conditioned stimuli eliciting expectancies. In Experiments 1–3, rats were trained under a schedule of partial reward (P), which did not produce increased resistance to extinction, and subsequently shifted to consistent reward (C). According to the tandem hypothesis, the shift to the C schedule should result in increased resistance to extinction if, as hypothesized, under the P schedule the memory of reward, S^R, came to elicit the expectancy of nonreward,_EN. This hypothesis was confirmed under a variety of conditions. It was shown that increased resistance to extinction could not be attributed to the P schedule alone, to the rats receiving two schedules, P and C, to stimuli other than S^R eliciting E_N, or to the rats forgetting reward-produced memories when expecting nonreward (Experiment 4). It was shown that the tandem hypothesis could explain the divergent findings obtained in prior studies employing a shift from P to C as well as in the present study.     

Spontaneous recovery varies inversely with the training-extinction interval

Four experiments found the magnitude of spontaneous recovery after extinction to be greater with a shorter interval between initial conditioning and extinction. Experiments 1 and 2 used a Pavlovian magazine approach procedure with rat subjects, Experiment 3 used an instrumental training procedure with rats, and Experiment 4 used a sign-tracking procedure with pigeons. These results are not anticipated by many accounts of spontaneous recovery that attribute it to the fading of learning that occurred during extinction.     

Secondary extinction in Pavlovian fear conditioning

Pavlov (1927/1960) reported that following the conditioning of several stimuli, extinction of one conditioned stimulus (CS) attenuated responding to others that had not undergone direct extinction. However, this secondary extinction effect has not been widely replicated in the contemporary literature. In three conditioned suppression experiments with rats, we further explored the phenomenon. In Experiment 1, we asked whether secondary extinction is more likely to occur with target CSs that have themselves undergone some prior extinction. A robust secondary extinction effect was obtained with a nonextinguished target CS. Experiment 2 showed that extinction of one CS was sufficient to reduce renewal of a second CS when it was tested in a neutral (nonextinction) context. In Experiment 3, secondary extinction was observed in groups that initially received intermixed conditioning trials with the target and nontarget CSs, but not in groups that received conditioning of the two CSs in separate sessions. The results are consistent with the hypothesis that CSs must be associated with a common temporal context during conditioning for secondary extinction to occur.     

The recency effect in pigeons’ long-term memory

Four experiments are reported in which pigeons first learned one wavelength discrimination (green S+, yellow S?) and then the reversal; finally, after various delays, they were tested for wavelength generalization in extinction. In Experiment 1, the two problems were learned in different contexts; testing in Context 1 produced maximal responding to green in only half of the subjects, even when testing was delayed 30 days. In Experiment 2, testing of the subjects repeatedly in both contexts showed good control by each context after a 30-day delay. In Experiment 3, both problems were learned in the same context, and all gradients showed recency, peaking at yellow, even after 30 days. In Experiment 4, the subjects learned a series of reversals in the same context, terminating in yellow, S+, green, S?, and their gradients peaked at yellow, even after a 30-day delay. In Experiments 3 and 4, the gradients became flatter with increasing delays, and they were flatter in Experiment 4 (after three reversals) than in Experiment 3 (after one reversal). The location of the peak was not affected by delay, but only by testing in a context that had been uniquely associated with Problem 1 (Experiments 1 and 2). It is proposed that the location of gradient peaks indicates what is being remembered, whereas the slope of the obtained gradients indicates how well the target memory has been retrieved.     

Ontogeny of persistence: Immediate extinction effects in preweanling and weanling rats

In Experiment I rats were trained for 21÷2 days under partial (PRF) or continuous reinforcement (CRF) conditions starting at 18, 22, 28, or 36 days of age and were then subjected to immediate extinction. At all ages there was a strong partial reinforcement extinction effect (PREE), and absolute size of PREE was greatest in the youngest rats. Rate of extinction increased as a function of age following both CRF and PRF. In Experiment II the youngest and oldest age groups of Experiment I were run under the two reward conditions of Experiment I and in a third condition, PRF with number of rewards rather than trials equated to CRF (PRF-R). The PRF-R and PRF groups were not different in extinction, and both were more persistent than CRF. The youngest rats were again more persistent than the oldest, particularly after PRF training. In Experiment III it was shown that the well-known paradoxical effect, greater reward in CRF acquisition leads to faster extinction, operates in our youngest and oldest animals, but is more pronounced in the oldest. The results are discussed in terms of whether they require different explanations than those often applied to extinction data from adult rats.     

The Organization of Reactivated Memory in Infancy

The specificity of memory retrieval by 3-month-old infants was examined in 3 experiments. All infants were trained in the mobile conjugate reinforcement paradigm to kick their feet to produce movement in an overhead crib mobile and were tested 2 weeks later. 24 hours prior to the test, subjects received a 3-min reminder treatment. The results of Experiment 1 demonstrated that only the moving training mobile alleviated forgetting after the 2-week retention interval; forgetting was not alleviated by exposure to the stationary training mobile or to the mobile stands and ribbon alone. The results of Experiments 2 and 3 demonstrated that, once retrieved, the reactivated memory was highly specific to the conditions of original training. Furthermore, the memory attributes that were the last to be forgotten (e.g., the general or global features) were the first to be retrieved following the reminder treatment. Conversely, those memory attributes that were forgotten first (e.g., the specific or local details) were the last to be retrieved. These findings have important implications for infant memory retrieval, reminiscence, and infantile amnesia.     

Contextual Variation and Memory Retrieval at Six Months

In 2 experiments we asked whether training in multiple contexts could eliminate context-dependent memory retrieval at 6 months as it does for adults. We found that 24-hour retention was disrupted when infants were trained in one context and tested in another but not when they were trained in multiple contexts prior to testing in a novel context (Experiment 1). After a long delay, however, training in multiple contexts did not facilitate memory retrieval in a novel context: An otherwise effective retrieval cue (the training mobile) did not alleviate forgetting 3 weeks later when it was presented in a novel context (Experiment 2). These findings demonstrate that multiple learning contexts can override the debilitating effects of an altered context on memory retrieval at 6 months, but only over the short term. The resistance of older memories to retrieval in novel contexts after long periods of disuse may be adaptive, insuring that potentially inappropriate or irrelevant memories will not be expressed.     

Role of proactive interference in infantile forgetting

Ontogenetic changes in the role of proactive interference in augmenting forgetting were tested with 444 rats as subjects. In Experiment 1, Phase 1 (the source of proactive interference) included events that were contingent or not contingent on responding in the context of either the Phase 2 training apparatus or a distinctly different apparatus. After learning a spatial discrimination for Phase 2, retention tests were given after intervals of 2 min, 1 day, 7 days, 30 days, or 65 days. The results indicated: (1) infantile amnesia, and (2) proactive interference for infant rats but not for adults, in spite of substantial simple forgetting among adults. Experiment 2 extended the test to a go/no-go avoidance task. The results of Experiment 2 gave some indication that infants were more susceptible than were adults to proactive interference over short intervals, but the generality of this relationship was sufficiently ambiguous as to suggest different mechanisms of interference for the discrimination and go/no-go tasks. These data indicate multiple mechanisms of infantile forgetting that may vary with certain characteristics of the task.     

The neurology of traumatic "dissociative" amnesia: commentary and literature review.

BACKGROUND: The relationship between traumatic emotional stress, hippocampal injury, memory loss, and traumatic ("dissociative") amnesia was examined. METHOD: A survey of the research on emotional trauma, learning, memory loss, glucocosteroid stress hormones, and the hippocampus was conducted, and animal and human studies were reviewed. RESULTS: It is well documented and has been experimentally demonstrated in animals and humans that prolonged and high levels of stress, fear, and arousal commonly induce learning deficits and memory loss ranging from the minimal to the profound. As stress and arousal levels dramatically increase, learning and memory deteriorate in accordance with the classic inverse U-shaped curve. These memory deficits are due to disturbances in hippocampal activation and arousal, and the corticosteroid secretion which can suppress neural activity associated with learning and memory and induce hippocampal atrophy. Risk and predisposing factors include a history of previous emotional trauma or neurological injury involving the temporal lobe and hippocampus, the repetitive and prolonged nature of the trauma, and age and individual differences in baseline arousal and level of cortisol. CONCLUSIONS: Although some victims may be unable to forget, amnesia or partial memory loss is not uncommon following severe stress and emotional trauma. Even well publicized national traumas may induce significant forgetting. Memory loss is a consequence of glucocosteroids and stress-induced disturbances involving the hippocampus, a structure which normally plays an important role in the storage of various events in long-term memory.     

Spontaneous recovery without interference: Why remembering is adaptive

Spontaneous recovery from extinction is a reliable result of two ingredients, variable training outcomes and the passage of time. Accounts of the phenomenon, which have come to focus on interference at the level of memory retrieval, have been based on simple associative learning tasks. The present study was designed to determine whether a more complex task—one requiring spatial mapping, timing, and patch assessment—would be subject to spontaneous recovery. Results showed that spontaneous recovery (1) makes a robust appearance in such tasks, (2) does not require interference among conflicting memories, but instead (3) requires ready access to training memories, and (4) is closely modeled by the temporal weighting rule, a quantitative model of patch choice that prescribes how value is best assigned to variable resources (L. D. Devenport & J. A. Devenport, 1994).     

Infantile amnesia across the years: a 2-year follow-up of children's earliest memories

Although infantile amnesia has been investigated for many years in adults, only recently has it been investigated in children. This study was a 2-year follow-up and extension of an earlier study. Children (4-13 years old) were asked initially and 2 years later for their earliest 3 memories. At follow-up, their age at the time of these memories shifted to several months later, with younger children unlikely to provide the same memories. Moreover, when given cues about memories recalled 2 years previously, many were still not recalled. In contrast, older children were more likely to recall the same memories, and cues to former memories were successful. Thus, older children were becoming consistent in terms of recalling very early memories.     

Extinction context as a conditioned inhibitor

Two lick suppression experiments using rats were conducted to determine whether extinction of a punctate excitor in a particular context would result in that context becoming a conditioned inhibitor, as defined by passing both summation and retardation tests. The role of extinction trial spacing was investigated as a possible determinant of whether the extinction context would become inhibitory. Experiment 1 demonstrated that, although inhibition was evident using either massed or spaced extinction trials, spaced trials reduced measurable inhibition as assessed by the summation test, but trial spacing had no influence on retardation test performance. Experiment 2 confirmed Experiment 1’s conclusions while controlling for the influence of latent inhibition on the retardation test. In Experiment 2, the context proved inhibitory only following massed extinction trials. These data suggest that, at least with select parameters, an extinction context can become inhibitory.     

Spontaneous recovery after extinction of a conditioned taste aversion

Four experiments examined whether or not spontaneous recovery could occur after extinction in the conditioned taste-aversion paradigm. After three extinction trials, spontaneous recovery was obtained over an 18-day retention interval (Experiments 1, 2, and 3). The effect was not due to changes in the unconditioned preference for saccharin over the retention interval (Experiment 2) or to an increase in a nonextinguished aversion over time, as indicated by tests with both the original, nonextinguished aversion (Experiment 1) and with a weaker one (Experiment 3). Spontaneous recovery was not obtained when extinction was overtrained (eight trials) and a 49-day retention interval was used (Experiment 4). However, saccharin intake at asymptote reached the level of baseline water intake, and not the highly preferred level shown by never-conditioned controls. Results of all four experiments suggest that extinction does not return an averted taste to the status of an unconditioned one.     

Signaling a change in cue-outcome relations in human associative learning

In three experiments, we assessed the role of signals for changes in the consequences of cues as a potential account of the renewal effect. Experiment 1 showed recovery of responding following extinction when acquisition, extinction, and test phases occurred in different contexts. In addition, extinction treatment in multiple contexts attenuated context-induced response recovery. In Experiment 2, we used presentations of an extraneous stimulus (ES), instead of context shifts, and found that responding recovered from extinction only when the ES was presented both between acquisition and extinction and between extinction and test. In Experiment 3, we used a reversal learning design in which, during training, two cues were first paired with different outcomes, then paired with the alternative outcomes, and finally paired again with the original outcomes. In this experiment, presentation, just prior to testing, of an ES that had previously been presented between the different phases produced an expectation of reversal in the meaning of the cues.     

"When I Was Little": Childhood Recollections in Chinese and European Canadian Grade School Children

Recollection of early childhood experiences was investigated in 225 European Canadian and 133 Chinese children (ages 8, 11, and 14) by a memory fluency task that measured accessibility of multiple early memories and elicited the earliest memory. Younger children provided memories of events that occurred at earlier ages than older children. Furthermore, Canadian children produced more memories and had an earlier age of first memory than did Chinese children, with cultural differences in both measures increasing with age. It appears that while adultlike childhood amnesia is still emerging among Canadian children, Chinese children by age 14 already resemble adults. Content of Canadian versus Chinese children's memories reflected an autonomous versus relational self-construal. Results are discussed in terms of sociocultural influences on memory.