共查询到20条相似文献,搜索用时 31 毫秒
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K. K. Mishra H. P. Pandey R. H. Singh 《Indian journal of clinical biochemistry : IJCB》2007,22(2):41-43
Present clinical study involved two groups of psychosomatic disorders, bronchial asthma and rheumatoid arthritis. In the study,
the levels of plasma cortisol, blood glucose, total cholesterol and triglycerides were estimated in 125 clinical subjects,
(50 normal controls, and 40 having bronchial asthma and 35 suffering from rheumatoid arthritis. The results showed a significant
change in the levels of plasma cortisol and blood glucose in both the stressed clinical groups' vis-à-vis normal controls.
The levels of atherogenic lipids (total cholesterol and triglycerides) were found quite elevated in both the diseased groups.
However, in rheumatoid arthritis, the physiological changes were relatively more pronounced. The findings of this study indicate
that rheumatoid arthritis is a relatively more chronic and late onset disorder as the functional performance of hypothalamopituitary-adrenocortical
axis gradually declines with passage of time and the ability of the adrenocortical response to return to normalcy becomes
impaired. 相似文献
3.
A number of factors are linked with non-alcoholic fatty liver diseases (NAFLD), a condition that ranges from clinically benign
fatty liver to its more severe form, non alcoholic steatohepatitis (NASH). In this study, we evaluated the role of cytokines
secreted from adipose tissue in the pathogenesis and progression of NAFLD. We also compared anthropometric profile, lipid
profile and insulin resistance data in 105 NAFLD patients with 77 normal subjects. These subjects showed a normal serum albumin
level, prothrombin time and renal function but elevated aminotransferases. Predisposing factors were diabetes mellitus (35%),
overweight (56%) and hyperlipidemia (44%). Insulin resistance (IR), determined by homeostasis model assessment (HOMA) was
confirmed in 70% patients with NAFLD and 42% patients fulfilled the minimum criteria for insulin resistance syndrome (IRS).
NAFLD patients showed elevated levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, and interleukin (IL)-6,
while anti-inflammatory cytokines IL-4 level decreased and IL-10 level remain unchanged; however, TGF-β1 level elevated significantly
compared to normal subjects. While insulin level and HOMA-IR both were significantly positively correlated with BMI, waist-to-hip
ratio, total cholesterol, VLDL-cholesterol, triglyceride and TGF-β1; glucose, IL-6 and TNF-α levels were significantly positively
correlated with HOMA-IR only. In conclusion, pro-inflammatory cytokines play an important link between metabolic and liver
disorders in the fat accumulation, and thereby cause IR, inflammation and liver fibrosis. 相似文献
4.
P. P. Naik M. S. Ghadge A. S. Raste 《Indian journal of clinical biochemistry : IJCB》2006,21(2):100-102
A number of epidemiologic studies has been published in recent years showing an increase risk of death from cancer in subjects
with low plasma cholesterol levels. Although several authors proposed that hypocholesterolemia is predisposing factor for
cancer development, no causative relation has been established so far and that it may be that low plasma cholesterol is secondary
to malignant disease. Hence, the present study was undertaken to examine the lipid profile in children patients with leukemia
and Hodgkin's disease in comparison with age matched controls. The study included 52 normal healthy controls and 105 patients
with leukemia and Hodgkin's disease. Lipid profile included serum cholesterol, HDL & LDL cholesterol and triglycerides. Serum
cholesterol, HDL & LDL cholesterol were found to be inversely associated with incidence of cancer, whereas triglycerides were
significantly elevated in cancer patients. The inverse association between cancer and serum cholesterol may reflect a physiological
response to early undiagnosed stages of cancer. 相似文献
5.
Vaishali N. Thorat Adinath N. Suryakar Pradeep Naik Bipin M. Tiwale 《Indian journal of clinical biochemistry : IJCB》2009,24(1):102-104
Liver transplantation is an accepted therapy for chronic liver disease patients. These patients generally have low levels
of fat soluble vitamins, which have important antioxidant roles. Therefore, this study was undertaken to investigate whether
such patients had evidence of antioxidant depletion and increased lipid peroxidation before transplant and whether the subsequent
ischemia and reperfusion encountered during liver transplantation have any effect on antioxidant levels and lipid peroxidation.
We assessed plasma total antioxidant capacity and serum lipid peroxide in 12 patients undergoing liver transplantation and
equal numbers of healthy subjects. We found that before reperfusion, antioxidant levels were significantly decreased along
with significantly elevated lipid peroxidation levels as compared with healthy controls (P<0.001). On reperfusion of the liver
graft, further declined values of total antioxidant accompanied with highly elevated lipid peroxidation were seen than those
of pre-reperfusion samples (P<0.001). This data shows that patients undergoing liver transplant have lowered antioxidant defenses
and evidence of free radical damage, which compound the additional insult of reperfusion injury. Therefore antioxidant therapy
in these patients before transplantation may ameliorate the effects of reperfusion. 相似文献
6.
Bina R. Baxi Prabhudas S. Patel Siddharth G. Adhvaryu 《Indian journal of clinical biochemistry : IJCB》1990,5(2):139-144
For evolving a potential Biochemical index for early diagnosis of oral cancer, serum levels of total sialic acid (TSA), lipid
bound sialic acid (LSA), mucoid proteins and hexoses (galactose and mannose) were determined in 30 patients with oral cancer.
The results were compared with similar values obtained for 30 patients with oral precancerous conditions, 24 healthy controls
and 15 normal individuals with a habit of tobacco chewing. All the biomarkers were significantly elevated in oral cancer patients
compared to the controls, the normal chewers and precancer patients. The levels of glycoconjugates showed significant increase
in patients with oral precancerous conditions compared to the controls. Only LSA and hexoses showed significantly elevated
levels in oral precancer patients compared to the normal chewers. The levels of glycoconjugates were more or less comparable
between normal chewers and the controls. The parameters evaluated in the oral cancer patients also showed a progressive rise
with the clinical stage of the malignant disease. The levels of the four glycoconjugates were also higher in patients with
metastasis compared to those with only primary disease. The present findings suggest that the glycoconjugates have clinical
utility in diagnosis of the patients with cancer of the oral cavity as well as in staging the disease. 相似文献
7.
V. N. Thorat A. N. Suryakar A. S. Sardeshmukh S. S. Sarawade 《Indian journal of clinical biochemistry : IJCB》2004,19(2):32-35
In the present study, the role of serum lipid peroxide and serum nitric oxide as oxidants and erythrocytic superoxide dismutase
& serum vitamin E as antioxidants were determined in the 50 neonates with hypoxic ischaemic encephalopathy. (HIE) as against
25 healthy neonates as controls 50 patients of HIE were further divided into two groups i. e. mild and moderate HIE patients.
All subjects were in the age group of 37–41 weeks of gestation. The levels of serum lipid peroxide, serum nitric oxide and
erythrocytic superoxide dismutase were significantly elevated in both groups of neonates with HIE than those of controls (P<0.001),
whereas serum vitamin E levels were significantly decreased in both groups of HIE patients than those of controls (P<0.001).
A positive correlation was obtained between serum lipid peroxide and erythrocytic superoxide dismutase (r=+0.86). Alterations
in the status of oxidants and antioxidants indicate role of free radicals in the development of HIE. 相似文献
8.
S. Jaya Kumari Nivedita Jayaram Lloyd Vincent T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):45-48
Type 2 diabetes is associated with a marked increase in the risk of coronary artery disease. Dyslipidaemia is believed to
be a major cause of this increased risk. Recently, elevated levels of lipoprotein (a), Lp(a), have been reported to be associated
with an increased risk. However there is very little data regarding Lp(a) concentrations and type 2 diabetes from India. The
objective of the study was to assess serum Lp(a) levels in type 2 diabetics with and with out evidence of clinical nephropathy.
We estimated serum Lp(a) levels in 30 control subjects, 30 diabetics without evidence of clinical nephropathy and 30 diabetics
with evidence of clinical nephropathy. Statistical analysis showed that Lp(a) levels were increased in diabetic patients with
nephropathy (mean 46.3±17.6 mg/dl). The Lp(a) levels however did not differ significantly between control (mean 20.2±15.9
mg/dl) and diabetics without nephropathy (mean 22.6±13.1mg/dl). Thus diabetes per se seems to have little or no influence
on serum Lp(a) levels, however elevated levels were seen in patients with nephropathy. 相似文献
9.
Sarama Saha Chandan Sarkar Subhash Chandra Biswas R. Karim 《Indian journal of clinical biochemistry : IJCB》2008,23(3):262-266
Abnormal lipid profile is often found in women with Polycystic Ovary Syndrome. To assess the impact of abnormal lipid profile
on atherosclerosis in young Polycystic Ovary Syndrome women, carotid intima-media thickness as judged by B-mode ultrasonography
were done in 30 young (18–35 yrs) Polycystic Ovary Syndrome women and in similarly age-matched 30 apparently healthy controls.
Compared to controls, young Polycystic Ovary Syndrome women had significantly elevated serum total cholesterol, triglyceride
and LDL-C levels and carotid intima-media thickness. HDL-C level did not differ significantly between two groups of women.
In Polycystic Ovary Syndrome women carotid intima-media thickness was positively correlated with serum total cholesterol,
triglyceride and LDL-C and negatively correlated with serum HDL-C. Our study suggests that even young Polycystic Ovary Syndrome
women are prone to atherosclerosis from early age. 相似文献
10.
Surapon Tangvarasittichai Suthap Pongthaisong Suwadee Meemark Orathai Tangvarasittichai 《Indian journal of clinical biochemistry : IJCB》2015,30(3):275-280
Abdominal obesity (AO) has a strong correlation with cardiovascular disease and has been linked to Alzheimer’s disease and type 2 diabetes. We investigated the association between AO and elevated serum butyrylcholinesterase (BChE) activity, insulin resistance and the serum lipid profile, including triglyceride (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels in AO and non-AO women subjects. A total of 500 AO subjects (age 49.1 ± 10.5 years), and 142 non-AO women subjects (age 49.9 ± 11.9 years) were enrolled for the general biochemistry tests, serum BChE, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR). Body mass index, waist circumference, Blood pressure (BP), plasma glucose (Glu), triglyceride (TG), BChE, insulin, HOMA-IR were significantly higher and HDL-C levels were significantly lower in AO subjects (p < 0.05). Waist circumference was significantly correlated with BP, Glu, TG, BChE, insulin and HOMA-IR in AO subjects. Multiple logistic regression demonstrated that AO was associated with elevated BChE, HOMA-IR, hypertension and reduced HDL-C after adjusting for these variables. AO is associated with elevated BChE, insulin resistance, HT and reduced HDL-C. These may predict the development of type 2 diabetes mellitus and may be associated with cognitive disorder in the future, both are mediated through insulin resistance. 相似文献
11.
M. Shafi Dar A. A. Pandith A. S. Sameer M. Sultan A. Yousuf Syed Mudassar 《Indian journal of clinical biochemistry : IJCB》2010,25(2):208-212
Hypertension is the most important public health problem in developing countries and one of the major risk factors for cardiovascular
diseases, and it has been reported that hypertension is in part an inflammatory disorder and several workers have reported
elevated levels of CRP in hypertensive individuals. The main aim of the present study was to evaluate the association between
blood pressure and serum CRP levels across the range of blood pressure categories including prehypertension. A total of 104
patients and 63 control subjects were included in the present study. The level of CRP in the serum samples was estimated by
a high sensitivity immunoturbidometric assay. Standard unpaired student’s ‘t’ test was used for comparison of hs-CRP levels
between hypertensive patients and normotensive control subjects and between patient groups with different grades of hypertension
and different durations of hypertensive histories. The mean serum hs-CRP level in hypertensive patients was 3.26 mg/L compared
with 1.36 mg/L among normotensive control subjects (P<0.001). On comparison with normotensive control subjects, the hs-CRP
levels vary significantly both with grades and duration of hypertension, with most significant difference found in patients
with prehypertension (P<0.001), followed by Stage-I (P=0.01) and Stage-II(P=0.02) hypertensives. Significant difference in
hs-CRP levels was also found in patients with shorter duration of hypertensive history (≤ 1year) when compared with those
with ≥5 years of hypertensive history (P<0.01). Our study reveals a graded association between blood pressure and CRP elevation
in people with hypertension. Individuals with prehypertension or with shorter duration of hypertension (≤1 Year) had significantly
a greater likelihood of CRP elevation in comparison to chronic stage-I or stage-II hypertensives. 相似文献
12.
C. R. Wilma Delphine Silvia D. M. Vasudevan K. Sudhakar Prabhu 《Indian journal of clinical biochemistry : IJCB》2001,16(1):113-115
The present study was conducted on thirty untreated oral cancer patients proved by clinical and histopathological evidence
and thirty healthy control subjects. The levels of glycoprotein-associated carbohydrates such as hexose, hexosamine, fucose
and sialic acid were found to be elevated significantly as compared to control subjects. There was a progressive rise in these
markers as the stages of oral cancer advanced. 相似文献
13.
Vikram Thakkar Purvi Patel Neelam Prajapati Ranjit Kaur Mukesh Nandave 《Indian journal of clinical biochemistry : IJCB》2014,29(3):345-350
Identification of reliable biomarkers for detection and staging of cancer and monitoring the outcome of anticancer therapy has been considered to be of high importance. We aimed to estimate the levels of serum glycoproteins, protein bound-hexose, protein bound hexosamine, protein bound fucose, protein bound sialic acid and protein bound carbohydrate in 32 ovarian cancer patients and compared them with the levels that found in 25 normal subjects. As compared to the normal subjects, all the four fractions of glycoproteins level were significantly elevated in ovarian cancer patients (p < 0.05). Chemotherapy in these patients significantly decreased the levels of serum glycoproteins (p < 0.05). Thus, high levels of serum glycoproteins in ovarian cancer patients could be due to abnormal protein glycosylation indicating malignant transformation of the cells. 相似文献
14.
Leucine amino peptidase (LAP) activity was studied in serum and urine samples of 25 healthy ambulant subjects, 20 patients
with localised and 41 patients with malignant disseminated disease. Serum levels of the enzyme were elevated but not significantly
in both localised and disseminated disease whereas the urinary activity of the enzyme was markedly elevated in disseminated
disease (p<0.001) as compared to localised disease. This quantitative method used for determination is reliable, accurate,
simple, rapid and cost effective and therefore has better application as an indicator of disseminated disease in a clincal
setting. 相似文献
15.
Neurodegenerative molecules play an important role in maintaining a supply for synaptic vesicles; and they are also likely to help regulate the dopamine release which is the primary mechanism of action in pharmacological treatments for attention deficit hyperactivity disorder (ADHD). It is suggested that there could be interactions between α-synuclein and tau in cytoskeletal disorganization and synaptic dystrophy. Therefore, we aim to determine the serum levels of neurodegenerative molecules such as α-synuclein and tau in children with ADHD. The study group consisted of 25 children, aged 6–10, diagnosed with ADHD according to DSM-IV criteria and who appeared at Dicle University, Faculty of Medicine, and Department of Child Psychiatry in Diyarbak?r, Turkey. 25 children, having no psychiatric disorders and medical illnesses, were selected as healthy control group. Serum α-synuclein and tau concentrations were determined by Enzyme-Linked Immuno Sorbent Assay. The α-synuclein levels of ADHD were not significantly different than those of controls. The tau levels of ADHD were found to be statistically significantly higher than those of controls. Moreover, α-synuclein levels showed a statistically significantly positive correlation with tau levels in children with ADHD. The results of our preliminary study can suggest that ADHD might possibly share a common disease mechanism with other diseases in terms of tau pathology. Increased serum tau level may be an indication of disturbance of microtubule transportation in the brains of children with ADHD. 相似文献
16.
Kiran Chaudhari S. Khanzode S. Khanzode G. Dakhale A. Saoji S. Sarode 《Indian journal of clinical biochemistry : IJCB》2010,25(1):77-81
Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective
Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined.
This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale
for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects
before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly
diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more
significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant
and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= −0.864,
P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid
and improves Hamilton Rating Scale for Depression score in major depressive disorder. 相似文献
17.
H. R. Mali M. L. B. Bhatt M. P. Singh S. M. Natu J. P. Gupta 《Indian journal of clinical biochemistry : IJCB》1996,11(1):56-58
Serum sialic acid levels were determined in 66 patients of carcinoma cervix and 25 control women matched for age. Mean sialic acid level was significantly elevated (p<0.001) in cancer cervix patients as compared to controls. Patients were treated with 50–65 Gy of radiation in 5–6.5 weeks. Post-therapy levels were again determined. Radiotherapy caused decline in serum sialic acid level in all the patients except one. Mean post-therapy level was significantly lower as compared to pretreatment level (p<0.001). It was also observed that fall in sialic acid level was significantly higher (p<0.05) in early stage patients as compared to late stage. No relationship was observed in the dose of radiation and fall in serum sialic acid level. A significantly higher fall in serum sialic acid level was observed in patients having complete clinical response as compared to partial or nonresponders to radiation treatment (p<0.001). 相似文献
18.
Srinivasa Nageswara Rao G Prema G Priya G Arumugam SB Kirthivasan V Saibabu R Cherian KM 《Indian journal of clinical biochemistry : IJCB》2011,26(1):22-27
There is a rising trend in the prevalence of insulin resistance among obese, overweight children and adolescents. The serum
insulin and its correlation with biochemical, clinical and anthropometric parameters were evaluated in 185 children and adolescents
(59 control, 52 obese, 49 overweight, 25 congenital heart disease) of age group 10–17 years. The levels of serum insulin were
measured by ELISA. Serum insulin levels were found to be significantly increased in children who were obese, overweight and
had congenital heart disease, than controls. Serum insulin levels positively correlated with BMI, WHR, and serum C-peptide,
serum leptin, total cholesterol, triglycerides, LDL-cholesterol, systolic and diastolic blood pressure. Fasting glucose levels
were found to be negatively correlated with serum insulin levels. HDL-cholesterol levels were non-significant among the study
groups. We identified nine obese children (five girls and four boys) with the features of metabolic syndrome and 69% of obese
and overweight children were identified with insulin resistance. Insulin resistance was strongly associated with metabolic
syndrome and its components, especially with central obesity and hypertriglyceridemia. 相似文献
19.
The purpose of this study was to evaluate the relationship between the physicochemical properties of saliva such as flow rate,
pH, buffering capacity, calcium level, total protein and total antioxidant levels in caries free and caries active children.
The present study included one hundred and twenty healthy children who were divided into two groups; group I and group II
comprising of age groups 7–10 and 11–14 years, respectively. Both the groups were then sub-divided equally according to gender.
They were further divided into caries free and caries active with 15 children in each group. Unstimulated saliva was collected
by suction method and flow rates were determined. The samples were then analyzed for pH, buffering capacity, total protein,
calcium and total antioxidant capacity. The data was statistically analyzed using student t test (unpaired). The results revealed that when all these parameters were compared among the caries free and caries active
children, flow rate, pH, buffering capacity were slightly reduced in caries active children, but total protein and total antioxidant
capacity of saliva increased significantly in caries active children and the total calcium decreased significantly in caries
active children. Within the limitation of this study, we conclude that, the physicochemical properties of saliva play a major
role in the development of caries. 相似文献
20.
G. N. Raval L. J. Parekh D. D. Patel F. P. Jha R. N. Sainger P. S. Patel 《Indian journal of clinical biochemistry : IJCB》2004,19(2):60-71
Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates
and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with
benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four
follow-up samples of 225 breast carcinoma patients were also evaluated. The association of sialic acid forms, sialyltransferase
and α-2–6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studied. Serum sialic
acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared
to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the
markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis
were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent
of malignant disease was observed. The changes in serum proteins with terminal α-2–6 sialic acid correlated well with alterations
in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase
as compared to surrounding normal tissues.
The results suggested potential utility of these markers in evaluation of clinical outcome. 相似文献