A New Anticancer Drug

After some six years of hard work, a research team headed by Prof. Liu Zhivu (Z.Y. Liu) at the Shanghai Institute of Organic Chemistry, CAS, has scored major progress in independently generating a novel cancer killer called epothilone. Their findings have been granted three patents, and their research paper Total Synthesis of Epothilone: A Thorough Stereospecific Expoxidation of the 3-0-(4-methoxy) Benzyl Ether of Epothilone C has been accepted for publication in the Chemistry - European Journal.     

New Origin for Coronary Vessels Revealed

Neonatal heart:Largely,postnatal coronary vessels might not have expanded from preexisting embryonic vasculature as formerly believed–see what CAS biologists revealed in page 311.     

Engineering Platelets for Combined Anticancer Therapy

正Tumor targeting and intratumoral penetration are long-standing issues for cancer therapeutics.In a recent study published inScience Advanceson March 26,researchers from the CAS Institute of Process Engineering (IPE) and the University of Chinese Academy of Sciences (UCAS) have developed a new platelet-based formulation which demonstrated potent therapeutic effects against cancer in murine models.     

The Missing Link Revealed in Ginkgo Evolution

Ginkgo, or the maidenhairtree, is considered a livingfossil, as it was found tohave existed early in the Jurassicperiod about 170 million years ago.However, a more than 100 million-year gap in the fossil record sincethe Jurassic period has hindereda full understanding of itsevolution.Recently Zhou Zhiyan, a CASmember with the CAS Nanjing In-stitute of Geology and Paleontology,and Zheng Shaolin, a researcherfrom Shenyang Institute of Geologyand Mineral Resources under theMinistry of La…     

Antioxidant and Anticancer Activities of Selected Persian Gulf Algae

In the present study, the effect of red (Gracillaria corticata), green (Ulva fasciata) and brown (Sargassum ilicifolium) seaweeds alcoholic extract, against five important human cancer cell lines (MCF-7, MDA-MB-231, HeLa, HepG2, and HT-29) proliferation, apoptosis and cell cycle arrest were evaluated. The reducing activity and total polyphenol content were also investigated. MTT assay was used for cytotoxicity test. Morphological alterations were examined using phase contrast, fluorescent and electron microscopy. All the extracts were antiproliferative against all the cancer cell lines, dose-dependently, with G. corticata methanol extract (GCME) having the greatest inhibition activity against MCF-7 cell line. The percentage of apoptosis increased from 18 to 78 %. The cell cycle analysis also showed that GCME can induce apoptosis which confirm by TEM. Algal extract reducing activities were as follows: G. corticata > S. ilicifolium > U. fasciata. The GCME is a good source of potential complementary and alternative functional food for prevention and treatment of cancer.     

Protein Dynamical Structure Revealed by Temperature-jump Time-resolved Infrared Spectroscopy

<正>Protein could carry out its biological function only when it is folded into the right conformation,and the conformation might be changing during the activation process,therefore protein dynamical structure provides a key clue to understand its function.Although many protein static structures have been resolved by X-ray crystallography,2D NM and cryoelectron microscope at atomic level,the static structure could be different from the dynamical structure,especially under physiological condition.In their continuous effort to study the protein dynamical structure with temperature-jump time-resolved infrared spectroscopy(Biophys.J.2007,93,2756–2766;Biophys.J.2009,97,2756–2766),a team lead by Prof.WENG Yuxiang from the Institute of Physics(IOP),Chinese Academy of Sciences recently collaborated with Prof.CHANG Zengyi’s     

Fresh Clues about the Origin of Mammalian Middle Ear Revealed

CAS paleontologists have identified a rod-like bone from two early Cretaceous mammals as ossified Meckel's cartilage (OMC). This clears some doubts on the controversial topic of the origin of definitive mannalian middle ear (DMME).     

MST4 Revealed a Molecular Brake to Prevent Overactive Inflammatory Responses

<正>Innate immunity is the frontline of defense against pathogens.Upon detection of pathogen-associated molecular patterns,Toll-like receptors(TLRs)will initiate innate immune responses,like inflammation,via activating the adaptor molecule TRAF6 to remove pathogens.However,excessive or prolonged inflammatory responses can cause severe host damage or even death;meanwhile chronic inflammation could lead to the     

Crustal Flows beneath the Eastern Tibetan Plateau Revealed by Magnetotelluric Observations

The ongoing collision of the Indian and Asian continents has created the Himalayan and Tibetan plateau through a range of deformation processes that include crustal thickening, delamination, lateral extrusion and crustal flow. A debate continues as to which of these processes are most significant in terms of the overall mass balance of this continent-continent collision. In eastern Tibet GPS data show large-scale motion of the     

SPOP Protein Revealed to Play a Key Role in Kidney Tumorigenesis

<正>The shortage of oxygen,termed as hypoxia,plays critical roles in many cancers.So far,however,very limited is known about the mechanism of hypoxia stress on the tumorigenesis.Understanding the mechanism can help the clinical treatment to many tumors.Recently,LIU Jiang’s lab from the Beijing Institute of Genomics(BIG),CAS in collaboration with the University of Chicago,     

Self-incompatibility and Ubiquitination/26 Proteasome Pathway:A Sexual Link Revealed

Most flowering plants are bisexual with both male and female gametes on the same individual or flower. Selfpollination or inbreeding often leads to a gradual decline in genetic diversity, which can cause the whole species to die off during evolution.To prevent inbreeding, some plants have evolved self-incompatibility (SI) mechanisms to recognize and reject "self" pollen.     

从中英教师隐喻看中西教师角色的异同

教师隐喻体现了教师对其职责、教育的本质以及师生关系的理解.本文借助隐喻理论分析了中英教师隐喻所体现的教师角色和教育理念的异同,以及在不同教师隐喻指导下的教学模式的优缺点.通过对比分析,本文旨在加深教师对其角色的理解,从而为改善教学提供启发.     

浅析审计报告揭露出中国的"小财政部"现象

现行有预算和分配权资金的部门并没有真正地将资金明确落实到项目,从而出现了预留预算资金的问题。当前国家发改委、科技部、国防科工委等三个有预算分配权的部门,按经费性质审查部门预算建议数和下达预算控制权,但仍未改变这些部门的分配权限,这也就是所谓的“小财政部”现象。之所以存在这种现象,是中国经济发展的特点决定的。“小财政部”现象的存在,破坏了部门预算的完整性,与部门预算改革目标是背离的,同时也直接制约了编报部门预算的及时、完整和统一。未来政府应将这些部门目前拥有的预算分配权统一起来。     

浅谈我国企业员工有效的激励机制

在现代企业发展中,激励在人力资源管理中占有重要的位置.如何有效的发挥激励的有效性,提升员工的创造力,发挥他们的积极性,是人力资源管理的最高目标.     

基于抉择机制的新兴技术演化机理研究

新兴技术（ Emerging Technology , ET）具有创造新行业的潜能,并能对现有行业产生巨大影响,因而在国家自主创新战略中占有突出重要的地位。就新兴技术的形成与演化一般过程以及基于抉择机制的新兴技术的演化机理进行分析,为我国新兴技术的发展提供理论支撑。     

论对经营者的约束与激励

从现代企业制度的一个显著特征即经营权与所有权的分离进行分析,提出降低经营者道德风险的两条基本途径即约束机制与激励机制.     

创新活动发生的机制

为研究创新活动发生机制,在计划行为理论模型中引入环境变量,分析环境变量对个人创新行为主观规范、个人对创新行为控制的感知和个人创新行为态度的影响,并在此基础上构建创新意向三维空间,用于对不同个体的创新意向的静态分析。引入环境要素后,个体的创新意向会因为外力的不同发生位移导致创新活动的增加或减少,因而说明了个体创新活动的发生机制,解释了区域创新活动发展差异的现象并提出了提升创新意向的路径。     

Java多线程机制

由于在语言级提供了线程支持,Java语言中使用多线程要远比在C或C 中来得简单。本文主要从线程的基本概念出发,对线程的生命周期、管理调度以及线程同步等方面的问题进行了阐述。