The Timing of Prenatal Exposure to Maternal Cortisol and Psychosocial Stress Is Associated With Human Infant Cognitive Development

The consequences of prenatal maternal stress for development were examined in 125 full-term infants at 3, 6, and 12 months of age. Maternal cortisol and psychological state were evaluated 5 times during pregnancy. Exposure to elevated concentrations of cortisol early in gestation was associated with a slower rate of development over the 1st year and lower mental development scores at 12 months. Elevated levels of maternal cortisol late in gestation, however, were associated with accelerated cognitive development and higher scores at 12 months. Elevated levels of maternal pregnancy-specific anxiety early in pregnancy were independently associated with lower 12-month mental development scores. These data suggest that maternal cortisol and pregnancy-specific anxiety have programming influences on the developing fetus.     

Prenatal Alcohol Exposure and Infant Information Processing Ability

403 black, inner-city infants born to women recruited prenatally on the basis of their alcohol consumption during pregnancy were assessed on a battery focusing on information processing and complexity of play. Prenatal alcohol exposure was not related to visual recognition memory or cross-modal transfer of information but was associated with longer fixation duration, a measure indicative of slower, less efficient information processing; lower scores on elicited play; and longer periods of toy exploration, possibly also due to slower cognitive processing. The effects on processing speed and elicited play were dose-dependent and not attributable to maternal depression, parental intellectual stimulation, other prenatal drug exposure, or postpartum maternal drinking. The processing speed deficit is consistent with deficits in older children prenatally exposed to alcohol; the present study is the first to identify slower cognitive processing in infancy and in tasks not dependent on motoric proficiency.     

Developmental Change in Infant Cortisol and Behavioral Response to Inoculation

Child Development, 1994, 65 , 1491–1502. Infant cortisol and behavioral responses to receiving 1 versus 2 inoculations on 1 pediatric office visit were observed at 2 and 6 months of age. Cortisol level (pre- plus postinoculation level) decreased with age, whereas cortisol response (post- minus preinoculation level) did not vary with age when the data were aggregated over infants showing a pre- to postinoculation cortisol increase and those showing a decrease. Nonetheless, for those infants who showed a cortisol increase, cortisol level and response decreased with age. Infants quieted faster at the older age. There was a moderate relation between quieting behavior and cortisol response, at least for infants who showed a pre- to postinoculation cortisol increase. These findings indicate a developmental trend for a decline over age in adrenocortical reactivity to inoculation for infants showing a cortisol release following the perturbation. Results were comparable whether infants received 1 or 2 inoculations.     

Prenatal Risk and Infant Regulation: Indirect Pathways via Fetal Growth and Maternal Prenatal Stress and Anger

Pathways from maternal tobacco, marijuana, stress, and anger in pregnancy to infant reactivity and regulation (RR) at 9 months of infant age were examined in a low‐income, diverse sample beginning in the first trimester of pregnancy, with fetal growth and postnatal stress/anger as potential mediators, and infant sex as a moderator. Participants were 247 dyads (173 substance‐exposed infants). There were no direct effects of prenatal risk on RR and no moderation by sex. However, there were significant indirect effects on RR via poor fetal growth and higher postnatal anger. The study adds to the sparse literature on joint effects of tobacco and marijuana, and highlights the role of fetal growth and maternal anger as important pathways from prenatal risk to infant RR.     

Cortisol in Neonatal Mother's Milk Predicts Later Infant Social and Cognitive Functioning in Rhesus Monkeys

Milk provides not only the building blocks for somatic development but also the hormonal signals that contribute to the biopsychological organization of the infant. Among mammals, glucocorticoids (GCs) in mother's milk have been associated with infant temperament. This study extended prior work to investigate rhesus monkey (Macaca mulatta) mother–infant dyads (N = 34) from birth through 8 months postpartum. Regression analysis revealed that cortisol concentrations in milk during the neonatal period predicted impulsivity on a cognitive task, but not global social behaviors, months later. During this time period, sex‐differentiated social behavior emerged. For female infants, milk cortisol concentrations predicted total frequency of play. Collectively, these findings support and extend the “lactational programming” hypothesis on the impact of maternal‐origin hormones ingested via milk.     

Prenatal Alcohol Exposure,Child Externalizing Behavior,and Maternal Stress

Objective. This study examined linkages between prenatal exposure to alcohol, current maternal alcohol use, child externalizing behavior, and maternal stress in a sample of 4- to 6-year-old children and their mothers. Design. Questionnaires, interviews, and behavioral observations were used to assess study variables in 42 mother - child dyads. Results. Current maternal alcohol use did not relate to children's behavior problems. However, children with higher levels of prenatal exposure to alcohol exhibited more externalizing behavior. In turn, higher levels of child externalizing behavior were associated with increased maternal stress. An alternative model, in which maternal stress was assumed to relate to less supportive mother - child interactions and higher levels of current maternal alcohol consumption, which in turn were expected to relate to higher rates of child externalizing behavior, did not fit the data. Conclusions. The impact of prenatal alcohol exposure likely extends to caregivers. Interventions must focus not only on affected individuals but also on their families, who may experience significant stress in trying to care for such individuals.     

Cortisol Reactivity to Social Stress as a Mediator of Early Adversity on Risk and Adaptive Outcomes

Children chronically exposed to stress early in life are at increased risk for maladaptive outcomes, though the physiological mechanisms driving these effects are unknown. Cortisol reactivity was tested as a mediator of the relation between prenatal substance exposure and/or early adversity on adaptive and maladaptive outcomes. Data were drawn from a prospective longitudinal study of prenatal substance exposure (N = 860). Cortisol reactivity was assessed at age 11. Among African Americans, prenatal substance exposure exerted an indirect effect through early adversity and cortisol reactivity to predict externalizing behavior, delinquency, and a positive student–teacher relationship at age 11. Decreased cortisol reactivity was related to maladaptive outcomes, and increased cortisol reactivity predicted better executive functioning and a more positive student–teacher relationship.     

Prenatal and Postnatal Diagnosis of Infant Disability: Breaking the News to Mothers

The birth of an infant with a disability is often perceived as the loss of a “perfect” baby and is typically an unanticipated event for the mother and family. Mothers may experience self-blame for the disability; therefore, sensitive communication is crucial. A private setting is recommended, with a minimum of health-care professionals in attendance when the diagnosis is revealed. The perinatal educator can guide the mother through the early emotional phases of processing and accepting the new information by offering support and incorporating timely information and interventions. The perinatal educator can also inform and prepare other expectant couples in the childbirth class and encourage them to support the mother and father in celebrating the forthcoming birth. The objective of nursing care for a mother whose infant is newly diagnosed with a disability is to facilitate a positive outcome for her and to promote optimal infant bonding. In all communication and information, replacing the term “disabled infant” with “infant with a disability” is emphasized in order to recognize the infant first and the disability second.     

Infant Attachment Insecurity and Baseline Physiological Activity and Physiological Reactivity to Interpersonal Stress: A Meta-Analytic Review

This meta-analytic review (k = 5–10; N = 258–895) examined links between attachment insecurity and physiological activity at baseline and in response to interpersonal stress elicited by separation–reunion procedures in the early life course (1–5 years). Insecurity was trivially, nonsignificantly associated with baseline physiological activity (heart rate [HR]: g = −.06; respiratory sinus arrhythmia [RSA]: g = −.06; cortisol: g = .01) and nonsignificantly associated with physiological reactivity to separation from parents (HR: g = −.001; RSA: g = .24). However, insecurity was moderately associated with heightened RSA (g = .26) and cortisol (g = .27) reactivity upon reunion with parents. Findings provide insight into the biobehavioral organization of attachment, suggesting that early insecurity is associated with heightened physiological reactivity to interpersonal stress.     

Hurricane Sandy Exposure Alters the Development of Neural Reactivity to Negative Stimuli in Children

This study examined whether exposure to Hurricane Sandy‐related stressors altered children's brain response to emotional information. An average of 8 months (M_age = 9.19) before and 9 months after (M_age = 10.95) Hurricane Sandy, 77 children experiencing high (n = 37) and low (n = 40) levels of hurricane‐related stress exposure completed a task in which the late positive potential, a neural index of emotional reactivity, was measured in response to pleasant and unpleasant, compared to neutral, images. From pre‐ to post‐Hurricane Sandy, children with high stress exposure failed to show the same decrease in emotional reactivity to unpleasant versus neutral stimuli as those with low stress exposure. Results provide compelling evidence that exposure to natural disaster‐related stressors alters neural emotional reactivity to negatively valenced information.     

Associations Between First‐Time Expectant Women's Representations of Attachment and Their Physiological Reactivity to Infant Cry

Associations among 53 primiparous women's Adult Attachment Interview classifications (secure–autonomous vs. insecure–dismissing) and physiological and self‐reported responses to infant crying were explored. Heart rate, skin conductance levels, and respiratory sinus arrhythmia (RSA) were recorded continuously. In response to the cry, secure–autonomous women demonstrated RSA declines, consistent with approach‐oriented responses. Insecure–dismissing women displayed RSA and electrodermal increases, consistent with behavioral inhibition. Furthermore, insecure–dismissing women rated the cries as more aversive than secure–autonomous women. Nine months postpartum, secure–autonomous women, who prenatally manifested an approach‐oriented response to the unfamiliar cry stimulus, were observed as more sensitive when responding to their own distressed infant, whereas women classified prenatally as insecure–dismissing were observed as less sensitive with their own infants.     

Understanding Cortisol Reactivity across the Day at Child Care: The Potential Buffering Role of Secure Attachments to Caregivers

Full-day center-based child care has been repeatedly associated with rising cortisol across the child care day. This study addressed the potential buffering role of attachment to mothers and lead teachers in 110 preschoolers while at child care. Using multi-level modeling and controlling for a number of child, family, and child care factors, children with more secure attachments to teachers were more likely to show falling cortisol across the child care day. Attachment to mothers interacted with child care quality, with buffering effects found for children with secure attachments attending higher quality child care. Implications for early childhood educators are discussed.     

The Positive Impact of Early Intervention for Children With Developmental Delays,Gestational Cocaine Exposure,and Co-Occurring Risk Factors

This article examined transition rates of young children (n = 102) from an early intervention program at the Linda Ray Intervention Program (LRIP) who had documented developmental delays and co-occurring prenatal drug exposure often coupled with verified child maltreatment. Findings indicated that there was significant group improvement from entrance to exit across all six Battelle Domains at the p < .05 level. Also, children who were enrolled for a longer period of time saw significantly better adaptive, personal-social, communication, and Battelle total scale scores at the p < .05 level. Finally, data revealed that boys were 5 times more likely than girls to be transitioned to Part B services after exit from LRIP. A longitudinal study of a subgroup of these children indicated that LRIP children who were in grades K–3 needed fewer special education services in elementary school than they needed at age 36 months, indicating a further reduction in special education needs for these children.     

Cortisol response to embarrassment and shame

This study examined individual differences in 4-year-old children's (N = 60) expression of the self-conscious emotions of embarrassment and shame and their relation to differences in cortisol response to stress. Results indicated the presence of two different types of embarrassment--one that reflected negative evaluation of the self, and the other a nonevaluative type that reflected simply exposure of the self when the individual was the object of attention of others. Results also indicated a relation between a higher cortisol response to stress and the greater expression of the self-conscious emotions of evaluative embarrassment and shame that reflected negative self-evaluation.     

Stress Reactivity and Self-Recognition

This study examined longitudinally whether early differences in reactivity to stress are related to self-recognition at 18 months of age. Adrenocortical and behavioral to Stress responses to routine inoculation at 2, and 4 months and at 6 and 18 months were obtained. Previous finding indicated a development shift in adrenocortical functioning by 6 months of age that included the emergence of stable individual differences in cortisol response from this point in development. Self-recognition was related to greater cortisol response and less rapid quieting at 6 to 18 months, whereas 2- to 4-month cortisol and quieting response did not differentiate self-recognizers and non-self-recognizators. These findings indicate a role for temperament differences in facilitating the emergence of self-recognition.     

Infant and preschool reinforcement survey

An empirically developed infant and preschool reinforcement survey was completed by 35 parents and 21 children. Test-retest reliability coefficients were computed on these data after a one-week interval. The development of the survey, as well as its usefulness for school psychologists, is described.     

对氯苯甲酸的结构及化学反应性

经X射线衍射方法测定了对氯苯甲酸的晶体结构。并对其结构进行量子化学从头计算,探讨化合物的稳定性、分子轨道能量、原子净电荷布居规律以及一些前沿分子轨道的组成特征。阐明了对氯苯甲酸分子中两个官能团的相互作用及化学反应性。对构建结构引导性质的教学思想有积极指导作用。