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少年宫是青少年社会教育的主阵地,是学校教育的延伸和补充。在新时期,如何开发青少年的智力、促进素质教育的全面发展、提供学习表现的机会、丰富青少年课余校外生活,这就需要对其进行更准确的定位,探索建立更适合拉萨市少年宫管理的发展模式。 相似文献
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提出一种基于灰色关联的安全态势感知预测方法,利用改进的GM(1,N)理论建立了安全态势预测模型。通过校园网中对异常流量的收集,并将安全数据进行关联分析,实现对系统安全潜在的威胁进行预警提示。最后对该方法行了性能对比。 相似文献
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为保证重庆马桑溪长江大桥整治工程施工过程中的桥梁结构安全,对该桥整治施工全过程开展施工监控,对不同施工工况下的实桥进行了试验量测和仿真分析。有限元分析和实测结果表明:桥梁结构主梁位移和应力与斜拉索索力的实测结果与变化趋势均符合理论变化规律,且均控制在安全指标之内。桥面施工整治中的配重方案对主梁影响不明显,此后同类整治工程中可简化配重方案,即可一次施加配重或者验算通过后不施加配重。此外,同类工程可考虑将主梁线形作为主要监控指标,索力及应力作为辅助监控指标以指导施工。施工监控结果表明该整治工程的施工方案是切实可行的,可为今后国内外大跨径斜拉桥整治工程提供参考。 相似文献
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土耳其伊斯坦布尔的托普卡帕故宫博物馆历史上是奥斯曼土耳其帝国皇宫,现为土耳其国立博物馆,是世界珍藏中国古代瓷器最多者之一。其珍藏并展示的各类奥斯曼王朝珍品包括中国宋、元、明、清的各式瓷器10358件,堪称数量众多,门类齐全,对研究中国瓷器及了解中土两国文化交流的历史颇具参鉴意义。其馆藏中国瓷器主要为青瓷、青花瓷、单彩瓷和多彩瓷等,来源为贡品、礼品、战利品和外贸商品等。 相似文献
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SUN Jie 《Journal of Zhejiang University. Science. B》2005,6(12):1141-1147
Objective: Detecting the expression and mutation of human telomeric repeat binding factor (hTRF1) in 10 malignant hematopoietic cell line cells on the base of determining its genomic structure and its four pseudogenes to clarify if h TRF1 mutation is one of the factors of the activation oftelomerase. Methods: hTRF1cDNA sequences were obtained from GenBank, its genome structure and pseudogenes were forecasted by BLAST and other biology information programs and then testified by sequencing.Real-time RT-PCR was used to detect the expression ofhTRF1mRNA in 10 cell line cells, including myelogenous leukemia cell lines K562, HL-60, U-937, NB4, THP-1, HEL and Dami; lymphoblastic leukemia cell lines 6T-CEM, Jurkat and Raji. Telomerase activities of cells were detected by using telomeric repeat amplification (TRAP)-ELISA protocol. PCR and sequencing were used to detect mutation of each exon of h TRF1 in 10 cell line cells. Results: h TRF1 gene, mapped to 8q 13, was divided into 10 exons and spans 38.6 kb. Four processed pseudogenes of hTRF1 located on chromosome 13, 18, 21 and X respectively, was named as ψhTRF1-13, ψhTRF1-18, ψhTRF1-21 and ψhTRF1-X respectively. All cell line cells showed positive telomerase activity. The expression of hTRF1 was significantly lower in malignant hematopoietic cell lines cells (0.0338, 0.0108~0.0749) than in normal mononuclear cells (0.0493, 0.0369~0.128) (P=0.004). But no significant mutation was found in all exons of hTRF1 in 10 cell line cells. Four variants were found in part of intron 1,2 and 8 ofhTRF1. Their infection on gene function is unknown and needs further studies. Conclusion: hTRF1 mutation is probably not one of the main factors for telomerase activation in malignant hematopoietic disease. 相似文献
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系统集成项目的工程质量受人员、材料、机械、方法和环境等因素的影响。确保系统集成项目的工程质量要从做好勘察设计阶段质量管理,明确工程质量事故处理的基本要求和处罚标准等多方面着手。 相似文献