Do PON1-Q192R and PON1-L55M polymorphisms modify the effects of hypoxic training on paraoxonase and arylesterase activity?

Background:Low levels of antioxidant paraoxonase 1(PON 1) enzyme activity,PON1-Q192R polymorphism(a glutamine(Q) to arginine(R)substitution at position 192),PON1-L55M polymorphism(a leucine(L) to methionine(M) substitution at position 55),and oxidized low-density lipoprotein(oxLDL) are risk factors for coronary heart disease.Aerobic exercise improves PON1 activity,but the effects of hypoxic exercise are yet unclear.The aim of this study was to determine the effects of hypoxic underwater rugby tr...     

如何应对新冠肺炎疫情期间的失学问题?

为帮助因新冠肺炎疫情而停课的学生恢复学习能力,世界各国实施了各种助力学生"迎头赶上"的计划.这些计划对教育政策、出资和教学等方面提出了严峻的挑战.     

对一道三角形问题的探究

本文通过对一道三角形试题的分析,培养学生处理这类问题计算或证明的一般方法和策略;通过对不同解法的探究,培养他们的发散思维能力,让其对这类问题有更深入的理解,做到举一反三、触类旁通。     

东西部发展差距与加快西部大开发问题探讨

我国东西部地区发展存在着较大的差距,加快西部大开发是缩小这种发展差距、实现社会主义现代化的重大战略举措,加快西部大开发应解放思想、更新观念,解决基础设施建设等问题．走可持续发展道路。     

Nitrogen addition delays the emergence of an aridity-induced threshold for plant biomass

Crossing certain aridity thresholds in global drylands can lead to abrupt decays of ecosystem attributes such as plant productivity, potentially causing land degradation and desertification. It is largely unknown,however, whether these thresholds can be altered by other key global change drivers known to affect the water-use efficiency and productivity of vegetation, such as elevated CO₂ and nitrogen(N). Using >5000 empirical measurements of plant biomass, we showed that crossing a...     

YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths

N6-methyladenosine(m⁶A) is a critical regulator in the fate of RNA, but whether and how m⁶A executes its functions in different tissues remains largely obscure. Here we report downregulation of a crucial m⁶A reader, YTHDF2, leading to tissue-specific programmed cell deaths(PCDs) upon fluorene-9-bisphenol(BHPF) exposure. Currently, Bisphenol A(BPA) substitutes are widely used in plastic manufacturing.Interrogating eight common BPA substitutes, we detected BHPF in ...     

Response to McAvoy and Tudor-Locke on their commentary on our manuscript: "Association of accelerometer-derived step volume and intensity with hospitalizations and mortality in older adults:A prospective cohort study"

<正>Dear Editor,We have read with interest the commentary by McAvoy and Tudor-Locke¹ on our article entitled "Association of accelerometer-derived step volume and intensity with ho spitalizations and mortality in older adults:A prospective cohort study".² The authors expressed some concerns about our methodology used to define accelerometer-derived step intensity and the analytical approach applied in our study.