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31.
Objective: Our aim was to investigate clinical and laboratory characteristics of osteoarthritic patients who had amyloid deposition in their knee joints. Methods: Synovial membranes were obtained from 36 patients with knee osteoarthritis (OA) who underwent joint replacement surgery. From this sample, the diagnosis of amyloid was deter- mined by Congo red staining, which demonstrated apple-green birefringence under a polarized microscope. All syn- ovial membranes were immunohistochemically characterized for the expressions of amyloid immunoglobulin light chain (AL-K and AL-,k), serum amyloid-A (SAA), amyloidogenic transthyretin (ATTR), and amyloidogenic 152- microglobulin (A152M). Matrix-assisted laser desorption-ionizaton/time of flight mass spectrometry (MALDI-TOF MS) was used to analyze transthyretin (TTR) isoforms in the serum of each patient. Results: Nine cases (25%) were found to be amyloid-positive. Immunohistochemicaliy, eight cases (88.9%) had ATTR deposition, and one sample (11.1%) was shown to be AL-K-positive. MALDI-TOF MS identified that the TTR in the serum of the patients was unmodified wild-type TTR, TTR-Cys-S-S-Cys, and TTR-Cys-S-S-CysGly. The age at surgery and the disease duration were sig- nificantly higher in the ATTR-positive group than in the ATTR-negative group. Knee score and function score were significantly lower in the ATTR-positive group than in the ATTR-negative group. Conclusions: Amyloid deposition in synovial membranes of OA patients was found to be ATTR and AL-K. TTR in the serum of the patients was unmodified wild-type TTR together with two isoforms. The high age at surgery, long disease duration, and a deteriorated knee function were associated with ATTR amyloid deposition in the osteoarthritic knee joints.  相似文献   
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正【经典文本】菊痴凌鼎年菊花种类繁多,黄白红紫中,品种也不胜枚举。唯绿色菊花极为少见,而绿色品种中,绿荷花朵最大,绿意最浓,一向被认为是菊之上上品。大凡名贵品种都娇贵,绿荷也极难培植,只少数大公园才有此品种,其珍其贵显而易见。私人有绿荷品种的更不多见,但老菊头有。说起老菊头这个人,可算一怪——他一辈子单身独居,仿宋代名士林逋"梅妻鹤子",自谓"菊  相似文献   
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记忆语录 “我从一个很赏识我的老师那里借到了一本《钢铁是怎样炼成的》。晚上,母亲在灶前忙饭,一盏小油灯挂程门框上,被腾腾的烟雾缭绕着。我个头矮,只能站在门槛上就着如驻的灯光看书。我沉浸在档里,头发被灯火烧焦也不知道。保尔和冬妮娅…肮脏的烧锅炉小工与穿着水兵服的林务富的女儿…的迷人的初恋,  相似文献   
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正【经典文本】一双长丝袜[美]凯特·肖邦一天,年轻的索莫斯太太意外拥有了十五美元,这对她来说是一大笔钱。这笔钱把她破旧的零钱包塞得鼓鼓的,让她觉得无比珍贵,也想起自己好几年没有享受过了。如何利用这笔钱成了萦绕在她脑海中的问题。有那么一两天她看起来像梦游一般,其实她在专心致志地思考和计算。她不想仓促行事,以免事后后悔。夜深人静的时候,她清醒地躺在床上,在脑海里反复斟酌。在她看来,一个合适而明智的用钱计划愈见清晰。  相似文献   
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本探讨绝句诗的结构形式,思想艺术,表现手法和内容题材,为继承,发展绝句诗创作提供借鉴。  相似文献   
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Computer integrated manufacturing system ( CIMS ) has received much attention in many industrialized countries. Shanghai Delphi Automobile Air Condition System Co., Ltd. (SDAAC), which is one of the large-scale key joint-venture enterprises engaged in developing, designing and manufacturing automobile air condition system in China, was selected for implementing 863/CIMS in 1998. The experience and lessons of the developing and implementing CIMS in the last 10 years have told us that SDAAC-CIMS is not meraly a technology exercise but an “organization revolution”. There are often much difficulties in implementing SDAAC-CIMS simply on the traditional business system. So the contents of the SDAAC-CIMS implementation is not only technical integration but also integration of people/organization, business processes and technologies. Therefore, several critical issues that must be carefully considered to ensure successful implementation of SDAAC-CIMS include commitment of the top management, reengineering of the existing processes in order to construct dynamic stable structures for aligning the SDAAC to the chaotic environment, and integration platform of information for coping with continuously changing circumstance. Supported by the Foundation of National High-Technology Research and Development Program (863-511-810-031)  相似文献   
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Great attention has been paid to cofacial porphyrins due to their many unique advantages over their monomeric analogs.However,their synthesis is usually complicated.In this work,a facile impregnation method for preparing heterogenized,cofacially stacked porphyrins is proposed.An anionic porphyrin is introduced as an underlayer for immobilization of cationic cobalt porphyrin via electrostatic force.The metal center of the underlying molecule contributes to the electronic structure of the upper ca...  相似文献   
40.
我国体育成人高等教育的现状与发展研究   总被引:6,自引:0,他引:6  
分析了我国体育成人高等教育的发展现状及影响因素,提出了发展对策:提高认识,准确定位,合理设置专业;加强政策引导,建立体育成人高等教育制度;加强横向合作,科学设立函授站;充分利用现代信息技术,拓展成人教育的时间和空间;加强科学研究与教材建设工作;改革和完善体育成人教育的考试制度;健全监控机制;提高管理人员和教师的素质。  相似文献   
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