快速制造与生物医学的交叉学科--仿生制造

This paper begins with a discussion of the emergence and applications of rapid manufacturing techniques, leading to the introduction of biomanufacturing: an interdisciplinary subject between rapid manufacturing and biomedicine. Fundamental knowledge of biomanufacturing is addressed, theories and topics related to biomanufacturing discussed, and methods of modeling in biomanufacturing described. Finally the present state of research and the application prospects of biomanufacturing are presented.     

结合生物3D 打印和静电纺丝制备复合生物可吸收血管支架用于血管狭窄治疗

设计一种新型血管支架用于血管狭窄治疗。针对目前制备生物可吸收血管支架（BVS）在装备和技术上的不足,提出了结合生物3D 打印和静电纺丝制备复合生物可吸收血管支架（CBVS）的新方法。首先,用 PPDO材料通过3D 打印制备支架内层;然后,配制壳聚糖和 PVA 混合溶液,通过静电纺丝制备支架外层。力学性能测试显示,结合3D 打印和静电纺丝制备的支架要好于仅采用3D 打印制备的支架。在支架上种植细胞试验表明,细胞在支架上有良好的粘附和增殖,因为外层含有天然生物材料壳聚糖。所提出的复合成形工艺和方法,为后续构建可控携载药物支架提供了很好的思路。该 CBVS 可用于血管狭窄治疗。