A single-domain protein catenane of dihydrofolate reductase

A single-domain protein catenane refers to two mechanically interlocked polypeptide rings that fold synergistically into a compact and integrated structure, which is extremely rare in nature. Here, we report a single-domain protein catenane of dihydrofolate reductase(cat-DHFR). This design was achieved by rewiring the connectivity between secondary motifs to introduce artificial entanglement and synthesis was readily accomplished through a series of programmed and streamlined post-translational ...     

How does Mei-yu precipitation respond to climate change?

Mei-yu is an important weather phenomenon in the middle-lower Yangtze River valley(YRV) region.This study investigates the changes in the characteristics of Mei-yu under global warming and the potential reasons based on observation and reanalysis data during 1961–2022. Notable increasing long-term trends are detected in the number of days without rainfall(NDWOR), the intensity of rainfall events, and the frequency and intensity of extreme precipitation events(EPEs) in the YRV region during the M...     

Two-dimensional semiconductors integrated with hybrid dielectrics for post-Moore electronics

<正>As the basic building blocks of modern electronics, field-effect transistors (FETs)use gate electrodes to control the conductivity of channel materials through the electrical polarization of dielectrics[1]. The performance of FETs relies not only on the channel materials and their contacts with the electrodes, but also on the dielectrics and their interfaces with the channel materials [1,2].     

The associated evolution of raptorial foreleg and mantispid diversification during 200 million years

<正>Adaptive evolution of predatory structure grants carnivores selective advantages[1], which evokes questions regarding the mechanism of functional adaptation via morphological variation and their potential impact on lineage diversification. Raptorial foreleg, as a key predatory structure in insects, is typically characterized by elongate coxae and stout femora possessing spines, and has evolved independently in many lineages [2].     

Oroclines in the Central Asian Orogenic Belt

<正>The term ’orocline’ was first proposed by Carey [1] to describe the structure as ’an orogenic system which has been flexed in plane to a horse-shoe or elbow shape’;it usually emphasizes that a previous straight mountain belt or tectonic units have been bended horizontally.Nowadays the orocline has been used to describe any curved mountain belt regardless of its original shape [2].     

Biocompatible zinc battery with programmable electro-cross-linked electrolyte

Aqueous zinc batteries(ZBs) attract increasing attention for potential applications in modern wearable and implantable devices due to their safety and stability.However,challenges associated with biosafety designs and the intrinsic electrochemistry of ZBs emerge when moving to practice,especially for biomedical devices.Here,we propose a green and programmable electro-cross-linking strategy to in situ prepare a multi-layer hierarchical Zn-alginate polymer electrolyte(Zn-Alg) via the superionic bi...     

High-efficiency nonlocal reflection-type vortex beam generation based on bound states in the continuumOA

Momentum-space polarization vortices centered at symmetry-protected bound states in the continuum of a periodic structure,e.g.photonic crystal slab,provide a novel nonlocal approach to generate vortex beams.This approach enjoys a great convenience of no precise alignment requirements,although the generation efficiency of the nonlocal generators requires further optimization before the practical application.In this work,we propose a temporal-coupled-mode-theory-based guideline for high-efficiency...     

Unraveling the electrophilic oxygen-mediated mechanism for alcohol electrooxidation on NiOOA

Aqueous organic electrosynthesis such as nucleophile oxidation reaction(NOR) is an economical and green approach.However,its development has been hindered by the inadequate understanding of the synergy between the electrochemical and non-electrochemical steps.In this study,we unravel the NOR me chanism for the primary alcohol/vicinal diol electro oxidation on NiO.Thereinto,the ele ctrochemical step is the generation of Ni³⁺-(OH)_ads,and the spontaneous reaction between Ni     

APPLICATION OF FUNCTIONAL-LINK NET AND NOVEL MOLECULAR DISTANCE-EDGE VECTOR (λ) TO THE PREDICTION OF THE RETENTION INDEX OF GAS CHROMATOGRAPHY

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