A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

Neuroimmune connections have been revealed to play a central role in neurodegenerative diseases(NDs).However, the mechanisms that link the central nervous system(CNS) and peripheral immune cells are still mostly unknown. We recently found that specific ablation of the Arf1 gene in hindbrain and spinal cord neurons promoted NDs through activating the NLRP3 inflammasome in microglia via peroxided lipids and adenosine triphosphate(ATP) releasing. Here, we demonstrate that IL-1β with elevated chemok...     

Glacial expansion of cold-tolerant species in low latitudes: megafossil evidence and species distribution modellingOA

<正>The Pleistocene was a time of repeated glaciations that severely affected the land biota over large areas of Eurasia and North America. Drastic climatic fluctuations during the Pleistocene drove largescale extinctions, migrations and diversification in plant and animal populations.These dramatic processes had a strong impact on the distribution of modern flora and fauna.     

Composites with high omnidirectional fracture toughness due to helical interlocking fasteners are found in gingko seed shellsOA

<正>Engineering of composites mimicking load-bearing materials from living organisms is essential for sustainable economic development and successful resolution of current and future bottle-necks of chemical,automotive,aviation,biomedical,and robotic technologies.As pointed out by G.Wiedemann[1]in 1853 and M.F.Ashby et al.     

‘灿烂’品种兔眼蓝莓花青素提取物在体内的抗氧化活性（英文）

蓝莓富含花青素等酚类化合物,具有良好的保健功能。本研究旨在研究从‘灿烂’品种兔眼蓝莓中提取的蓝莓花青素在小鼠体内的抗氧化活性。C57BL/6J健康雄性小鼠被分成不同剂量组,各组蓝莓花青素提取物（BAE）浓度分别为100、400和800 mg/kg。在不同时间点（0.1、0.5、1、2、4、8和12 h）将小鼠处死,收集其血浆、眼球、肠、肝和脂肪组织,比较其抗氧化活性,测定指标包括总抗氧化能力（T-AOC）、超氧化物歧化酶（SOD）活性、谷胱甘肽过氧化物酶（GSH-PX/GPX）含量,以及氧化应激标志物丙二醛（MDA）水平。结果表明：蓝莓花青素在小鼠体内具有良好的抗氧化活性,并呈浓度依赖性,BAE浓度越高,T-AOC值越高,MDA水平越低。抗氧化酶SOD活性、GSH-PX含量以及Cu,Zn-SOD、Mn-SOD和GPX的m RNA水平均证实,BAE在小鼠消化后通过改善其抗氧化防御系统发挥抗氧化作用。蓝莓花青素提取物的体内抗氧化活性表明,蓝莓花青素可以被开发成功能性食品或营养配料,用于预防或治疗氧化应激相关的疾病。     

超超临界机组机炉协调系统的min-max模糊模型预测跟踪控制

为了提高非线性超超临界火电机组的控制性能,提出了一种改进的min-max模糊模型预测跟踪控制.首先,建立了 T-S模糊模型来近似非线性机炉协调系统的动态特性.然后,基于包含状态变量和输出变量的扩展模糊模型,在保证闭环系统稳定性和输入在给定约束的同时,推导了 min-max模糊模型预测跟踪控制用于输出调节.为了获得更大的...     

Association of daily sitting time and leisure-time physical activity with body fat among U.S. adults

Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged ...     

Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

Background:Achilles tendinopathy(AT) is a common problem among runners.There is only limited evidence for risk factors for AT,and most studies have not defined the AT subcategories.No study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered distinct.This study aimed to assess incidence and risk factors of AT based on data from a large prospective cohort.The secondary aim was to explore differences in risk factors between insertional an...     

五位拳坛巨星的拳击哲学

拳击是一项很特别的运动。一方面,任何人都可以学习拳击。另一方面,只有极少数的人才能达到卓越的水平。立志要成为冠军的人,为了寻求技术上的提高,会日复一日在训练馆里挥汗如雨,同一个动作重复成千上万次,直到达到完美。从这个角度上来说,拳击能够帮你探测身体和意志上的极限。纵观拳击的历史,有许多已经到达巅峰的传奇人物。     

我在马来西亚看到的羽毛球

这里是马来西亚紫色联盟最著名的俱乐部——八打灵羽毛球娱乐部,日本队首次拿到汤姆斯杯的功臣田児贤一退役后,也加盟到这里,做教练兼球员。我也不知道他吃了什么,居然胖成这样,人很nice,只是他一口马来口音的英语让我有点儿猝不及防。俱乐部楼道墙上挂起来的比赛服见证了俱乐部的发展,如果说都认识,这一定是暴露年龄的行为了。     

商品个性标志的定义及其在美国流行文化中的角色

在过去的一个多世纪,商品的个性标志一直是美国人钟爱的广告工具。各种各样被广告商作为传播体系的＂会说话的动物＂和＂会跳舞的产品＂已悄无声息地蔓延在美国的流行文化中。1982年,有人在做调查后发现,凡是商品特征明显的广告,在改变品牌偏好的能力上要比同行业其他品牌强。这一点表明社会正在接收商品个性标志这样的讯息。然而,尽管商品个性标志的运用在广告商和消费者中大受欢迎,却几乎被完全遗忘在广告和流行文化研究的角落。本文将从相关文学的角度解析什么是商品个性标志,以及其如何运用在现代广告业中,并与消费者进行交流。