用鸡胚心脏进行器官培养的实验

本文所述的实验是想告诉学生怎样用器官培养来研究发育问题,而此实验只需将目前许多普遍生物实验课中都进行的活鸡胚一般观察的实验,加以延伸即可。先让学生观察制作孵化48小时鸡胚标本的全过程,使他们熟悉鸡胚的介剖:要他们特别注意静脉窦、心房、心室和主动脉弓的位置。接下来发给学生一个生活了55—72小时的鸡胚,按照实验指导(许多实验手册中的指导是适用的,如Evert. Saigo,和Eichhorn 1979 Eberhard,Arms,和Camp 1927),把鸡胚     

计划之外有惊喜

正有计划、有目标、有希望、有梦想固然是有益的,但也还是要敞开心扉、不带偏见的接受新变化。"太好了!"亚娜一边说一边打开清单,看萨姆说的项目是否在她的清单上。萨姆打开电脑:"你想当哪只蝙蝠?""哪只蝙蝠?"亚娜机械地重复了一遍,一时没有弄清楚他的意思。"我刚弄到最新的一款电脑游戏,名叫《蝙蝠的冒险》。"萨姆解释道,"蝙蝠是最酷的小动物。虽然说游戏里有大量的动作和     

A parametric study on the contact stress of half toroidal continuously variable transmission

1. Introduction A toroidal continuously variable transmission (CVT) that uses a traction drive to transmit torque has a vastly larger torque capacity than a conventional CVT. This transmission technology has attracted considerable interest owing to its capability in substantially improving vehicle fuel economy and power performance [1]. The half toroidal CVT transmits torque by means of shear resistance of the traction fluid film taking advantage of the property of the fluid solidificatio…     

生命是什么？——活细胞的物理学观

这是一位物理学家（很大程度上是从物理学的角度）对生物学的思考.如作者所言,这样的综合是有风险的,但在学科越来越专门化的今天,必须要有人冒着风险,来把已知的知识综合成为一个统一体.事实上,薛定谔深远的洞见与天才的预测,曾促使许多富有创造力的头脑被遗传机制和生命本质的奥秘所吸引,从而投身其中,J.沃森和F.克里克对生物学研究最初的兴趣很大程度上都是来自这本小册子.作为物理学家的薛定谔,是二十世下半叶这场轰轰烈烈、充满浪漫色彩的分子生物学革命的先驱.     

关于气候分析在建筑设计策略中的思考

由于气候条件不同,我国的传统建筑,南北差异很大。传统建筑不但体现着气候的特点,也将地方特色体现了出来。本文主要分析了在建筑设计中气候和地域的影响,并对地域在现代建筑设计中的体现进行了研究,希望能够帮助设计师更好的进行建筑设计,推动我国建筑行业的发展。     

教育工作者及其报酬： 政策、实施与系统协调问题（上）

本文从管理学和政策学的视角,探讨了公立学校教师薪酬改革的问题.文章在回溯了教师薪酬制度历史沿革的基础上,分析了当前教师薪酬体制的结构及其对个人和组织层面的消极后果.作者认为,绩效工资改革是增强学校效能、促进学生成绩提高的有效途径;改革的未来取决于一系列多变因素之间的复杂互动,而系统的整合与协调是确保绩效工资计划有效并持久推进的关键.     

细胞遗传工程:植物育种的一项新技术吗?

有一项道传工程的新技术,它不象重组DNA技术那样被广为宣传,那就是通过无性细胞融合来转移遗传物质。采用这一有前途的方法交换整块基因,不必象在重组DNA技术中那样需事先进行鉴定和分离。今后几年内,这类方法可使基因块(geneblock)从一物种转侈到另一物种成为可能,例如可以把杂草的抗除草剂抗性赋予农作物。     

Mystery unraveled about antifungal drug targets

A long-standing mystery about the functional roles of the N-terminal region of protein N-myristoyltransferase, an ideal target for antifungal drugs, was recently decoded, thanks to the threeyear joint efforts of researchers from the CAS Key Laboratory of Molecular Biology and their US colleagues at the DuPont Stine Haskell Research Center.     

Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population简

Objective

A study in a Caucasian population has identified two single-nucleotide polymorphisms (SNPs) in ZNF533, one in DOCK4, and two in IMMP2L, which were all significantly associated with autism. They are located in AUTS1 and AUTS5, which have been identified as autism susceptibility loci in several genome-wide screens. The present study aimed to investigate whether ZNF533, DOCK4, and IMMP2L genes are also associated with autism in a northeastern Chinese Han population.

Methods

We performed a similar association study using families with three individuals (one autistic child and two unaffected parents). A family-based transmission disequilibrium test (TDT) was used to analyze the results.

Results

There were significant associations between autism and the two SNPs of ZNF533 gene (rs11885327: χ ²=4.5200, P=0.0335; rs1964081: χ ²=4.2610, P=0.0390) and the SNP of DOCK4 gene (rs2217262: χ ²=5.3430, P=0.0208).

Conclusions

Our data suggest that ZNF533 and DOCK4 genes are linked to a predisposition to autism in the northeastern Chinese Han population.