Effect of methyl mercury induced free radical stress on nucleic acids and protein: Implications on cognitive and motor functions

Mercury pollution and acute neurotoxicity of mercury is well known. The recent reports suggest the adverse effect of low dose mercury, though the available literature is still silent on its mechanism. This study was therefore undertaken to probe the effect of low dose methyl mercury induced heavy metal toxicity on free radical stress and its impact on behaviour of male albino rats. Male albino rats were exposed to 1 mg/kg body wt of methylmercury chloride for seven days, on day 8 they were tested for motor and memory functions. They were sacrificed later for biochemical estimations for rate of lipid peroxidation, nucleic acids, proteins in cerebrum, cerebellum and brain stem. There was an increase in the rate of lipid peroxidation showing methyl mercury induced free radical stress. The motor and memory functions demonstrated a clear decline, besides there was a lowering in the levels of nucleic acids and proteins as compared to controls. The results are important in view of recent reports that methyl mercury induced free radical stress results in early ageing and may serve as an initiating factor more specifically for neurodegenerative disorders like Alzeihemer's disease and dementias. The current findings support the notion that incorporating dietary antioxidants like curcumin, ascorbic acid and α-tocopherol in routine diet from early age may help combat the risk of developing such disorders in ensuing years.     

Physicochemical characteristics of various milk samples available in Pakistan

We report physicochemical characteristics of various kinds of liquid milk commercially available in Pakistan in comparison with those of fresh natural milk from animals. Milk samples were collected from local markets at Peshawar, Pakistan,and analyzed for their physical features, including moisture, total solids, specific gravity, conductivity, viscosity and titratable acidity (lactic acid equivalent), and chemical components and macro-minerals, including total protein, casein, lactose, ash and minerals (Na, K and Mg). These items were compared with the physicochemical characteristics of the fresh natural milk samples from buffalo, cow and goat. The results were also compared with reported nutritional quality of milk from various countries and World Health Organization (WHO) standards. We found that all the physical features and chemical components of commercially available milk in Pakistan markets meet WHO's requirements, except for Na, K, Ca and Mg, which are below the standards.     

Dialogue in the support of learning to teach: a case study of a mentor/mentee pair in a teacher education programme

In this paper, we examine the role of reflection in teacher preparation, specifically within a mentoring relationship between cooperating and preservice teacher. We report findings from a case analysis of this pair who engaged in problem-posing dialogue within pre- and post-conferences around practice over one year of their work together in an elementary-level classroom. The context is an innovative programme in which cooperating teachers pursue their Master’s degree while undergraduates (preservice teachers) complete their elementary education degrees. Our analysis of talk about teaching during six coaching cycles as well as supporting documents illustrates how Jane’s mentoring supported reflective practices and disrupted a notion of a field experience as simply a place to ‘practice’ pedagogical knowledge with corrective feedback. Additionally, we explore the tensions in this approach to mentoring. This case study has implications for teacher educators who seek to bolster teacher preparation through the support of mentoring relationships.     

开放灵活的分布式学习环境

为了帮助设计者创建开放、灵活的分布式E-Learning环境,该文提出了一个E-Learning框架模型,从八个维度列出了E-Learning设计中需要考虑的关键问题:机构,教学,技术,界面设计,评价,管理,资源支持,伦理。     

Towards An Understanding of Muslim American Adolescent High School Experiences

The researchers conducted a grounded theory study to explore the experiences of Muslim American adolescents in high school. Findings indicate that students had to navigate unique challenges because of their religious faith, but those obstacles presented opportunities to confront bias and discrimination. Recommendations for how school counselors can support the development of Muslim American adolescents are presented.     

The spread of private tutoring in English in developing societies: exploring students’ perceptions

ABSTRACT

Although research on private tutoring has gained visibility in recent years, private tutoring in English (PT-E) has not received notable attention. This paper examines students’ perceptions of PT-E in Bangladesh in terms of its necessity and helpfulness, peer pressure in PT-E participation and ethicality of PT-E practice and government intervention. Our analysis of survey data (N?=?572) leads to characterising PT-E and explaining the reasons for its popularity. As a popular learning space beyond formal schooling, PT-E is available in various forms and quality catering to the purchasing power of different social groups. We argue that students may resort to PT-E not because of its proven effectiveness but because of their declining faith in school English teaching. The paper contributes to our understanding of the complex interactions between the curricular (school) and non-curricular (PT-E) settings and family socioeconomic resources in the teaching of English as a globally desired language.     

Control of switch-sharing-based multilevel inverter suitable for photovoltaic applications

Owing to the higher amount and the better quality of power transferred, three-phase multilevel inverters have strengthened their presence in low-power photovoltaic (PV) applications. However, the existing topologies investigated for low-power PV systems are basically meant for medium- and high-power applications, thus making them underutilized for low-power range. In order to address this shortcoming, this paper proposes a three-phase multilevel inverter with a switch-sharing capability and its control solution. It combines the characteristics of the two-level full-bridge topology and the diode-clamped multilevel structure. As a result, the inverter can be used with full capacity and without being underutilized, and significantly improves the output quality. A control strategy that is able to maximize the full potential of the inverter is developed. A digital proportional-integral (PI) controller with a new tuning algorithm is designed to effectively deal with the load changes. The result reveals that the load current is always retained at the intended quality level despite the variations in load. The performance of the inverter is validated from the experimental work conducted on a laboratory prototype under closed-loop conditions.     

Analysis and experimental investigation into a finite time current observer based adaptive backstepping control of buck converters

In this paper, the issue of output voltage regulation in buck type dc-dc converters is addressed using a current sensorless control technique. The proposed strategy integrates a finite time current observer with an adaptive backstepping control scheme to yield a cost-effective and robust control mechanism. The overall controller stability in the sense of Lyapunov is proved. Applicability of the proposed control is verified experimentally on a buck converter in the laboratory. The control scheme is implemented on dSPACE DS1103 platform based on DSP TM320F240 processor. To examine the efficacy of the proposed method, the buck converter is subjected to a wide change in input voltage, load resistance and reference voltage. For comparison purpose, a conventional adaptive backstepping control scheme is evaluated under identical conditions of experimental study to examine the merit of the proposed control. The results obtained reveal that the proposed control is prompt in rejecting perturbations and achieves a smooth, reliable and satisfactory output voltage regulation with faithful and time bound estimation of inductor current. Thereby, this investigation demonstrates the validity of the proposed control in maintaining a stringent output voltage regulation in buck converters.     

Probing the mechanical properties of brain cancer cells using a microfluidic cell squeezer device

Despite being invasive within surrounding brain tissues and the central nervous system, little is known about the mechanical properties of brain tumor cells in comparison with benign cells. Here, we present the first measurements of the peak pressure drop due to the passage of benign and cancerous brain cells through confined microchannels in a “microfluidic cell squeezer” device, as well as the elongation, speed, and entry time of the cells in confined channels. We find that cancerous and benign brain cells cannot be differentiated based on speeds or elongation. We have found that the entry time into a narrow constriction is a more sensitive indicator of the differences between malignant and healthy glial cells than pressure drops. Importantly, we also find that brain tumor cells take a longer time to squeeze through a constriction and migrate more slowly than benign cells in two dimensional wound healing assays. Based on these observations, we arrive at the surprising conclusion that the prevailing notion of extraneural cancer cells being more mechanically compliant than benign cells may not apply to brain cancer cells.