Evidence-based practice: extending the search to find material for the systematic review

BACKGROUND: Cochrane-style systematic reviews increasingly require the participation of librarians. Guidelines on the appropriate search strategy to use for systematic reviews have been proposed. However, research evidence supporting these recommendations is limited. OBJECTIVE: This study investigates the effectiveness of various systematic search methods used to uncover randomized controlled trials (RCTs) for systematic reviews. Effectiveness is defined as the proportion of relevant material uncovered for the systematic review using extended systematic review search methods. The following extended systematic search methods are evaluated: searching subject-specific or specialized databases (including trial registries), hand searching, scanning reference lists, and communicating personally. METHODS: Two systematic review projects were prospectively monitored regarding the method used to identify items as well as the type of items retrieved. The proportion of RCTs identified by each systematic search method was calculated. RESULTS: The extended systematic search methods uncovered 29.2% of all items retrieved for the systematic reviews. The search of specialized databases was the most effective method, followed by scanning of reference lists, communicating personally, and hand searching. Although the number of items identified through hand searching was small, these unique items would otherwise have been missed. CONCLUSIONS: Extended systematic search methods are effective tools for uncovering material for the systematic review. The quality of the items uncovered has yet to be assessed and will be key in evaluating the value of the systematic search methods.     

Bilateral arm power imbalance in swim bench exercise to exhaustion

We examined the supposition that swimmers may exhibit an imbalance in bilateral arm power output during simulated swimming exercise. Ten competitive front crawl swimmers (5 males, 5 females; age 20.5+/-2.3 years; height 1.74+/-0.09 m; body mass 72.0+/-16.7 kg; 400 m freestyle swim time 278+/-20.5 s; mean +/- s) performed four incremental (10 W x min(-1)) swim ramp tests on a computer-interfaced biokinetic swim bench ergometer. External power output from each arm was measured continuously to exhaustion. The results showed that, throughout the course of the simulated swim, external power output clearly favoured the left arm (F1,9 = 12.5, P= 0.006). This was especially evident in the final 30 s to exhaustion, when 54.0+/-3.87% of external power output was derived from the left arm versus 46.0+/-3.87% from the right arm. The disparity in external power output was further highlighted when the participants were grouped into unilateral and bilateral breathers. Unilateral breathers (n = 5) produced 57.1+/-2.62% of external power output from the left armversus 42.9+/-2.62% from the right arm (P= 0.001). Bilateral breathers (n = 5) exhibited a more balanced external power output of 51.0+/-1.82% from the left arm and 49.0+/-1.82% from the right arm (P = 0.177). Evidence of power imbalance in the simulated swimming stroke may have important implications for optimizing swim performance. The observed power imbalance may be reduced when a bilateral breathing technique is adopted.     

The influence of ventilatory control on heart rate variability in children

The aim of this study was to determine the influence of breathing frequency and tidal volume on resting heart rate variability in children aged 9 years (n = 29) and 16 years (n = 19). Heart rate variability was measured in four conditions: (1) without the control of ventilation followed at random by (2) a fixed breathing frequency of 12 breaths x min(-1), (3) a breathing frequency of 12 breaths x min(-1) but with a fixed tidal volume of 30% vital capacity and (4) a fixed breathing frequency of 6 breaths x min(-1) and a tidal volume of 30% vital capacity. A total of 128 RR intervals (the time between two spikes in the heart rate) were detected and absolute high- and low-frequency spectral components were calculated using autoregressive modelling. The younger children were unable to control ventilation to achieve conditions 3 and 4; therefore, a 2 x 2 (group x condition) analysis of variance was used to analyse conditions 1 and 2. There were significant interactions between group and heart rate variability conditions for the low-frequency component and the ratio of low to high frequencies (P < 0.001). The main effect for condition showed that at 12 breaths x min(-1) with no fixed tidal volume there was a significantly higher standard deviation of the RR interval, total power and high-frequency (P< 0.01) and low-frequency spectral components (P < 0.05) than in the condition with no ventilatory control. Across the four breathing conditions for the older participants, the high-frequency spectral component was significantly higher in the condition at 6 breaths x min(-1) with a fixed tidal volume than in that with no ventilatory control (P < 0.005); the ratio of high to low frequencies was significantly lower for the spontaneous condition than those performed at 12 breaths x min(-1) (P < 0.001). The results provide evidence of the need for ventilatory control when assessing short-term resting heart rate variability in children.     

Using focus groups to guide development of a public health Web site

This paper explores a project funded through the National Network of Libraries of Medicine to enhance effective use of the Internet by public health professionals. The processes and outcome of an effort to develop a statewide Web site for public health professionals are described. A series of focus groups was conducted as a preliminary data-gathering tool to evaluate the information needs of the target population. Results of the focus group provided a valuable framework upon which to build a successful schema for Web site development.     

A quiver full of arrows: recommended Web-based tutorials for PubMed,PowerPoint, Ovid MEDLINE,and FrontPage

Librarians often are responsible for instructing their patrons in the use of various databases and popular software packages. When this instruction can't be provided through face-to-face contact, Web-based tutorials can be useful tools to bridge the information gap. This article recommends Web-based tutorials for PubMed, Ovid MEDLINE, PowerPoint, and FrontPage.     

Generalized Hamming Distance

Many problems in information retrieval and related fields depend on a reliable measure of the distance or similarity between objects that, most frequently, are represented as vectors. This paper considers vectors of bits. Such data structures implement entities as diverse as bitmaps that indicate the occurrences of terms and bitstrings indicating the presence of edges in images. For such applications, a popular distance measure is the Hamming distance. The value of the Hamming distance for information retrieval applications is limited by the fact that it counts only exact matches, whereas in information retrieval, corresponding bits that are close by can still be considered to be almost identical. We define a Generalized Hamming distance that extends the Hamming concept to give partial credit for near misses, and suggest a dynamic programming algorithm that permits it to be computed efficiently. We envision many uses for such a measure. In this paper we define and prove some basic properties of the Generalized Hamming distance, and illustrate its use in the area of object recognition. We evaluate our implementation in a series of experiments, using autonomous robots to test the measure's effectiveness in relating similar bitstrings.     

The effect of exercise training on the kinetics of the antibody response to influenza vaccination

The significance of in vitro changes in immune function accompanying exercise training is unclear. To determine the effect of exercise on the response of the intact immune system to a challenge in vivo, we measured the speed and overall immunoglobulin G (IgG) response to influenza vaccination in humans engaged in different intensities of activity. Male participants (n = 21) were split into heavy and light training groups. Venous blood samples were collected 0, 2, 4, 7, 10 and 14 days after vaccination with trivalent influenza vaccine, and also 12 months after initial vaccination. Serum IgG was determined by enzyme-linked immunosorbant assay. There was a significant difference in baseline IgG between groups, but no difference in IgG concentration 14 days after vaccination. The IgG concentration remained elevated 12 months post-vaccination in the heavy training group. The results suggest a positive relationship between habitual physical activity and baseline antibody concentrations, which, in turn, affects the relative magnitude (fold or percentage increase) of the antibody response to vaccination. The training loads of the participants in this study had no effect on overall IgG measured 14 days after vaccination.