The antidyslipidemic activity of Ocimum sanctum leaf extract was studied in streptozotocin induced diabetic rats. In this model, there was significant increase in plasma markers of diabetic-dyslipidemia following diminution of lipid metabolizing enzymes. Oral administration of leaf extract (500 mg/kg b.w.p.o.) for 15 days resulted in significant decrease in diabetogenic and dyslipidemia parameters; namely blood glucose, glycosylated hemoglobin, lipid peroxide, free fatty acids, small dense low density lipoprotein, lipid and protein components of plasma lipoproteins, adipose and liver. The regulation of lipids was accompanied by stimulation of postheparin lipolytic activity, reactivation of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase enzymes. The results of the present study demonstrated antidyslipidemic and antioxidant activities in leaf extract of O. sanctum which could be used in prevention of diabetic-dyslipidemia and related complications. 相似文献
The purpose of this research was to investigate the perceptions of home and school concerning ideally implemented primary
democracy and human rights education. In this qualitative study, data were collected from six voluntary classroom teachers
and 16 parents in a selected school through interviews. The results of the interview yielded five major themes: physical and
environmental issues, instructional process, teacher characteristics, assessment practices, and communication patterns for
teaching democracy and human rights ideally. Most of the participants also indicated the lack of partnership between home
and school. The results showed that there are gaps between the existing and desired conditions of democracy and human rights
education in schools. 相似文献
We evaluated the effect of different syringe volume, needle size and sample volume on blood gas analysis in syringes washed with heparin.
Materials and methods:
In this multi-step experimental study, percent dilution ratios (PDRs) and final heparin concentrations (FHCs) were calculated by gravimetric method for determining the effect of syringe volume (1, 2, 5 and 10 mL), needle size (20, 21, 22, 25 and 26 G) and sample volume (0.5, 1, 2, 5 and 10 mL). The effect of different PDRs and FHCs on blood gas and electrolyte parameters were determined. The erroneous results from nonstandardized sampling were evaluated according to RiliBAK’s TEa.
Results:
The increase of PDRs and FHCs was associated with the decrease of syringe volume, the increase of needle size and the decrease of sample volume: from 2.0% and 100 IU/mL in 10 mL-syringe to 7.0% and 351 IU/mL in 1 mL-syringe; from 4.9% and 245 IU/mL in 26G to 7.6% and 380 IU/mL in 20 G with combined 1 mL syringe; from 2.0% and 100 IU/mL in full-filled sample to 34% and 1675 IU/mL in 0.5 mL suctioned sample into 10 mL-syringe. There was no statistical difference in pH; but the percent decreasing in pCO2, K+, iCa2+, iMg2+; the percent increasing in pO2 and Na+ were statistical significance compared to samples full-filled in syringes. The all changes in pH and pO2 were acceptable; but the changes in pCO2, Na+, K+ and iCa2+ were unacceptable according to TEa limits except fullfilled-syringes.
Conclusions:
The changes in PDRs and FHCs due nonstandardized sampling in syringe washed with liquid heparin give rise to erroneous test results for pCO2 and electrolytes. 相似文献
Cinnamon has been used as an anti-diabetic agent for centuries but only in recent few years its mechanism of action has been under investigation. Previous studies showed that cinnamon might exert its anti-diabetic effect via increasing glucose transporter isotype-4 (GLUT4) gene and glycoprotein contents in fat cells. To study if hydro-alcoholic cinnamon extract (HACE) enhances GLUT4 translocation from intracellular compartments of nuclear or endoplasmic reticulum membranes (N/ER) into the cytoplasmic membrane (CM). C2C12 myoblastic cell line were seeded in DMEM plus 20 % FBS and differentiated to myotubes using 2 % horse serum. After myotubes formation, 100 or 1,000 μg/ml HACE, as intervention, and as control 1 % DMSO were added for 3 h. Cells were washed and homogenized followed by ultracentrifuge fractionation, protein separation by SDS-PAGE and GLUT4 detection using semi-quantitative Western blotting. Data analysis was done by two-independent samples t test for comparison of mean ± SD of GLUT4 percent in categories. GLUT4 contents were higher in CM of groups 100 and 1,000 μg/ml HACE and lower in 1 % DMSO treated myotubes (CI = 0.95, P < 0.05). For N/ER reverse results were obtained (CI = 0.95, P < 0.05). As our results have shown HACE induces GLUT4 translocation from intra-cell into cell surface. We conclude that cinnamon maybe a choice of type-2 diabetes mellitus treatment because its extract enhances GLUT4 contents in CM where it facilitates glucose entrance into the cell. However it is necessary to trace the signaling pathways which are activated by HACE in muscular tissue. 相似文献
The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-α were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS. 相似文献
Contrary to the common belief of Arabic language users that the Arabic writing system has descenders as an inherent quality, some historical examples demonstrate that there were some artistic attempts to create non-descender, all-cap calligraphic systems, but they have never been studied as a phenomenon. This article draws attention to the existence of these examples, and analyses and classifies them according to their form.
The article begins with an analysis of the current Arabic writing system in terms of descenders, differentiating between artistic and functional writing, defining the need for harmonious balance in artistic writing, and demonstrating that descenders do disrupt the balance in Arabic writing, which could be considered as an ascender-system.
Then, historical examples of the non-descender system are introduced, categorised into four visual stages, and the descender handling for each stage is described; all-capital letter examples are then introduced.
Finally, some historical texts describing the beauty of calligraphy in this specific system of writing are analysed.
Abbreviations: MET: The Metropolitan Museum of Art, www.metmuseum.org; LACMA: The Los Angeles County Museum of Art, www.lacma.org; No. : Accession Number 相似文献
Constrained minimization problems considered in this paper arise in the design of beamformers for radar, sonar, and wireless communications, and in the design of precoders and equalizers for digital communications. The problem is to minimize a quadratic form under a set of linear or quadratic constraints. We present solutions to these problems and establish a connection between them. A majorization result for matrix trace and Poincare's separation theorem play key roles in establishing the connection. We show that our solutions can be formulated as generalized sidelobe cancellers (GSCs), which tie our constrained minimizations to linear minimum mean-squared error (LMMSE) estimations. We then express our solutions in terms of oblique projection matrices and establish the geometry of our constrained minimizations. 相似文献