异亮氨酸对大鼠空肠形态和抗菌肽表达的影响

目的:研究不同浓度的异亮氨酸对大鼠空肠形态和抗菌肽表达的影响;方法:选用40只健康断奶SD大鼠,随机分为四组,分别饲喂含有不同浓度异亮氨酸的饲粮(基础日粮+0％、0.5％、1.0％或1.5％异亮氨酸),试验期为14 d.HE染色观察空肠形态变化,通过荧光定量PCR测定空肠中抗菌肽的表达水平.结果:1)对照组大鼠空肠绒毛整齐,黏膜上皮界限清晰,隐窝较浅,0.5％和1.0％异亮氨酸组大鼠空肠绒毛较对照组排列整齐,绒毛较高,隐窝较浅;与0％、0.5％和1.0％异亮氨酸组相比,1.5％异亮氨酸组大鼠绒毛高度较低,隐窝深度增加.2)与对照组相比,0.5％、1.0％和1.5％异亮氨酸均在不同程度上显著提高了空肠防御素rBD -1的表达,其中0.5％异亮氨酸组大鼠空肠防御素rBD -1表达增加了2.3倍,1.0％异亮氨酸组rBD -1表达量增加了13.1倍,1.5％异亮氨酸组rBD -1表达量增加了14.2倍.结论:添加异亮氨酸可显著增加大鼠空肠防御素基因的表达,适量的异亮氨酸对空肠黏膜形态具有改善作用,过量异亮氨酸可能破坏空肠黏膜形态.     

Relationships between different instructional approaches and students' Classical Chinese reading comprehension and motivation

Previous studies comparing teacher‐centred (TC) and learner‐centred (LC) instruction have presented a mixed picture of the effectiveness of these two instructional approaches. By examining the effectiveness of different types of instruction on students' Classical Chinese (CC) reading comprehension and motivation, this study aims to contribute to instructional research by elucidating the positive and negative aspects of TC and LC instruction when they are applied in the context of teaching CC reading. A total of 454 Secondary 4 students between the ages of 15 and 17 years agreed to participate in this study on a voluntary basis. They completed a CC reading comprehension test and a questionnaire that measured their CC reading motivation and perceived CC reading instruction. Relationships between students' perceived CC reading instruction, reading motivation and reading comprehension were examined by correlation and path analyses. The findings of the correlation analyses indicated that traditional TC instruction positively and significantly correlated with students' CC reading performance and extrinsic motivation. Motivating tasks, one type of LC instruction, positively and significantly correlated with all types of motivation but did not significantly correlate with CC reading performance. In the path analysis, TC instruction exhibited a significant positive effect on reading comprehension, whereas motivating tasks continued to exhibit a significant positive effect on intrinsic motivation after the effect of the examined schools' achievement level was controlled for. The findings highlight the essential role of teachers in instructing students who are weak in particular subjects. Instead of viewing TC and LC instruction as two contradictory approaches, the findings indicate that a combined approach of TC and LC instruction can more effectively facilitate students' learning in a difficult school subject.     

高速公路建设BOT融资方式的利弊分析

BOT方式的有利之处在于：具有较高的社会经济效益；可以缓解我国急需加快高速公路建设和资金不足的矛盾；便于引进先进的管理经验和技术；加强竞争和效率；提高高速公路项目建设的质量与效率；增广我国利用外资的渠道。而不利之处在于：项目的立项和实施过程较长，不利于比较急需的项目；以牺牲我方的较长时期内的一部分经济利益为代价；导致我国外汇的流出；政府易于失去对设计过程和质量的控制。但总的来说，对于我国现阶段，高速公路建设的BOT融资方式是利大于弊的。     

论毛泽东对党的学风问题的论述及其现实意义

毛泽东是我们党内第一个提出党的学风问题的领导人 ,他深刻分析了党的学风的实质与内涵 :党的学风问题实质上是我们党如何对待马克思列宁主义的问题 ,是一个理论联系实际的问题 ,关系到党的学习 ,党的思想方法 ,党的工作态度问题。在新的历史时期 ,毛泽东对党的学风问题的论述具有重大的现实意义     

The Early Literacy Support Programme (ELS) and the blend and clash of national educational policy ideologies in England

In this article we consider the development of key policy issues in England, related to the area of literacy learning and children who are considered to have difficulties in literacy in their early years. We trace the tensions which have arisen since the 1980s between different policies and practices in these areas. These tensions include pressures to raise standards of literacy and to support children with difficulties, and the establishment of a prescribed curriculum for young children. In particular, we focus on the blend and clash of national educational policy ideals in areas related to literacy and children who have been categorised as having ‘special educational needs’, and how these have influenced the development of the Early Literacy Support Programme (ELS) (DfES, 2001 Department for Education and Skills 2001a Early Literacy Support Programme, materials to support teachers working in partnership with teaching assistants London DfES  [Google Scholar]a; 2001 Department for Education and Skills 2001b Early Literacy Support Programme, session materials for teaching assistants London DfES  [Google Scholar]b). This is a programme set up by the Department for Education and Science in England for children in Year 1, aged 5 to 6 years old.     

输入输出理论与听说训练

现实中的英语教学,听力和口语课分别开设的弊端显而易见,如课堂沉闷,学生积极性不高,听不懂又说不出常常是大多数学习者面临的主要问题。根据语言研究的输入与输出理论,信息输入与输出有着不可分割的联系,由此分析,听力和口语合二为一的教学模式更具优势,更符合英语教学的交际宗旨。     

浅谈《3U财务微机管理系统》的软件开发

本文介绍了我们在开发研制《用3U财务微机管理系统》软件中的工作方法及采用的技术,突出了该系统的特点,体现了系统的设计思想。     

血液白细胞图像自动识别系统开发与应用

目的:开发并应用血液白细胞图像自动识别系统.方法:运用数据挖掘、模式识别和人工智能等技术,并与手工显微镜分类计数法(参考方法)比较.结果:白细胞图像自动识别系统的准确率为94.9％,重复率为0.1％,漏检率为0.6％,稳定性达到97.6％,检测速度低于5 min/片.与手工显微镜分类法的相关系数:中性粒细胞为0.997 1,淋巴细胞为0.994 2,嗜酸性粒细胞为0.989 9,单核细胞的相关系数为0.982 2,嗜碱性粒细胞为0.852 8,其他细胞为0.979 8.结论:研制的血液白细胞图像自动识别系统的检测结果与手工显微镜分类计数法相近,能够满足临床要求.