Association of Elevated Serum Lipoprotein(a), Inflammation,Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients

Hypertension is the most common cardiovascular risk factor. Lipoprotein(a) [Lp(a)], inflammation, oxidative stress and chronic kidney disease (CKD) exacerbate the response to tissue injury and acts as markers of the vascular disease, especially in glomerulosclerosis. We compared the clinical characteristics of 138 non-diabetes hypertensive women (ndHT) patients with 417 non-diabetes normotensive subjects and tested the association of hypertension with Lp(a), inflammation, CKD and oxidative stress by using multiple logistic regression. BP, BMI, waist circumference, creatinine, Lp(a), inflammation and malondialdehyde levels were significantly higher and CKD state in the ndHT patients (p < 0.05). Multiple logistic regression showed hypertension associated with increased Lp(a), inflammation, ORs and 95 % CIs were 2.52 (1.33, 4.80), 2.75 (1.44, 5.27) after adjusting for their covariates. Elevated serum Lp(a) and inflammation levels concomitants with increased oxidative stress and CKD were the major risk factors associated with hypertension and implications for the increased risk of HT and vascular disease.     

The effect of extremely high glucose concentrations on 21 routine chemistry and thyroid Abbott assays: interference study

Introduction

Extremely high glucose concentrations have been shown to interfere with creatinine assays especially with Jaffe method in peritoneal dialysate. Because diabetes is the fastest growing chronic disease in the world, laboratories study with varying glucose concentrations. We investigated whether different levels of glucose spiked in serum interfere with 21 routine chemistry and thyroid assays at glucose concentrations between 17-51 mmol/L.

Materials and methods

Baseline (group I) serum pool with glucose concentration of 5.55 (5.44-5.61) mmol/L was prepared from patient sera. Spiking with 20% dextrose solution, sample groups were obtained with glucose concentrations: 17.09, 34.52, and 50.95 mmol/L (group II, III, IV, respectively). Total of 21 biochemistry analytes and thyroid tests were studied on Abbott c8000 and i2000sr with commercial reagents. Bias from baseline value was checked statistically and clinically.

Results

Creatinine increased significantly by 8.74%, 31.66%, 55.31% at groups II, III, IV, respectively with P values of < 0.001. At the median glucose concentration of 50.95 mmol/L, calcium, albumin, chloride and FT4 biased significantly clinically (-0.85%, 1.63%, 0.65%, 7.4% with P values 0.138, 0.214, 0.004, < 0.001, respectively). Remaining assays were free of interference.

Conclusion

Among the numerous biochemical parameters studied, only a few parameters are affected by dramatically increased glucose concentration. The creatinine measurements obtained in human sera with the Jaffe alkaline method at high glucose concentrations should be interpreted with caution. Other tests that were affected with extremely high glucose concentrations were calcium, albumin, chloride and FT4, hence results should be taken into consideration in patients with poor diabetic control.Key words: assay interference, glucose interference, preanalytical phase, creatinine, Jaffe kinetic assay, thyroid function tests     

Locus and nature of perceptual phonological deficit in Spanish children with reading disabilities

The aims of this study were (a) to determine whether Spanish children with reading disabilities (RD) show a speech perception deficit and (b) to explore the locus and nature of this perceptive deficit. A group of 29 children with RD, 41 chronological age-matched controls, and 27 reading ability-matched younger controls were tested on tasks of speech perception. The effect of linguistic unit (word vs. syllable) and type of phonetic contrast (voicing, place and manner of articulation) were analyzed in terms of the number of errors and the response time. The results revealed a speech perception deficit in Spanish children with RD that was independent of the type of phonetic contrast and of linguistic unit.     

罗斯书库

今年（1944年,译者注）二月末,我奉台湾总督府之命到广州出差,对驻广州意大利总领事罗斯的书库做了调查。罗斯收藏了为数众多的珍贵图书和标本,固这在很早以前就在我国的专业领域中广为人知,也有不少学者慕名前去拜访,然而毕竟是私人书库,迄今为止能有幸观摩到书库全貌的还没有一个人。罗斯也曾几度忍痛割爱,将书库的一部分珍藏品转卖出去,     

Determinants of public engagement on municipal Facebook pages

Abstract

This article analyzes the determinants of public engagement on the Facebook pages of municipalities. The sample consists of 170 Italian and Spanish municipalities that used Facebook in 2014. The findings show that posting a lot of information on municipal Facebook pages does not increase the engagement of citizens. Also, frequent posting of information per se does not engage public engagement. However, if the posts are published when public can pay attention to them (e.g., off days), the likelihood of public engagement increases. Furthermore, the citizens’ engagement on municipal Facebook page depends on the level of citizens’ income – there is a negative relationship between citizens’ income and the level of participation.     

Learning to be prejudiced: A test of unidirectional and bidirectional models of parent–offspring socialization

According to Allport's (1954) model of socialization of prejudice the level of prejudice of parents and their offspring should co-vary due to the offspring's adaptation to the parents’ attitudes. Available empirical studies and literature reviews support Allport's assumption. Modern models of socialization give reason to extend Allport's unidirectional influence model to a bidirectional perspective which assumes that parents influence their offspring's attitudes and are simultaneously influenced by them. In a cross-sectional study, 408 parent–offspring dyads (64% female parents, 55% female offspring, mean age of children = 16.47 years, SD 1.87, parents = 42.08 years, SD 7.08) from the ethnic majority population in Costa Rica were asked about their prejudice towards immigrants and ethnic minorities in Costa Rica. Using structural equation modelling, unidirectional and bidirectional models of prejudice determination were tested. The data clearly support the unidirectional model of prejudice transmission from parents to offspring, even if moderator effects of sex, age, and importance of contact are taken into account.     

IPv6: The next generation Internet Protocol

IPv4, the workhorse protocol of the currently popular TCP/ IP protocol suite, is fast becoming obsolete. The exponential growth of the Internet is the main reason that has required the creation of the next generation of Internet Protocol-IPv6. IPv6 is much more flexible and promises to take care of the address space and security issues in the foreseeable future. Part 1 of the paper lays the foundation of the various issues involved in designing the Internet Protocol and motivates the need for an upgraded version of this protocol.