Filling the Information Gap: Radio Free Europe–Radio Liberty and the Politics of Accreditation at the 1984 Los Angeles Olympic Games

Due to the decision of the Soviet Union and nearly all of its East European satellites to withdraw from the 1984 Los Angeles Summer Games, the communist media provided audiences in the Soviet bloc with few reports on the sporting events in the Olympic city. When Radio Free Europe and Radio Liberty, broadcasters funded by the US government, attempted to fill this ‘information gap’ by beaming coverage of the Los Angeles Games behind the Iron Curtain, the Soviet Union protested to the International Olympic Committee. They claimed, with a mixture of fact and fiction, that the Radios were tools of the American intelligence establishment and accused them of broadcasting ‘subversive’ propaganda to Eastern Europe and the USSR. Stirred into action by this Soviet manoeuvre, leading spokesmen for the Radios were joined by government officials, private citizens, US Olympic Committee members and the American media in a concerted attempt not only to defend the work of the broadcasters, but also to secure their press accreditation for Los Angeles.     

Core-shell hydrogel beads with extracellular matrix for tumor spheroid formation

Creating multicellular tumor spheroids is critical for characterizing anticancer treatments since they may provide a better model of the tumor than conventional monolayer culture. Moreover, tumor cell interaction with the extracellular matrix can determine cell organization and behavior. In this work, a microfluidic system was used to form cell-laden core-shell beads which incorporate elements of the extracellular matrix and support the formation of multicellular spheroids. The bead core (comprising a mixture of alginate, collagen, and reconstituted basement membrane, with gelation by temperature control) and shell (comprising alginate hydrogel, with gelation by ionic crosslinking) were simultaneously formed through flow focusing using a cooled flow path into the microfluidic chip. During droplet gelation, the alginate acts as a fast-gelling shell which aids in preventing droplet coalescence and in maintaining spherical droplet geometry during the slower gelation of the collagen and reconstituted basement membrane components as the beads warm up. After droplet gelation, the encapsulated MCF-7 cells proliferated to form uniform spheroids when the beads contained all three components: alginate, collagen, and reconstituted basement membrane. The dose-dependent response of the MCF-7 cell tumor spheroids to two anticancer drugs, docetaxel and tamoxifen, was compared to conventional monolayer culture.     

CRP,but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Objective

The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy.

Methods

The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m². Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m².

Results

In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced.

Conclusion

The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.

     

题目：一种支持产品平台设计的多准则模块划分方法

目的：研究多准则约束下的产品模块划分方法,为企业建立稳健的模块化产品平台奠定基础。方法：采用改进的多目标进化算法对建立的多准则模块划分数学模型求解,并采用模糊集合评价机制进行最优解的寻取,得到基于多准则模块划分方法的产品模块划分结果。结论：通过改进的多目标进化算法求解多准则模块划分模型,能够得到有效支持产品平台设计的产品模块划分方案。通过与已有优化方法的比较验证了本文提出的多准则模块划分方法的优越性。     

A Strategy for the Management,Preservation, and Reutilization of Geographical Information Based on the Lifecycle of Geospatial Data: An Assessment and a Proposal Based on Experiences from Spain and Europe

In recent years, there has been a growing recognition of the fact that the proper management of information has to include concern for its preservation and future re-use. This ambition is particularly significant for geospatial data. The primary aim of this article is to define the European and Spanish frameworks for the preservation and reutilization of geographical information, with the ultimate goal of proposing an articulated, lifecycle-based data management model. With this, the intent is to shed some light on a complex, difficult and ever-evolving subject.

The article is divided into two main parts. The first part begins with a conceptual justification for geospatial data management and continues by synthesizing the current normative and technological framework for the preservation and reutilization of geographical information. Within this context, the implementation of Spatial Data Infrastructures (SDI) in Spain is evaluated. The second part begins with a case study from Spain that aims to identify different agents and flows that influence the lifecycle of geographical data, as well as the strengths and weaknesses found in each stage of the process under examination. Finally, the foregoing ideas are used in order to propose a SDI-related system for the management of geographical information.     

Sustainability Strategies in the Forestry–Wood Chain Driven by Market Demands on Books and Other Products

This paper focuses on sustainability strategies for the Forestry–Wood chain (FWC) driven by market demands on books and other products. The main objective is to draft and suggest a process for market driven pro-active sustainability strategies for the FWC, based on a SWOT-analysis (strengths, weaknesses, opportunities and threats). Further to highlight the possible strategic implications and critical areas for actors upstream in the FWC, in the context of uncertain external future scenarios. Higher demands on product differentiation were found throughout the FWC, where also collaboration and stakeholder interaction was found important to improve sustainability. The work broadens the “traditional” perspectives on FWC sustainability to encompass also interacting value chains such as book production and publishing, to get a more holistic view.     

Ugandan health libraries in the 21st century: key initiatives and challenges

This article is part of a series in this regular feature which looks at new directions in health science libraries. This paper highlights new initiatives aimed at ensuring health libraries can contribute to the development of Uganda in the 21st century and the challenges facing libraries. It stresses that for libraries to be successful they need to form networks and collaborations for resource sharing; take advantage of the benefits of information technology; computerise their library systems; as well as invest in the development of staff. The paper highlights the main challenge facing the library service as inadequate funding both from government for public‐funded health libraries and the private sector (for privately funded health libraries). The paper concludes that, despite the bottlenecks brought about by inadequate funding, Ugandan health libraries have taken positive steps to support health research and education, as well as patient care, not just for Uganda, but for the whole of the East African region. J.M.