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72.
Dil-Afroze Dinesh Sharma G. N. Dhobi Sonaullah Shah Rafiqa Eachkoti Ishraq Hussain Zafar A. Shah Mushtaq A. Siddiqi 《Indian journal of clinical biochemistry : IJCB》2006,21(2):76-79
Pleural effusion is one of the commonest presentations of tuberculosis, the clinical manifestations being typically abrupt
resembling bacterial pneumonia. Since delayed hypersensitivity is the underlying immune response, bacterial load is very low.
Owing to these facts, tuberculous pleurisy as an extra-pulmonary disease poses a diagnostic dilemma. The conventional bacteriological
methods rarely detect Mycobacterium tuberculosis in pleural fluid and are of limited use in diagnosis of tuberculous pleurisy.
We evaluated the efficacy of polymerase chain reaction (PCR) in the diagnosis of tuberculous pleurisy by targeting the gene
segment coding for MPB64 protein specific forMycobacterium tuberculosis. Based on the clinical criteria, 82 patients with lymphocytic exudative pleural effusion were included in the study. Patients
were analyzed in two groups; one group consisting of 48 patients of tubercular pleural effusion confimed by various diagnostic
procedures and another group of 34 patients comprising of non-tubercular pleural effusion. There were no false positive results
by PCR and the specificity worked out to be 100%. Twenty two patients tested positive for Mantoux with a sensitivity of 45%.
ZN-staining for AFB was found in samples from 15 patients (20% sensitivity). ADA was positive for 28 patients with a sensitivity
of 53%. PCR was positive for 32/48 patients (67% sensitivity). Thus, PCR was found to be more sensitive than any other conventional
method in diagnosis of clinically suspected tubercular pleurisy. 相似文献
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74.
Simbita A. Marwah Hitesh Shah Kiran Chauhan Amit Trivedi N. Haridas 《Indian journal of clinical biochemistry : IJCB》2014,29(2):161-166
Currently employed markers for the detection of acute coronary syndrome are Troponin T, CK (Creatine Kinase) and CKMB activity. CKMB activity measured by immunoinhibition method can give falsely elevated results due to the presence of atypical CK and CKBB and at times lead to the mis-diagnosis of acute coronary syndrome. Hence, CKMB mass (CKMB) measured by electrochemiluminence sandwich principle was employed. In this cross-sectional study 183 samples of 61 patients were analyzed within 6 h of diagnosis of acute coronary syndrome and followed up to 72 h. The correlation coefficient between CKMB activity and CKMBM at 4–6 h was 0.744, while at 12–24 h it was 0.909 and at 48–72 h it was 0.337. Thus there was good association between the two methods at 12–24 h but, statistically for method comparison studies and for replacing one method by another, the two methods need to be in agreement with one another. In this study the two methods are not in agreement with one another and thus analytically not replaceable. Another finding was obtained that CKMBM reached cut off levels prior to CKMB enzyme activity and hence, CKMBM is clinically better than CKMB activity to detect reinfarction. 相似文献
75.
Scholars have neglected the privatization of the Internet's backbone network, despite the obvious significance of the U.S. government turning control of a powerful new communication technology over to the private sector. This article analyzes the transition from a government-sponsored backbone network to multiple commercially owned backbone networks. The authors also analyze the implications of the privatization on the Internet's governance, competition, and performance. 相似文献
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78.
Higher education policies related to quality assurance are implemented in many countries. The purposes of such policies are
to ensure the provision for high-quality education, university accountability and transparency in the use of public funding
and meeting the needs of the diverse stakeholders. The current Australian Higher Education Quality Assurance Framework was
implemented in the year 2000. It can be described that the framework has been enjoyed by universities, academics and other
providers in Australia. This paper provides a brief history of quality assurance, its evolution in higher education in Australia
and current changes and trends in quality assurance in other developed countries. It then provides an analysis of the success
and deficiencies of the current framework used in Australia and suggestions which may be helpful in the development of the
new framework. The analysis includes the thoughts of the three authors based on their experience in managing quality and reviews
in seven different institutions and the views of more than 40 participants who are staff members from 25 Australian universities. 相似文献
79.
Jaeho Cho Ph.D. Dhavan V. Shah Ph.D. Seungahn Nah Ph.D. Dominique Brossard Ph.D. 《广播与电子媒介杂志》2013,57(2):242-261
This experimental research examines how different presentation modalities in presidential debates and post-debate spin influence the ability to form evaluations about candidates' character, shape perceptions of their incivility, and alter judgments of political trust and news credibility. Results indicate that these experimental factors work together to encourage character judgments, diminish perceptions of candidate civility, and reduce levels of trust in government. In addition, political talk conditioned experimental effects on perceptions of news credibility, with the adverse effects of split screen presentations concentrated among those who talked about the debate. Thus, the negative effects of “in your face” politics conveyed by the “split-screen” modality appear to be most pronounced among those primed to think about performance and those attuned to politics through interpersonal talk. 相似文献
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