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21.
Cystic fibrosis is a common autosomal recessive disorder usually found in population of white Caucasian descent. Now it is
well documented the presence of CF disease in India with the advancement of laboratory testing. As once it was thought non
existence of this disease in our population. Most of the phenotype of CF disease was in accordance of western population.
Genetic analysis of CFTR gene in Indian CF patients revealed that most common mutation was delta F508 mutation. However, it
was less than Caucasian population. CFTR mutations are also a causative factor in the pathogenesis of male infertility due
to obstructive azoospermia. There are two most common mutation viz. IVS8-T5 and delta F508 which are responsible for congenital
absence of vas deferens in male infertility patients. Elevated levels of sweat chloride at two occasions along with the presence
of two mutations in CFTR gene was gold standard method for diagnosis of CF disease. It is noteworthy here that due to magnitude
of Indian population, the total CF disease load would be more than many European countries. Clinical data demonstrate the
prevalence of both classical and genetic form of CF in India. 相似文献
22.
23.
Amrita Chaudhary Pradeep Kumar Vandana Rai 《Indian journal of clinical biochemistry : IJCB》2021,36(3):257
Catechol-O-methyl transferase (COMT) enzyme catalyzes the metabolism of dopamine and other catechols in the brain. Several articles investigated catechol-O-methyltransferase (COMT) Val158Met polymorphism as risk factor for alcohol dependence (AD) but the results were inconclusive. The aim of present meta-analysis was to evaluate the association of Val158Met (COMT) polymorphism with AD. Authors performed keyword search of the 4 electronic databases—Pubmed, Google Scholar, Springer Link and Science Direct databases up to December 31, 2019. Total eighteen studies that investigated the association of Val158Met polymorphism with AD were retrieved. The pooled results from the meta-analysis (2278 AD cases and 3717 healthy controls) did not show association with AD using all 5 genetic models (allele contrast model: OR = 1.02, 95% CI = 0.90–1.14, p = 0.03; homozygote model: OR = 1.06, 95% CI = 0.81–1.38, p = 0.69; dominant model: OR = 0.99, 95% CI = 0.85–1.14, p = 0.87; co-dominant model: OR = 0.97, 95% CI = 0.86–1.11, p = 0.71; recessive model: OR = 1.05;95% CI = 0.85–1.29, p = 0.61). Results of subgroup analysis showed that Val158Met is not risk for AD in Asian and Caucasian population. In conclusion, COMT Val158Met is not a risk factor for alcohol dependence. 相似文献
24.
Jasvir Kaur Nachatar Singh 《Higher Education Quarterly》2023,77(3):501-514
Limited scholarly work has been conducted on obtaining equal opportunities to participate in employability-related programmes by international students while studying in Australia. Drawing on a qualitative study, 20 South Asian postgraduates were interviewed to explore their experiences in accessing employability-related programmes. Based on the findings, South Asian graduates have experienced unequal opportunities in accessing employability-related programmes as postgraduate international students in Australia. They are disadvantaged by generic career advice and resume assistance offered by their university career office, and companies invited to university career fairs offer internships, placements or graduate programme opportunities mostly to domestic students. As a result, South Asian graduates were unable to gain employment in their field of studies. South Asian graduates have also offered several useful recommendations to facilitate more equal chances of developing employability and thereby gaining successful employment in Australia. These include partnerships with companies in providing employment opportunities, diversification of university career office roles, and establishing connections with alumni. The paper also discusses implications for Australian higher education institutions and higher education policy and practice in Australia. 相似文献
25.
Kenneth K. Poon Zijia Ng Meng Ee Wong Sarinajit Kaur 《Asia Pacific Journal of Education》2016,36(1):84-97
In this study, we sought to examine the perceptions of teachers and other school professionals towards the inclusion of secondary school students with special educational needs (SEN), and the associated factors. The Sentiments, Attitudes and Concerns about Inclusive Education Revised scale (SACIE-R) was completed by 131 teachers and school professionals from two mainstream secondary schools in Singapore. The findings revealed an overall neutral attitude towards inclusion. Together, confidence in teaching students with SEN, the level of training SEN support, as well as experience teaching students with SEN account for a large proportion of the variance in ratings of inclusive perceptions. Further analyses revealed that confidence in teaching or supporting students with SEN was found to be a significant predictor of inclusive perceptions. The findings suggest that schools seeking to engage in inclusive practices should focus on ways to develop the confidence of personnel to support students with SEN. Professional development and mentorship were suggested as possible avenues. 相似文献
26.
Bhupinder Kaur Gill Promila Jindal Raj Kumar Shweta Tiwari Namrata Sharma Anupama Goel 《Indian journal of clinical biochemistry : IJCB》2007,22(1):148-151
Study was undertaken to assess thyroid status in hyperemesis gravidarum. 150 women pregnant with <20 weeks of gestation were
selected randomly and out of these 100 women presenting with hyperemesis formed study group while 50 normal pregnant women
served as controls. 53% of hyperemetic pregnant women were primigravidae and 82% of pregnant women presented with vomiting
at less than 12 weeks of gestation. Statistically significant, 22% of hyperemetic women had increased serum T3 levels while T4 levels were increased in 67% of women in study group as compared to 8% and 16% respectively in control group. TSH levels
were decreased in 18% of hyperemetic women as compared to 8% in control group with decrease in mean TSH level statistically
significant. 22% of hyperemetic women had electrolyte disturbances and 7% were ketonuric. In clinically euthyroid women, biochemically
altered thyroid function can attribute to vomiting and its prolongation to second trimester 相似文献
27.
Harbans Lal Kiran Chugh Varinder Saini Jasbinder Kaur A. S. Saini 《Indian journal of clinical biochemistry : IJCB》1993,8(1):33-35
Glutathione-5-transferase (GST) and glutathione (GSH) levels were estimated in the lungs of 3 and 30 months old rats. GST activity was found to be significantly reduced in the old rats (30 months age) compared to the young rats (3 months age). In old rats, with methionine supplementation GST activity was increased whereas with vitamin C supplementation GSH levels were increased. The data show that the supplementation of methionine as well as of vitamin C have beneficial effect on the scavenging system and protect lungs against the free radical damage during ageing. 相似文献
28.
Sukhdeep Kaur Chohan 《Early Childhood Education Journal》2011,39(1):39-50
This study involved the development, implementation, and assessment of a comprehensive schoolwide mailing program as a practical
tool to communicate enthusiasm towards writing to children and actively engage them in letter writing. The author played the
dual role of teacher-researcher and worked for one school year with one teacher from each grade level from grade 1 to grade
5. The objective of the study was to explore the relationship between an innovative mailing program and children’s attitudes
towards letter writing. This study employed both qualitative (conference with teachers) and quantitative (survey) methods.
The author initiated the study with a presentation to the teachers (during a staff meeting) and to the children (in an assembly),
systematically collected feedback from teachers to assess the program throughout the year, informed parents (through school
newsletters), and assessed children’s attitudes towards both writing and letter writing at the beginning and end of the program.
It was anticipated that the program would provide children with authentic writing experiences, foster positive attitudes towards
writing, enhance their literacy skills, and in turn strengthen a “friendship culture” in the school by being coparticipants
as readers and writers in the letter writing process. Data analysis indicated that children enjoyed the responsive letter
writing process and that their self-perceptions as writers and their writing skills improved. Results support the introduction
of an elementary school mailing program as a means to cultivate and strengthen positive relationships between pupils and invite
family participation. 相似文献
29.
Kumar Amit Mantri Archana Singh Gurjinder Kaur Deepti Prit 《Education and Information Technologies》2022,27(5):6015-6036
Education and Information Technologies - Collaborative learning is the favored approach educators use to inculcate social skills and promote peer interactions in students. Embedded Systems is a... 相似文献
30.
Gloria Dall’Alba Jörgen Sandberg Ravinder Kaur Sidhu 《Educational Philosophy and Theory》2018,50(3):270-286
This article offers a philosophical-empirical account of embodied skilful performance in the practice of plant biotechnology. Drawing on the work of Merleau-Ponty and others, we elaborate how skilful performance emerges from and through reciprocal relations encompassing the body-in-the-world and the world-in-the-body. The contribution of this article lies in offering an account of skilful performance that is attentive to a perceiving, motile, feeling body entwined with world. In genetically modifying plants, scientists direct their senses of touch and vision to manipulating plant materials and matter, ‘reading’ subtle changes in tissue cultures, plantlets and so on. In rhythmic movements, they extend their bodies through skilful use of complex equipment, while calling on ‘intuition’ to guide their work. Skilful performance, then, relies on our lived body that is not merely a physical object among other objects, nor a passive instrument for the mind, but dynamic and inescapably entwined with people and things in a world in flux. Bringing to the fore how perceiving, motile, feeling bodies are implicated in skilful performance has significant implications for education and workplace training. 相似文献