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Rats confronted with the onset of a light gradient display a transient increase in locomotion called theactivity response (AR) and a dark preference (Godsil & Fanselow, 2004). These experiments demonstrate that the magnitude of the AR can be blunted
with Pavlovian fear-conditioning procedures via associative and nonassociative fear. Although manifested in decreased locomotion,
the blunted AR effect was not due to increased freezing or immobility behaviors. Instead, rats displayed reduced rearing and
an increase in a class of behaviors calledstationary activity. These results suggest that the lighting differential supplied by the cue influences the topography of defensive behavior
and reduces the expression of freezing. This procedure provides a means by which to examine learned and unlearned defensive
responses to the same stimulus. 相似文献
995.
Kavita Shalia Sudha Savant Vijaya A. Haldankar Tulip Nandu Poonam Pawar Siddhi Divekar V. K. Shah Purvi Bhatt 《Indian journal of clinical biochemistry : IJCB》2012,27(1):74-82
To analyse the association of high sensitivity C-reactive (hsCRP) protein levels and −717A/G single nucleotide polymorphism
of CRP with acute myocardial infarction (AMI) in the Indian population. Study population included 100 MI cases wherein 32
patients had experienced previous MI (MI-Group-1), 68 MI cases were recruited at presentation (MI-Group-2) and equal number
of age and gender matched healthy individuals. hsCRP levels were determined by ELISA and genotyping of −717A/G was carried
out by polymerase chain reaction-based restriction digestion method. The −717A/G genotypes did not influence hsCRP level and
their distribution did not differ between groups. However, in the present study hsCRP demonstrated significant correlation
with BMI in controls of both the genders and with triglycerides in females of AMI at presentation who otherwise are with low
risk profile. Identifying traditional risk factors associated with inflammation may help in controlling the acute event. 相似文献
996.
Meera S. Ghadge Purva P. Naik Bijaynath P. Tiwari Ruprekha M. Hegde Tanaji J. Matale 《Indian journal of clinical biochemistry : IJCB》2012,27(1):97-99
Breast cancer is one of the most frequent malignancies in the world. Available staging procedures to detect breast cancer
are bone scan, chest X-ray, liver ultrasonography, computerized tomography, estimation of tumor markers like carbohydrate
antigen (CA15-3) and carcino embryonic antigen. These procedures are expensive and may not be required in all cases. Out of
70 patients studied, 55 had normal CA15-3 and 15 had elevated levels of Ca15-3. Eight (14.5%) of the 55 patients with normal
CA15-3 had abnormal bone scan. Fifteen patients had CA15-3 levels above the normal range and among these 9 (60%) had abnormal
bone scan. While prime facie it would appear that a high level of CA15-3 correlate with abnormal bone scan, it is also true
that the numbers are small at present and conclusions about the validity of CA15-3 as marker of bone metastasis may be premature. 相似文献
997.
Michael J. Shoemaker Amy B. Curtis Eric Vangsnes Michael G. Dickinson 《Cardiopulmonary Physical Therapy Journal》2012,23(3):5-15
Purpose
The purpose of the present review was to use existing, published data to provide an estimate of the amount of change in six-minute walk test distance (Δ6MWT) that represents a clinically meaningful change in individuals with chronic heart failure (CHF).Methods
The present review included two separate literature searches of the CINAHL and Medline databases for articles that: (1) reported the intraclass correlation coefficient (ICC) of the 6MWT in individuals with CHF, and (2) used the 6MWT along with either aerobic capacity or health-related quality of life (HRQL) as study endpoints in randomized controlled trials (RCTs) of exercise-based intervention for individuals with CHF. The ICCs were used to calculate the minimum detectable difference (MDD) at the 95% confidence interval for each included study. The Δ6MWT associated with aerobic capacity and HRQL within-group effect sizes for the intervention and control groups in each included RCT was analyzed using receiver operating characteristic (ROC) curves.Results
Thirteen articles reported the ICC for the 6MWT. The mean (standard deviation) MDD calculated based on these data was 43.1(16.8) m. Eighteen RCTs measured the 6MWT and either aerobic capacity and/or HRQL. A Δ6MWT of 40–45 m was associated with at least moderate aerobic capacity and HRQL effect sizes in the intervention groups. The Δ6MWT thresholds that discriminated between intervention and control groups using ROC curves revealed the following sensitivity/specificity for the respective thresholds: 19 m, 94.4/83.3%, 32 m, 83.3/94.4%, and 48 m 44.4/100% (AUC = .935, p = .009, CI95% .855, 1.015).Conclusions
A Δ6MWT of approximately 45 m appears to exceed measurement error and be associated with significant changes in either aerobic capacity and/or HRQL.Key Words: heart failure, six-minute walk test, clinically meaningful change, minimum detectable difference 相似文献998.
Yong Huo 《Journal of Zhejiang University. Science. B》2010,11(8):631-633
##正##Dr.Gruntzig et al.(1979) successfully completed the world's first percutaneous coronary intervention (PCI),a percutaneous transluminal coronary 相似文献
999.
Ling Xia Ying-lan Gong Xiu-wei Zhu Yu Zhang Qi Sun Heng-gui Zhang 《Journal of Zhejiang University. Science. B》2010,11(6):402-416
The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria.The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche(RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data.A model of right atria was then built by considering the differences between right atria and left atria.The two developed models well reproduced the exper... 相似文献
1000.
Qing-jun Liu Wei-wei Ye Hui Yu Ning Hu Li-ping Du Ping Wang 《Journal of Zhejiang University. Science. B》2010,11(5):323-331
Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals d... 相似文献