Protection against muscle damage in competitive sports players: the effect of the immunomodulator AM3

Strenuous physical exercise of the limb muscles commonly results in damage, especially when that exercise is intense, prolonged and includes eccentric contractions. Many factors contribute to exercise-induced muscle injury and the mechanism is likely to differ with the type of exercise. Competitive sports players are highly susceptible to this type of injury. AM3 is an orally administered immunomodulator that reduces the synthesis of proinflammatory cytokines and normalizes defective cellular immune fractions. The ability of AM3 to prevent chronic muscle injury following strenuous exercise characterized by eccentric muscle contraction was evaluated in a double-blind and randomized pilot study. Fourteen professional male volleyball players from the First Division of the Spanish Volleyball League volunteered to take part. The participants were randomized to receive either placebo (n?=?7) or AM3 (n?=?7). The physical characteristics (mean±s) of the placebo group were as follows: age 25.7±2.1 years, body mass 87.2±4.1?kg, height 1.89±0.07?m, maximal oxygen uptake 65.3±4.2?ml?·?kg^?1?·?min^?1. Those of the AM3 group were as follows: age 26.1±1.9 years, body mass 85.8±6.1?kg, height 1.91±0.07?m, maximal oxygen uptake 64.6±4.5?ml?·?kg^?1?·?min^?1. All participants were evaluated for biochemical indices of muscle damage, including concentrations of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatine kinase (CK) and its MB fraction (CK-MB), myoglobin, lactate dehydrogenase, urea, creatinine and γ-glutamyltranspeptidase, both before and 30 days after treatment (over the peak of the competitive season). In the placebo group, competitive exercise (i.e. volleyball) was accompanied by significant increases in creatine kinase (494±51 to 560±53?IU?·?l^?1, P?<?0.05) and myoglobin (76.8±2.9 to 83.9±3.1?μg?·?l^?1, P?<?0.05); aspartate aminotransferase (30.8±3.0 to 31.1±2.9?IU?·?l^?1) and lactate dehydrogenase (380±31 to 376±29?IU?·?l^?1) were relatively unchanged after the 30 days maximum effort. AM3 not only inhibited these changes, it led to a decrease from baseline serum concentrations of creatine kinase (503±49 to 316±37?IU?·?l^?1, P?<?0.05) and myoglobin (80.1±3.2 to 44.1±2.6?IU?·?l^?1, P?<?0.05), as well as aspartate aminotransferase (31.1±3.3 to 26.1±2.7?IU?·?l^?1, P?<?0.05) and lactate dehydrogenase (368±34 to 310±3?IU?·?l^?1, P?<?0.05). The concentration of CK-MB was also significantly decreased from baseline with AM3 treatment (11.6±1.2 to 5.0±0.7?IU?·?l^?1, P?<?0.05), but not with placebo (11.4±1.1 to 10.8±1.4?IU?·?l^?1). In conclusion, the use of immunomodulators, such as AM3, by elite sportspersons during competition significantly reduces serum concentrations of proteins associated with muscle damage.     

Aerobic plus resistance training was more effective in improving the visceral adiposity,metabolic profile and inflammatory markers than aerobic training in obese adolescents

Abstract

The purpose of this study was to determine whether aerobic plus resistance training (AT + RT) is more effective than aerobic training (AT) at reducing inflammatory markers and cardiovascular risk in obese adolescents. A total of 139 obese adolescents were enrolled, aged 15–19 years, body mass index (BMI) ≥ 95th percentile and participated in 1 year of interdisciplinary intervention. They were randomised into two groups: AT (n = 55), AT + RT (n = 61). Blood samples were collected to analyse glycaemia, insulin, the lipid profile, leptin and adiponectin concentrations. Insulin resistance was measured by homeostasis model assessment of insulin resistance index (HOMA-IR). The AT + RT group showed better results with regard to decreased body fat mass, low-density lipoprotein concentration (LDL-c) levels, subcutaneous and visceral fat and increased body lean mass. Indeed, a reduction of hyperleptinaemia and an increase in adiponectin concentrations, promoting an improvement in the leptin/adiponectin ratio, was observed. Important clinical parameters were improved in both types of exercise; however, AT + RT was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than AT alone, suggesting clinical applications for the control of intra-abdominal obesity and cardiovascular risk in the paediatric population.     

Biomedical Discourse on Women's Physical Education and Sport in France (1880–1922)

This article aims at studying the contradictions in scientific discourse on physical education for women in France from 1880 to 1922. In 1880 a law made gymnastics compulsory at school, and physical practices became a topic of public and scientific debate. 1922 is the date of the first medical congress on women's and children's physical education. Our study is based on a corpus of more than 200 scholarly texts about physical education or sport. They discuss women, exclusively conceived in their biological functions as procreators, thus physiologically qualifying the socially constructed properties of femininity. However, as soon as the first steps towards female physical practices appeared, contradictions came up. On the one hand, some doctors wanted to preserve reproductive organs from any violent exercises. On the other hand, other doctors wanted to reinforce female bodies through sport practices.     

International Trends in Health Science Librarianship Part 20: The Balkan States (Serbia and Slovenia)

This is the 20th in a series of articles exploring international trends in health science librarianship in the 21st century. The focus of the present issue is the Balkan region (Serbia and Slovenia). The next regular feature will look at Russia and the Ukraine. JM     

A Meta-analysis of the Impact of Social and Emotional Learning Interventions on Teachers’ Burnout Symptoms

Educational Psychology Review - Over the last decades, extensive research has given considerable attention to teachers’ burnout. Owing to its negative personal, organizational, and social...     

The Development of Health Knowledge in Low-Income Mexican-American Children

Children growing up in poverty are at risk for various health problems. For low-income, Mexican-American children, these risks include obesity, diabetes, and accidental injuries, 3 conditions that can largely be prevented by healthy life-styles. Despite the potential for prevention through education leading to health-promoting behaviors, very little is known about the development of health knowledge in this population. The present study examined low-income, Mexican-American children's understanding of the relation between health behavior and health status in 3 areas: nutrition, hygiene, and safety. 79 children (41 boys, 38 girls) ages 4 to 8 years participated. Children's knowledge was assessed in a structured play situation conducted in a laboratory setting. Results revealed that children knew the least about the relation between food consumption and their health, and knew the most about beneficial and harmful practices in the areas of safety and hygiene. Age and gender differences were also significant, with girls and older children more likely to provide elaborate and complex rationales for their responses. Implications of the findings for understanding the role of cognitive development and experience in the development of health knowledge are considered.     

Predicting Graduation Rates at 4-year Broad Access Institutions Using a Bayesian Modeling Approach

This study models graduation rates at 4-year broad access institutions (BAIs). We examine the student body, structural-demographic, and financial characteristics that best predict 6-year graduation rates across two time periods (2008–2009 and 2014–2015). A Bayesian model averaging approach is utilized to account for uncertainty in variable selection in modeling graduation rates. Evidence suggests that graduation rates can be predicted by religious affiliation, proportion of students enrolled full-time, socioeconomic status of the student body, enrollment size and institutional revenue and expenditures. Findings also demonstrate that relatively fewer variables predict institutional graduation rates for Latina/o and African American students at 4-year BAIs. We conclude with implications for policy and key recommendations for research focused on 4-year BAIs.     

“How do You Know this Answer?” – Children’s Use of Text Data and General Knowledge in Story Comprehension

This study investigates how, and to what extent, young readers (7–8 year-olds) use text information or their prior knowledge when answering comprehension questions about narrative texts. The children were asked to explain how they found out their responses by answering the following question: “how do you know this answer?” Their answers and justifications were analysed both qualitatively and quantitatively. The text proved to be the main source of information for these readers. However, sometimes the children seemed to ignore the text and over rely on their prior knowledge to answer the questions. The procedure of asking children to justify their answers was shown to be a good way of specifying more precisely some of their problems in text comprehension. It also seemed to encourage them to look back at the text and review their responses and, as such, it could be considered a useful tool to improve children’s reading comprehension.     

Making the most of “external” group members in blended and online environments

Although the importance of boundary spanning in blended and online learning is widely acknowledged, most educational research has ignored whether and how students learn from others outside their assigned group. One potential approach for understanding cross-boundary knowledge sharing is Social Network Analysis (SNA). In this article, we apply four network metrics to unpack how students developed intra- and inter-group learning links, using two exemplary blended case studies in Spain and the UK. Our results indicate that SNA based upon questionnaires can provide researchers some useful indicators for a more fine-grained analysis how students develop these inter- and intra-group learning links, and which cross-boundary links are particularly important for learning performance. The mixed findings between the two case-studies suggest the relevance of pre-existing conditions and learning design. SNA metrics can provide useful information for qualitative follow-up methods, and future interventions using learning analytics approaches.