On the influence of the architecture of poly(ethylene glycol)-based thermoresponsive polymers on cell adhesion

Thermoresponsive polymer surface coatings are a promising tool for cell culture applications. They allow for a mild way of cell detachment that preserves the activity of membrane proteins—a prerequisite for reliable cell analysis. To enlarge the application range of these coatings to cells with different adhesion properties, we synthesized various novel poly(ethylene glycol)-based thermoresponsive polymers and describe how (i) their chemical structure and (ii) their surface density affect their efficiency. In order to quantify the influence of both factors, the time for cell spreading and rounding efficiency were observed. As a result, efficiency of cell rounding, which is closely correlated to cell detachment, is less affected by both factors than the time needed for cell spreading. This time can effectively be adjusted by the molecular architecture which includes the length of the polymer backbone and the side chains. Based on this work, recommendations are given for future optimization of functionality of thermoresponsive polymer coatings for cell culture applications.     

Experiences in education innovation: developing tools in support of active learning

The paper focuses on educational projects developed in the ETSII (Escuela Técnica Superior de Ingenieros Industriales) of the Polytechnic University of Madrid during the past few years. These projects were developed as new tools for enhancing the active role of students, for improving practical teaching, especially by means of virtual laboratories and different sets of problems and exercises, and for promoting self-learning. The paper analyses the use of ICT in teaching, with the case of a developed e-learning platform as a tracking system for subjects. The paper concludes by discussing the new educational trends in the Centre, devoted to develop an active role of students by activities such as peer mentoring and laboratory monitors programs, and competitions for achieving multidisciplinary engineering challenges.     

Twelve- and Fourteen-Year-Old School Children Differentially Benefit from Sensorimotor- and Multisensory-Enriched Vocabulary Training

Educational Psychology Review - Both children and adults have been shown to benefit from the integration of multisensory and sensorimotor enrichment into pedagogy. For example, integrating pictures...     

“It's in Your Heart”: How the California Mini-Corps Program and Hispanic Serving Institutions are Transforming Migrant Student Education

ABSTRACT

This paper provides a deep dive case study of the California Mini-Corps Program within the context of an Hispanic Serving Institution.     

The Responses of Higher Education Institutions to Global Challenge: Innovative Universities and Human Resources Development

Before a higher education institution can develop international impact and reputation, it must first have developed its regional impact and reputation. Universities can contribute to the creation of wealth in given regions in a number of ways, not the least of which is technology transfer, the creation of firms and other spin‐off activities, and the furtherance of the their reputations for excellence. Staff and students spend a good deal of money in such regions, thus increasing regional wealth, and if given institutions pursue entrepreneurial policies in regard to the course programmes that they offer, their graduates will not only find nearby employment but will create employment for others. The “Innova” Project of the Polytechnic University of Catalonia is an illustration of how a major regional university is attempting to apply new teaching models to enhance entrepreneurial culture in the Barcelona area of Spain and thereby to increase regional human capital.     

A distributional analysis of the effect of physical exercise on a choice reaction time task

The aim of this study was to examine the facilitating effects of physical exercise on the reaction process. Eleven participants with specific expertise in decision-making sports performed a choice reaction time task during moderate sub-maximal exercise (90% of their ventilatory threshold power). Participants were tested at rest and while cycling. During exercise, the participants were faster, without being more variable. We suggest that the effect of exercise on cognitive performance was due to a major generalized improvement of the whole distribution of response time and, although the benefit effect was small, it was consistent throughout the entire range of reaction times.     

A hybrid numerical method to develop America’s Cup yacht appendages

A method aimed at the development of an America’s Cup racing yacht bulb is developed and validated against experimental data. The method relies heavily on Reynolds Averaged Navier Stokes computational fluid dynamics (CFD) and also factors in gravitational and aerodynamics effects through the use of a Velocity Prediction Program. Initial extensive use of towing tank results is made to be able to validate the CFD solution and thus develop a solid ground for predictive work. Then, in order to narrow down the focus on bulb developments, decoupled hypotheses are made on the influence of the hull and free surface wave. The development of a detailed performance analysis chart of a known base bulb allows the use of a relatively small series of CFD simulations together with physical hypotheses to assess any given bulb performance relative to the known base. The discussion of the results on a specific development highlights the promises and limitations of the method; final full scale results are discussed and analysed as well.     

The organizing and regulation of mountain guiding in Scandinavia 1820–2016, with a glance at the Alps

Abstract

In this article, we study how mountain guiding was organized and regulated in Scandinavia and the Alps between 1820 and 2015 and focus on the most important differences and similarities in Scandinavia, and between Scandinavia and the Alps. We conclude that Switzerland and Chamonix (France) represent two different systems in the Alps during the nineteenth century. However, through the emergence of national and international guide unions the regulation of mountain guiding in the Alps today appears unified, with a close connection between national regulation and mountain guide unions. In Scandinavia, Norway and Sweden historically had similar practices organizing and regulating mountain guiding, where a relatively strong layman tradition emerged during the 1960s and 1970s. In 2008, legal decisions led Sweden to change its system to match the Alp model, while Norway held on to the layman tradition. This leaves mountain guiding in Norway as a distinctly less regulated field than in France, and Switzerland, as in and Sweden.