When ‘national innovation system’ meet ‘varieties of capitalism’ arguments on labour qualifications: On the skill types and scientific knowledge needed for radical and incremental product innovations

The literatures on ‘varieties of capitalism’ (VoC) and ‘national innovation systems’ (NIS) propose very similar arguments about how firms require different types of labour qualifications to pursue strategies of radical product innovation (RPI), incremental product innovation (IPI), and product imitation (PI) respectively. Despite their similar lines of reasoning, however, the VoC scholars are concerned with the skill profiles of a firm's entire workforce, whereas the NIS proponents focus on the knowledge base of scientists. Given that both literatures have developed without explicitly taking the arguments of the neighbouring discipline into account, it is thus unclear whether they explain the same, or different, phenomena. Furthermore, both literatures propose firm level arguments but test them on the basis of macro- rather than micro-level indicators. This paper therefore asks: first, does micro-level evidence support the VoC and NIS arguments that particular types of employee skills and knowledge backgrounds of scientists are needed for different competitive strategies? And, if so, do RPI, IPI, and PI firms need to employ scientists in combination with a workforce having the respective qualifications, or is it sufficient if scientists or employees alone are adequately qualified. Quantitative analyses indicate that a particular mix of scientific knowledge combined with employee skills facilitate RPI, IPI, and PI strategies. The article thus concludes that - despite their similar reasoning - the VoC and the NIS literatures indeed describe different phenomena, without being aware of the synergies created whenever adequate employee and scientific qualifications are hired together.     

英国大学专利技术转移研究及其借鉴意义

英国大学不仅在研究水平方面而且在与产业界的合作方面均处于全球领先的地位.本文以英国大学专利技术转移活动为研究对象,首先介绍了英国大学专利技术转移活动在许可合同数量和收入两个方面的情况,继而提出英国大学的大学技术转移中心和国家大学技术转移协会是大学专利技术转移活动的重要组织保障,优秀的研究成果和商业化、国际化意识的培养是大学专利技术转移活动的先决条件,政府法律法规的设立和政府项目的支持是大学专利技术转移活动的指导因素.最后,提出了英国大学专利技术转移对我国大学专利技术转移活动的借鉴意义.     

Membrane-integrated microfluidic device for high-resolution live cell imaging

The design and fabrication of a membrane-integrated microfluidic cell culture device (five layers,≤500 μm total thickness) developed for high resolution microscopy is reported here. The multi-layer device was constructed to enable membrane separated cell culture for tissue mimetic in vitro model applications and pharmacodynamic evaluation studies. The microdevice was developed via a unique combination of low profile fluidic interconnect design, substrate transfer methodology, and wet silane bonding. To demonstrate the unique high resolution imaging capability of this device, we used oil immersion microscopy to image stained nuclei and mitochondria in primary hepatocytes adhered to the incorporated membrane     

Disposable parallel poly(dimethylsiloxane) microbioreactor with integrated readout grid for germination screening of Aspergillus ochraceus

In this work a disposable, parallel microbioreactor (MBR) suitable for screening in batch or continuous mode is presented. The reactor consists of five parallel microchambers made of poly(dimethylsiloxane) bonded to a glass substrate. A grid structure is engraved on each chamber, allowing subsequent morphology imaging. Measurements are recorded over the entire cultivation period with constant parameters, namely, position and focus in the z-axis. The microdevice may be used for either parallel, uni- or multiparametric screening, and overcomes the drawback of gridless microwell plates which require expensive equipment such as an inverted microscope with an automatic stage. To validate the scalability from laboratory scale to microscale, and thus the cultivation protocol in the MBR, the germination of fungal spores (A. ochraceus) is evaluated for two different key magnitudes (pH and temperature) and compared to the results obtained from conventional laboratory scale systems (flasks and agar plates). Information on germination capacity with regard to interspecies' variability allows for optimization of industrial processes as optimal pH and temperature matched to the mesoscopic cultivation systems. The germination conditions therefore remain unaffected inside the MBR, while providing the following advantages: (i) dramatic reduction of medium consumption, (ii) submerged cultivation with constant oxygen supply, (iii) assured low cost and disposability, and (iv) possibility of a continuous cultivation mode.     

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing

In this study, carbon fiber electrodes were incorporated within a hollow microneedle array, which was fabricated using a digital micromirror device-based stereolithography instrument. Cell proliferation on the acrylate-based polymer used in microneedle fabrication was examined with human dermal fibroblasts and neonatal human epidermal keratinocytes. Studies involving full-thickness cadaveric porcine skin and trypan blue dye demonstrated that the hollow microneedles remained intact after puncturing the outermost layer of cadaveric porcine skin. The carbon fibers underwent chemical modification in order to enable detection of hydrogen peroxide and ascorbic acid; electrochemical measurements were demonstrated using integrated electrode-hollow microneedle devices.     

Adept through adaptation: Third culture individuals’ interpersonal sensitivity

This study evaluated the interpersonal sensitivity of third culture individuals, defined as people who lived in a country other than that of their nationality during their developmental years, by comparing them to mono-cultured individuals. While the notion that third culture individuals develop enhanced perceptual skills as a result of intercultural adaptation is widely accepted in popular and professional literature, this assertion has not been empirically tested. Previous research on intercultural communication competence and adaptation has almost exclusively focused on intercultural exposure among adults. This study collected data from 142 individuals using web-based surveys. The instruments measured two aspects of participants’ interpersonal sensitivity: social and emotional sensitivity. Results showed that third culture individuals have significantly higher social sensitivity than mono-cultured individuals, while mono-cultured individuals reported higher emotional sensitivity. Additionally, no significant correlation was found between greater intercultural experience and increased interpersonal sensitivity.     

New walkers with Down syndrome use cautious but effective strategies for crossing obstacles

Perception of affordances research in children with developmental disabilities has only examined well practiced skills. Ten toddlers with Down syndrome and 10 with typical development walked across a GAITRite mat, with and without an obstacle. We coded the toddlers' behaviors after 1 and 3 months of walking experience when they encountered the obstacle (avoid, crawl, error and walk successfully) and calculated gait parameters (step length, width, and velocity). Both groups actively explored their affordances. Despite similar decreases in step length and velocity when approaching the obstacle, toddlers with Down syndrome were more likely to select successful but conservative crawling strategies that minimized balance requirements and reduced risk of falling. Group differences were due to risk management rather than difficulty perceiving affordances.