Intermittent hypoxia exposure in a hypobaric chamber and erythropoietin abuse interpretation

Abstract

The aim of this study was to assess the effect of intermittent hypoxia exposure on direct and indirect methods used to evaluate recombinant human erythropoietin (rhEPO) misuse. Sixteen male triathletes were randomly assigned to either the intermittent hypoxia exposure group (experimental group) or the control normoxic group (control group). The members of the experimental group were exposed to simulated altitude (from 4000 to 5500 m) in a hypobaric chamber for 3 h per day, 5 days a week, for 4 weeks. Blood and urine samples were collected before and after the first and the final exposures, and again 2 weeks after the final exposure. While serum EPO significantly increased after the first [from a mean 8.3 IU · l^?1 (s = 3.2) to 16.6 IU · l^?1 (s = 4.7)] and final exposures [from 4.6 IU · l^?1 (s = 1.4) to 24.8 IU · l^?1 (s = 9.3)], haemoglobin, percentage of reticulocytes, and soluble transferrin receptor were not elevated. Second-generation ON/OFF models (indirect rhEPO misuse detection) were insensitive to intermittent hypoxia exposure. The distribution of the urinary EPO isoelectric profiles (direct rhEPO misuse detection) was altered after intermittent hypoxia exposure with a slight shift towards more basic isoforms. However, those shifts never resulted in misinterpretation of results. The intermittent hypoxia exposure protocol studied did not produce any false-positive result for indirect or direct detection of rhEPO misuse in spite of the changes in EPO serum concentrations and urinary EPO isoelectric profiles, respectively.     

Landing techniques in volleyball

Abstract

Knee injuries such as anterior cruciate ligament lesions and patellar tendonitis are very frequent in volleyball, and are often attributed to micro traumas that occur during the landing phase of airborne actions. The aim of the present study was to compare different jumping activities during official men's and women's volleyball games. Twelve top-level matches from the Italian men's and women's professional leagues were analysed. The jumps performed during the games were classified according to the landing technique used by the player (left or right foot or both feet together), court position, and ball trajectory. Chi-square analyses were performed to detect differences in landing techniques between the sexes, court positions, and trajectories when serving, attacking, blocking, and setting. Significant differences (P < 0.05) were found between the sexes for block, set, and spike but not for the jump serve. The frequency of landings on one foot was related to court position and the trajectory of the sets: when spiking faster sets, the players were more likely to use a one-footed landing. The present results should help coaches and physiotherapists to devise appropriate training and prevention programmes, and reveal the need for further detailed biomechanical investigations of the relationships between landings and knee injuries.     

Reflexiones sobre el lenguaje autista. I.—Análisis descrpitivos y diferencias con la disfasia receptiva

Resumen

En este articulo, se revisan las descripciones clínicas y los estudios sistemáticos que tratan de establecer los rasgos que definen al lenguaje de los autistas cuando se les compara con el dé los sujetos normales o con otras clases de alteraciones. En la última parte de él, se analizan especialmente las semejanzas y diferencias entre el lenguaje autista y el de los niños con disfasia receptiva del desarrollo y anlizaremos la llamada «tesis de continuidad», que concibe el autismo como una especie de disfasia receptiva grave. En un trabajo posterior, se analizarán más específicamente algunas de las alteraciones más características del lenguaje de los autistas (p.e. ecolalia, inversión pronominal, problemas de comprensión) y se discutirán sus anomalías y retrasos en relación con los distintos componentes (fonológico, morfosintáctico, léxico, etc.) en que puede analizarse el lenguaje.     

Clase social y situación dentro de la fratria: Interacción y efectos sobre el desarrollo del individuo

Resumen

En este estudio se analiza la influencia de la clase social, el número de hermanos y el orden de nacimiento sobre una serie de variables cognitivas y de rendimiento escolar.

Se ha realizado la investigación sobre una muestra de 507 alumnos de 1° de E.G.B., pertenecientes a los Centros Públicos de Valladolid y provincia. Las variables de rendimiento escolar se evaluaron a través de la opinión del profesor. La valoración, en cambio, de las cognitivas se realizó por medio de pruebas estandarizadas. Dentro de los efectos principales, y dejando aparte las diferencias marcadas por el medio social, obviamente esperadas, destacamos una fuerte influencia del orden de nacimiento sobre prácticamente todas las variables dependientes. Su interacción con la variable socio cultural es el resultado más destacable del presente trabajo. Dedujimos como hipótesis explicativa las diferentes pautas culturales que propician o no la estabilidad de los patrones educativos familiares.     

Comparative study of the evaluation of professional competencies by experienced and trainee Spanish primary teachers

Taking as reference the proposals of the European Higher Education Area, the aim of this study is to identify the competencies which a wide sample of teachers in Spanish primary schools (6–12 age group) consider to be important for their professional performance and which they use in their everyday teaching, and to what extent their university training prepared them for their practising professional development. To do this, an ad hoc instrument was devised and applied to experienced practising teachers and to teacher trainees who were on teacher training placements during the last semester of their course. The results of the study show that initial teacher training should deal in depth with the competencies related to the organisation and management of teaching–learning, the use of new technologies in the primary classroom, the involvement of the families, education in values, social skills and skills for working in professional groups. Finally, proposals are made for training based on the articulation between theory and practice, to allow the professional competencies mentioned to be developed and used in practice, as well as encouraging close collaboration between teacher trainers and experienced practising teachers.     

Hacia un lenguaje gráfico en la enseñanza

En este trabajo se parte del supuesto de que el uso de recursos gráficos, además de ser positivo, está creciendo continuamente en la enseñanza. Con el fin de facilitar la utilización de recursos gráficos en la realización de transparencias, mapas mentales, mapas conceptuales, resúmenes, etc., se proponen unas reglas básicas que constituyen en sí mismas un lenguaje gráfico     

Munchausen by proxy: a case, chart series, and literature review of older victims

The history of an older child victim of Munchausen by proxy (MBP) is described. He was referred for evaluation after repeated sinus surgeries for recurrent sinus infections believed to be related to a falsified history of an immunodeficiency. The perpetrator was the mother of this 14-year-old victim, consistent with the majority of such cases. This case prompted a review of cases of MBP in older children reported in our hospital as well as a literature search for other cases in older children. METHODS: This study was a chart review of children over 6 years of age who had been evaluated by social services at the Children's Hospital at the Cleveland Clinic and reported as cases of Munchausen by proxy to Child Protective Services between January 2001 and June 2003. Also, an OVID, Psychline, and Pubmed literature review of published cases of Munchausen by proxy were identified, and cases occurring in the older child were selected for review. RESULTS: Older children who are the victims of Munchausen by proxy may have an induced illness, but falsified reports of symptoms and medical history to coerce the child to undergo medical procedures may be more common. Collusion of the victim with the perpetrator may also become a factor as the child ages and adopts the deception. Given the complex relationship that exists between the parent and child, it is difficult to predict whether the victim either will assist the caregiver in maintaining the factitious illness or be able to recognize the falsification. CONCLUSIONS: Older children who are the victims of Munchausen by proxy may fear consequences of revealing the factitious illness. Physicians must consider the possibility of this diagnosis whenever there are discrepancies in a child's illness that makes a factitious illness a consideration.     

Empirical Research on Ethnic Minority Students: 1995–2009

Ethnic minority disproportionality has been a topic of extensive discussion and research for many years. In 1997, Artiles, Trent, and Kuan conducted a seminal review of the special education research literature to identify how often researchers report and disaggregate data in ways that would support conclusions about specific ethnic minority groups. These authors found alarmingly low rates of publication on identifiable minority groups. The purpose of this review is to replicate the work of Artiles et al. and extend this literature analysis to the subsequent 15‐year period (1995–2009). We found increases in the proportion of articles reporting ethnic minority information 15 years following the Artiles et al. publication. Discussion focuses on the gap in our knowledge of evidence‐based practices for ethnic minority students in special education.     

Glenohumeral internal rotation deficit in table tennis players

ABSTRACT

Table tennis requires rapid and extreme movements that may result in shoulder adaptations, such as glenohumeral internal rotation deficit, which is a risk factor for several injuries. This study compared range of motion of internal and external rotation and total rotation motion of glenohumeral joint between dominant and non-dominant shoulders of table tennis players. This is a cross-sectional observational study. Twenty healthy male table tennis players that were enrolled in an official table tennis league took part in this study (mean age: 22.9 ± 12.9 years, time of sports practice: 6.2 ± 7.12 years). Measurements of passive glenohumeral external rotation and internal rotation were taken with the individuals in the supine and sidelying positions. Total rotation motion was calculated by summing external and internal rotations. The dominant side showed decreased internal rotation when compared to non-dominant side in both supine (mean difference: 14.9°, p = 0.02) and sidelying positions (mean difference: 16.3°, p = 0.01). No significant difference (p > 0.05) was found for external rotation and total rotation motion between dominant and non-dominant shoulders. The findings indicate that table tennis players exhibit glenohumeral internal rotation deficit of dominant shoulder.