Role of Oncofetal Protein CR-1 as a Potential Tumor Marker for Oral Squamous Cell Carcinoma

Cripto-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancer, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Late detection, associated with increased morbidity and mortality, is mainly attributed to non-availability of a suitable biomarker for the disease. In the present pilot study, we have evaluated the role of soluble CR-1, in serum as a potential tumor marker for OSCC. CR-1 was estimated using sandwich ELISA in serum samples of 50 biopsy proven OSCC patients (pre and post treatment) along with age and gender matched healthy controls. Immunohistochemistry was also done in corresponding tumor tissue sections to check the expression of CR-1. Pre-treatment CR-1 was found to be 2.25-fold higher in serum of OSCC patients as compared to control (p < 0.0001***), which was reduced to 1.6 folds post treatment (p = 0.0006***). CR-1 levels were comparatively higher in early stage of disease. Upon IHC 80% of the cases were found to be positive for CR-1. This study provides evidence that serum levels of CR-1 are elevated in patients of Oral Squamous Cell Carcinoma, which decrease post treatment. Also, the association of expression of protein with tumor progression predicts CR-1 as a molecule that can be further evaluated as a potential tumor maker in OSCC.     

Commitment in the Context of a Merger

The University of Eastern Finland was established through a merger at the beginning of the year 2010. The article focuses on the commitment of the personnel to the organization prior to and after the merger process. The data are based on 42 theme-interviews. The study discusses the merger and its impacts on the personnel’s commitment by analysing: (a) the interviews with members of staff, and (b) key intentions, messages and choices by the university management. The differences between the orientations and viewpoints of the personnel and university management will be discussed in relation to the changing operational environment of universities. Implications for the leadership in the context of a merger will be discussed, especially from the point of view of the impact of leadership and governance on research, teaching and learning.     

The model of pre-acculturative stress—A pre-migration study of potential migrants from Russia to Finland

This study tested a model of factors predicting pre-acculturative stress among potential migrants from Russia to Finland prior to their migration (N = 244). By applying the theory of stress (Lazarus & Folkman, 1984), the model of acculturative stress (e.g., Berry, 2006) and the expectations model (e.g., [Black, 1992] and [Black et al., 1992]) to the pre-acculturation stage, it was hypothesized that the potential migrants’ pre-acculturative stress is a result of expectations about future (post-migration) adaptation. These expectations are developed through direct and indirect pre-migration contacts with, as well as knowledge about, the society of immigration. Three types of expectations during the pre-acculturation stage were studied: expected difficulties in socio-cultural adaptation, expected duration of adaptation, and expected discrimination. In line with the hypotheses, experiences of pre-acculturative stress clearly originated from the expectations that potential migrants had regarding their upcoming post-migration adaptation. Also, socioeconomic status, gender, general well-being, self-efficacy, perceived social support, and length of the pre-acculturation stage played important roles in predicting expectations and/or stress among the potential migrants. The study highlights that pre-acculturation is a complex process that begins at the pre-migration stage. It contributes to our understanding of pre-acculturation in general, as well as the factors affecting the formation of pre-acculturative stress among voluntary ethnic migrants.     

A multidimensional adapted process model of teaching

Educational Assessment, Evaluation and Accountability - In the present study, we aimed to specify the key competence domains perceived to be critical for the teaching profession and depict them as...     

Effect of herbal hypoglycemic agents on oxidative stress and antioxidant status in diabetic rats

In the present study the antioxidative potential ofMomordica charantia, Azadirachta indica, Allium sativum andOcimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude thatM. charantia, A. indica, A. sativum andO. sanctum are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.     

Financial autonomy and challenges to being a regionally responsive higher education institution

Abstract

This paper discusses some current problems and challenges of the Finnish AMKs (polytechnic institutions), and whether financial autonomy could contribute to finding solutions for some of these problems. It provides an overview of the current status of financial autonomy of polytechnics in 6 European countries, and finally attempts to find links from financial autonomy to the AMKs’ role as regional ‘boosters’. The AMKs are still faced with some administrative and cultural traditions related more or less to secondary level vocational institutions. The new Polytechnic Act (2003), 351/2003, guarantees self‐governance for the AMKs as regards with their internal issues. At the same time, the Act stipulates that budget power and strategic steering belongs to their public or private maintainers. This raises the question of to what extent institutions actually are autonomous. The essence of autonomy rests on independent decision‐making processes. The study shows that the Finnish maintenance system reflects strongly on the area of financial autonomy compared with the similar institutions in other European countries. Financial autonomy may be a factor that strengthens a higher education institution in becoming an organisationally uniform, responsive and flexible entity.     

Parent-Child Similarity in Environmental Attitudes: A Pairwise Comparison

Are adolescents’ environmental attitudes similar to their parents’ attitudes? The main objective of this study is to examine what quantitative associations, if any, exist in parent-child environmental attitudes within the family. The survey data was collected assessing attitudes toward the environment and nature from 15-year-old students (n = 237) and their parents (n = 212) in Finland. A significant positive correlation emerged in environmental attitudes between mothers and fathers. Interestingly, the results revealed some indicative evidence that girls’ environmental attitudes could relate more to their father's than mother's attitudes. Girls were as positive in their environmental attitudes as their parents and in contrast boys were noticeably more negative than either their parents or girls of the same age. The parental level of education was not found to be significantly related to the level of environmental attitudes of their adolescent offspring. Implications of these findings are discussed.     

Evaluating university-industry collaboration: the European Foundation of Quality Management excellence model-based evaluation of university-industry collaboration

Tertiary Education and Management - The growth in university-industry collaboration has resulted in an increasing demand for methods to evaluate it. This paper presents one way to evaluate an...