Granite desalination using electromigration. Influence of type of granite and saline contaminant

We describe the results of electromigration desalination of two soluble salt-contaminated Galician granites. The efficacy of electromigration, which had not been previously applied to granite, was assessed for two types of granite contaminated with a 20% NaCl solution and seawater. Desalination effectiveness was evaluated as follows: (1) analysis of anode and cathode ion content during testing; (2) analysis of ions at different distances from the electrodes after testing; (3) pH assessment of the stone surfaces; and (4) evaluation of colour changes. Results were very satisfactory; by the end of testing, chloride was reduced by almost 100% in both the NaCl and seawater contaminated samples. Sulfate reduction was also significant, despite this ion's lower mobility. The granite pH values remained close to neutral and colour changes were minimal. The difference in effectiveness of the process for the two types of stone was associated with their dissimilar pore structure.     

Rapid determination of erythrocyte sedimentation rate (ESR) by an electrically driven blood droplet biosensor

In healthcare practice, the sedimentation rate of red blood cells (erythrocytes) is a widely used clinical parameter for screening of several ailments such as stroke, infectious diseases, and malignancy. In a traditional pathological setting, the total time taken for evaluating this parameter varies typically from 1 to 2 h. Furthermore, the volume of human blood to be drawn for each test, following a gold standard laboratory technique (alternatively known as the Westergren method), varies from 4 to 5 ml. Circumventing the above constraints, here we propose a rapid (∼1 min) and highly energy efficient method for the simultaneous determination of hematocrit and erythrocyte sedimentation rate (ESR) on a microfluidic chip, deploying electrically driven spreading of a tiny drop of blood sample (∼8 μl). Our unique approach estimates these parameters by correlating the same with the time taken by the droplet to spread over a given radius, reproducing the results from more elaborate laboratory settings to a satisfactory extent. Our novel methodology is equally applicable for determining higher ranges of ESR such as high concentration of bilirubin and samples corresponding to patients with anemia and patients with some severe inflammation. Furthermore, the minimal fabrication steps involved in the process, along with the rapidity and inexpensiveness of the test, render the suitability of the strategy in extreme point-of-care settings.     

Problem Solving, Contention, and Struggle: How Siblings Resolve a Conflict of Interests

In a laboratory setting, 48 sibling dyads age 4 and 6 or 6 and 8 years negotiated the division of six toys. Findings revealed that, in general, children reached divisions while using a preponderance of constructive problem-solving strategies, rather than contentious tactics. The degree of conflict of interests and the quality of sibling relationships predicted the children's use of problem-solving and contentious negotiation strategies, and was related to the types of resolutions achieved. Dyads experiencing low conflict of interests resolved their differences quickly. High conflict of interests coupled with positive relationships and constructive negotiation resulted in longer negotiations and creative, agreeable resolutions. High conflict of interests coupled with more negative relationships and destructive negotiations resulted in children's failures to reach agreement. Developmental differences indicated that older siblings within the pairs took the lead in negotiation, and benefited slightly more from the divisions. Furthermore, children in older dyads were more sophisticated and other oriented in their negotiations.     

Nonlinear growth curves in developmental research

Developmentalists are often interested in understanding change processes, and growth models are the most common analytic tool for examining such processes. Nonlinear growth curves are especially valuable to developmentalists because the defining characteristics of the growth process such as initial levels, rates of change during growth spurts, and asymptotic levels can be estimated. A variety of growth models are described beginning with the linear growth model and moving to nonlinear models of varying complexity. A detailed discussion of nonlinear models is provided, highlighting the added insights into complex developmental processes associated with their use. A collection of growth models are fit to repeated measures of height from participants of the Berkeley Growth and Guidance Studies from early childhood through adulthood.     

Microfluidic wet spinning of chitosan-alginate microfibers and encapsulation of HepG2 cells in fibers

The successful encapsulation of human hepatocellular carcinoma (HepG2) cells would greatly assist a broad range of applications in tissue engineering. Due to the harsh conditions during standard chitosan fiber fabrication processes, encapsulation of HepG2 cells in chitosan fibers has been challenging. Here, we describe the successful wet-spinning of chitosan-alginate fibers using a coaxial flow microfluidic chip. We determined the optimal mixing conditions for generating chitosan-alginate fibers, including a 1:5 ratio of 2% (w∕w) water-soluble chitosan (WSC) solution to 2% (w∕w) alginate solution. Ratio including higher than 2% (w∕w) WSC solution increased aggregation throughout the mixture. By suspending cells in the WSC-alginate solution, we successfully fabricated HepG2 cell-laden fibers. The encapsulated HepG2 cells in the chitosan-alginate fibers were more viable than cells encapsulated in pure alginate fibers, suggesting that cross-linked chitosan provides a better environment for HepG2 cells than alginate alone. In addition, we found that the adhesion of HepG2 cells on the chitosan-alginate fiber is much better than that on the alginate fibers.     

Switching intentions in the context of open-source software movement: The paradox of choice

Education and Information Technologies - Open-source software movement presents a viable alternative to commercial operating systems. Linux-based operating systems are freely available and a...     

A meta-analysis of maturation-related variation in adolescent boy athletes’ adaptations to short-term resistance training

This meta-analysis investigated the maturation-related pattern of adaptations to resistance training in boy athletes. We included studies examining the effects of 4–16-week resistance training programmes in healthy boy athletes aged 10–18 years. Pooled estimates of effect size for change in strength across all studies (n = 19) were calculated using the inverse–variance random effects model for meta-analyses. Estimates were also calculated for groups based on likely biological maturity status (“before”, “during” and “after” peak height velocity). Using the standardised mean difference, resistance training increased strength across all groups (effect size = 0.98, [CI: 0.70–1.27]). Strength gains were larger during (1.11 [0.67–1.54]) and after (1.01 [0.56–1.46]) peak height velocity than before (0.5 [?0.06–1.07]). Adaptations to resistance training are greater in adolescent boys during or after peak height velocity. These findings should help coaches to optimise the timing of training programmes that are designed to improve strength in boy athletes.     

A Theory of Questions and Question Asking

This article focuses on knowledge goals, that is, the goals of a reasoner to acquire or reorganize knowledge. Knowledge goals, often expressed as questions, arise when the reasoner's model of the domain is inadequate in some reasoning situation. This leads the reasoner to focus on the knowledge it needs, to formulate questions to acquire this knowledge, and to learn by pursuing its questions. I develop a theory of questions and of question asking, motivated both by cognitive and computational considerations, and I discuss the theory in the context of the task of story understanding. I present a computer model of an active reader that learns about novel domains by reading newspaper stories.     

Agents control in intelligent learning systems: The case of reactive characteristics

Intelligent learning systems (ILSs) have evolved in the last few years basically because of influences received from multi-agent architectures (MAs). Conflict resolution among agents has been a very important problem for multi-agent systems, with specific features in the case of ILSs. The literature shows that ILSs with cognitive or pedagogical agents are prone to arbitration methods, where as ILSs with reactive agents are much in favor of control mechanisms. For these kind of systems, different control types are proposed based on the different stimuli that these agents will receive. These stimuli are aspects to be evaluated during the teaching/learning process such as: (1) error analysis, (2) learning styles, (3) analogies, (4) social aspects, etc.

The paper reviews several ILSs, related to our work; different control mechanisms are proposed to solve the agents' intervention conflicts. Finally, the use of several mechanisms is exemplified by the results of a specific ILS.