Role of HAMP Genetic Variants on Pathophysiology of Iron Deficiency Anemia

Hepcidin is a 25-amino acid peptide hormone produced by hepatocytes and plays a key role in body iron metabolism. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemia, and its excess is associated with anemia of inflammation, chronic disease and iron deficiency anemia (IDA). The aims of this study was to evaluate HAMP gene mutation, namely IVS2 + 1(–G) (c.148–150 + 1del) and Gly71 Asp (c.212G > A (rs104894696) association with iron status in IDA conditions. Our study participants were 500 IDA patients and 550 age and sex-matched healthy controls. Hepcidin, ferritin and CRP analysis was done by ELISA method while ESR analysis was done according to Wintrobe method. CBC analysis was done by auto-analyzer. Two mutations in the HAMP genes were analysed by PCR RFLP method. Among the IDA patients, 7 were heterozygous for Met50del IVS2 + 1(–G) mutation. Nine IDA patients were heterozygous for G71D G–A mutation and homozygous were not identified in both mutations.Controls were showing heterozygous frequency 1.8 and 2.1% of Met50del IVS2 + 1(–G) and G71D G–A mutations respectively. Mutation of HAMP (Met50del IVS2 + 1(–G) and G71D G–A) were clinically associated with IDA and act as modulator of disease.     

Trends in private higher education in Australia

The last decade has witnessed a significant growth of private higher education around the world. The growth included the number of private education providers, and also the growing number of students. While some countries are experiencing trend growth, others are witnessing decline. Some of the reasons for the decline include increased regulation and stringent accreditation and reaccreditation of higher education institutions and courses, government policies to encourage the growth of public universities, and acquisition of small providers by large private education institutions. The growth of private higher education has increased competition, and it has also established collaboration with public institutions. The growth of private higher education has also raised concerns about ethical governance, maintenance of academic standards, and mechanisms to plan, review, and improve educational outcomes. This paper focuses on Australia where despite growth, there is limited research about private higher education. This paper reviews literature on the global growth and decline of private higher education. It then analyses the trends in Australia and possible scenarios for the future of private higher education in the country.     

Equal Opportunity Issues in the Context of the National Curriculum: a black perspective

This article examines the context and content of the National Curriculum documentation published so far within the framework of educational debates on the education of black children (black referring to non‐white). In particular it focuses on the interpretation of equal opportunities, the proposed strategies for implementation within the National Curriculum, and the prospects for success because of the other changes brought about by the 1988 Education Reform Act (ERA). The main conclusion is that in some respects more appears to have been achieved than would have seemed possible in the early stages of the debates relating to ERA; on the other hand, there is a probability that an education system that provides true equal opportunities for groups and individuals currently being denied that will remain more of a hope than a reality. The article concludes that equality of opportunity is still a long way off, especially from a black perspective.     

Goodbye conflict, hello development? Curriculum reform in Timor-Leste

Motivations to reform curriculum in post-conflict, or post-colonial states are often driven by the need to (re) construct a cohesive and publicly legitimated national identity that is starkly different to that which existed prior. This paper explores the context behind such action in the Timor-Leste (East Timor) and some challenges which policy makers and citizens have wrestled with in developing and implementing the country's first post-independence primary curriculum. The author argues that specific aspects of this new curriculum have effectively alienated and/or divided large segments of its population, despite a desire for the reforms to result in a more inclusive, democratic and distinctly “Timorese” educational system. The assertion is that the desire to institute change rapidly after independence has in fact hampered the ability of the reforms to constructively serve the political and social project of nation building. The paper cautions that education's role in promoting human development, and reducing the triggers of conflict in this country hang in the balance as long as this new curriculum fails to deliver on its aspirations.     

US news magazine images of black‐Asian American relationships, 1980–1992

During the past 20 years, primarily Latinos and Asians have immigranted to these shores and settled in urban areas. Media sources assert that this influx created particularly problematic relations between blacks and Asian Americans. Using Frame theory and textual analysis, we explored the images newsmagazines produced of this relationship. We found that one frame predominated: the nature of group relations had to do with each group's “essential”; qualities. Within this frame there also appeared four media packages: 1) the nature of the urban space, 2) the role of culture in the quality of relationships, 3) the essential qualities of urban residents and 4) the preeminence of class over race. Analysis of black‐Asian American relationships, while not strictly hegemonic, rarely deviated from accepted critiques. The nature of the coverage constrained understanding to personal shortcomings, while poverty and racial strife were rarely associated with historical and structural factors.     

The Impact of Quality on Satisfaction,Revenue, and Cost as Perceived by Providers of Higher Education

Researchers have found a strong relationship between improvements in quality and satisfaction, revenue, and cost. However, no study to date investigates the same for higher education. This study investigates whether institutions of higher education have implemented quality improvement programs, and if so, if the results are similar to what has been observed with firms in the private sector. The study proposes and tests five hypotheses, and findings support four of the five hypotheses, with partial support for the fifth hypothesis. The study finds that implementing quality programs leads to an increase in satisfaction among constituent groups, increase in revenue, and a reduction in costs. The findings also show that increased satisfaction (due to improved quality) also leads to increase in revenue and reduction in costs.     

Glimpses of a century-old story

The story of Agrobacterium has been widely discussed for over a century. Fridiano Cavara in 1897 first described the occurrence of plant-derived tumors with bacterial origin. Detailed molecular analysis of this microbe accelerated in the last 30 years and it gained worldwide acceptance as a ‘natural genetic engineering tool’. This tool has an interesting history starting from the tumors that it makes, nomenclature, genome, pathogenicity and DNA transfer, to its economic importance. This review is a glimpse of some basic and interesting facts of the unique Agrobacterium.     

Private for-profit higher education in Australia: widening access,participation and opportunities for public-private collaboration

Private for-profit higher education has grown rapidly in many parts of the world. This growth is attributed to many factors, including a broadening of the student population and the recognition that wider access to higher education will be economically beneficial to individuals, governments and society as a whole. In Australia, the number of students in private for-profit higher education is rising, with dramatic projections for the next 10 years. The Australian government has set a target to increase the participation of students in higher education, with a focus on increasing the access and success of students from disadvantaged backgrounds. It is unclear, however, what role the burgeoning private for-profit institutions will play in meeting the government's targets, and what incentives will be provided for them to increase the access and participation of students from disadvantaged groups. This paper analyses the key drivers of growth in private for-profit higher education in Australia, and discusses issues around quality and standards. It examines the strengths and limitations of the sector, and the extent to which it contributes to diversity, access and the participation of students from disadvantaged backgrounds. It argues that the sector needs clear government directions to improve levels of access, and new government policies to encourage public-private collaborations to help ensure sustainability. The paper also briefly touches on the need for a review into the current structure of Australia's higher education sector as a whole, and whether higher education would benefit from the formation of public community colleges with the explicit aim of widening access for disadvantaged student groups. Further, the paper suggests that encouraging such public-private collaboration may be beneficial to ensure access and participation of students from all walks of life, including disadvantaged groups.     

New age adjuvants and delivery systems for subunit vaccines

The dramatic advancements in the field of vaccinology has led to the formulation of chemically well defined vaccines composed of synthetic peptides and recombinant proteins derived from the immunologically dominant regions of the pathogens. Though these subunit vaccines are safer compared to the traditional vaccines they are known to be poorly immunogenic. This necessitates the use of adjuvants to enhance the immunogenicity of these vaccine formulations. The most common adjuvant for human use is alum. Research in the past has focused on the development of systemic immunity using conventional immunization protocols. In the present are, the emphasis is on the development and formulation of alternative adjuvants and delivery systems in generating systemic as well as mucosal immunity. This review mainly focuses on a variety of adjuvants (particulate as well as non-particulate) used with protective antigens of HIV, malaria, plague, leprosy using modified delivery vehicles. The experience of our laboratory and other researchers in this field clearly proves that these new age adjuvants and delivery systems undoubtedly generate enhanced immune response-both humoral and cell mediated. The choice of antigens, the nature of adjuvant used and the mode of delivery employed have a profound effect on the type of immune response generated. Besides the quantity, the quality of the antibodies generated also play a vital role in protection against these diseases. Some of the adjuvants and delivery systems used promoted high titre and affinity antibodies, which were shown to be cytophilic in nature, an important criteria in providing protection to the host. Thus the studies on these adjuvants/delivery systems with respect to various infectious diseases indicate their active role in efficient modulation of immune response along with safety and permissibility.     

Research agenda for social and collaborative information seeking

Scholars in diverse fields of inquiry have identified the need to expand individual-based information seeking and behavior models and systems to incorporate social as well as collaborative dimensions. However, the research areas of Social Information Seeking (SIS) and Collaborative Information Seeking (CIS) have been largely disconnected from one another despite a few notable attempts to study them under one umbrella. Researchers in these communities have recently realized the value of bringing SIS and CIS together for two main reasons: often it is impossible to separate social and collaborative dimensions in a project; and by considering these two aspects of information seeking, we may be able to support human information behavior in ways not previously possible. A brief synthesis of work in the domains of SIS and CIS is presented here. Then, an integrated view is presented to consider Social and Collaborative Information Seeking (SCIS) as an intersection and extension of SIS and CIS. Benefits of this approach are discussed and the integrated view is used as the basis to present a research agenda that outlines opportunities and challenges unique to SCIS.