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To examine the possible involvement of human B cell leukemia/lymphoma 2 (Bcl-2), CD4+ cells, hepatocyte growth factor (HGF), and metalloproteinase-9 (MMP-9), as biomarkers in early diagnosis of hepatocellular carcinoma (HCC), activities of these biomarkers in serum were demonstrated by the method of Enzyme Linked Immunosorbant Assay. Two groups of subjects (60 for each), were examined in this study; healthy controls and patients with HCC. The present results declare that, significant decrease in Bcl-2 (p ≤ 0.0001), and CD 4+ (p ≤ 0.001), while significant increase in HGF and MMP-9 (p ≤ 0.05). These findings imply an influence of these biomarkers by the existence of hepatic carcinoma that might reflect the progression of disease and a distinction between the pathological mechanisms involved in hepatic carcinoma. Since, the serum MMP-9 activity was significantly varied between each stage of HCC. An individual profile of the present investigated parameters was detected that might serve as an easy accessing serum marker to monitor the progression of hepatic cell disorders.  相似文献   
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This study examined the teaching styles of online instructors at Florida's 28 community colleges in an effort to determine if the instructors had adopted the learner–centered model touted in the literature. The Principles of Adult Learning Scale was the primary instrument used to collect data from 292 online instructors. The study revealed that nearly half of the participants (n?=?135) scored in the middle range, with 84% (n?=?244) of the participants’ scores falling into the teacher-centered range. Although online distance education does have the potential to transition education from a teacher-centered orientation to a more student-centered orientation, continued efforts are needed to accomplish this shift.  相似文献   
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There has been significant technological advancement in the game of tennis over the past two decades. In particular, tennis rackets have changed in size, shape and material composition. The effects of these changes on ball rebound speed have been well documented, but few studies have considered the effects on ball angular velocity. The purpose of this study was to investigate the effects of three factors on post-impact ball spin. Tennis balls were projected at three velocities toward a clamped racket simulating three levels of stiffness and strung at three string tensions. The angular velocity of each tennis ball was measured from stroboscopic images during an oblique impact with the racket. A three-way factorial ANOVA revealed significant (P < 0.01) differences in the post-impact angular velocity for string tension, racket stiffness and impact velocity, as well as two-way interactions between string tension and impact velocity, and between racket stiffness and impact velocity. The possibility of tangential elastic strain energy being stored in the racket and ball was evident in low impact velocity trials. These displayed a post-impact angular velocity where the circumference of the ball was translating faster than the relative velocity between the ball’s centre of mass and the string surface. It was concluded that increasing the relative impact velocity between the racket and ball was the best means of increasing the post-impact angular velocity of the tennis ball.  相似文献   
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The way students experience higher education in today's world is rapidly changing, and students have the choice to earn their college degree in a number of non-traditional ways. Library services also need to transform to meet the needs of all students regardless of how they experience higher education. The following article outlines how library circulation and document delivery services can be provided to distance education students. Two institutions' services are compared: the distance education circulation services offered at the Leatherby Libraries at Chapman University and the equivalent services at the Ottenheimer Library at University of Arkansas at Little Rock. This case study provides examples of how document delivery and interlibrary loan can fill the resource needs of distance education patrons.  相似文献   
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艾拜都拉·易卜拉欣的历史小说以民族、集体为单位,反映了丰富的社会生活,在某种意义上已有"史诗"的整体性模式。他历史小说的"史诗性"特征体现在英雄人物的典型化塑造、所写社会生活的广度和深度、对历史必然性的理性把握和本质开拓等方面。另外,作家在补正史之阙的写作目的上表现出了史传模式的一些特征。这种融入史传模式一些特征的史诗模式的产生跟维吾尔民族的历史文学传统、历史记载方法、文学观以及维吾尔族人民还保持和崇尚"集体主义"的社会风貌有着密切的关系。  相似文献   
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This paper reports the results of a four-week questionnaire survey carried out at the National Lending Library (N.L.L.), Great Britian, to discover which types of organizations were the principal users of medical literature, what types of literature were used, and which were the main sources of references to medical publications. Industrial organizations and universities accounted for the majority (62 percent) of the loans, most of which were English-language periodicals published since 1960. For the whole sample, citation lists in periodical articles were the principal sources of references, although for literature published in the last fifteen months, abstracting and indexing journals were the main sources. Of the latter, Index Medicus proved to be the most fruitful source of references. By asking whether the item requested was really useful to their work, a measure of the reliability of the different sources of references was obtained.Appendixes include the questionnaire, a list of the most frequently borrowed journals, and a list of abstracting and indexing journals used as sources of references.  相似文献   
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